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Search Results: 1 - 10 of 127684 matches for " Li-Tzu Li "
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Structural and Functional Analyses of Five Conserved Positively Charged Residues in the L1 and N-Terminal DNA Binding Motifs of Archaeal RadA Protein
Li-Tzu Chen, Tzu-Ping Ko, Yu-Wei Chang, Kuei-An Lin, Andrew H.-J. Wang, Ting-Fang Wang
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0000858
Abstract: RecA family proteins engage in an ATP-dependent DNA strand exchange reaction that includes a ssDNA nucleoprotein helical filament and a homologous dsDNA sequence. In spite of more than 20 years of efforts, the molecular mechanism of homology pairing and strand exchange is still not fully understood. Here we report a crystal structure of Sulfolobus solfataricus RadA overwound right-handed filament with three monomers per helical pitch. This structure reveals conformational details of the first ssDNA binding disordered loop (denoted L1 motif) and the dsDNA binding N-terminal domain (NTD). L1 and NTD together form an outwardly open palm structure on the outer surface of the helical filament. Inside this palm structure, five conserved basic amino acid residues (K27, K60, R117, R223 and R229) surround a 25 ? pocket that is wide enough to accommodate anionic ssDNA, dsDNA or both. Biochemical analyses demonstrate that these five positively charged residues are essential for DNA binding and for RadA-catalyzed D-loop formation. We suggest that the overwound right-handed RadA filament represents a functional conformation in the homology search and pairing reaction. A new structural model is proposed for the homologous interactions between a RadA-ssDNA nucleoprotein filament and its dsDNA target.
CSE1L/CAS, the cellular apoptosis susceptibility protein, enhances invasion and metastasis but not proliferation of cancer cells
Ching-Fong Liao, Shue-Fen Luo, Li-Tzu Li, Chuang-Yu Lin, Ying-Chun Chen, Ming-Chung Jiang
Journal of Experimental & Clinical Cancer Research , 2008, DOI: 10.1186/1756-9966-27-15
Abstract: We enhanced or reduced CAS expression by transfecting CAS or anti-CAS expression vectors into human MCF-7 breast cancer cells. The proliferations of cells were determined by trypan blue exclusion assay and flow cytometry analysis. Invasion of cancer cells were determined by matrigel-based invasion assay.Our studies showed that increased CAS expression was unable to enhance cancer cell proliferation. Immunofluorescence showed CAS was distributed in cytoplasm areas near cell membrane and cell protrusions. CAS was localized in cytoplasmic vesicle and immunogold electronmicroscopy showed CAS was located in vesicle membrane. CAS overexpression enhanced matrix metalloproteinase-2 (MMP-2) secretion and cancer cell invasion. Animal experiments showed CAS reduction inhibited the metastasis of B16-F10 melanoma cells by 56% in C57BL/6 mice.Our results indicate that CAS increases the invasion but not the proliferation of cancer cells. Thus, CAS plus ECM-degradation proteinases may be used as the markers for predicting the advance of tumour metastasis.The cellular apoptosis susceptibility (CAS) protein is highly expressed in various cancers including melanomas, lymphomas, breast cancers, hepatomas, ovarian carcinomas, endometrial carcinomas, and colorectal cancers [1-8]. Also, the expression of CAS is correlated positively with high stage and high-grade cancers as well as worse outcome of the cancer patients [1-8]. Thus, CAS may play an important role in regulating cancer development and progression.CAS is the human homologue of the yeast chromosome segregation gene, CSE1 [9]. CAS is associated with microtubules and mitotic spindles, the cellular organelles for cell cycle mitosis division; hence CAS is speculated to play a role in cell proliferation and is regarded as a proliferation-associated protein [1,10]. Consequently, many pathological studies demonstrated that the expression of CAS in tumors is related with tumor proliferation in cancer development [2-5]; although there i
Using Hydraulic Engineering Model Experiment to Study the Sediment Trapping Efficiency of Adjustable Check Dam  [PDF]
Shu-Tzu Chen, Hung-Ming Shu, Shin-En Chiu, Chung-Li Hsu
Engineering (ENG) , 2016, DOI: 10.4236/eng.2016.87044
Abstract: The construction of fully closed check dam (CD) is a conventional flood prevention mechanism implemented on rivers. Fully closed CDs trap large amounts of sediments in rivers to stabilize the river slopes and control erosion. However, fully closed CDs cannot selectively trap sediment and may easily overflow, causing them to losing their ability to mediate and hold sediments. Previous studies proposed the concept of “breathable CDs”. The researcher introduced metal slit dam (SD) that could be assembled and disassembled quickly and conveniently. Once a CD reaches maximum capacity, operators must ensure that the water channels of the dam are free from blockage. Moreover, they must inspect the internal accumulation conditions of the dam periodically or immediately following heavy typhoon rains. When necessary, either the sediment buildup in the upriver blockage must be cleared, or the transverse structure of the dam must be removed to allow fine particles to be discharged along with a moderate amount of water. These actions can free up the sediment-storing capacity of the dam for the next heavy typhoon rains. In addition, operators should also inspect the damages inflicted on the dam, such as erosion, wear and tear, and deformation conditions. Damaged components should be disassembled and repaired if possible, or recycled and reused. The present study performed channel tests to simulate closed CDs, SDs, steel pipe dam (SPDs), and steel pipe plus slit dam (SPSDs) for 50-year and 100-year frequency floods. Results were then analyzed to determine the sediment trapping (ST) effects of various CDs, the effects of “adjustable CDs”, and the changes of moderated riverbeds.
A Systematic Review of Single Chinese Herbs for Alzheimer's Disease Treatment
Li-Min Fu,Ju-Tzu Li
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep136
Abstract: The objectives here are to provide a systematic review of the current evidence concerning the use of Chinese herbs in the treatment of Alzheimer's disease (AD) and to understand their mechanisms of action with respect to the pathophysiology of the disease. AD, characterized microscopically by deposition of amyloid plaques and formation of neurofibrillary tangles in the brain, has become the most common cause of senile dementia. The limitations of western medications have led us to explore herbal medicine. In particular, many Chinese herbs have demonstrated some interesting therapeutic properties. The following databases were searched from their inception: MEDLINE (PUBMED), ALT HEALTH WATCH (EBSCO), CINAH and Cochrane Central. Only single Chinese herbs are included. Two reviewers independently extracted the data and performed quality assessment. The quality assessment of a clinical trial is based on the Jadad criteria. Seven Chinese herbs and six randomized controlled clinical trials were identified under the predefined criteria. Ginkgo biloba, Huperzine A (Lycopodium serratum) and Ginseng have been assessed for their clinical efficacy with limited favorable evidence. No serious adverse events were reported. Chinese herbs show promise in the treatment of AD in terms of their cognitive benefits and more importantly, their mechanisms of action that deal with the fundamental pathophysiology of the disease. However, the current evidence in support of their use is inconclusive or inadequate. Future research should place emphasis on herbs that can treat the root of the disease.
The Suitability of Typhoon Disaster Reconstruction Work Planning—A Case of Meizuolyu Stream in Taitung County  [PDF]
Shu-Tzu Chen, Hung-Ming Shu, Shin-Yi Dai, Jie-Ming Huang, Chung-Li Hsu
Engineering (ENG) , 2015, DOI: 10.4236/eng.2015.75021
Abstract: Due to effects of succession typhoons and heavy rainfall, central government often invests the funds within shortest time of contingency promptly after disaster occurring to handle the planning and design project of taking precautions against natural disaster. Because the time limit of design project operating so generally were planned without many detail investigations, it was necessary to probe into the project effect and reconstruction security behind constructed. In this study, we choose the Meizuolyu stream watershed in Taitung County of eastern Taiwan as the research area to realize the situation and effect of setting up the control work reconstructions by inspecting, surveying and according to hydrology analysis and topography measured, and combined to carry on hydrology mathematical calculations. We adopted HEC-RAS software to make hydrology mathematical calculations, used the result to examine whether the position of each construction was proper, and finally submitted the complete of mend suggestion. The study concluded that no matter how urgent governance was, application of appropriate scientific tools to checklist designed could avoid the mistakes of the generation.
The Linkage between Imported Energy and Trade in Taiwan
Jin-Li Hu,Tzu-Pu Chang,Fang-Yu Yeh,Tzu-Cheng Yang
ISRN Economics , 2012, DOI: 10.5402/2012/816964
The Linkage between Imported Energy and Trade in Taiwan
Jin-Li Hu,Tzu-Pu Chang,Fang-Yu Yeh,Tzu-Cheng Yang
ISRN Economics , 2012, DOI: 10.5402/2012/816964
Abstract: This study examines the Granger causality between Taiwan's aggregate and disaggregate energy consumption and trade variables, including total imports (IM), total exports (EX), total energy consumption (ENERGY), oil and petroleum products consumption (OIL), coal and coal products consumption (COAL), natural gas consumption (GAS), export value of the industrial sector (EX_I), export value of heavy-chemical industrial products (EX_HI), and export value of non-heavy-chemical industrial products (EX_NHI) with monthly data during 1998–2009. Via applying Hsiao's version of the Granger causality method, the results find causality running from ENERGY to IM, EX, EX_I, and EX_HI. The impulse-response simulations show that the above relations have positive responses at the initial period. OIL Granger causes all trade variables. The impulse directions to IM and EX_NHI are negative, whereas others are positive. On the other hand, COAL responds to impulses in all trade variables. The impulse-response simulations show that these relations have positive responses at the initial period except for causality running from EX_HI and EX_NHI to COAL. GAS positively responds to impulses in EX, EX_I, and EX_HI at the initial period. The bidirectional Granger causality between pairs of variables (such as GAS and EX_NHI as well as GAS and EX_HI) is found. 1. Introduction The 1973 energy crisis prompted countries all over the world to see the importance of energy to national security as well as economic development. Moreover, greenhouse gases produced by energy consumption have had drastic impacts on global climate change, attracting attention and efforts under the UN Framework Convention on Climate Change. Since domestic energy sources in Taiwan are scarce, Taiwan’s dependence on imported energy was rated up at 99.34% in 2008 [1]. The cost of imported energy accounts for 11.31% of Taiwan’s GDP [2]. Total energy consumption has grown greatly over the past two decades, going from 48.04 million kiloliters of oil equivalent (KLOE) in 1989 to 113.09 million kiloliters in 2009, which is an average annual growth of 4.41% (Table 1) [3]. In the face of a constant rise in energy prices, the heavy cost of imported energy impacts not only household expenditures, but also the country’s overall economic growth [4, 5]. As international energy prices skyrocket, they raise the production costs for energy-consuming industries and hence directly reduce firms’ profit margins and production. Table 1: Total domestic energy consumption quantity and growth rate. Taiwan’s primary imported energy resources
Higgs Boson Decays into Single Photon plus Unparticle
Cheung, Kingman;Li, Chong Sheng;Yuan, Tzu-Chiang
High Energy Physics - Phenomenology , 2007, DOI: 10.1103/PhysRevD.77.097701
Abstract: The decay of the standard model Higgs boson into a single photon and a vector unparticle through a one-loop process is studied. For an intermediate mass Higgs boson, this single photon plus unparticle mode can have a branching ratio comparable with the two-photon discovery mode. The emitted photon has a continuous energy spectrum encoding the nature of the recoil unparticle. It can be measured in precision studies of the Higgs boson after its discovery.
New Cryptanalysis of an ID-based Password Authentication Scheme using Smart Cards and Fingerprints
International Journal of Engineering Science and Technology , 2010,
Abstract: In 2002, Lee, Ryu and Yoo proposed a fingerprint-based remote user authentication scheme using a smart card. Their scheme would strengthen system security by verifying the smart card owner’s fingerprint. In 2003, Kim, Lee and Yoo proposed two ID-based password authentication schemes without passwords or verification tables,with smart card and fingerprints. The proposed nonce-based and timestamp-based schemes can withstand message replay attacks. In addition, the schemes can withstand impersonation attack. In this paper, we will first review Kim et al.’s ID-based password authentication schemes. Next, we will show that Kim et al.’s scheme still has the disadvantage of being vulnerable to impersonation attack.
Jin-Li Hu,Hsiang-Tzu Wan,Hang Zhu
Australian Journal of Business and Management Research , 2011,
Abstract: This study defines Shanzhai mobile phone (ShanzhaiGi) as an indigenous innovation product supported by a group of value chain suppliers that provide good-enough products by charging reasonable prices in a rapid time frame to fulfill the needs of target customers. Through examining the business model of Shanzhai mobile phone firms, we find that the value created by them is to provide products that benefit the countryside people so that everyone can get connected. Moreover, ShanzhaiGi offers more features than premium international brands to fulfill the market demand of the masses. Shanzhai mobile phone firms capture values, sales revenues, and market shares through cost control by utilizing Shanzhai’s value chain suppliers and innovative channel management. While contrasting the business model of Tianyu (as the ‘King of Shanzhai’) with other market leaders (Nokia and Samsung), we find that the market leaders have a relatively more developed business model than Tianyu. Therefore, Tianyu should further enhance its segment, value chain relationship, and competitive strategy
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