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Search Results: 1 - 10 of 731 matches for " Lazarus SC "
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Mannose-binding lectin deficiency and acute exacerbations of chronic obstructive pulmonary disease
Albert RK, Connett J, Curtis JL, Martinez FJ, Han MK, Lazarus SC, Woodruff PG
International Journal of Chronic Obstructive Pulmonary Disease , 2012, DOI: http://dx.doi.org/10.2147/COPD.S33714
Abstract: nnose-binding lectin deficiency and acute exacerbations of chronic obstructive pulmonary disease Original Research (852) Total Article Views Authors: Albert RK, Connett J, Curtis JL, Martinez FJ, Han MK, Lazarus SC, Woodruff PG Published Date November 2012 Volume 2012:7 Pages 767 - 777 DOI: http://dx.doi.org/10.2147/COPD.S33714 Received: 09 May 2012 Accepted: 09 July 2012 Published: 23 November 2012 Richard K Albert,1 John Connett,2 Jeffrey L Curtis,3,4 Fernando J Martinez,3 MeiLan K Han,3 Stephen C Lazarus,5 Prescott G Woodruff5 1Medicine Service, Denver Health and Department of Medicine, University of Colorado Denver, Denver, CO, 2Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 3Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI, 4Pulmonary and Critical Care Medicine, VA Medical Center, Ann Arbor, MI, 5Pulmonary and Critical Care Medicine, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, CA, USA Background: Mannose-binding lectin is a collectin involved in host defense against infection. Whether mannose-binding lectin deficiency is associated with acute exacerbations of chronic obstructive pulmonary disease is debated. Methods: Participants in a study designed to determine if azithromycin taken daily for one year decreased acute exacerbations had serum mannose-binding lectin concentrations measured at the time of enrollment. Results: Samples were obtained from 1037 subjects (91%) in the trial. The prevalence of mannose-binding lectin deficiency ranged from 0.5% to 52.2%, depending on how deficiency was defined. No differences in the prevalence of deficiency were observed with respect to any demographic variable assessed, and no differences were observed in time to first exacerbation, rate of exacerbations, or percentage of subjects requiring hospitalization for exacerbations in those with deficiency versus those without, regardless of how deficiency was defined. Conclusion: In a large sample of subjects with chronic obstructive pulmonary disease selected for having an increased risk of experiencing an acute exacerbation of chronic obstructive pulmonary disease, only 1.9% had mannose-binding lectin concentrations below the normal range and we found no association between mannose-binding lectin concentrations and time to first acute exacerbation or frequency of acute exacerbations during one year of prospective follow-up.
Contemporaneo e política
Lazarus, Sylvain;
Educa??o & Realidade , 2012, DOI: 10.1590/S2175-62362012000200004
Abstract: the article deals with the crisis of politics and of the contemporary as a result of a name capture from the state field. regarding politics, all the attempts since 1968 of reconstituting it away from the state, from the point of view of people and the interior of situations, are now over. there is also a reflection about the separate nature of the state and about the thinking of people and the forms of subjectivity. therefore, this text aims at evaluating the rupture of thinking using the thesis that the contemporary nature of the state as a separate state is incompatible with the thinking of people guided to the possible. the article searches, at the end, questions the anthropological discipline and what it can enunciate about the contemporary today.
An Interesting Neonatal Abdominal Mass
J Lazarus
African Journal of Urology , 2010,
Abstract: We present the case of a neonate who was born with an antenatal ultrasound diagnosis of a cystic abdominal mass of uncertain origin. The diagnosis of pelviureteric junction obstruction (PUJO) was obscured by difficulty determining the origin of the extremely large cystic abdominal mass. Sonographically, the kidneys appeared relatively normal, creating a diagnostic dilemma – the hydronephrosis was almost exclusively in an extrarenal pelvis. Additionally, contralateral hydronephrosis secondary to the mass effect further confused the diagnosis. We discuss the differential diagnosis of neonatal cystic abdominal masses and review the literature of giant hydronephrosis. Key Words: Abdominal mass, neonate, diagnosis, ultrasonography, ureteropelvic junction obstruction
Have we Overtreated Children with Vesicoureteric Reflux?
J Lazarus
African Journal of Urology , 2010,
Abstract: Urinary tract infections (UTI) are the most common serious bacterial infections in young children. These UTIs have a high association with vesicoureteric reflux (VUR). The pathophysiology of VUR’s renal sequelae, its investigation and management is presently undergoing a reassessment. This review documents these changes focusing on compelling new data. With regard to the need for and benefit of imaging procedures in children with UTIs we present an algorithm for investigation that is tailored to the African context. The value of continuous antibiotic prophylaxis is questioned and the role of injectable ureteric bulking is discussed with reference to the Swedish Reflux Trial. Key Words: Vesicoureteric reflux, children, etiology, pathophysiology, investigation, managment
Short communication: Ureterocystoplasty using the lower pole ureter of a duplex kidney with preservation of ipsilateral renal function
J Lazarus
African Journal of Urology , 2012,
Abstract: We describe the case of a 9 year old boy with neurogenic bladder dysfunction who co-incidentally had a unilateral duplex kidney with Grade 5 vesico-ureteric reflux into a poorly functioning lower moiety allowing heminephrectomy and ureterocystoplasty with preservation of ipsilateral renal function.
Exciting times: Towards a totally minimally invasive paediatric urology service
J Lazarus
South African Journal of Surgery , 2011,
Abstract: Following on from the first paediatric laparoscopic nephrectomy in 1992, the growth of minimally invasive ablative and reconstructive procedures in paediatric urology has been dramatic. This article reviews the literature related to laparoscopic dismembered pyeloplasty, optimising posterior urethral valve ablation and intravesical laparoscopic ureteric reimplantation.
Professional and career issues in administrative medicine
Arthur Lazarus
Journal of Healthcare Leadership , 2009, DOI: http://dx.doi.org/10.2147/JHL.S7846
Abstract: ofessional and career issues in administrative medicine Perspectives (5358) Total Article Views Authors: Arthur Lazarus Published Date November 2009 Volume 2009:1(Default) Pages 1 - 5 DOI: http://dx.doi.org/10.2147/JHL.S7846 Arthur Lazarus Senior Director, Global Clinical Development, AstraZeneca Pharmaceuticals, Wilmington, DE, USA Abstract: Administrative medicine is not recognized as a medical specialty in the United States, but increasingly, management-trained physicians are being recruited to fill important roles in hospitals and the life sciences industry. While the opportunities may be substantial, physicians who are interested in pursuing an administrative career should be aware of the challenges embodied in the role of physician executive, such as job turnover, alienation from peers, and overcoming the “caducean ceiling.” Healthcare systems that are serious about transforming themselves must harness the energies of physicians as organizational leaders, and physicians who are equal to the task must supplement their medical training with training in business and management.
Saint Just: Le bien et le mal comme catégorie de la conscience politique
Sylvain Lazarus
Scienza & Politica : per una Storia delle Dottrine , 1990, DOI: 10.6092/issn.1825-9618/3055
Abstract: Saint Just: Le bien et le mal comme catégorie de la conscience politique
The Micropaleontological Reference Centers Network
David Lazarus
Scientific Drilling , 2006, DOI: 10.2204/iodp.sd.3.10.2006
Abstract: The Micropaleontological Reference Centers (MRCs)comprise large microfossil slide collections prepared from core samples obtained through the Deep Sea Drilling Project(DSDP) and Ocean Drilling Program (ODP). The MRCs have been maintained for three decades, largely as a volunteer effort by a global network of curators at more than a dozen institutions (Fig.1, Table 1). They were originallyintended to provide a permanent micropaleontological archive for the DSDP; however, as their geographic and stratigraphic coverage has increased they have become increasingly valuable for research and teaching. This article describes the MRCs and their current usage, identifi es the need to maintain and improve the accuracy of the microfossil taxonomy upon which most DSDP and ODP geochronologyis based, and cites the potential for the future use of the MRCs by the Integrated Ocean Drilling Program (IODP).
Professional and career issues in administrative medicine
Arthur Lazarus
Journal of Healthcare Leadership , 2009,
Abstract: Arthur LazarusSenior Director, Global Clinical Development, AstraZeneca Pharmaceuticals, Wilmington, DE, USAAbstract: Administrative medicine is not recognized as a medical specialty in the United States, but increasingly, management-trained physicians are being recruited to fill important roles in hospitals and the life sciences industry. While the opportunities may be substantial, physicians who are interested in pursuing an administrative career should be aware of the challenges embodied in the role of physician executive, such as job turnover, alienation from peers, and overcoming the “caducean ceiling.” Healthcare systems that are serious about transforming themselves must harness the energies of physicians as organizational leaders, and physicians who are equal to the task must supplement their medical training with training in business and management.Keywords: healthcare administration, medical management, physician executive, leadership
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