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Search Results: 1 - 10 of 6826 matches for " Leonardo Fainboim "
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IL28B SNPs rs12979860 and rs8099917 Are Associated with Inflammatory Response in Argentine Chronic HCV Patients  [PDF]
Andrés Machicote, Diego Flichmann, Eloisa Arana, Silvia Paz, Hugo Fainboim, Leonardo Fainboim, Pablo M. Fernández
International Journal of Clinical Medicine (IJCM) , 2018, DOI: 10.4236/ijcm.2018.92009
Abstract: Background: Hepatitis C virus (HCV) is a major cause of chronic liver disease, including cirrhosis and liver cancer. The aim of our study was to determine whether IL28B single nucleotide polymorphisms (SNPs) rs12979860 and rs8099917 can be considered a prognostic host factor in untreated chronic HCV patients. Methods: We set up a real-time Allele Specific PCR amplification to determine the allele present in each polymorphic site, and statistically grouped and compared this result with clinical data. Results: We determined rs12979860 and rs8099917 genotype and allele frequencies in a single cohort of untreated chronically HCV-infected patients. We found significant associations between higher inflammatory activity, measured as ALT levels or METAVIR scores and rs12979860 CC (P = 0.0013 and P = 0.0033, respectively) and rs8099917 TT (P = 0.0005 and P = 0.0264, respectively) genotypes. Interestingly, considering both genotypes together, we also found association with ALT levels (P = 0.0003; OR = 5.125) or METAVIR scores (P = 0.0038; OR = 5.179), suggesting and additive effect on liver inflammation in these patients. Conclusion: we show association between hepatic inflammatory activity in a single Argentinean untreated chronically HCV cohort and SNPs located in the interferon lambda gene region. The studied polymorphisms, together with further innate and adaptive immune responses, clearly play a role in modulating the HCV infected patients outcome, contributing to hepatic inflammation and possible fibrosis/cirrhosis.
NGcGM3 Ganglioside: A Privileged Target for Cancer Vaccines
Luis E. Fernandez,Mariano R. Gabri,Marcelo D. Guthmann,Roberto E. Gomez,Silvia Gold,Leonardo Fainboim,Daniel E. Gomez,Daniel F. Alonso
Clinical and Developmental Immunology , 2010, DOI: 10.1155/2010/814397
Abstract: Active specific immunotherapy is a promising field in cancer research. N-glycolyl (NGc) gangliosides, and particularly NGcGM3, have received attention as a privileged target for cancer therapy. Many clinical trials have been performed with the anti-NGc-containing gangliosides anti-idiotype monoclonal antibody racotumomab (formerly known as 1E10) and the conjugated NGcGM3/VSSP vaccine for immunotherapy of melanoma, breast, and lung cancer. The present paper examines the role of NGc-gangliosides in tumor biology as well as the available preclinical and clinical data on these vaccine products. A brief discussion on the relevance of prioritization of cancer antigens in vaccine development is also included.
Banco Público de Sangre de Cordón Umbilical: etapa inicial del Programa No Relacionado en Argentina
Gamba,Cecilia; Marcos,María Angélica; Trevani,Hugo; Van der Velde,Juan; Marcos,Cintia Yanina; Theile,Graciela; Ross,Jorge; Zelasko,Marta; Fainboim,Leonardo; del Pozo,Ana Emilia;
Acta bioqu?-mica cl?-nica latinoamericana , 2006,
Abstract: the umbilical cord blood (ucb) is a rich source of hematopoietic progenitor cells (hpc). the unrelated program has been recently established and it has received financial support by the ministry of health to acquire new equipment. this program was aimed at collecting and preserving ucb from altruistic donors. the units are potentially used for allogeneic bone marrow transplantation in those patients who lack a suitable compatible donor. from august 2005 to january 2006 110 donors have been enrolled and 96 units collected. units processed (n=70) yield a mean recovery of 76.4 ± 7.4% of the total nucleated cell (tnc) collected with a final count of 0.8 ± 0.3 x 109 tnc and 2.79 ± 2.57 x 106 cd34+ cells per unit. by hla analysis, those variants common in the argentine population (a68, b3519, dr08) along with the less frequently found alleles were detected. this program will make it possible to increase the availability of units from hispanic-latin american background that are scarce in registries from other countries.
Analysis of Suppressor and Non-Suppressor FOXP3+ T Cells in HIV-1-Infected Patients
Lourdes Arruvito, Juan Sabatté, Julieta Pandolfi, Plácida Baz, Luis A. Billordo, Maria B. Lasala, Horacio Salomón, Jorge Geffner, Leonardo Fainboim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052580
Abstract: Recently, it was shown that peripheral blood FOXP3+CD4+ T cells are composed of three phenotypic and functionally distinct subpopulations. Two of them having in vitro suppressive effects were characterized as resting Treg cells (rTregs) and activated Treg cells (aTregs). A third subset, identified as FOXP3+ non-Tregs, does not display any suppressor activity and produce high levels of Th1 and Th17 cytokines upon stimulation. In the present study we focus on the characteristics of these three subsets of FOXP3+CD4+ T cells in untreated HIV-1-infected patients. We found that the absolute counts of rTregs, aTregs and FOXP3+ non-Tregs were reduced in HIV-1 patients compared with healthy donors. The relative frequency of rTregs and aTregs was similar in HIV-1 patients and healthy donors, while the frequency of FOXP3+ non-Tregs was significantly higher in HIV-1 patients, reaching a maximum in those patients with the lower values of CD4 counts. Contrasting with the observations made in FOXP3- CD4+ T cells, we did not find a negative correlation between the number of rTregs, aTregs or FOXP3+ non-Tregs and virus load. Studies performed with either whole PBMCs or sorted aTregs and FOXP3+ non-Tregs cells showed that these two populations of FOXP3+ T cells were highly permissive to HIV-1 infection. Upon infection, FOXP3+ non-Tregs markedly down-regulates its capacity to produce Th1 and Th17 cytokines, however, they retain the ability to produce substantial amounts of Th2 cytokines. This suggests that FOXP3+ non-Tregs might contribute to the polarization of CD4+ T cells into a Th2 profile, predictive of a poor outcome of HIV-1-infected patients.
NGcGM3 Ganglioside: A Privileged Target for Cancer Vaccines
Luis E. Fernandez,Mariano R. Gabri,Marcelo D. Guthmann,Roberto E. Gomez,Silvia Gold,Leonardo Fainboim,Daniel E. Gomez,Daniel F. Alonso
Journal of Immunology Research , 2010, DOI: 10.1155/2010/814397
Abstract: Active specific immunotherapy is a promising field in cancer research. N-glycolyl (NGc) gangliosides, and particularly NGcGM3, have received attention as a privileged target for cancer therapy. Many clinical trials have been performed with the anti-NGc-containing gangliosides anti-idiotype monoclonal antibody racotumomab (formerly known as 1E10) and the conjugated NGcGM3/VSSP vaccine for immunotherapy of melanoma, breast, and lung cancer. The present paper examines the role of NGc-gangliosides in tumor biology as well as the available preclinical and clinical data on these vaccine products. A brief discussion on the relevance of prioritization of cancer antigens in vaccine development is also included. 1. Ganglioside-Based Cancer Vaccines The field of cancer vaccines definitively changed after April 2010 when the US Food and Drug Administration (FDA) approved Provenge (sipuleucel-T), a vaccine for advanced prostate cancer patients [1]. For the first time sipuleucel-T convincingly increased overall survival by about four months in a randomized Phase III trial conducted in 512 patients. While this immunotherapeutic agent is relatively inconvenient as a personalized vaccine, it seems that selecting the recombinant version of the prostatic acid phosphatase (PAP)—expressed in 95% of prostatic tumor cells—as antigen was critical [2], reaffirming target selection as a key feature in cancer vaccine design. Reasoning in the same way, gangliosides, a broad family of structurally related glycolipids, were firstly suggested as potential targets for cancer immunotherapy [3, 4] based on their higher abundance in tumors when compared with the matched normal tissues. Disappointingly, at the beginning of the present century the failure of the best developed ganglioside-based cancer vaccine for that time, GMK [5], irradiated an unfavorable risky perception to all the projects in the field, even those not related with the target antigen, the GM2 ganglioside. Nevertheless, in these days ganglioside cancer vaccinologists were facing a kind of “polarization” of positions in view of new facts. Eggermont et al. reported an earlier stop of the Phase III GMK vaccine clinical trial in stage II melanoma patients because the Independent Data Monitoring Committee detected an inferior survival rate for the vaccine arm [6]. While difficult to interpret with respect to potential detrimental effects, this result was considered as a significant setback for ganglioside-based specific immunotherapy in melanoma. In the opposite side, a more optimistic outlook of gangliosides as targets for
Immune response to racotumomab in a child with relapsed neuroblastoma
C. Sampor,M. D. Guthmann,L. Fainboim,G. L. Chantada
Frontiers in Oncology , 2012, DOI: 10.3389/fonc.2012.00195
Abstract: Immunotherapy targeting ganglioside antigens is a powerful tool for the treatment of high risk neuroblastoma. However, only treatment with anti-GD2 antibodies has been used in clinical practice and other options may be pursued. We report the use of racotumomab, an anti-idiotype vaccine against N-glycolyl neuraminic acid (NeuGc)- containing gangliosides, eliciting an immune response in a child with relapsed neuroblastoma expressing the NeuGcGM3 ganglioside.
Thermal Soliton Correlation Functions in Theories with a Z(N) Symmetry  [PDF]
Leonardo Mondaini
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.311221
Abstract: We show that the quantum solitons occurring in theories describing a complex scalar field in (1 + 1)-dimensions with a Z(N) symmetry may be identified with sine-Gordon quantum solitons in the phase of this field. Then using both the Euclidean thermal Green function of the two-dimensional free massless scalar field in coordinate space and its dual, we obtain an explicit series expression for the corresponding solitonic correlation function at finite temperature.
The Rise of Solitons in Sine-Gordon Field Theory: From Jacobi Amplitude to Gudermannian Function  [PDF]
Leonardo Mondaini
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.213141
Abstract: We show how the famous soliton solution of the classical sine-Gordon field theory in (1 + 1)-dimensions may be obtained as a particular case of a solution expressed in terms of the Jacobi amplitude, which is the inverse function of the incomplete elliptic integral of the first kind.
Obtaining a New Representation for the Golden Ratio by Solving a Biquadratic Equation  [PDF]
Leonardo Mondaini
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.213134
Abstract: In the present work we show how different ways to solve biquadratic equations can lead us to different representations of its solutions. A particular equation which has the golden ratio and its reciprocal as solutions is shown as an example.
Towards a Field Theoretical Stochastic Model for Description of Tumour Growth  [PDF]
Leonardo Mondaini
Journal of Applied Mathematics and Physics (JAMP) , 2017, DOI: 10.4236/jamp.2017.55095
Abstract: We develop a field theory-inspired stochastic model for description of tumour growth based on an analogy with an SI epidemic model, where the susceptible individuals (S) would represent the healthy cells and the infected ones (I), the cancer cells. From this model, we obtain a curve describing the tumour volume as a function of time, which can be compared to available experimental data.
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