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Search Results: 1 - 10 of 178 matches for " Leonie "
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Slow Gamma Activity of Local Field Potentials (LFP) in the Freely Moving Rat Relates to Movement  [PDF]
Wilfried Dimpfel, Leonie Schombert
Journal of Behavioral and Brain Science (JBBS) , 2015, DOI: 10.4236/jbbs.2015.510040
Abstract: Quantitative assessment of local field potentials by means of Fast Fourier Transformation (FFT) results in the so-called power density spectrum. Within this spectrum particular frequency ranges are defined in order to relate these to behavior. Frequencies above 35 Hz are generally labeled as gamma oscillations, especially as low gamma (40 - 55 Hz) or high gamma (70 - 100 Hz). In order to learn more about this feature, we implanted a set of 4 bipolar concentric steel electrodes in frontal cortex, hippocampus, striatum and midbrain reticular formation of 10 rats. After recovery, field potentials were recorded and wirelessly transmitted to our computer for frequency analysis. At the same time, motion was registered during the whole experimental period of 5.75 hours. Results revealed that low gamma activity only emerged when the animal moved—at least his head. FFT of the data showed—besides other frequencies—a slow gamma activity peaking around 47 Hz pre-dominantly within the striatum, less in frontal cortex and reticular formation and nearly none in the hippocampus. Spectral analysis was performed for single epochs of 4 seconds and all 15 minutes intervals. Correlation analysis of these intervals was done to motion data. All rats showed a highly significant correlation between gamma activity and movement. We therefore conclude from these experiments that this slow gamma activity of the field potentials is not only related to movement, but possibly part of the general neuronal coding of movement.
Gefühlsgemeinschaft“ – Autobiographische Erinnerungen an den BDM und der Erinnerungsdiskurs Community of Feeling—Autobiographical Memories of the BDM and Memory Discourse
Leonie Wagner
querelles-net , 2008,
Abstract: Gisela Miller-Kipp dokumentiert und analysiert 27 Auszüge aus ver ffentlichten Erinnerungen ehemaliger BDM-Mitglieder mit dem Ziel, deren Empfindungen und Gefühle zu rekonstruieren. Dabei sind interessante Einblicke m glich, die jedoch die von der Autorin intendierte Repr sentativit t nicht einl sen (k nnen). Zudem handelt es sich um Erinnerungen und damit um retrospektiv vorgenommene Konstruktionen, die meist noch mit dem Ziel einer Ver ffentlichung aufgeschrieben wurden. Der Band liefert insofern wichtige Anregungen, ist aber in wissenschaftlicher Hinsicht nicht zufriedenstellend. Gisela Miller-Kipp documents and analyzes 27 excerpts from the published memories of former BDM-members with the goal of reconstructing their feelings and perceptions. This approach makes interesting insights possible but it cannot honor the author’s intended representativeness. In addition, because the book is about memories it presents retrospectively collected constructions that were mostly written down after the fact with the goal of publication. The volume therefore provides important perspectives that are not satisfying in a scientific respect.
Sobre o "envelhecimento" dos "novos" movimentos sociais na Alemanha: Reflec es teóricas acerca de crise, paralisia a fim de um modelo exitoso
Wagner, Leonie
Civitas , 2002,
Abstract: Por volta de meados da década de 1970, a opini o pública e a política na República Federal da Alemanha foram surpreendidas pelo surgimento em grande escala de movimentos sociais. Com uma presen a pública inicialmente em constante crescimento e u efeito mobilizador notável, novos atores entraram em cena e chamaram a aten o para problemas sociais e políticos. O texto persegue a pergunta sobre o que resultou desta irrup o surpreendente, poderosa e cheia de imagina o. O desenvolvimento dos movimentos sociais na América Ocidental é discutido dentro do contexto histórico-político e das teorias sobre movimentos sociais. Com isso pretende-se elucidar influências dos movimentos sociais sobre contextos da sociedade e, ao revés, a import ncia da mudan a na sociedade para os movimentos sociais. Depois de uma vis o panoramica sobre "velhos" e "novos" movimentos sociais na Alemanha, s o analisadas as condi es para o desenvolvimento de novos movimentos sociais na Alemanha Ocidental sob o prisma da institucionaliza o, da mudan a nas formas de a o e de fazer política, das tendências à homogeneiza o e individualiza o, assim como da aceita o da diferen a.
Servi o social e movimentos sociais - uma n o-rela o?
Wagner, Leonie
Civitas , 2004,
Abstract:
Modelling the Financial Value of the Maroochy River to Property Values: An Application of Neural Networks  [PDF]
Andrew HIGGINS, Leonie PEARSON, Luis LAREDO
Journal of Water Resource and Protection (JWARP) , 2009, DOI: 10.4236/jwarp.2009.14029
Abstract: The Maroochy River, which is located on east coast of Australia, provides a variety of uses and values to the community. Changes in structure, function and management of the river will influence the value that the community derives from it. Therefore, critical to the river’s continued management is the development of policy relevant tools based on the community’s value of the river. This paper focuses on estimating the fi-nancial value the local residents derive from living close to the river through investigation of changes in residential property values due to attributes of the Maroochy River. It is a complex analysis since there are several confounding geographical and property variables. Given a large and complete dataset of 28,000 properties for the Maroochy region, Artificial Neural Networks (ANN) was applied to estimate the economic value of the properties. This ANN was then able to simulate scenarios for property values with respect to changes in environmental features. It showed the Maroochy River contributed AU$900,000,000 to the unim-proved capital value of the whole region, a value that could not be estimated previously, and much higher than anticipated. Calculating potential annual payments to the Shire Council through land tax analysis from these property values, provides the council with means to justify expenditure to maintain a standard of water quality and ecosystem health.
A population-based model for priority setting across the care continuum and across modalities
Leonie Segal, Duncan Mortimer
Cost Effectiveness and Resource Allocation , 2006, DOI: 10.1186/1478-7547-4-6
Abstract: The key features of the HsW model are i) a disease/health problem framework, ii) a sequential approach to covering the entire health sector, iii) comprehensiveness of scope in identifying intervention options and iv) the use of objective evidence. The HsW model redefines the unit of analysis over which priorities are set to include all mutually exclusive and complementary interventions for the prevention and treatment of each disease/health problem under consideration. The HsW model is therefore incompatible with the fragmented approach to priority setting across multiple program budgets that currently characterises allocation in many health systems. The HsW model employs standard cost-utility analyses and decision-rules with the aim of maximising QALYs contingent upon the global budget constraint for the set of diseases/health problems under consideration. It is recognised that the objective function may include non-health arguments that would imply a departure from simple QALY maximisation and that political constraints frequently limit degrees of freedom. In addressing these broader considerations, the HsW model can be modified to maximise value-weighted QALYs contingent upon the global budget constraint and any political constraints bearing upon allocation decisions.The HsW model has been applied in several contexts, recently to osteoarthritis, that has demonstrated both its practical application and its capacity to derive clear evidenced-based policy recommendations.Comparisons with other approaches to priority setting, such as Programme Budgeting and Marginal Analysis (PBMA) and modality-based cost-effectiveness comparisons, as typified by Australia's Pharmaceutical Benefits Advisory Committee process for the listing of pharmaceuticals for government funding, demonstrate the value added by the HsW model notably in its greater likelihood of contributing to allocative efficiency.The primary task of priority setting is to determine desirable resource shifts – hea
Is the value of a life or life-year saved context specific? Further evidence from a discrete choice experiment
Duncan Mortimer, Leonie Segal
Cost Effectiveness and Resource Allocation , 2008, DOI: 10.1186/1478-7547-6-8
Abstract: Discrete choice experiment to estimate the marginal rate of substitution between cost, effectiveness and various non-health arguments. Odds of selecting profile B over profile A estimated via binary logistic regression. Marginal rates of substitution between attributes (including cost) then derived from estimated regression coefficients.Respondents were more likely to select less costly, more effective interventions with a strong evidence base where the beneficiary did not contribute to their illness. Results also suggest that respondents preferred prevention over cure. Interventions for young children were most preferred, followed by interventions for young adults, then interventions for working age adults and with interventions targeted at the elderly given lowest priority.Results confirm that a trade-off exists between cost, effectiveness and non-health arguments when respondents prioritise health programs. That said, it is true that respondents were more likely to select less costly, more effective interventions – confirming that it is an adjustment to, rather than an outright rejection of, simple health maximisation that is required.A number of recent findings imply that the value of a life saved, life-year (LY) saved or quality-adjusted life year (QALY) saved varies depending on an increasingly diverse set of non-health contextual factors that includes characteristics of the patient and intervention [1]. For example, a number of studies suggest that the value of outcomes varies according to the age or life-stage of recipients [2-5]. These age-based distributive preferences might arise from one of several motivations including capacity to benefit [6-8], interaction between capacity to benefit and net productive contribution to society at different life-stages [9], deviations from a 'fair innings' [10], or 'vicarious utility' associated with an emotive response to saving particular types of people such as children or their parents [11].The significance of such f
Assessing the origin of species in the genomic era
Leonie C Moyle
Genome Biology , 2005, DOI: 10.1186/gb-2005-6-4-217
Abstract: Ever since Darwin laid out overwhelming evidence for the mutability of species, biologists have sought to explain the forces driving the genesis of new species and the genetic changes involved in speciation. Frequently, this goal has been translated into the study of the genetic basis of species differences, especially the genetic causes of inviability or sterility in hybrids between species. Despite creative early approaches to these problems [1], however, classical genetic studies provided insufficient resolution for identifying the specific genomic regions and genes responsible for these traits. It is unsurprising, then, that the field of speciation genetics is being revolutionized by the rapidly expanding availability of genomic tools, techniques, and data, especially in the model speciation systems such as Drosophila. The resulting contemporary studies of the genetics of speciation most frequently involve detailed linkage-mapping analyses of the quantitative trait loci (QTLs) underlying the isolating barriers and hybrid incompatibility between closely related species.By far the most likely, and most explicable, form of speciation occurs when populations diverge from each other while separated by an external barrier to gene flow, such as simple physical distance. Genetic changes can accumulate in these isolated populations, either in response to different environmental pressures or purely through random sampling processes (genetic drift). As a consequence, when diverged populations are brought back into contact, exchange of genes between them is restricted; for example, diverged mating signals may prevent hybridization, or hybrids may be unfit either because of inappropriate genie interactions or because they are phenotypically intermediate and thus ill-suited to either parental environment. Most of the recent QTL mapping approaches have examined species differences and hybrid incompatibility in the context of this model of 'allopatric' speciation (speciation du
Impact of steroid hormone signals on Drosophila cell cycle during development
Nicola Cranna, Leonie Quinn
Cell Division , 2009, DOI: 10.1186/1747-1028-4-3
Abstract: The Drosophila melanogaster imaginal discs provide an ideal model for understanding how developmental signaling pathways control the cell proliferation required for animal growth and development. Imaginal discs develop into the adult head structures (eyes and antenna), appendages (wings and legs) and genitalia. The imaginal disc precursor cells arise early in embryonic development, where they are established and localised as groups of cells in specific regions of the embryo. Each imaginal disc develops from invaginations of the embryonic epithelium and by the early larval stage, consist of a ball of around 10–50 undifferentiated stem cells, which undergo massive growth and proliferation to comprise up to 100,000 cells by the end of the third larval instar. The imaginal discs start differentiation at the end of third instar and complete the process by the end of pupariation, when all adult structures such as the wings, legs and eyes have developed [1]. The third instar larval stage is therefore a critical stage of Drosophila development, containing the major growth and proliferation of all tissues required to form the adult fly [2]. Correct development of adult structures requires coordination of proliferation with the onset of cell differentiation in the imaginal discs.The major developmental hormone in Drosophila, the steroid hormone 20-hydroxyecdysone, commonly known as ecdysone, is secreted from the prothoracic gland (PG) and plays a major role in regulating imaginal disc development. Ecdysone release is controlled by a complex combination of upstream factors, including peptide hormones and neuropeptide signals [3]. For example, Prothoracicotropic hormone (PTTH) from the central nervous system (CNS) is required to regulate the synthesis and release of ecdysone from the PG [4]. Ecdysone pulses are required for all aspects of morphogenesis, starting with the formation of the body plan during late embryogenesis required to develop to first instar larvae and for the
Job Satisfaction of a selected group of hospital dietitians
Leonie E. Van Heernden
South African Journal of Industrial Psychology , 1976, DOI: 10.4102/sajip.v0i0.273
Abstract: Research on the job satisfaction of a selected group of hospital dietitians is reported in an attempt to explain the interrelationship of various aspects contributing to such satisfaction. General job satisfaction, satisfaction with specific aspects of the job and personality profiles of a newly developed Job Factor scale. The study is a further contribution to the understanding of job satisfaction of professional women in a specific work environment - in this case professional dietitians in hospitals. Opsomming Die werkstevredenheid van hospitaaldieetkundiges word ondersoek na aanleiding van die interverwantskap van verskillende aspekte wat tot 'n beter verklaring daarvan kan lei. Die algemene werkstevredenheid, werkstevredenheid met spesifieke aspekte van die werk en persoonlikheidstrekke van dieetkundiges word met bestaande skale en ‘n ontwikkelde meetmiddel ondersoek. Die studie is 'n bydrae tot die verdere verklaring en moontlike bevraagtekening van die werkstevredenheid van professionele vroue in 'n bepaalde werksomgewing - in hierdie geval professionele dieetkundiges in hospitale.
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