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Search Results: 1 - 10 of 220529 matches for " Laura Sierra-López "
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Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells
Miguel A Mendoza-Catalán, Gema R Cristóbal-Mondragón, Jesús Adame-Gómez, Heidi N del Valle-Flores, José Coppe, Laura Sierra-López, Mirna A Romero-Hernández, Luz del Carmen Alarcón-Romero, Berenice Illades-Aguiar, Eduardo Casta?eda-Saucedo
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-116
Abstract: Protein expression was analyzed by immunochemistry on 102 cervical paraffin-embedded biopsies: 20 without Squamous Intraepithelial Lesions (SIL), 51 Low- grade SIL, and 31 High-grade SIL; and in cervical cancer cell lines C33A and SiHa, and non-tumorigenic HaCat cells. Nuclear localization of Rac1 in HaCat, C33A and SiHa cells was assessed by cellular fractionation and Western blotting, in the presence or not of a chemical Rac1 inhibitor (NSC23766).Immunoreacivity for Rac1, RhoA, Tiam1 and beta-Pix was stronger in L-SIL and H-SIL, compared to samples without SIL, and it was significantly associated with the histological diagnosis. Nuclear expression of Rac1 was observed in 52.9% L-SIL and 48.4% H-SIL, but not in samples without SIL. Rac1 was found in the nucleus of C33A and SiHa cells but not in HaCat cells. Chemical inhibition of Rac1 resulted in reduced cell proliferation in HaCat, C33A and SiHa cells.Rac1 is expressed in the nucleus of epithelial cells in SILs and cervical cancer cell lines, and chemical inhibition of Rac1 reduces cellular proliferation. Further studies are needed to better understand the role of Rho-GTPases in cervical cancer progression.Cervical cancer is the second most common malignant neoplasia affecting woman worldwide. Infection with High-Risk Human Papillomavirus (HR-HPV) is considered the main risk factor for developing cervical cancer and its precursor lesions [1-3]. Development of cervical Low-grade Squamous Intraepithelial Lesions (L- SIL) and High-grade Squamous Intraepithelial Lesions (H-SIL), and progression to invasive carcinoma, are associated with alterations in the regulation of several cellular processes such as cell cycle progression, apoptosis, and DNA repair [2,4,5]. The HR-HPV oncoproteins E6 and E7 are responsible for many of these alterations, they act by binding to, and/or modifying the expression/activity of a growing number of cellular proteins [6], including p53 [7], pRb [8], p21 [9,10], and p27 [11,12]. Rho-GTPases
Análisis cualitativo de las competencias para la especialidad de Enfermería Familiar y Comunitaria. Construyendo el camino hacia la enfermería clínica avanzada.
María Bego?a Sánchez-Gómez,Gonzalo Duarte-Clíments,Armando Aguirre-Jaime,Antonio Sierra-López
ENE : Revista de Enfermería , 2012,
Abstract: Las competencias a adquirir en la especialidad de Enfermería Familiar y Comunitaria se establecen en la Orden SAS/1729/2010. El objetivo principal del estudio es conocer su distribución más apropiada para la formación. Entendiendo la enfermería clínica avanzada como una profesión centrada en las necesidades de cuidados de los pacientes, las familias y la comunidad, cuya práctica clínica se basa en la evidencia, en el uso del método clínico, y en el uso de técnicas de intervención complejas, mediante un enfoque holístico de la salud. Para ello se eligen dos técnicas cualitativas: grupos focales y la técnica semicualitativa Delphi. El resultado principal permite decidir que competencias alcanzar, en cada curso de la especialidad. Objetivo principal: Analizar el contenido y la distribución de las competencias que establece la orden SAS/1729/2010, de 17 de junio para la especialidad de EFyC.
Unusual treatment of postoperative bleeding after cardiac surgery  [PDF]
José Rubio-Alvarez, Juan Sierra-Quiroga, Belén Adrio-Nazar, Laura Reija López, ángela Granda Bauza, Carola Rubio Taboada, Jose Manuel Martinez-Cereijo
World Journal of Cardiovascular Diseases (WJCD) , 2013, DOI: 10.4236/wjcd.2013.35058
Abstract: A young patient was presented to the emergency department with chest pain and palpitations. A transthoracic echocardiogram showed a right atrial mass. Coronary angiography showed a right coronary artery with collateral circulation to a large mass. The tumor could only be partially resected and the patient experienced persistent postoperative bleeding. We performed a new right coronary artery angiography which showed an important free extravasation of contrast into the pericardium through the collateral circulation. Using covered stents, the bleeding was controlled. The pathological examination performed later revealed a primary cardiac angiosarcoma. After asymptom-free survival of 14 months the patient presented bone metastases.
Early Recurrence of a Cardiac Malignant Fibrous Histiocytoma  [PDF]
Laura Reija López, ángela Granda Bauza, Jose Manuel Martínez Cereijo, José Rubio álvarez, Belén Adrio Názar, Juan Sierra Quiroga
World Journal of Cardiovascular Surgery (WJCS) , 2013, DOI: 10.4236/wjcs.2013.35028
Abstract: Malignant fibrous histiocytoma (MFH) is a rare tumor of the heart and the patients with these tumors usually have a poor prognosis. We report a case of MFH with an origin from the left superior pulmonary vein, involving the left atrium and protruding through the mitral valve, which needed urgent surgery. Complete resection was performed but local recurrence was detected one month later.
O conceito de racismo institucional: aplica??es no campo da saúde
López, Laura Cecilia;
Interface - Comunica??o, Saúde, Educa??o , 2012, DOI: 10.1590/S1414-32832012005000004
Abstract: the aim of this paper was to reflect on the concept of institutional racism and its appositeness for thinking about brazilian social contexts; and on how this relates to the actions, demands and disputes of the contemporary black movement towards the public authorities. institutional racism acts diffusely within institutions' and organizations' everyday routines, such that it leads to inequality in the distribution of services, benefits and opportunities to different segments of the population, from a racial point of view. this paper indicates that, for institutional racism to be deconstructed, public policies promoting deracialization are needed, as well as academic reflections on how these mechanisms operate. in the healthcare field, they can be assessed as biopower devices, since they manage the population's lives from a racial perspective. there is a requirement for qualitative research with an ethnographic approach that reflects on how these mechanisms operate within institutions' everyday routine.
Guía metodológica para la asistencia a mujeres víctimas de violencia: Una propuesta de indicadores
López Angulo,Laura;
MediSur , 2009,
Abstract: women abuse is an obstacle to achieve equality, development, peace and social inclusion. this is a violation of human rights limiting their personal freedom and annulling their main warranties as their right to have security, integrity and even life. in the 90′ it has been identified as a health problem due to its frequency and severity, its magnitude and influence in health recovery. with the objective of supporting the decrease of this invisible plague from a public health perspective, we considered timely and pertinent to adjust a format of methodological guidelines aimed at setting rules and unifying procedures, including the complexity and implications of violence, based on the needs of each part.
Una apuesta analítica del funcionamiento del dispositivo psi pericial en el campo penal
López Gallego, Laura;
Psicologia & Sociedade , 2010, DOI: 10.1590/S0102-71822010000200021
Abstract: the approach made here about the "expert psy assemblage" inserted into the criminal field draws a path of analysis that considers the operation of this assemblage, highlighting the intertwined relationships between the legal and psychological knowledge. to undertake such analysis, specific documents produced by the psy experts, working under the judiciary power in uruguay, are used. the psy practices are understood as the effect of certain historical confluences related to strategies of objectivation, the translation of psy categories in juridical categories, and the incorporation of the logic of individualization as a central point of the "expert psy assemblage". the research question is what allows the incorporation of the "expert psy assemblage" in the criminal field.
Uma Análise das Políticas de Enfrentamento ao HIV/Aids na Perspectiva da Interseccionalidade de Ra?a e Gênero
López, Laura Cecilia;
Saúde e Sociedade , 2011, DOI: 10.1590/S0104-12902011000300006
Abstract: this article aims to analyze the hiv/aids policies, particularly campaigns, in the perspective of race and gender intersection. such perspective enables the understanding of how gender oppression and race oppression intersect each other, whereas, on the other hand, political action deconstructs these inequalities and enables the transformation of institutions in the promotion of gender and race equality. the ethnographic data i analyzed were collected during a qualitative research that focused on the actions carried out by organizations of the black movement and on their demands before the public power for participation in the struggle against the spread of the epidemics among the black population of the southern region of brazil. in the first part, i employ the concept of biopower to analyze the relation between race, gender and health. in the second part, i analyze the representations of body and subject activated in two nationwide hiv/aids campaigns centered on the image of a black woman, and the debates they brought about. the analysis reveals the centrality of the body as the expression of the black women movement's political struggle, stressing on and questioning the social vulnerability that results from the impact of biopolitics on the bodies, especially when gender and race are brought together.
Más alla del concepto: desarrollo sostenible
Laura Benavides López
Tecnología en Marcha , 2013,
Abstract: El artículo tiene la finalidad de promover la reflexión con respecto al desarrollo sostenible, como un marco de referencia para el educador, que le permita comprender la Década de la Educación para el Desarrollo Sostenible y la Declaratoria Paz con Naturaleza. La autora describe y reflexiona sobre el concepto, desde una perspectiva basada en la alteridad; por lo tanto, parte de una posición ética donde se potencializa a la persona para que sea constructora del desarrollo sostenible que requiere el país, donde la educación, la justicia social y la democracia conforman la plataforma para el logro de este. Se se alan aspectos fundamentales, como cuál fue el origen de desarrollo sostenible y como está idea se fue encuadrando dentro de una nueva ética centrada en la gente y para la gente. Se parte de que el desarrollo sostenible es un proceso de cambio y de transición hacia nuevas formas de producir, de consumir, pero también hacia nuevas formas de ser. Es un proceso multidimensional y complejo, que debe caracterizarse por su innovación, creatividad y apertura. Sin embargo, la dependencia de la política nacional e internacional de la economía micro y macro, de la cultura regional y global, hacen que el concepto se torne difícil de visualizar como un proceso autóctono y que obedezca a las necesidades reales de las personas y comunidades de un país.
Witnesses Inside/Outside the Stage: The Purpose Of Representing Violence In Edward Bond's Saved (1965) And Sarah Kane's Blasted (1995)
López Pe?a,Laura;
Folios , 2009,
Abstract: in spite of the thirty years span of time between the two productions, edward bond's saved and sarah kane's blasted provoked a similar outburst of reactions when they first opened at the royal court theatre in 1965 and 1995, respectively. depicting various types of violence onstage, the two plays aim at making spectators connect different forms of cruelty so that they can be moved to react against them in real life. in order to do so, both plays highlight the question of witnessing at two levels: on the one hand, at the level of character, the plays portray individuals who witness, suffer and/or inflict brutality, becoming, thus, participants in the ongoing cycles of violence onstage; whereas, on the other hand, at the level of audience, spectators too become direct -and silent- witnesses to the plays and their depicted cruelties, at the same time that they are called to react against the horrors they have experienced in the theatrical fictional world. the aim of this paper is, therefore, to analyze how saved and blasted engage in arising spectators' awareness of their own passivity in front of several forms of violence, and invite their audience to actively denounce not only wars and conflicts taking place in distant places but also in their own immediate surroundings.
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