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Search Results: 1 - 10 of 227787 matches for " LOUIS R; "
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TIM Lecture Series - Born Global: A Pharmaceutical Startup Perspective
Louis R. Lamontagne
Technology Innovation Management Review , 2012,
Abstract:
De vieilles obsessions sous des habits neufs ?
Louis Quéré
SociologieS , 2011,
Abstract: Cet article fait le tri dans le texte de Laurence Kaufmann et Laurent Cordonier entre ce qui para t et ce qui ne para t pas plausible dans leurs conjectures. Il spécifie à quelles conditions on peut admettre l'hypothèse du cerveau social . Il est par contre plus critique à l'égard de l'idée d'une régulation neuroendocrinienne du lien social . L'argument est que les auteurs n'estiment pas correctement les possibilités et les limites des explications neuroscientifiques des conduites humaines et des relations sociales. Enfin l'article confronte la forme de naturalisme social défendue par les auteurs à celle de la tradition pragmatiste (John Dewey et George Herbert Mead) et s'appuie sur la seconde pour faire ressortir le caractère problématique de la première. A new look for old obsessions?This paper tries to sift out the plausible in what Laurence Kaufmann and Laurent Cordonier tell in their article. It specifies some conditions for the acceptation of their surmise about the social brain . It criticizes much more their speculations about a neuroendocrinous regulation of the social bond . It argues that the authors don't estimate properly the capacities and the limits of the neuroscientific explanations of human conduct and social relations. Finally, it compares the version of social naturalism assumed by the authors with the pragmatist tradition's one (John Dewey and George Herbert Mead) and uses this last to show the problematic character of the first. Nuevas apariencias de a ejas obsesiones?El autor pasa por la criba el texto de Laurence Kaufman y Laurent Cordonier y distingue entre lo que parece plausible y lo que no lo es. Específica bajo qué condiciones puede admitirse la hipótesis de un cerebro social . Es mucho más crítico con respecto a la regulación neuro-endocrina de los lazos sociales . Estos autores no analizan correctamente las posibilidades y los límites de las explicaciones neuro-científicas del comportamiento humano y de las relaciones sociales. El autor también confronta la forma de naturalismo social defendida por los autores con la de la tradición pragmatista (John Dewey y George Herbert Mead) apoyándose en este último para resaltar el carácter problemático de la primera.
Arteriosclerosis and the promise of GPIIb/IIIa inhibitors in stroke
SAPOSNIK, GUSTAVO;CAPLAN, LOUIS R;
Arquivos de Neuro-Psiquiatria , 2000, DOI: 10.1590/S0004-282X2000000100001
Abstract: ischemic mechanisms in patients with brain and heart attacks have been studied for more than 150 years. antiplatelets agents did show benefit in secondary prevention. aspirin is the most common antiaggregant in clinical use today. however, the benefit produced by the "best" antiplatelet regimen in stroke prevention is lower than 40%. the adherence of circulating platelets to the subendothelium is mediated by glycoprotein (gp) residing on the cell's surface. gpiib/iiia is the most important platelet membrane receptor that mediates the process of platelet aggregation, and thrombus formation. thus, new drugs that block the gpiib/iiia receptor have recently emerged. clinical trials using these agents have shown effectiveness in acute coronary syndromes. however, the absence of studies in cerebrovascular disease and the potential hemorrhagic complications questioned their use in stroke prevention. we review the clinical trials using the new gpiib/iiia agents in myocardial ischemia, and consider the potential implications for cerebrovascular disease.
Arteriosclerosis and the promise of GPIIb/IIIa inhibitors in stroke
SAPOSNIK GUSTAVO,CAPLAN LOUIS R
Arquivos de Neuro-Psiquiatria , 2000,
Abstract: Ischemic mechanisms in patients with brain and heart attacks have been studied for more than 150 years. Antiplatelets agents did show benefit in secondary prevention. Aspirin is the most common antiaggregant in clinical use today. However, the benefit produced by the "best" antiplatelet regimen in stroke prevention is lower than 40%. The adherence of circulating platelets to the subendothelium is mediated by glycoprotein (GP) residing on the cell's surface. GPIIb/IIIa is the most important platelet membrane receptor that mediates the process of platelet aggregation, and thrombus formation. Thus, new drugs that block the GPIIb/IIIa receptor have recently emerged. Clinical trials using these agents have shown effectiveness in acute coronary syndromes. However, the absence of studies in cerebrovascular disease and the potential hemorrhagic complications questioned their use in stroke prevention. We review the clinical trials using the new GPIIb/IIIa agents in myocardial ischemia, and consider the potential implications for cerebrovascular disease.
Generalized effective depletion potentials
A. A. Louis,R. Roth
Physics , 2001,
Abstract: We propose that the behavior of asymmetric binary fluid mixtures with a large class of attractive or repulsive interparticle interactions can be understood by mapping onto effective non-additive hard-sphere models. The latter are best analyzed in terms of their underlying depletion potentials which can be exactly scaled onto known additive ones. By tuning the non-additivity, a wide variety of attractive or repulsive generalized depletion potential shapes and associated phase behavior can be ``engineered'', leading, for example, to two ways to stabilize colloidal suspensions by adding smaller particles.
Theory of asymmetric non-additive binary hard-sphere mixtures
R. Roth,R. Evans,A. A. Louis
Physics , 2001, DOI: 10.1103/PhysRevE.64.051202
Abstract: We show that the formal procedure of integrating out the degrees of freedom of the small spheres in a binary hard-sphere mixture works equally well for non-additive as it does for additive mixtures. For highly asymmetric mixtures (small size ratios) the resulting effective Hamiltonian of the one-component fluid of big spheres, which consists of an infinite number of many-body interactions, should be accurately approximated by truncating after the term describing the effective pair interaction. Using a density functional treatment developed originally for additive hard-sphere mixtures we determine the zero, one, and two-body contribution to the effective Hamiltonian. We demonstrate that even small degrees of positive or negative non-additivity have significant effect on the shape of the depletion potential. The second virial coefficient $B_2$, corresponding to the effective pair interaction between two big spheres, is found to be a sensitive measure of the effects of non-additivity. The variation of $B_2$ with the density of the small spheres shows significantly different behavior for additive, slightly positive and slightly negative non-additive mixtures. We discuss the possible repercussions of these results for the phase behavior of binary hard-sphere mixtures and suggest that measurements of $B_2$ might provide a means of determining the degree of non-additivity in real colloidal mixtures.
The Surviving Sepsis Campaign sepsis change bundles and clinical practice
R Phillip Dellinger, Jean-Louis Vincent
Critical Care , 2005, DOI: 10.1186/cc3952
Abstract: As members of the Surviving Sepsis Campaign (SSC), we are pleased to comment on the study by Gao et al. published in this issue of Critical Care [1].Protocolized care now exists for a heart attack or a stroke, based on advances detailed in the medical literature. Until now there has been no attempt to reproduce such an approach in severe sepsis despite recently published studies that have shown decreased mortality and morbidity as a result of interventions applied to patients with severe sepsis [2-6]. The SSC http://www.survivingsepsis.org webcite hopes to change that. The campaign is administered by the Society of Critical Care Medicine (SCCM), the European Society of Intensive Care Medicine (ESICM) and the International Sepsis Forum (ISF), and is partly funded by unrestricted industry educational grants.Phase 1 of the SSC was the introduction of the campaign at several major international critical care medicine conferences, beginning in late 2002, with the intent of decreasing the mortality in severe sepsis by 25% in 5 years.Phase 2 of the campaign was the production of evidence-based guidelines for the management of severe sepsis. In 2003, critical care and infectious disease experts representing 11 international organizations developed evidence-based management guidelines for severe sepsis and septic shock for use by the bedside clinician. The guidelines manuscript was published in 2004 in both Critical Care Medicine and Intensive Care Medicine [7,8].Transfer of research from the bench to the bedside is typically a long and tortuous process and is minimally accelerated by guidelines.Phase 3 of the SSC campaign seeks to facilitate operationalizing the guidelines to create a global standard of care for sepsis management [9]. The guidelines are transformed into a core of user-friendly tools that will allow clinicians to incorporate these new recommendations more easily into bedside care. The first step in this next phase has been a joint effort with the Institute o
Efeito do ferro (59Fe) e do zinco (65Zn) e da natureza de três tipos de solos na produ??o de matéria seca e na composi??o química do feijoeiro (Phaseolus vulgaris L.) cv. carioca e na fixa??o de nitrogênio atmosférico por esta leguminosa
Suhet, Allert R.;Neptune, André M. Louis;
Anais da Escola Superior de Agricultura Luiz de Queiroz , 1979, DOI: 10.1590/S0071-12761979000100001
Abstract: the aim of this work was to study in greenhouse conditions the effects of two levels of iron and zinc on yield and chemical composition of common bean (phaseolus vulgaris l.) and on atmospheric nitrogen fixation, in three soils, classified as terra roxa estruturada (tre), latossol vermelho escuro (lve), and podzolico vermelho amarelo (pva). the coefficient of utilization of these micronutrients by this crop and its distribution in above-ground parts and roots were also assessed. the rates for iron were 1.5 and 3.0 ppm, and for zinc, 2.5 and 5.0 ppm. it was applied 7.5 μci of 59fe/kg of soil with the lower rate of the stable iron, and 5.0 and 10.0 μci of zn/kg of soil in the pots corresponding to the lower and higher rate of the stable zinc, respectively. the plants were harveste at the age of 60 days and nitrogen, phosphorus, potassium, iron and zinc contents were determined. immediately after harvest, symbiotic nitrogen fixation was assessed, using the acetylene reduction method. the detection of 59fe and 65zn radioactivity were carried out on nitric percloric extract, by gamma ray spectrometry. the behavior of common bean presented high variation among the three soils, for all the variables. there was no influence of treatments of iron and zinc on dry matter of above ground part and root and also on the weight and number of nodules. the rate of 3.0 ppm of iron decreased the capacity of nodules to fix atmospheric nitrogen in relation to rate of 1.5 ppm, while the rate of 5.0 ppm of zinc increased this capacity, in relation to the rate of 2.5 ppm. there was significative effect of treatments on nitrogen, potassium and zinc contents in above ground part and on nitrogen and zinc contents in the root. the absorption of zinc from the fertilizer and the percentagem of zinc in the plant derived from fertilizer were diretly influenced by rate of zinc the higher coefficient of utilization of zinc from the fertilizer was 4.0%.
Intra-Uterine Nutrition of the “Beetle-Roach” DiplopteraDytiscoides (Serv.)During Embryogenesis, With Notes on its Biologyin the Laboratory (Blattaria: Diplopteridae)
Louis M. Roth,Edwin R. Willis
Psyche , 1955, DOI: 10.1155/1955/12542
Abstract:
Light Gluino Contribution in Hadronic Decays of Z boson and tau lepton to O(alpha_s^3)
Louis J. Clavelli,Levan R. Surguladze
Physics , 1996, DOI: 10.1103/PhysRevLett.78.1632
Abstract: The results of calculation of light gluino contributions to Gamma(Z--->hadrons) and Gamma(tau--->hadrons) to O(alpha_s^3) are presented. The net effect in the case of Z decay is noticeable. For the tau width the effect is very large and, if a light gluino exists, suggests that alpha_s increases by more than 15% relative to the Standard Model analysis.
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