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Search Results: 1 - 10 of 127067 matches for " Li XD "
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Birth Defects Data from Surveillance Hospitals in Hubei Province, China, 200l - 2008
Lh Tu,H Li,Hp Zhang,Xd Li
Iranian Journal of Public Health , 2012,
Abstract: Background: To determine the prevalence and characteristics of birth defects in perinatal infants in Hubei Province during 200l-2008.Methods: The prevalence of birth defects in perinatal infants delivered after 28 weeks or more was analyzed in Hubei surveillance hospitals during 200l-2008.Results: The incidence of birth defects in perinatal infants from 200l to 2008 was 120.0 per 10,000 births, and was increased by about 41% from 81. 1 in 2001 to 138.5 per 10,000 births in 2008. The incidence in the first 4 years (2005-2008) was much higher than the latter four (2001-2004) (χ2=77.64 , P <0.05). The difference in prevalence between urban and rural was of no significance in 2008 (χ2=0.03,P >0.05), but that between male and female was significant (χ2=5.24 , P <0.05), as the former prevalence was much higher. The prevalence of birth defects was slightly higher among mothers over 35 years old than those under 35 years old, but with no significance (χ2=1.98, P >0.05). The two leading birth defects were cleft lip and/or palate and polydactyly, followed by congenital heart disease, hydrocephaly, external ear malformation and neural tube defects. The prevalence of congenital heart disease was rising.Conclusions: Eight years birth defects data indicate that the birth defect rate was on the rise and the birth defects prevalence in Hubei province should be valued.
Isolation and characterization of Rhodococcus ruber CGMCC3090 that hydrolyzes aliphatic, aromatic and heterocyclic nitriles
J Zhang, M Wang, H Sun, XD Li, LP Zhong
African Journal of Biotechnology , 2009,
Abstract: A bacterial strain was isolated from soil samples that had been polluted by nitrile compounds. This strain converts acrylonitrile to acrylamide with high activity. The nitrile hydrolysis activity was tested using eight substrates, including aliphatic, aromatic and heterocyclic (di)nitriles. All of the nitrile compounds were hydrolyzed by the resting cells. The main (cyano-)amide products demonstrated that nitrile hydratase was abundantly produced in this strain and that it mediated monohydrolysis. The specific conversion rate decreased in the following order: acrylonitrile > 3-cyanopyridine > valeronitrile > adiponitrile > 2,3,4,5,6-pentafluorobenzonitrile > -hydroxyphenylacetonitrile > 3-indoleaceto-nitrile > phthalonitrile, suggesting a higher conversion capability towards aliphatic nitriles. The strain that had broad substrate spectra was identified and named Rhodococcus ruber CGMCC3090 based on the 16S rDNA sequence.
Improved biocompatibility of novel poly(L-lactic acid)/ -tricalcium phosphate scaffolds prepared by an organic solvent-free method
Zhao XF, Li XD, Kang YQ, Yuan Q
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S20743
Abstract: oved biocompatibility of novel poly(L-lactic acid)/ -tricalcium phosphate scaffolds prepared by an organic solvent-free method Original Research (2895) Total Article Views Authors: Zhao XF, Li XD, Kang YQ, Yuan Q Published Date July 2011 Volume 2011:6 Pages 1385 - 1390 DOI: http://dx.doi.org/10.2147/IJN.S20743 Xue-Feng Zhao1,2, Xiao-Dong Li3, Yun-Qing Kang4, Quan Yuan1,2 1State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, People's Republic of China; 2West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; 3Affiliated Hospital of Stomatology and College of Stomatology, Chongqing Medical University, Chongqing, People's Republic of China; 4College of Materials Science and Engineering, Sichuan University, Chengdu, People's Republic of China Abstract: A porous poly(L-lactic acid)/ -tricalcium phosphate (PLLA/ -TCP) composite scaffold was fabricated using a novel technique comprising powder mixing, compression molding, low-temperature treatment, and particulate leaching without any organic solvent. The effect of this scaffold on osteoblast proliferation and differentiation was evaluated in vitro. The fabricated scaffold had a homogeneously interconnected porous structure with a porosity of 70% and compressive strength of 1.35 MPa. The methylthiazol tetrazolium values and alkaline phosphatase (ALP) activity of osteoblasts seeded on the solvent-free scaffold were significant higher than those of the control. Using real-time PCR, gene expressions of ALP, osteocalcin, and type 1 collagen were shown to be upregulated. As the method does not use any organic solvent, it eliminates problems associated with organic solvent residue and therefore improves the cell compatibility. It has a promising potential for the preparation of porous scaffold for bone tissue engineering.
A Simple Method to Synthesize Cadmium Hydroxide Nanobelts
Zhang DE,Pan XD,Zhu H,Li SZ
Nanoscale Research Letters , 2008,
Abstract: Cd(OH)2nanobelts have been synthesized in high yield by a convenient polyol method for the first time. XRD, XPS, FESEM, and TEM were used to characterize the product, which revealed that the product consisted of belt-like crystals about 40 nm in thickness and length up to several hundreds of micrometers. Studies found that the viscosity of the solvent has important influence on the morphology of the final products. The optical absorption spectrum indicates that the Cd(OH)2nanobelts have a direct band gap of 4.45 eV.
Improved biocompatibility of novel poly(L-lactic acid)/ß-tricalcium phosphate scaffolds prepared by an organic solvent-free method
Zhao XF,Li XD,Kang YQ,Yuan Q
International Journal of Nanomedicine , 2011,
Abstract: Xue-Feng Zhao1,2, Xiao-Dong Li3, Yun-Qing Kang4, Quan Yuan1,21State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, People's Republic of China; 2West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; 3Affiliated Hospital of Stomatology and College of Stomatology, Chongqing Medical University, Chongqing, People's Republic of China; 4College of Materials Science and Engineering, Sichuan University, Chengdu, People's Republic of ChinaAbstract: A porous poly(L-lactic acid)/ -tricalcium phosphate (PLLA/ -TCP) composite scaffold was fabricated using a novel technique comprising powder mixing, compression molding, low-temperature treatment, and particulate leaching without any organic solvent. The effect of this scaffold on osteoblast proliferation and differentiation was evaluated in vitro. The fabricated scaffold had a homogeneously interconnected porous structure with a porosity of 70% and compressive strength of 1.35 MPa. The methylthiazol tetrazolium values and alkaline phosphatase (ALP) activity of osteoblasts seeded on the solvent-free scaffold were significant higher than those of the control. Using real-time PCR, gene expressions of ALP, osteocalcin, and type 1 collagen were shown to be upregulated. As the method does not use any organic solvent, it eliminates problems associated with organic solvent residue and therefore improves the cell compatibility. It has a promising potential for the preparation of porous scaffold for bone tissue engineering.Keywords: biocompatibility, biomaterials, composites, poly(L-lactic acid), -tricalcium phosphate
Degradable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer
Li H, Gong M,Yang AP, Ma J, Li XD, Yan YG
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S28978
Abstract: radable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer Original Research (2321) Total Article Views Authors: Li H, Gong M,Yang AP, Ma J, Li XD, Yan YG Published Date March 2012 Volume 2012:7 Pages 1287 - 1295 DOI: http://dx.doi.org/10.2147/IJN.S28978 Received: 08 December 2011 Accepted: 15 January 2012 Published: 08 March 2012 Hong Li1, Min Gong1, Aiping Yang1, Jian Ma2, Xiangde Li3, Yonggang Yan1 1School of Physical Science and Technology, Sichuan University, Chengdu People’s Republic of China; 2Hospital of Stomatology, Tongji University, ShanghaiPeople’s Republic of China; 3Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People’s Republic of China Background and methods: A nano calcium-deficient hydroxyapatite (n-CDHA)-multi(amino acid) copolymer (MAC) composite bone substitute biomaterial was prepared using an in situ polymerization method. The composition, structure, and compressive strength of the composite was characterized, and the in vitro degradability in phosphate-buffered solution and preliminary cell responses to the composite were investigated. Results: The composite comprised n-CDHA and an amide linkage copolymer. The compressive strength of the composite was in the range of 88–129 MPa, varying with the amount of n-CDHA in the MAC (ranging from 10 wt% to 50 wt%). Weight loss from the composite increased (from 32.2 wt% to 44.3 wt%) with increasing n-CDHA content (from 10 wt% to 40 wt%) in the MAC after the composite was soaked in phosphate-buffered solution for 12 weeks. The pH of the soaking medium varied from 6.9 to 7.5. MG-63 cells with an osteogenic phenotype were well adhered and spread on the composite surface. Viability and differentiation increased with time, indicating that the composite had no negative effects on MG-63 cells. Conclusion: The n-CDHA-MAC composite had good cytocompatibility and has potential to be used as a bone substitute.
Biocompatibility of magnetic Fe3O4 nanoparticles and their cytotoxic effect on MCF-7 cells
Chen DZ, Tang QS, Li XD, Zhou XJ, Zang J, Xue WQ, Xiang JY, Guo CQ
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S35140
Abstract: iocompatibility of magnetic Fe3O4 nanoparticles and their cytotoxic effect on MCF-7 cells Original Research (2298) Total Article Views Authors: Chen DZ, Tang QS, Li XD, Zhou XJ, Zang J, Xue WQ, Xiang JY, Guo CQ Published Date September 2012 Volume 2012:7 Pages 4973 - 4982 DOI: http://dx.doi.org/10.2147/IJN.S35140 Received: 19 June 2012 Accepted: 01 August 2012 Published: 14 September 2012 Daozhen Chen,1,3,* Qiusha Tang,2,* Xiangdong Li,3,* Xiaojin Zhou,1 Jia Zang,1 Wen-qun Xue,1 Jing-ying Xiang,1 Cai-qin Guo1 1Central Laboratory, Wuxi Hospital for Matemaland Child Health Care Affiliated Medical School of Nanjing, Jiangsu Province; 2Department of Pathology and Pathophysiology, Medical College, Southeast University, Jiangsu Province; 3The People’s Hospital of Aheqi County, Xinjiang, China *These authors contributed equally to this work Background: The objective of this study was to evaluate the synthesis and biocompatibility of Fe3O4 nanoparticles and investigate their therapeutic effects when combined with magnetic fluid hyperthermia on cultured MCF-7 cancer cells. Methods: Magnetic Fe3O4 nanoparticles were prepared using a coprecipitation method. The appearance, structure, phase composition, functional groups, surface charge, magnetic susceptibility, and release in vitro were characterized by transmission electron microscopy, x-ray diffraction, scanning electron microscopy-energy dispersive x-ray spectroscopy, and a vibrating sample magnetometer. Blood toxicity, in vitro toxicity, and genotoxicity were investigated. Therapeutic effects were evaluated by MTT [3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide] and flow cytometry assays. Results: Transmission electron microscopy revealed that the shapes of the Fe3O4 nanoparticles were approximately spherical, with diameters of about 26.1 ± 5.2 nm. Only the spinel phase was indicated in a comparison of the x-ray diffraction data with Joint Corporation of Powder Diffraction Standards (JCPDS) X-ray powder diffraction files. The O-to-Fe ratio of the Fe3O4 was determined by scanning electron microscopy-energy dispersive x-ray spectroscopy elemental analysis, and approximated pure Fe3O4. The vibrating sample magnetometer hysteresis loop suggested that the Fe3O4 nanoparticles were superparamagnetic at room temperature. MTT experiments showed that the toxicity of the material in mouse fibroblast (L-929) cell lines was between Grade 0 to Grade 1, and that the material lacked hemolysis activity. The acute toxicity (LD50) was 8.39 g/kg. Micronucleus testing showed no genotoxic effects. Pathomorphology and blood biochemistry testing demonstrated that the Fe3O4 nanoparticles had no effect on the main organs and blood biochemistry in a rabbit model. MTT and flow cytometry assays revealed that Fe3O4 nano magnetofluid thermotherapy inhibited MCF-7 cell proliferation, and its inhibitory effect was dose-dependent according to the Fe3O4 nano magnetofluid concentration. Conclusion: The Fe3O4 nanopart
Enhanced oral absorption of 20(S)-protopanaxadiol by self-assembled liquid crystalline nanoparticles containing piperine: in vitro and in vivo studies
Jin X, Zhang ZH, Sun E, Tan XB, Li SL, Cheng XD, You M, Jia XB
International Journal of Nanomedicine , 2013, DOI: http://dx.doi.org/10.2147/IJN.S38203
Abstract: hanced oral absorption of 20(S)-protopanaxadiol by self-assembled liquid crystalline nanoparticles containing piperine: in vitro and in vivo studies Original Research (506) Total Article Views Authors: Jin X, Zhang ZH, Sun E, Tan XB, Li SL, Cheng XD, You M, Jia XB Published Date February 2013 Volume 2013:8 Pages 641 - 652 DOI: http://dx.doi.org/10.2147/IJN.S38203 Received: 17 September 2012 Accepted: 22 October 2012 Published: 13 February 2013 Xin Jin,1,2 Zhen-hai Zhang,1 E Sun,1 Xiao-bin Tan,1 Song-lin Li,3 Xu-dong Cheng,4 Ming You,4 Xiao-bin Jia1 1Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, People's Republic of China; 2College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China; 3Department of Pharmaceutical Analysis and Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, People's Republic of China; 4ALG Bioscience Co, Ltd, Suzhou, People's Republic of China Background: 20(S)-protopanaxadiol (PPD), similar to several other anticancer agents, has low oral absorption and is extensively metabolized. These factors limit the use of PPD for treatment of human diseases. Methods: In this study, we used cubic nanoparticles containing piperine to improve the oral bioavailability of PPD and to enhance its absorption and inhibit its metabolism. Cubic nanoparticles loaded with PPD and piperine were prepared by fragmentation of glyceryl monoolein (GMO)/poloxamer 407 bulk cubic gel and verified using transmission electron microscopy and differential scanning calorimetry. We evaluated the in vitro release of PPD from these nanoparticles and its absorption across the Caco-2 cell monolayer model, and subsequently, we examined the bioavailability and metabolism of PPD and its nanoparticles in vivo. Results: The in vitro release of PPD from these nanoparticles was less than 5% at 12 hours. PPD-cubosome and PPD-cubosome loaded with piperine (molar ratio PPD/piperine, 1:3) increased the apical to basolateral permeability values of PPD across the Caco-2 cell monolayer from 53% to 64%, respectively. In addition, the results of a pharmacokinetic study in rats showed that the relative bioavailabilities of PPD-cubosome [area under concentration–time curve (AUC)0–∞ ] and PPD-cubosome containing piperine (AUC0–∞) compared to that of raw PPD (AUC0–∞) were 166% and 248%, respectively. Conclusion: The increased bioavailability of PPD-cubosome loaded with piperine is due to an increase in absorption and inhibition of metabolism of PPD by cubic nanoparticles containing piperine rather than because of improved release of PPD. The cubic nanoparticles containing piperine may be a promising oral carrier for anticancer drugs with poor oral absorption and that undergo extensive metabolism by cytochrome P450.
Formulation and pharmacokinetic evaluation of a paclitaxel nanosuspension for intravenous delivery
Wang YL, Li XM, Wang LY, Xu YL, Cheng XD, Wei P
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S21097
Abstract: rmulation and pharmacokinetic evaluation of a paclitaxel nanosuspension for intravenous delivery Original Research (5866) Total Article Views Authors: Wang YL, Li XM, Wang LY, Xu YL, Cheng XD, Wei P Published Date July 2011 Volume 2011:6 Pages 1497 - 1507 DOI: http://dx.doi.org/10.2147/IJN.S21097 Yonglu Wang1,4, Xueming Li1,2*, Liyao Wang3, Yuanlong Xu1, Xiaodan Cheng1, Ping Wei4 1College of Pharmacy, Nanjing University of Technology, Nanjing; 2State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing; 3College of Life Science, Anhui Agricultural University, Hefei; 4College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, People’s Republic of China *These authors contributed equally to this work. Abstract: Paclitaxel is a diterpenoid isolated from Taxus brevifolia. It is effective for various cancers, especially ovarian and breast cancer. Due to its aqueous insolubility, it is administered dissolved in ethanol and Cremophor EL (BASF, Ludwigshafen, Germany), which can cause serious allergic reactions. In order to eliminate Cremophor EL, paclitaxel was formulated as a nanosuspension by high-pressure homogenization. The nanosuspension was lyophilized to obtain the dry paclitaxel nanoparticles (average size, 214.4 ± 15.03 nm), which enhanced both the physical and chemical stability of paclitaxel nanoparticles. Paclitaxel dissolution was also enhanced by the nanosuspension. Differential scanning calorimetry showed that the crystallinity of paclitaxel was preserved during the high-pressure homogenization process. The pharmacokinetics and tissue distribution of paclitaxel were compared after intravenous administration of paclitaxel nanosuspension and paclitaxel injection. In rat plasma, paclitaxel nanosuspension exhibited a significantly (P < 0.01) reduced area under the concentration curve (AUC)0–∞ (20.343 ± 9.119 μg · h · mL 1 vs 5.196 ± 1.426 μg · h · mL 1), greater clearance (2.050 ± 0.616 L · kg 1 · h 1 vs 0.556 ± 0.190 L · kg 1 · h 1), and shorter elimination half-life (5.646 ± 2.941 vs 3.774 ± 1.352 hours) compared with the paclitaxel solution. In contrast, the paclitaxel nanosuspension resulted in a significantly greater AUC0–∞ in liver, lung, and spleen (all P < 0.01), but not in heart or kidney.
Corrosion Inhibition of X70 Steel in Saline Solution Saturated With CO2 By Thiourea

XY He,HY Deng,R Li,XD Fei,HY Wang,ZY Deng,

金属学报(英文版) , 2008,
Abstract: Corrosion monitoring techniques were performed on X70 steel in saline solution saturated with CO2 with and without thiourea additives within the concentration range 5-25 mg/L. It was found that when the concentration of the inhibitors were increased, the inhibitor efficiencies(IE) of thiourea varied with solution temperature and immersion time. The results indicated that thiourea had the highest inhibition efficiency. The potentiondynamic polarization studies revealed that thiourea are mixed-type inhibitor that mainly restrains the anodic process.
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