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Search Results: 1 - 10 of 149916 matches for " Lauranell H. Burch "
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Histo-Blood Group Gene Polymorphisms as Potential Genetic Modifiers of Infection and Cystic Fibrosis Lung Disease Severity
Jennifer L. Taylor-Cousar, Maimoona A. Zariwala, Lauranell H. Burch, Rhonda G. Pace, Mitchell L. Drumm, Hollin Calloway, Haiying Fan, Brent W. Weston, Fred A. Wright, Michael R. Knowles, for the Gene Modifier Study Group
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004270
Abstract: Background The pulmonary phenotype in cystic fibrosis (CF) is variable; thus, environmental and genetic factors likely contribute to clinical heterogeneity. We hypothesized that genetically determined ABO histo-blood group antigen (ABH) differences in glycosylation may lead to differences in microbial binding by airway mucus, and thus predispose to early lung infection and more severe lung disease in a subset of patients with CF. Methods and Principal Findings Clinical information and DNA was collected on >800 patients with the ΔF508/ΔF508 genotype. Patients in the most severe and mildest quartiles for lung phenotype were enrolled. Blood samples underwent lymphocyte transformation and DNA extraction using standard methods. PCR and sequencing were performed using standard techniques to identify the 9 SNPs required to determine ABO blood type, and to identify the four SNPs that account for 90–95% of Lewis status in Caucasians. Allele identification of the one nonsynonymous SNP in FUT2 that accounts for >95% of the incidence of nonsecretor phenotype in Caucasians was completed using an ABI Taqman assay. The overall prevalence of ABO types, and of FUT2 (secretor) and FUT 3 (Lewis) alleles was consistent with that found in the Caucasian population. There was no difference in distribution of ABH type in the severe versus mild patients, or the age of onset of Pseudomonas aeruginosa infection in the severe or mild groups. Multivariate analyses of other clinical phenotypes, including gender, asthma, and meconium ileus demonstrated no differences between groups based on ABH type. Conclusions and Significance Polymorphisms in the genes encoding ABO blood type, secretor or Lewis genotypes were not shown to associate with severity of CF lung disease, or age of onset of P. aeruginosa infection, nor was there any association with other clinical phenotypes in a group of 808 patients homozygous for the ΔF508 mutation.
Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis
Aimee K. Zaas ,Guochun Liao,Jason W. Chien,Clarice Weinberg,David Shore,Steven S. Giles,Kieren A. Marr,Jonathan Usuka,Lauranell H. Burch,Lalith Perera,John R. Perfect,Gary Peltz,David A. Schwartz
PLOS Genetics , 2008, DOI: 10.1371/journal.pgen.1000101
Abstract: Invasive aspergillosis (IA) is a common and life-threatening infection in immunocompromised individuals. A number of environmental and epidemiologic risk factors for developing IA have been identified. However, genetic factors that affect risk for developing IA have not been clearly identified. We report that host genetic differences influence outcome following establishment of pulmonary aspergillosis in an exogenously immune suppressed mouse model. Computational haplotype-based genetic analysis indicated that genetic variation within the biologically plausible positional candidate gene plasminogen (Plg; Gene ID 18855) correlated with murine outcome. There was a single nonsynonymous coding change (Gly110Ser) where the minor allele was found in all of the susceptible strains, but not in the resistant strains. A nonsynonymous single nucleotide polymorphism (Asp472Asn) was also identified in the human homolog (PLG; Gene ID 5340). An association study within a cohort of 236 allogeneic hematopoietic stem cell transplant (HSCT) recipients revealed that alleles at this SNP significantly affected the risk of developing IA after HSCT. Furthermore, we demonstrated that plasminogen directly binds to Aspergillus fumigatus. We propose that genetic variation within the plasminogen pathway influences the pathogenesis of this invasive fungal infection.
Spectropolarimetry of the borderline Seyfert 1 galaxy ESO 323-G077
H. M. Schmid,I. Appenzeller,U. Burch
Physics , 2003, DOI: 10.1051/0004-6361:20030558
Abstract: We report the detection of high linear polarization in the bright Seyfert 1 galaxy ESO 323-G077. Based on optical spectropolarimetry with FORS1 at the VLT we find a continuum polarization which ranges from 2.2 % at 8300A to 7.5 % at 3600A. Similar amounts of linear polarization are found for the broad emission lines, while the narrow lines are not polarized. The position angle of the polarization is independent of the wavelength and found to be perpendicular to the orientation of the extended [OIII] emission cone of this galaxy. Within the standard model of Seyfert nuclei the observations can be well understood assuming that this AGN is observed at an inclination angle where the nucleus is partially obscured and seen mainly indirectly in the light scattered by dust clouds within or above the torus and the illuminated inner edge of the dust torus itself. Hence we conclude that ESO 323-G077 is a borderline Seyfert 1 galaxy which can provide important information on the geometric properties of active nuclei.
Norden, Reframed
Stuart Burch
Culture Unbound : Journal of Current Cultural Research , 2010,
Abstract: This paper calls for Norden to be understood as a metaframe. Related formulations like “Nordic art” or “Nordic welfare” function as mesoframes. These trigger multiple framing devices. A cache of related framing devices constitutes a framing archive. Framing devices work best when operating unobtrusively such that inclusions, exclusions and inconsistencies are condoned or naturalised. Their artifice, however, becomes apparent whenever a frame is questioned. Questioning or criticising a frame gives rise to a framing dispute. The theoretical justification for these typologies is provided at the outset. This schema is then applied to a select range of empirical examples drawn largely from the disciplinary frames (Ernst 1996) of art history and museum studies. Despite this specificity it is envisaged that the general principles set out below can and will be used to address a variety of devices, disputes and archives in Norden and beyond.
Blood Transfusions following Trauma: Finding an Evidence-Based Vein
Druin Burch
PLOS Medicine , 2014, DOI: 10.1371/journal.pmed.1001665
Does Diagnosing Fatty Liver and Chronic Kidney Disease Do More Good Than Harm?
Druin Burch
PLOS Medicine , 2014, DOI: 10.1371/journal.pmed.1001681
Heart Failure: Gaps in Knowledge and Failures in Treatment
Druin Burch
PLOS Medicine , 2014, DOI: 10.1371/journal.pmed.1001702
What Could Computerized Brain Training Learn from Evidence-Based Medicine?
Druin Burch
PLOS Medicine , 2014, DOI: 10.1371/journal.pmed.1001758
Heavy hadrons on $N_f=2$ and $2+1$ improved clover-Wilson lattices
Tommy Burch
Physics , 2015,
Abstract: We present the masses of singly ($B$, $B_s$, $\Lambda_b$, $\Sigma_b$, etc.), doubly ($B_c$, $\eta_b$, $\Upsilon$, $\Xi_{bc}$, $\Xi_{bb}$, etc.), and triply ($\Omega_{bcc}$, $\Omega_{bbc}$, $\Omega_{bbb}$, etc.) heavy hadrons arising from (QCDSF-UKQCD) lattices with improved clover-Wilson light quarks. For the bottom quark, we use an $O(a,v^4)$-improved version of lattice NRQCD. Part of the bottomonia spectrum is used to provide an alternative scale and to determine the physical quark mass and radiative corrections used in the heavy-quark action. Results for spin splittings, opposite parities, and, in some cases, excited states are presented. Higher lying states and baryons with two light quarks appear to be especially affected by the relatively small volumes of this (initially) initial study. This and other systematics are briefly discussed.
Histories Electromagnetism
Aidan Burch
Mathematics , 2003, DOI: 10.1063/1.1723702
Abstract: Working within the HPO (History Projection Operator) Consistent Histories formalism, we follow the work of Savvidou on (scalar) field theory and that of Savvidou and Anastopolous on (first-class) constrained systems to write a histories theory (both classical and quantum) of Electromagnetism. We focus particularly on the foliation-dependence of the histories phase space/Hilbert space and the action thereon of the two Poincare groups that arise in histories field theory. We quantise in the spirit of the Dirac scheme for constrained systems.
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