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Search Results: 1 - 10 of 235 matches for " Lene Mellemkjaer "
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Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study
Sharon N Teraoka, Jonine L Bernstein, Anne S Reiner, Robert W Haile, Leslie Bernstein, Charles F Lynch, Kathleen E Malone, Marilyn Stovall, Marinela Capanu, Xiaolin Liang, Susan A Smith, Josyf Mychaleckyj, Xuanlin Hou, Lene Mellemkjaer, John D Boice, Ashley Siniard, David Duggan, Duncan C Thomas, The WECARE Study Collaborative Group, and Patrick Concannon
Breast Cancer Research , 2011, DOI: 10.1186/bcr3057
Abstract: We genotyped 21 SNPs in 708 women with contralateral breast cancer and 1394 women with unilateral breast cancer who serve as the cases and controls in the Women's Environment, Cancer and Radiation Epidemiology (WECARE) Study. Records of treatment and ER status were available for most of WECARE Study participants. Associations of SNP genotypes and risk for contralateral breast cancer were calculated with multivariable adjusted conditional logistic regression methods.Multiple SNPs in the FGFR2 locus were significantly associated with contralateral breast cancer, including rs1219648 (per allele rate ratio (RR) = 1.25, 95%CI = 1.08-1.45). Statistically significant associations with contralateral breast cancer were also observed at rs7313833, near the PTHLH gene (per allele RR = 1.26, 95%CI = 1.08-1.47), rs13387042 (2q35) (per allele RR = 1.19, 95%CI = 1.02-1.37), rs13281615 (8q24) (per allele RR = 1.21, 95%CI = 1.04-1.40), and rs11235127 near TMEM135 (per allele RR = 1.26, 95%CI = 1.04-1.53). The A allele of rs13387042 (2q35) was significantly associated with contralateral breast cancer in ER negative first tumors while the A allele of rs11235127 (near TMEM135) was significantly associated with contralateral breast cancer in ER positive first tumors. Although some SNP genotypes appeared to modify contralateral breast cancer risk with respect to tamoxifen treatment or particular radiation doses, trend tests for such effects were not significant.Our results indicate that some common risk variants associated with primary breast cancer also increase risk for contralateral breast cancer, and that these risks vary with the ER status of the first tumor.Patients with breast cancer are two to five times more likely to develop a second primary cancer in the contralateral breast than are unaffected women to develop an initial breast cancer [1-4]. Established risk factors for asynchronous second primary contralateral breast cancer (CBC) include those suggesting a genetic basis, suc
Predicted Aerobic Capacity of Asthmatic Children: A Research Study from Clinical Origin
Lene Lochte
Pulmonary Medicine , 2012, DOI: 10.1155/2012/854652
Abstract: Objective. To compare longitudinally PAC of asthmatic children against that of healthy controls during ten months. Methods. Twenty-eight asthmatic children aged 7–15 years and 27 matched controls each performed six submaximal exercise tests on treadmill, which included a test of EIA (exercise-induced asthma). Predicted aerobic capacity (mLO2/min/kg) was calculated. Spirometry and development were measured. Physical activity, medication, and “ever asthma/current asthma” were reported by questionnaire. Results. Predicted aerobic capacity of asthmatics was lower than that of controls ( ) across observation times and for both groups an important increase in predicted aerobic capacity according to time was observed ( ). FEV1 of the asthmatic children was within normal range. The majority (86%) of the asthmatics reported pulmonary symptoms to accompany their physical activity. Physical activity (hours per week) showed important effects for the variation in predicted aerobic capacity at baseline ( , ) and at the T4 observation ( , ) and the analyses showed important asthma/control group effects at baseline, month four, and month ten. Physical activity of the asthmatics correlated positively with predicted aerobic capacity. Conclusion. The asthmatic children had consistently low PAC when observed across time. Physical activity was positively associated with PAC in the asthmatics. 1. Introduction Children with asthma often experienced breathlessness during physical activity and therefore tended to avoid vigorous physical activity with disadvantageous consequences to their physical conditioning [1, 2]. There are few paediatric pulmonary conditions in which physical activity has had such potentially harmful effect on patients, not only by limiting exercise capability, but also by acting as a direct stimulus to the underlying pathophysiology [3]. Exercise-induced asthma (EIA) has been recognized as one major manifestation of untreated asthma [4] with physical activity acknowledged as a powerful trigger of asthmatic disease [3, 5]. Physical activity in paediatric asthma has been influenced by physical as well as psychosocial variables. The comprehensive psychosocial variables included attitudes towards exercise. Asthmatic children have demonstrated negative attitudes towards physical activity [6] to be influenced by the limitations that they experienced in safely and unrestrictedly to join physical activities [5]. The cardiopulmonary fitness of asthmatic children was often suboptimal. Some studies revealed lower predicted aerobic capacity (PAC) among asthmatic
Klummen som politisk barometer
Lene Rimestad
Journalistica : Tidskrift f?r Forskning i Journalistik , 2009,
Abstract: Columns generally take up a lot of space in the media. But what can an employed journalist write in his column? How is this particular freedom managed and shaped? In this article the columns written by journalists working for Berlingske Tidende are analyzed. The analysis covers two months before and after substantial changes in the paper in 2003. Two parameters are used in the analysis: Political: Is the column pro-government, anti-government, apolitical or mixed. And what sphere does the column cover: Does the column take place in the private sphere or the public sphere? Finally the changes in the period are discussed. But initially the column as a genre is defined.
At ndre nutiden gennem fortiden – mundtlig historiefort lling i Danmark
Lene Andersen
Kulturstudier , 2010,
Abstract: Mange i dag t nker umiddelbart, at mundtlig fort lling af traditionelle sagn og eventyr mest h rer fortiden til. Men inden for de sidste rtier er der opst et en ny interesse for mundtlig historiefort lling i Danmark. De nye fort llere beretter traditionelle sagn og eventyr, men ogs historier de selv har oplevet eller fundet p , eller historier fra sk nlitter re v rker. Man f r indtryk af, at historiefort lling stadig har en forbindelse til fortiden. De st rste fort llefestivaler finder sted i historiske omgivelser p museer, og nutidens historiefort llere henviser ofte til fort lletraditionens lange historie, n r de taler og skriver om historiefort lling.Hidtil har den nye interesse for historiefort lling ikke v ret genstand for forskning, men artiklen freml gger et studie af historiefort lleres syn p fort lling og fortid. Fokus er, hvilke betydninger begreberne nostalgi og autenticitet har for fort llerne. Artiklen bygger prim rt p interviews med historiefort llere. Fort llerne blev blandt andet bedt om at beskrive, hvordan de umiddelbart forestillede sig, at historiefort lling fandt sted i fortiden. Det er et positivt billede af fortiden, der toner frem, og fort llerne bruger billederne af fortiden som afs t til at kritisere tr k af den moderne levem de. De kritiserer medierne og de elektriske apparater for at g re mennesker passive og del gge deres n rv r med andre levende mennesker. Ved at genoptage - hvad fort llerne opfatter som - en ldgammel og udd d tradition, nsker de at skabe nogle oplevelser, som det moderne menneske savner i vore dages samfund. For fort llerne danner fortiden et idealiseret modbillede til nutiden og rummer dermed mulighed for, at fort llerne kan tale om deres idealer og h b for historiefort lling. Changing the Present through the Past - Oral Story-Telling in Denmark Today, many people spontaneously think that oral transmission of traditional legends and fairy tales are a thing of the past. But in the last few decades a new interest has arisen in Denmark in oral story-telling. The new story-tellers relatetraditional legends and fairy tales, but also adventures that they themselves have experienced or invented, or stories from works of fiction. One has the impressionthat story-telling still has a link to the past. The major story-telling festivalstake place in historical surroundings in museums, and present-day story-tellers frequently point to the long history of the story-telling tradition when they speakor write about story-telling.So far, the new interest in story-telling has not been a subject for research, but the
Intelligent design af fokusgrupper - om metodisk design af fokusgrupper og menneskets forskellige intelligenser
Lene Heiselberg
MedieKultur : Journal of Media and Communication Research , 2008,
Abstract: N r man arbejder professionelt med at gennemf re kvalitative mini- og fokusgruppeanalyser, kan det ikke undg s, at man som moderator indimellem t nker: Hvorfor deltager hun ikke? Hvad kan jeg g re for at inkludere hende i diskussionen? Ofte skyldes nogle deltageres manglende engagement, at mini- eller fokusgruppens metodiske design favoriserer de deltagere, som har en fremtr dende verbalsproglig intelligens, og samtidig ekskluderes de, der har andre fremtr dende intelligenser, fra at yde det maksimale. En s dan situation er meget uheldig og kan i v rste fald give en unders gelse bias. Derfor har vi i DR Medieforskning arbejdet med en pragmatisk tilgang til problemet, hvor vi har afpr vet et metodisk design, som inkluderer kvalitative interviewteknikker og procesv rkt jer, som appellerer til samtlige intelligenser. Som et resultat af en m lrettet indsats for at inkludere flere intelligenser i det metodiske design, oplever vi, at deltagerne har mere lyst til at engagere sig og g r det med st rre selvsikkerhed. Desuden oplever vi i mindre grad f nomenet “cognitive tuning” , og derfor kan vi arbejde med flere og bedre data i analyse- og fortolkningsfasen. Intelligent design of focus groups - article about methodological design of focus groups and the different intelligences When you work professionally with the conducting and moderating of qualitative mini- and focus groups, you can't avoid sometimes thinking: Why isn’t she participating? What can I do to include her in the discussion? A participant's apparent lack of enthusiasm is often caused by the methodological design of the focus group giving preference to participants who have an explicit verbal intelligence, and as a consequence excludes participants with other explicit intelligences from contributing. A situation like the one described above is very undesirable and in a worst-case scenario it can cause a study to be biased. In order to try to solve this problem DR Media Research applied a methodological design which includes qualitative interviewing techniques and processing tools, which appeal to all of the intelligences instead of just one. As a result of this work, we find that the participants are more eager to participate and that they do it with greater self-confidence. In addition we encounter less cognitive tuning, and are therefore able to work with richer data in the phases of analysis and interpretation.
Lene Tanggaard
Coaching Psykologi : the Danish Journal of Coaching Psychology , 2011,
Increasing Incidence of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae (ESBL) and the Relation to Consumption of Broad-Spectrum Antimicrobial Agents 2003-2011 in a Large Area of Copenhagen, Denmark  [PDF]
Lene Nielsen, Anne Kjerulf, Magnus Arpi
Open Journal of Medical Microbiology (OJMM) , 2015, DOI: 10.4236/ojmm.2015.51005
Abstract: Purpose: To investigate 1) the development in the incidence of ESBL-producing bacteria in hospitals and primary health care, 2) the contribution of primary health care to the incidence of ESBL-producing bacteria, and 3) the development in resistance patterns for all Escherichia coli and Klebsiella pneumoniae isolates in relation to antimicrobial consumption in hospitals and primary health care. Methods: ESBL-data were retrospectively collected from bacterial isolates from all specimens received at the Department of Clinical Microbiology from 2003 to 2011 together with the corresponding patient data. ESBL-production was detected in isolates from 1067 of 59,373 patients (1.8%) with an E. coli infection and in 263 of 8660 patients (3.0%) with a K. pneumoniae infection. Results: From 2003 to 2009, an increase in patients with an ESBL-producing isolate occurred in both hospitals and primary health care at the same time as an increased consumption of broad-spectrum antimicrobial agents was seen. Interventions to reduce prescription of cephalosporins and ciprofloxacin at the hospitals from 2010 resulted in a remarkable decrease in patients with ESBL-producing K. pneumoniae whereas a continuing increase was seen in patients with ESBL-producing E. coli both at hospitals and in primary health care. The proportion of patients with community-acquired ESBL-producing E. coli was stable with an increase of only 1.4% from 2007 to 2011. Conclusions: Reduction in prescription of broad-spectrum antimicrobial agents at the hospital level had an important impact on the incidence of ESBL-producing K. pneumoniae, but not on ESBL-producing E. coli.
Algorithms for optimizing drug therapy
Peter Wanger, Lene Martin
BMC Medical Informatics and Decision Making , 2004, DOI: 10.1186/1472-6947-4-10
Abstract: One hundred and ten officially endorsed text documents, published between 1996 and 2004, containing guidelines for drug therapy in 246 disorders, were analyzed with regard to information about patient-, disease- and drug-related factors and relationships between these factors. This information was used to construct algorithms for identifying optimum treatment in each of the studied disorders. These algorithms were categorized in order to define as few models as possible that still could accommodate the identified factors and the relationships between them. The resulting program prototypes were implemented in HTML (user interface) and JavaScript (program logic).Three types of algorithms were sufficient for the intended purpose. The simplest type is a list of factors, each of which implies that the particular patient should or should not receive treatment. This is adequate in situations where only one treatment exists. The second type, a more elaborate model, is required when treatment can by provided using drugs from different pharmacological classes and the selection of drug class is dependent on patient characteristics. An easily implemented set of if-then statements was able to manage the identified information in such instances. The third type was needed in the few situations where the selection and dosage of drugs were depending on the degree to which one or more patient-specific factors were present. In these cases the implementation of an established decision model based on fuzzy sets was required. Computer programs based on one of these three models could be constructed regarding all but one of the studied disorders. The single exception was depression, where reliable relationships between patient characteristics, drug classes and outcome of therapy remain to be defined.Algorithms for optimizing drug therapy can, with presumably rare exceptions, be developed for any disorder, using standard Internet programming methods.During the last decades the possibility
Amphotropic murine leukemia virus is preferentially attached to cholesterol-rich microdomains after binding to mouse fibroblasts
Christiane Beer, Lene Pedersen
Virology Journal , 2006, DOI: 10.1186/1743-422x-3-21
Abstract: Here, we show that a high amount of cell-bound A-MLV was attached to large rafts of NIH3T3 at the time of investigation. These large rafts were not enriched in caveolin-1, a major structural component of caveolae. In addition, they are rather of natural occurrence in NIH3T3 cells than a result of patching of smaller rafts by A-MLV. Thus cells incubated in parallel with vesicular stomatitis virus glycoprotein (VSV-G) pseudotyped MLV particles showed the same pattern of large rafts as cells incubated with A-MLV, but VSV-G pseudotyped MLV particles did not show any preference to attach to these large microdomains.The high concentration of A-MLV particles bound to large rafts of NIH3T3 cells suggests a role of these microdomains in early A-MLV binding events.Retroviral vectors carrying the envelope protein of amphotropic murine leukemia virus (A-MLV) are some of the most widely used retroviral vector pseudotypes in gene therapy trials. Achievement of controlled but efficient gene delivery will, however, depend on a detailed insight into virus biology. We have previously shown that A-MLV entry is closely associated with cholesterol-rich microdomains like rafts and caveolae [1] and that A-MLV envelope protein is associated with rafts in infected cells suggesting a possible role of rafts in A-MLV assembly [2]. It has also been shown for other viruses that rafts and/or caveolae are important for their entry and assembly [3-8]; specifically, has caveola-mediated entry been shown for, e.g., SV40 [4], echovirus 1 [7], and human coronavirus 229E [8]. Both domains consist of high concentrations of cholesterol, sphingomyelin, ganglioside GM1, and other saturated lipids [9,10] but in contrast to rafts do caveolae build omega-shaped invaginations within the plasma membrane of cells [11]. The unique lipid composition of rafts and caveolae leads to the specific incorporation or exclusion of proteins in these domains thereby creating distinct microenvironments for cellular processes [
Is Lean Management implementable in a department of radiology?
Jens Karstoft,Lene Tarp
Insights into Imaging , 2011, DOI: 10.1007/s13244-010-0044-5
Abstract: Lean Management can successfully be used in a hospital radiology department. However, introducing Lean Management caused resistance from especially the mid-level managers.
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