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Search Results: 1 - 10 of 159986 matches for " Li-Qin Zhao "
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3′,7′,7′-Trimethyl-1′-phenyl-5′,6′,7′,8′-tetrahydrospiro[indoline-3,4′-(1H,4H-pyrazolo[3,4-b]chromene)]-2,5′-dione
Li-Qin Zhao,Bin Li,Yi-Qun Li
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810045253
Abstract: The title spirooxindole compound, C26H23N3O3, was prepared by the reaction of isatin, 3-methyl-1-phenyl-2-pyrazolin-5-one and 5,5-dimethylcyclohexane-1,3-dione in an ethanol solution. The fused cyclohexene ring adopts an envelope conformation. The dihedral angle between the aromatic and pyrazoline rings is 23.70 (8)°. An intramolecular C—H...O interaction occurs. The crystal structure is stabilized by N—H...N hydrogen-bonding interactions, leading to a zigzag chain along the b axis.
Liver and spleen volume variations in patients with hepatic fibrosis
Peng Liu, Peng Li, Wen He, Li-Qin Zhao
World Journal of Gastroenterology , 2009,
Abstract: AIM: To study the liver and spleen volume variations in hepatic fibrosis patients at different histopathological stages.METHODS: Multidetector computed tomography (MDCT) scan was performed in 85 hepatic fibrosis patients. Liver volume (LV) and spleen volume (SV) were measured. Fifteen healthy individuals served as a control group (S0). The patients were divided into stage 1 (S1) group (n = 34), stage 2 (S2) group (n = 25), stage 3 (S3) group (n = 16), and stage 4 (S4) group (n = 10) according to their histopathological stage of liver fibrosis.RESULTS: The LV and standard LV(SLV)had a tendency to increase with the severity of fibrosis, but no statistical difference was observed in the 5 groups (LV: F = 0.245, P = 0.912; SLV: F = 1.902, P = 0.116). The SV was gradually increased with the severity of fibrosis, and a statistically significant difference in SV was observed among the 5 groups (P < 0.01). The LV/SV ratio and SLV/SV ratio were gradually decreased with the aggravation of hepatic fibrosis, and statistically significant differences in both LV/SV and SLV/SV were found among the 5 groups (P < 0.01).CONCLUSION: The absence of obvious LV reduction in patients with chronic liver disease may be a morphological index of patients without liver cirrhosis. The SV is related to the severity of fibrosis, and the spleen of patients with advanced fibrosis is enlarged evidently. The LV/SV ratio and SLV/SV ratio are of a significant clinical value in the diagnosis of advanced liver fibrosis.
Necessary and Sufficient Conditions for the Global Weak Attractivity and Global Attractivity of a Class of Nonlinear Differential Equations
一类微分方程零解全局弱吸引和全局吸引到充要条件

ZHAO Li-qin,
赵丽琴

数学物理学报(A辑) , 2009,
Abstract: 考虑二阶微分方程 x =φ(y)-F(x),y=- g(x)q(y) 零解的全局弱吸引和全局吸引性, 说明了Filippov条件(A2) 不能排除最大椭圆扇形S* 的存在性, 也不能排除 S* 作为其外侧邻域轨线正向极限集的可能. 全面回答了文献8]末提出的问题;得到了方程(E)满足或不满足Filippov 条件时零解全局弱吸引和全局吸引的一系列充分必要条件, 同时也得到了零解全局渐近稳定的一些新条件.
Characteristics of paraesophageal varices: A study with 64-row multidetector computed tomography portal venography
Li-Qin Zhao, Wen He, Guang Chen
World Journal of Gastroenterology , 2008,
Abstract: AIM: To identify the characteristics of morphology, location and collateral circulation involved in paraesophageal varices (para-EV) of portal hypertension patients with 64-row multidetector computed tomography (MDCT).METHODS: Fifty-two of 501 patients with portal hypertensive cirrhosis accompanied with esophageal varices were selected for 64-row MDCT examination after the observation of para-EV. The CT protocol included unenhanced, arterial and portal phases with a slice thickness of 0.625 mm and a scanning field of 2 cm above the bifurcation to the lower edge of kidney. The CT portal venography (CTPV) was reformatted on AW4.3 workstation. The characteristics of origination, location, morphology and collateral circulation in para-EV were observed.RESULTS: Among the 52 cases of para-EV, 50 showed the originations from the posterior branch of left gastric vein, while the others from the anterior branch. Fifty cases demonstrated their locations close to the esophageal-gastric junction, and the other two cases were extended to the inferior bifurcation of the trachea. The circuitous pattern was observed in 16 cases, while reticulated pattern was seen in 36 cases. Collateral circulation identified 4 cases of single periesophageal varices (peri-EV) communication, 3 cases of single hemiazygous vein, one case of single inferior vena cava, 41 cases of mixed type (collateral communications of at least 2 of above mentioned types) and 3 cases of undetermined communications. Among all the cases, 43 patients showed the communications between para-EV and peri-EV, while hemiazygous vein (43 cases) and inferior vena cava (5 cases) were also involved.CONCLUSION: Sixty-four-row multidetector computed tomography portal venography could display the location, morphology, origin, and collateral types of para-EV, which provides important and referable information for clinical management and disease prognosis.
64-row multidetector computed tomography portal venography of gastric variceal collateral circulation
Li-Qin Zhao, Wen He, Ming Ji, Peng Liu, Peng Li
World Journal of Gastroenterology , 2010,
Abstract: AIM: To study characteristics of collateral circulation of gastric varices (GVs) with 64-row multidetector computer tomography portal venography (MDCTPV).METHODS: 64-row MDCTPV with a slice thickness of 0.625 mm and a scanning field from 2 cm above the tracheal bifurcation to the lower edge of the kidney was performed in 86 patients with GVS diagnosed by endoscopy. The computed tomography protocol included unenhanced, arterial and portal vein phases. The MDCTPV was performed on an AW4.3 workstation. GVs were classified into three types according to Sarin’s Classification. The afferent and efferent veins of each type of GV were observed.RESULTS: The afferent venous drainage originated mostly from the left gastric vein alone (LGV) (28/86, 32.59%), or the LGV more than the posterior gastric vein/short gastric vein [LGV > posterior gastric vein/short gastric vein (PGV/SGV)] (22/86, 25.58%), as seen by MDCTPV. The most common efferent venous drainage was via the azygos vein to the superior vena cava (53/86, 61.63%), or via the gastric/splenorenal shunt (37/86, 43.02%) or inferior phrenic vein (8/86, 9.30%) to the inferior vena cava. In patients with gastroesophageal varices type 1, the afferent venous drainage of GV mainly originated from the LGV or LGV > PGV/SGV (43/48, 89.58%), and the efferent venous drainage was mainly via the azygos vein to the super vena cava (43/48, 89.58%), as well as via the gastric/splenorenal shunt (8/48, 16.67%) or inferior phrenic vein (3/48, 6.25%) to the inferior vena cava. In patients with gastroesophageal varices type 2, the afferent venous drainage of the GV mostly came from the PGV/SGV more than the LGV (PGV/SGV > LGV) (8/16, 50%), and the efferent venous drainage was via the azygos vein (10/16, 62.50%) and gastric/splenorenal shunt (9/16, 56.25%). In patients with isolated gastric varices, the main afferent venous drainage was via the PGV/SGV alone (16/22, 72.73%), and the efferent venous drainage was mainly via the gastric/splenorenal shunt (20/22, 90.91%), as well as the inferior phrenic vein (3/23) to the inferior vena cava.CONCLUSION: MDCTPV can clearly display the afferent and efferent veins of all types of GV, and it could provide useful reference information for the clinical management of GV bleeding.
Computed tomography perfusion in evaluating the therapeutic effect of transarterial chemoembolization for hepatocellular carcinoma
Guang Chen, Da-Qing Ma, Wen He, Bao-Feng Zhang, Li-Qin Zhao
World Journal of Gastroenterology , 2008,
Abstract: AIM: To prospectively assess the changes in parameters of computed tomography (CT) perfusion pre- and post-transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) in different treatment response groups, and to correlate the changes with various responses of HCC to TACE.METHODS: Thirty-nine HCC patients underwent CT perfusion examinations pre-(1 d before TACE) and post-treatment (4 wk after TACE). The response evaluation criteria for solid tumors (RECIST) were referred to when treatment responses were distributed. Wilcoxon-signed ranks test was used to compare the differences in CT perfusion parameters pre- and post-TACE for different response groups.RESULTS: Only one case had treatment response to CR and the CT perfusion maps of post-treatment lesion displayed complete absence of signals. In the PR treatment response group, hepatic artery perfusion (HAP), hepatic arterial fracture (HAF) and hepatic blood volume (HBV) of viable tumors post-TACE were reduced compared with pre-TACE (P = 0.001, 0.030 and 0.001, respectively). In the SD group, all CT perfusion parameters were not significantly different pre- and post-TACE. In the PD group, HAP, HAF, portal vein perfusion (PVP) and hepatic blood flow (HBF) of viable tumors post-TACE were significantly increased compared with pre-TACE (P = 0.005, 0.012, 0.035 and 0.005, respectively).CONCLUSION: Changes in CT perfusion parameters of viable tumors are correlated with different responses of HCC to TACE. Therefore, CT perfusion imaging is a feasible technique for monitoring response of HCC to TACE.
Controllable Preparation of Quasi-monodispersed Spherical Titania Particles
XIANG Li-Qin,YIN Jian-Bo,GAO Wen-Shuai,ZHAO Xiao-Peng
无机材料学报 , 2007, DOI: 10.3724/sp.j.1077.2007.00253
Abstract: Quasi-monodispersed spherical titania particles with variable sizes were prepared by the sol-gel synthesis with the addition of surfactant. The particles were characterized by the scanning electron microscope, transmission electron microscope, X-ray diffraction and nitrogen absorption. The influence of surfactant of ODA, Span-80, F-127 and PEG with various molecular weight on the morphology, the size, and the size distribution of particles was investigated respectively.The research results show that the steric hindrance of surfactant is very important to morphology, size and size distribution of titania particles. Perfect spherical particles can be obtained when the steric hindrance of surfactant is big enough. Nitrogen absorption measurements reveal that titania particles synthesized by addition of F-127 or PEG-20000 possess meso-pore structure, and the pore diameter is about 3.4nm and 2.6nm, respectively.
Combining Automatic Tube Current Modulation with Adaptive Statistical Iterative Reconstruction for Low-Dose Chest CT Screening
Jiang-Hong Chen, Er-Hu Jin, Wen He, Li-Qin Zhao
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0092414
Abstract: Objective To reduce radiation dose while maintaining image quality in low-dose chest computed tomography (CT) by combining adaptive statistical iterative reconstruction (ASIR) and automatic tube current modulation (ATCM). Methods Patients undergoing cancer screening (n = 200) were subjected to 64-slice multidetector chest CT scanning with ASIR and ATCM. Patients were divided into groups 1, 2, 3, and 4 (n = 50 each), with a noise index (NI) of 15, 20, 30, and 40, respectively. Each image set was reconstructed with 4 ASIR levels (0% ASIR, 30% ASIR, 50% ASIR, and 80% ASIR) in each group. Two radiologists assessed subjective image noise, image artifacts, and visibility of the anatomical structures. Objective image noise and signal-to-noise ratio (SNR) were measured, and effective dose (ED) was recorded. Results Increased NI was associated with increased subjective and objective image noise results (P<0.001), and SNR decreased with increasing NI (P<0.001). These values improved with increased ASIR levels (P<0.001). Images from all 4 groups were clinically diagnosable. Images with NI = 30 and 50% ASIR had average subjective image noise scores and nearly average anatomical structure visibility scores, with a mean objective image noise of 23.42 HU. The EDs for groups 1, 2, 3 and 4 were 2.79±1.17, 1.69±0.59, 0.74±0.29, and 0.37±0.22 mSv, respectively. Compared to group 1 (NI = 15), the ED reductions were 39.43%, 73.48%, and 86.74% for groups 2, 3, and 4, respectively. Conclusions Using NI = 30 with 50% ASIR in the chest CT protocol, we obtained average or above-average image quality but a reduced ED.
MOLECULAR DOCKING FOR IN STRUCTURE-BASED DRUG DESIGNING
分子对接在基于结构药物设计中的应用

ZHAO Li-qin,XIAO Jun-hai,LI Song,
赵丽琴
,肖军海,李松

生物物理学报 , 2002,
Abstract: Molecu lar docking serves as a method to simulate the interactions of two molecu les (such as ligand and receptor) and to predict their binding mode a nd affinity. In recent years, molecular docking has emerged as an imp ortant technology in the field of computer-aided drug research, includi ng database searching, combinatorial library design and protein-protein interaction investigation.
Effect of Coherence on Radiation Forces acting on a Rayleigh Dielectric Sphere
Li-Gang Wang,Cheng-Liang Zhao,Li-Qin Wang,Xuan-Hui Lu,Shi-Yao Zhu
Physics , 2006, DOI: 10.1364/OL.32.001393
Abstract: The radiation forces on a Rayleigh dielectric sphere induced by a partially coherent light beam are greatly affected by the coherence of the light beam. The magnitude of the radiation forces on a dielectric sphere near the focus point greatly decreases as the coherence decreases. For the light beam with good coherence, the radiation force may be used to trap a particle; and for the light beam with intermediate coherence, the radiation force may be used to guide and accelerate a particle.
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