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Search Results: 1 - 10 of 1654 matches for " LEUKEMIA "
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"Survey of Intestinal Parasitic Infection in Leukemic Children and Evaluation of their Serum Immunoglobulins"
MJ Gharavi,F Ashraf,P Vosough,MB Rokni
Iranian Journal of Public Health , 2003,
Abstract: Infection is one of the cardinal difficulties in the children with acute leukemia and is the leading cause of mortality among them. The prevalence of infection in these patients has several reasons including usage of cytotoxic agents, corticosteriods, broad consumption of antibiotics, duration of confinement in hospital, defective of cellular and humoral Immunity, neutropenia and dysfunction of neutrophils. Despite the fact that intestinal parasitic infection is a rather frequent finding and a health problem in developing countries, in our experience the incidence of helminthic and protozoa infections among children with leukemia was uncommon. Totally 141 patients with leukemia and 70 cases of control group were examined in a period of 12 months, which 40% and 2.8% of former and latter groups, had intestinal pathogen and non-pathogen parasites, respectively. When we compared the frequency of parasitic infection in the control group with the leukemic children, we found no significant difference. It is speculated that parasitic infections may uncommon in these children for numerous reasons such as immunologic and pharmacologic parameters.
Ph-negative chronic myeloproliferative neoplasm (primary myelofibrosis)– as one of the reasons of the Budd-Chiari syndrome.
Maria Dmitrievna Sanatko
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
Li Zhang,Xiaofan Zhu
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
Abstract: The limited available data suggest that the rate of early mortality is high and that long-term survival is poor in many developing countries. Death from bleeding and infection during chemotherapy, relapse and treatment abandonment are among the main cause of treatment failure in APL children. The status of children APL treatment in China is not described in general.
Ramzi Jeddi,Hèla Ghédira,Ramzi Ben Amor,Yosr Ben Abdennebi
Mediterranean Journal of Hematology and Infectious Diseases , 2011, DOI: 10.4084/mjhid.2011.
Abstract: In Tunisia, the ATRA era began in 1998 with the use, consecutively, of two regimens combining ATRA and an anthracycline with cytarabine (APL93), and without cytarabine (LPA99). From 2004, 51 patients with confirmed APL either by t(15;17) or PML/RARA were treated according to the PETHEMA LPA 99 trial. Forty three patients achieved CR (86%). The remaining seven patients had early death (one died before treatment onset): four caused by differentiation syndrome (DS) and three died from central nervous system hemorrhage. Multivariate analysis revealed that female gender (P=0.045), baseline WBC> 10 G/L ( P=0.041) and serum creatinine > 1.4mg/dl ( P=0.021) were predictive of mortality during induction. DS was observed in 16 patients (32%) after a median onset time of 15 days from treatment onset (range, 2–29). Body mass index ≥ 30 (P=0.01) was the only independent predictor of DS. Occurrence of hypertensive peaks significantly predicted occurrence of DS (P=0.011) and was significantly associated with high BMI (p=0.003). With a median follow-up of 50 months, 5 year cumulative incidence of relapse, event free and overall survival were 4.7%, 74% and 78%, respectively.
Oral ulcerations as the first manifestations of acute leukemia: A case report  [PDF]
Somayeh Alirezaei, Mahin Bakhshi, Jamileh-Bigom Taheri, Ahmad R. Mafi, Omid Moghaddas
Open Journal of Stomatology (OJST) , 2013, DOI: 10.4236/ojst.2013.39083

Acute myeloblastic leukemia (AML) is a highly fatal malignant bone marrow disease. Physicians, dentists and all other healthcare professionals should be aware of sinister oral signs and symptoms in order to early diagnosis and referral of patients. Here we report a case of AML who presented with oral ulcers. Ulcers developed after a parrot bite, which initially misled the physicians. Unfortunately our patient did not survive, but early diagnosis and prompt investigation and treatment can be life-saving in many other similar cases.

Population Pharmacokinetics of Methotrexate in Egyptian Children with Lymphoblastic Leukemia  [PDF]
Ehab Said EL Desoky, Mohamed H. Ghazal, Rajendra P. Singh, Omnia N. Abdelhamid, Hartmut Derendorf
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.42020
Abstract: Background: Individualization of high dose regimen of methotrexate (MTX) in pediatric patients with acute lymphoblastic leukemia based on pharmacokinetic (PK) parameters can help in optimization of the dose and better control of the disease. Building up of a pharmacokinetic model can help dose optimization. Objectives: A NONMEM based population (POP) PK model has been subsequently developed to evaluate the effect of demographics as covariates to address variability in pharmacokinetics of MTX. Method: Forty one patients (24 males & 17 females) with ranges of age, body weight and height of 3 - 15 years, 13 - 54 kg and 100 - 177 cm respectively and diagnosed as acute lymphoblastic leukemia (ALL) were involved in the study. MTX was administered as i.v. infusion at a dose of 2 gm/m2 over a period of two hour and its plasma concentrations were determined primarily at 24 hr post-dose to be utilized in the building-up of PK model.The initial/prior estimates of volumes of central (V1) and peripheral compartments (V2) and clearance (CL) and inter-compartmental clearance (Q2) for MTX were extracted from literature. The inter-subject variability was estimated for V1 &
Charicleia Kelaidi,Lionel Ades,Pierre Fenaux
Mediterranean Journal of Hematology and Infectious Diseases , 2011, DOI: 10.4084/mjhid.2011.
Abstract: Acute promyelocytic leukemia (APL) with WBC above 10 G/L has long been considered, even in the all-trans retinoic acid (ATRA) era, to carry a relatively poor prognosis (compared to APL with WBC below 10 G/L), due to increased early mortality and relapse. However, early deaths can to a large extent be avoided if specific measures are rapidly instigated, including prompt referral to a specialized center, immediate onset of ATRA and chemotherapy, treatment of coagulopathy with adequate platelet transfusional support, and prevention and management of differentiation syndrome. Strategies to reduce relapse rate include chemotherapy reinforcement with cytarabine and/or arsenic trioxide during consolidation, prolonged maintenance treatment, especially with ATRA and low dose chemotherapy, and possibly, although this is debated, intrathecal prophylaxis to prevent central nervous system relapse. By applying those measures, outcomes of patients with high risk APL have considerably improved, and have become in many studies almost similar to those of standard risk APL patients.
Correlates of Age at Initial Diagnosis of Chronic Lymphocytic Leukemia: Exercise, ASA & Emotional Distress  [PDF]
Mark W. Ketterer, Emily A. Ketterer, Bernd Barthel, Phillip Kuriakose, Amr Hanbali, Yue Guo, Walter Knysz
Open Journal of Medical Psychology (OJMP) , 2012, DOI: 10.4236/ojmp.2012.12002
Abstract: Objective: No studies of either the cross-sectional or prospective association of behavioral lifestyle characteristics and the onset of Chronic Lymphocytic Leukemia (CLL) exist. Methods: Multiple interview or questionnaire measures of emotional distress and social support, as well as personality characteristics, exercise, sleep quality, aspirin or lipid-lowering medication use, smoking status and history, educational history and farming/pesticide exposure were tested as correlates of age at initial diagnosis of CLL (AAID-CLL) in 183 patients recruited from the electronic records of Henry Ford Hospital or internet support sites. Results: Aspirin use, having always been “Fit” and living alone were positively associated with AAID. Negative associations were observed for farming/pesticide exposure, years of education, being married, self description as a “Lone Wolf” or “Worrier”, taking “nerve” or “sleeping” pills, awakenings per night, Packyears of Smoking and the Interpersonal Sensitivity, Depression, Anxiety, Hostility and Paranoia scales of the Symptom Checklist 90 - Revised, as well as the AIAI (anger), Depression and Anxiety scales of the Spouse/Friend Ketterer Stress Symptom Frequency Checklist. Conclusions: Aspirin use and exercise may exert a modifiable delaying influence in the onset of CLL. Conversely, emotional distress and smoking may hasten its onset. Prospective, and interventional, tests of these findings are needed.
Bilateral nephromegaly and arthritis: A rare presentation of acute lymphoblastic leukemia  [PDF]
Tapas Kumar Sabui, Syamal Sardar, Sumanta Laha, Abhishek Roy
Open Journal of Pediatrics (OJPed) , 2013, DOI: 10.4236/ojped.2013.33044

A 2.5 years old boy presented with fever, intermittent small joint arthritis of hands and feet, bilateral nephromegaly with normal hemogram and uric acid level. Bone marrow aspiration revealed pre-B acute lymphoblastic leukemia without leukemic infiltration of kidneys. Leukemia should be suspected in any patient with arthritis and nephromegaly.

Iatrogenic calcinosis cutis in a child affected by Acute Lymphoblastic Leukemia  [PDF]
Teresa Perillo, Giampaolo Arcamone, Domenico Bonamonte, Michele Pascone, Nicola Santoro
Case Reports in Clinical Medicine (CRCM) , 2014, DOI: 10.4236/crcm.2014.31004

Iatrogenic calcinosis cutis is a rare disorder that can be due to the intravenous administration of calcium or phosphate-containing infusions such as calcium gluconate or calcium chloride with extravasation. Fortunately, the course of calcinosis cutis is benign in immunocompetent children. The treatment remains supportive therapy. After about 6 months, there is no evidence of tissue calcification. We describe a 4-year-old girl with Acute Lymphoblastic Leukemia (ALL) who developed severe calcinosis cutis in the left humerus after extravasation of calcium gluconate during the treatment for the tumor-lysissyndrome-related hypocalcaemia. Surgical debridement and local wound care were not successful, and so a temporary suspension of chemotherapy was necessary to achieve complete healing of the lesion. Notwithstanding this complication, her ALL is in complete hematological remission after 8 months from the diagnosis. No functional or sensitive impairment due to the cutis has persisted.

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