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Search Results: 1 - 10 of 628422 matches for " L.V.M.;Rodrigues "
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A retrospective comparison of cyclophosphamide plus antithymocyte globulin with cyclophosphamide plus busulfan as the conditioning regimen for severe aplastic anemia
Ommati, L.V.M.;Rodrigues, C.A.;Silva, A.R.;Silva, L.P.;Chaufaille, M.L.L.F.;Oliveira, J.S.R.;
Brazilian Journal of Medical and Biological Research , 2009, DOI: 10.1590/S0100-879X2009000300005
Abstract: allogeneic hematopoietic stem cell transplantation (ahsct) is the treatment of choice for young patients with severe aplastic anemia (saa). the association of antithymocyte globulin (atg) and cyclophosphamide (cy) is the most frequently used conditioning regimen for this disease. we performed this retrospective study in order to compare the outcomes of hla-matched sibling donor ahsct in 41 patients with saa receiving cyclophosphamide plus atg (atg-cy, n = 17) or cyclophosphamide plus busulfan (bu-cy, n = 24). the substitution of bu for atg was motivated by the high cost of atg. there were no differences in the clinical features between the two groups, including age, gender, cytomegalovirus status, abo match, interval between diagnosis and transplant, and number of total nucleated cells infused. no differences were observed in the time to neutrophil and platelet engraftment, or in the risk of veno-occlusive disease and hemorrhage. however, there was a higher risk of mucositis in the bu-cy group (71 vs 24%, p = 0.004). there were no differences in the incidence of neutrophil and platelet engraftment, acute and chronic graft-versus-host disease, and transplant-related mortality. there was a higher incidence of late rejection in the atg-cy group (41 vs 4%, p = 0.009). although the atg-cy group had a longer follow-up (101 months) than the bu-cy group (67 months, p = 0.04), overall survival was similar between the groups (69 vs 58%, respectively, p = 0.32). we conclude that the association bu-cy is a feasible option to the conventional atg-cy regimen in this population.
Implanta o de um programa de avalia o terminal do desempenho dos graduandos para estimar a eficácia do currículo na Faculdade de Medicina de Ribeir o Preto
Troncon L.E. de A.,Figueiredo J.F. de C.,Rodrigues M. de L.V.,Peres L.C.
Revista da Associa??o Médica Brasileira , 1999,
Abstract: Nos últimos cinco anos, um programa de avalia o final do desempenho dos graduandos vem sendo desenvolvido na Faculdade de Medicina de Ribeir o Preto, visando colher dados sobre a eficácia do currículo médico. OBJETIVO. Descrever as principais etapas de implanta o deste programa, bem como as medidas tomadas para superar as dificuldades encontradas. MéTODOS. A avalia o consiste em uma prova de conhecimentos e em exames práticos de habilidades clínicas nas cinco áreas terminais do curso médico. As provas s o elaboradas e aplicadas por docentes das áreas envolvidas sob a supervis o de um grupo coordenador supra-departamental, que avalia todo o programa. Os graduandos participam como voluntários e os resultados s o utilizados somente para os fins institucionais propostos. A ades o dos graduandos foi registrada e as impress es dos docentes e dos graduandos sobre o programa foram colhidas por meio de questionários específicos. RESULTADOS. Nos dois primeiros anos a ades o dos graduandos à prova de conhecimentos foi superior a 85%, mas o percentual de inscri es nas provas práticas foi de apenas 55%. Além disso, do primeiro para o segundo ano, houve diminui o considerável do grau de empenho dos docentes envolvidos, obrigando medidas corretivas voltadas ao recrutamento dos graduandos, à participa o docente e aos métodos de avalia o prática. Em conseqüência, houve aumento notável da ades o dos estudantes que atingiu mais de 90% nos anos seguintes. Houve, também, acréscimo considerável do empenho docente, o que garantiu adequado nível de qualidade à avalia o. CONCLUS O. As medidas tomadas aumentaram a aceita o do programa e a qualidade das provas, permitindo que a avalia o do desempenho dos graduandos traga dados fidedignos sobre a eficácia do currículo.
Implanta??o de um programa de avalia??o terminal do desempenho dos graduandos para estimar a eficácia do currículo na Faculdade de Medicina de Ribeir?o Preto
Troncon, L.E. de A.;Figueiredo, J.F. de C.;Rodrigues, M. de L.V.;Peres, L.C.;Cianflone, A.R.L.;Picinato, C.E.;Colares, M. de F. A.;
Revista da Associa??o Médica Brasileira , 1999, DOI: 10.1590/S0104-42301999000300005
Abstract: purpose. to describe the main steps in the implementation of such assessment, as well as to present the measures taken in order to overcome the difficulties that have been found. methods. the proposed two-step assessment consists of a test of cognitive aspects based on multiple choice questions (mcq) and practical exams of clinical skills in each of 5 terminal areas. students enrolled as volunteer for either step or both. the examinations were developed and carried out by faculty members nominated by the involved departments under the supervision of an institutional work group. the rates of student enrollment for the summative assessment has been recorded and the responses of both students and faculty members were evaluated by means of specific questionnaires. results. in the first two years, adhesion of students to the mcq test was consistently high, but volunteering to the practical exams was persistently low. moreover, there was a sharp decrease in faculty involvement, from the first to the second year. to overcome these difficulties, a number of measures were implemented aiming at increasing student adhesion and faculty involvement, as well as to improve assessment methods. as a consequence, a remarkable increase in both student adhesion and faculty involvement was recorded. conclusion. the measures taken resulted in sharp increases in both acceptance of the proposed assessment and the quality of the examination methods, which have allowed a more reliable characterization of the strenghts and weaknesses of the local curriculum.
Dynamics of lower urinary tract of a fetus in intrauterine development retardation
Glybochko Р.V.,Chekhonatskaya M.L.,Piskunova L.V.
Saratov Journal of Medical Scientific Research , 2011,
Abstract: The research goal is to study and analyze the relationship between the level of intrauterine development retardation and urine dynamics indicators of lower urinary tract of a fetus with the help of ultrasonic examination. The urinary function of 89 fetuses was under study. Methods of prenatal ultrasonic cystometry and urofluometry were used to examine the urinary function of a fetus. Statistical software package (Statgraphics 6.0) was used for the statistical analyses of the results. The study has shown that decrease in bladder capacity, increase in residual urine volume and frequent urination are usually the indicators of intrauterine development retardation. The third-degree of intrauterine development retardation is characterized by decrease in diuresis and increase in duration of micturition cycle according to gestational norm
DNA Single Strand Conformation Polymorphisms (SSCP′s) Studies on Spanish Red-Legged Partridges
Tejedor, M. T.,Monteagudo, L.V.,Arruga, M. V.
Wildlife Biology in Practice , 2006,
Abstract: Restocking from captive-reared red-legged partridges (Alectoris rufa) is a frequent practice in some Spanish regions, due to the strong decrease of wild populations size in the last years. Chukar partridges (A. chukar), which never lived as wild game birds in Spain, are more prolific and efficient meat producers, being legally bred in many Spanish farms to be directly sent to slaughterhouses. Releasing foreign partridges species or hybrids is strictly forbidden by hunting and environment preservation laws. However, eventual hybridization with chukar partridges in breeding farms is a worrying possibility as, in many cases, farms produce birds for both meat and restocking purposes. DNA analyses might be useful to elucidate the genetic purity of wild or farmed partridges. Single Strand Conformation Polymorphisms (SSCP′s) were studied on individual DNA samples from Spanish supposed red-legged and captive chukar partridges. Two mitochondrial (Cytochrome B and D-loop) and one nuclear (Ribosomal DNA-intervening transcribed spacer, ITS) regions were considered for Polymerase Chain Reaction (PCR) design and further polyacrylamide gel electrophoresis. The results suggest that these techniques might identify interspecific A.rufa x A.chukar hybrids among wild and captive supposed red-legged partridges by detecting chukar partridge ancestors in their genealogies. On the other hand, these markers showed intra population genetic variability.
Perfil físico-químico do soro de queijos mozarela e minas-padr?o produzidos em várias regi?es do estado de Minas Gerais
Teixeira, L.V.;Fonseca, L.M.;
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2008, DOI: 10.1590/S0102-09352008000100033
Abstract: the physical-chemical profile of the whey of mozzarella and minas-padr?o cheeses was studied in four regions ("alto s?o francisco", "zona metalúrgica", "zona da mata" and "sul de minas") which produce milk and cheese in minas gerais. due to the lack of a specific identity and a quality pattern for cheese whey, the results can be taken as a base to develop such patterns. the mean values found for mozzarella cheese whey were: - 0.565± 0.031oh for freezing point; 6.19± 0.26 for ph; 13.16± 3.08od for titratable acidity; 6.33± 0.43g/100g for total solids; 93.67± 0.43g/100g for moisture; 0.77± 0.26g/100g for fat; 0.84± 0.04g/100g for protein; 4.42± 0.68g/100g for lactose; 0.47± 0.04 g/100g for ashes; 0.18± 0.01g/100g for chlorine and 1.0253± 0.0006 for density. in relation to minas-padr?o cheese whey, the following mean results were obtained: - 0.555± 0.030oh for freezing point; 6.30± 0.31 for ph; 12.48± 2.07od for titratable acidity; 6.28± 0.51g/100g for total solids; 93.97± 0.54 g/100g for moisture; 0.70± 0.21g/100g for fat; 0.80± 0.04g/100g for protein; 4.12± 0.36g/100g for lactose; 0.49± 0.03g/100g for ashes; 0.20± 0.01g/100g for chlorine and 1.0249± 0.0009 for density. no statistical difference between those types of whey was observed, but difference among wheys from regions for freezing point, total solids, moisture and density as well as interaction whey x regions for protein, titratable acidity, fat, and chorine were found. only lactose and ash contents did not present any statistical difference.
Interpretación de la estructura del frente monta oso en la zona del río Diamante, Mendoza Structural interpretation of the mountain front in the Río Diamante zone, Mendoza
M.M. Turienzo,L.V. Dimieri
Revista de la Asociación Geológica Argentina , 2005,
Abstract: En la zona de unión entre el arroyo Las Aucas y el río Diamante (69° 30' LO; 34° 40' LS) se observan una serie de estructuras, de escala kilométrica, que afectan a las rocas de la Cordillera Principal y de la Cordillera Frontal. Un bloque rígido de basamento es ascendido sin sufrir plegamiento mediante una falla inversa ubicada al este del mismo mientras que la cubierta sedimentaria adosada a dicho bloque constituye una estructura anticlinal volcada hacia el antepaís, cuyo flanco más empinado es deformado intensamente. Las características observadas pueden ser explicadas por más de un modelo para estructuras que involucran al basamento. Realizar múltiples interpretaciones puede constituir una herramienta útil para conocer los procesos geológicos actuantes y ser así una guía al momento de dilucidar las estructuras resultantes, de macro y meso escala, tanto en afloramientos como en el subsuelo. Un retrocorrimiento que se desprende del bloque de basamento elevado produce un anticlinal con vergencia hacia el oeste. Esta estructura es interpretada mediante un modelo geométrico y cinemático que puede combinarse con cualquiera de los utilizados para las estructuras mayores. Los estudios realizados remarcan el estilo de deformación que afecta al basamento y la cubierta, y sus características diagnósticas pueden ser utilizadas para comprender la deformación en los sectores más internos del orógeno, incluso donde no se hallen expuestas las rocas del basamento. Mediante dos secciones retrodeformables, interpretadas con un modelo de unión triple y un modelo de trishear, se calcularon los valores de acortamiento. At the junction of Las Aucas stream with the Diamante river (69° 30' W; 34° 40' S) kilometre-scale structures affecting both Cordillera Principal and Cordillera Frontal rocks were surveyed. A rigid basement block is uplifted, without folding, by a reverse fault at its eastern edge. Sedimentary cover above this block forms an anticline whose steeply dipping limb is highly deformed. Several models for basement-involved structures can explain the observed features. Multiple interpretations can be a useful tool to understand the geological process involved and a guide for predicting both macro- and mesoscale structures in outcrops or at the subsurface. A backthrust which detached from the uplifted basement block, produced a west-verging anticline. This structure is interpreted using a geometric and kinematic model, which can be combined with any of those used for major structures. Our studies highlight the deformation style affecting both basement and cover roc
Geometría y cinemática de las estructuras que involucran al basamento en la zona del arroyo Tordillo, faja corrida y plegada de Malargüe, Mendoza Geometry and kinematic of the basement-involved structures at the Arroyo Tordillo zone, Malargüe fold-thrust belt, Mendoza
M.M. Turienzo,L.V. Dimieri
Revista de la Asociación Geológica Argentina , 2005,
Abstract: El estudio detallado realizado en la zona de los arroyos Tordillo y Blanco, en la faja corrida y plegada de Malargüe, permitió reconocer una gran variedad de estructuras tectónicas que afectan tanto al basamento como a la cubierta sedimentaria. Con los datos estructurales relevados e información de subsuelo, confeccionamos una sección estructural retrodeformable de las estructuras aflorantes y su continuidad en profundidad, e interpretamos su evolución cinemática. Dos pares anticlinal-sinclinal, que posiblemente involucran al basamento, tienen lugar en el sector más occidental del área de estudio. Estos son transportados sobre una cu a de basamento, la cual en su avance hacia el antepaís genera un pliegue por propagación de falla en la cubierta sedimentaria. Cuando el desplazamiento hacia el este de la cu a es obstaculizado, en su extremo se generan dos retrocorrimientos. En este intrincado marco estructural, el corrimiento que dio origen a la cu a es reactivado como una falla fuera de secuencia. Finalmente un nuevo corrimiento desarrollado más al este genera otra escama de basamento que eleva a las estructuras previas. La interpretación cinemática permitió calcular los acortamientos tectónicos para cada estadio de la estructuración así como visualizar la estrecha relación existente entre las estructuras. Detailed studies made at the Tordillo and Blanco streams, in the Malargüe fold-thrust belt, allowed us to recognize a broad variety of tectonic structures affecting both, basement and cover rocks. Using surface structural data together with sub-surface information we made a retrodeformable structural cross-section of the outcropping structures and its continuity in deep, and interpreted the kinematic evolution. Two pairs anticline-syncline, possibly involving basement rocks, occur at the westernmost area. These structures are carried by an eastward vergent basement wedge that in its movement toward the east produces a fault-propagation fold in the sedimentary cover. When this slip is obstructed, two basement-involved backthrusts occur at the toe of the wedge. In this complicated structural setting, the thrust responsible for the basement wedge is reactivated like an out-of-sequence fault. Finally, a new thrust generated at the east, produce another basement wedge which uplift the previous structures. The kinematic interpretation presented here allowed the measurement of tectonic shortenings for each structural stage and the understanding of close relationship between the different structures.
Cultured myoblasts from patients affected by myotonic dystrophy type 2 exhibit senescence-related features: ultrastructural evidence
M. Malatesta,M. Giagnacovo,L.V. Renna,R. Cardani
European Journal of Histochemistry , 2011, DOI: 10.4081/ejh.2011.e26
Abstract: Myotonic dystrophy type 2 (DM2) is an autosomal dominant disorder caused by the expansion of the tetranucleotidic repeat (CCTG)n in the first intron of the Zinc Finger Protein-9 gene. In DM2 tissues, the expanded mutant transcripts accumulate in nuclear focal aggregates where splicing factors are sequestered, thus impairing the whole mRNA processing. Interestingly, the ultrastructural alterations in the splicing machinery observed in the myonuclei of DM2 skeletal muscles are reminiscent of the nuclear changes occurring in age-related muscle atrophy. Here, we investigated structural and functional features of satellite cell-derived myoblasts from biceps brachii, in the attempt to investigate cell senescence indices in DM2 patients by ultrastructural cytochemistry. We observed that in satellite cell-derived DM2 myoblasts, cell-senescence alterations and impairment of the pre-mRNA maturation pathways occur earlier than in myoblasts from healthy patients. This suggests that also in vivo the regeneration capability of satellite cells could be reduced in dystrophic muscles.
GROUND SURFACE TEMPERATURE HISTORIES INFERRED FROM 15 BOREHOLES TEMPERATURE PROFILES: COMPARISON OF TWO APPROACHES
Eppelbaum,L.V; Kutasov,I.M; Barak,G;
Earth Sciences Research Journal , 2006,
Abstract: understanding the climate change processes requires application of special methodologies for revealing a ground surface temperature history (gsth). it was proved by different authors that the gsth may be determined on the basis of analysis of the temperature field observed in short boreholes. in this paper, the authors analyze four mathematical models describing the gsth: (1) sudden change, (2) linear increase, (3) square root of time increase and (4) exponential increase. fifteen borehole temperature profiles from europe, asia and north america were selected in three groups based on their geographical proximity. after careful analysis of temperature-depth profiles in these boreholes it was found out that two models (linear increase and square root of time increase) provide the best fit with field data. the calculated warming rates in the 20th century were compared with those obtained by a few parameters estimation (fpe) technique.
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