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Search Results: 1 - 10 of 303052 matches for " L. T. Rasmussen "
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Climate change effects on irrigation demands and minimum stream discharge: impact of bias-correction method
J. Rasmussen,T. O. Sonnenborg,S. Stisen,L. P. Seaby
Hydrology and Earth System Sciences Discussions , 2012, DOI: 10.5194/hessd-9-4989-2012
Abstract: Climate changes are expected to result in a warmer global climate, with increased inter-annual variability. In this study, the possible impacts of these climate changes on irrigation and low stream flow are investigated using a distributed hydrological model of a sandy catchment in western Denmark. The IPCC climate scenario A1B was chosen as the basis for the study, and meteorological forcings (precipitation, reference evapotranspiration and temperature) derived from the ECHAM5-RACMO2 regional climate model for the period 2071–2100 was applied to the model. Two bias correction methods, Delta Change and Distribution-Based Scaling, were used to evaluate the importance of the bias correction method. Using the annual irrigation amounts, the minimum stream flow, the median minimum stream flow and the mean stream flow as indicators, the irrigation and the stream flow predicted using the two methods were compared. The study found that irrigation is significantly underestimated and low stream flow in overestimated when using the delta change method, due to the inability of this method to account for changes in inter-annual variability of precipitation and reference ET and the resulting effects on irrigation demands. Additionally, future increases in CO2 are found to have a significant effect on both irrigation and low flow, due to reduced transpiration from plants.
Gold Standard Program for Heavy Smokers in a Real-Life Setting
Tim Neumann,Mette Rasmussen,Berit L. Heitmann,Hanne T?nnesen
International Journal of Environmental Research and Public Health , 2013, DOI: 10.3390/ijerph10094186
Abstract: Background: High-intensity smoking cessation programs generally lead to more continuous abstinence, however, lower rates of success have been reported among heavy smokers. The aim was to evaluate continuous abstinence among heavy smokers during the intensive 6-week Gold Standard Program (GSP) and to identify modifiable factors associated with continuous abstinence. Methods: In this nationwide clinical study based on 36,550 smokers attending an intensive cessation program in Denmark. Heavy smoking was defined as ≥7 points in the Fagerstr?m Nicotine Dependency Test, smoking ≥20 cigarettes daily or ≥20 pack-years. Results: Overall, 28% had a Fagerstr?m score ≥7 points, 58% smoked ≥20 cigarettes daily and 68% smoked ≥20 pack-years. Continuous abstinence was 33% in responders (6-months response rate: 78%); however, abstinence was approximately 1–6% lower in the heavy smokers than the overall population. Attending GSP with an individual format ( vs. group/other, OR 1.23–1.44); in a hospital setting ( vs. pharmacy/municipality services, OR 1.05–1.11); and being compliant (attending the planned meetings OR 4.36–4.89) were associated with abstinence. Abstinence decreased in a dose-dependent manner with increasing smoking severity. Conclusions: Abstinence after GSP was 1–6% lower in the heavy smokers than in the overall study population. Modifiable factors may be used for small improvements in continued abstinence. However attempts to improve compliance seemed especially promising.
BLMH and APOE genes in Alzheimer Disease: A possible relation  [PDF]
J. P. B. Ximenez, L. T. Rasmussen, W. A. Orcini, R. W. Labio, G. V. Arruda, P. H. F. Bertolucci, M. A. Smith, S. L. M. Pay?o
Advances in Alzheimer's Disease (AAD) , 2013, DOI: 10.4236/aad.2013.23015
Abstract: Alzheimer disease (AD) is a progressive and irreversible neurodegenerative disorder that is characterized by cognitive decline, memory loss and confusion. The E4 allele of the apolipoprotein E gene (APOE) is associated with AD and it is the main genetic risk factor for disease. Although the exact physiological function is unknown, bleomycin hydrolase (BLMH) may also be associated with AD development, although previous immunohistochemical findings havebeen inconsistent. Therefore, the purpose ofthis study was to evaluate the genotypic and allele frequencies of theAPOEgene andBLMH1450 G> A polymorphism and assessBLMHexpression using PCR-RFLP and RT-qPCR analyses ofblood samples from patients with Alzheimer disease (AD), healthy elderly adults (EC) andhealthyyoung subjects(YC). BLMHexpression wassignificantly different among groups (p= 0.015) and there was substantial reduction with age and with AD. TheAPOEandBLMHgenotype frequency did not diverge from the Hardy-Weinberg equilibrium. There was a higher frequency of genotype 3/3 inall subjects (61.1%) and the AD group demonstrated a higher frequency of allele 4; however, differences ingenotype and allele distributions were statistically different among groups.

Prevalence of Helicobacter pylori cagA and sabA Genotypes in Patients with Gastric Disease  [PDF]
Jéssica Nunes Pereira, Wilson A. Orcini, Rita L. Peruquetti, Marilia A. C. Smith, Spencer L. M. Pay?o, Lucas T. Rasmussen
Advances in Microbiology (AiM) , 2019, DOI: 10.4236/aim.2019.93017
Abstract: Gastric cancer is one of the most common types of cancer worldwide. Helicobacter pylori is considered one of the most important causes of this condition specially because of its virulence markers as sabA and cagA. Therefore, we aim to investigate the relation between these markers and the gastric diseases in 400 patients who underwent upper digestive endoscopy. To detect the bacteria and its genes by Polymerase Chain Reaction (PCR), the presence of H. pylori was significant when comparing the groups control vs. cancer (p value < 0.0001) OR [95% CI] 12.73 (5.45 - 29.69) and the groups control vs. chronic gastritis (p value < 0.0001) OR [95% CI] 12.99 (7.44 - 22.66). cagA was statistically significant considering its presence when comparing the chronic gastritis vs. cancer groups (p value = 0.0434) OR [95% CI] 2.44 (1.021 - 5.845). Associating both sabA and cagA, we found a statistically significant result (p value < 0.0001) OR [95% CI] 13.68 (3.95 - 47.33) considering the gastritis vs. cancer groups. Helicobacter pylori is directly associated to gastric diseases such as gastritis and cancer and its virulence markers: sabA and cagA increase the injury process to the gastric epithelium making the host more susceptible to cancer.
Proceedings of a symposium on lions and leopards as game ranch animals, J. van Heerden (ed.) : book review
L. Rasmussen
Journal of the South African Veterinary Association , 2012, DOI: 10.4102/jsava.v69i1.812
Abstract:
Elevation correction of ERA-Interim temperature data in complex terrain
J. Rasmussen, T. O. Sonnenborg, S. Stisen, L. P. Seaby, B. S. B. Christensen,K. Hinsby
Hydrology and Earth System Sciences (HESS) & Discussions (HESSD) , 2012,
Abstract: Climate changes are expected to result in a warmer global climate, with increased inter-annual variability. In this study, the possible impacts of these climate changes on irrigation and low stream flow are investigated using a distributed hydrological model of a sandy catchment in western Denmark. The IPCC climate scenario A1B was chosen as the basis for the study, and meteorological forcings (precipitation, reference evapotranspiration and temperature) derived from the ECHAM5-RACMO regional climate model for the period 2071–2100 was applied to the model. Two bias correction methods, delta change and Distribution-Based Scaling, were used to evaluate the importance of the bias correction method. Using the annual irrigation amounts, the 5-percentile stream flow, the median minimum stream flow and the mean stream flow as indicators, the irrigation and the stream flow predicted using the two methods were compared. The study found that irrigation is significantly underestimated when using the delta change method, due to the inability of this method to account for changes in inter-annual variability of precipitation and reference ET and the resulting effects on irrigation demands. However, this underestimation of irrigation did not result in a significantly higher summer stream flow, because the summer stream flow in the studied catchment is controlled by the winter and spring recharge, rather than the summer precipitation. Additionally, future increases in CO2 are found to have a significant effect on both irrigation and low flow, due to reduced transpiration from plants.
Bubble Statistics and Dynamics in Double-Stranded DNA
B. S. Alexandrov,L. T. Wille,K. O. Rasmussen,A. R. Bishop,K. B. Blagoev
Physics , 2006, DOI: 10.1103/PhysRevE.74.050901
Abstract: The dynamical properties of double-stranded DNA are studied in the framework of the Peyrard-Bishop-Dauxois model using Langevin dynamics. Our simulations are analyzed in terms of two probability functions describing coherently localized separations ("bubbles") of the double strand. We find that the resulting bubble distributions are more sharply peaked at the active sites than found in thermodynamically obtained distributions. Our analysis ascribes this to the fact that the bubble life-times significantly afects the distribution function. We find that certain base-pair sequences promote long-lived bubbles and we argue that this is due to a length scale competition between the nonlinearity and disorder present in the system.
Review of Survey activities 2011: Geological assessment of the East Greenland margin
Fyhn, M.B.W.,Rasmussen, T.M.,Dahl-Jensen, T.,Weng, W.L.
Geological Survey of Denmark and Greenland Bulletin , 2012,
Abstract:
Evaluation of two commercial global miRNA expression profiling platforms for detection of less abundant miRNAs
Steffen G Jensen, Philippe Lamy, Mads H Rasmussen, Marie S Ostenfeld, Lars Dyrskj?t, Torben F ?rntoft, Claus L Andersen
BMC Genomics , 2011, DOI: 10.1186/1471-2164-12-435
Abstract: Using synthetic miRNA samples and plasma RNA samples spiked with different ratios of 174 synthetic miRNAs we assessed the performance characteristics reproducibility, recovery, specificity, sensitivity and linearity. It was found that while the qRT-PCR based platforms were sufficiently sensitive to reproducibly detect miRNAs at the abundance levels found in human plasma, the array based platform was not. At high miRNA levels both qRT-PCR based platforms performed well in terms of specificity, reproducibility and recovery. At low miRNA levels, as in plasma, the miRCURY platform showed better sensitivity and linearity than the TaqMan platform.For profiling clinical samples with low miRNA abundance, such as plasma samples, the miRCURY platform with its better sensitivity and linearity would probably be superior.microRNAs (miRNAs) are short 20-23 nucleotide long non-coding RNAs that are widely distributed in almost all eukaryotic organisms. They have multiple functions however the main function is believed to be post transcriptional regulation of protein levels [1,2]. While miRNAs are often abundant in tissues, the amount found circulating in body fluids such as plasma and serum is often limited. It has been reported that the total RNA level in plasma is in the range 6-300 ng/ml [3,4] and that the miRNA fraction constitutes only a few percent of this [5]. The mechanisms regulating secretion of miRNA into circulation is still unclear. Reports have shown that while endogenous miRNAs appear stable in plasma/serum exogenous miRNAs are not, and as a result of this it has been suggested that endogenous circulating miRNAs are either encapsulated in microvesicles or bound to RNA-binding proteins in complexes, e.g. Ago2 and NPM1, protecting them from degradation [6-8]. Detailed knowledge of the biological function of circulating miRNA does not exist, however it has been shown that vesicular miRNAs can be transferred from cell to cell and influence the behavior of the recipient c
Intercomparison of aerosol-cloud-precipitation interactions in stratiform orographic mixed-phase clouds
A. Muhlbauer, T. Hashino, L. Xue, A. Teller, U. Lohmann, R. M. Rasmussen, I. Geresdi,Z. Pan
Atmospheric Chemistry and Physics (ACP) & Discussions (ACPD) , 2010,
Abstract: Anthropogenic aerosols serve as a source of both cloud condensation nuclei (CCN) and ice nuclei (IN) and affect microphysical properties of clouds. Increasing aerosol number concentrations is hypothesized to retard the cloud droplet coalescence and the riming in mixed-phase clouds, thereby decreasing orographic precipitation. This study presents results from a model intercomparison of 2-D simulations of aerosol-cloud-precipitation interactions in stratiform orographic mixed-phase clouds. The sensitivity of orographic precipitation to changes in the aerosol number concentrations is analysed and compared for various dynamical and thermodynamical situations. Furthermore, the sensitivities of microphysical processes such as coalescence, aggregation, riming and diffusional growth to changes in the aerosol number concentrations are evaluated and compared. The participating numerical models are the model from the Consortium for Small-Scale Modeling (COSMO) with bulk microphysics, the Weather Research and Forecasting (WRF) model with bin microphysics and the University of Wisconsin modeling system (UWNMS) with a spectral ice habit prediction microphysics scheme. All models are operated on a cloud-resolving scale with 2 km horizontal grid spacing. The results of the model intercomparison suggest that the sensitivity of orographic precipitation to aerosol modifications varies greatly from case to case and from model to model. Neither a precipitation decrease nor a precipitation increase is found robustly in all simulations. Qualitative robust results can only be found for a subset of the simulations but even then quantitative agreement is scarce. Estimates of the aerosol effect on orographic precipitation are found to range from 19% to 0% depending on the simulated case and the model. Similarly, riming is shown to decrease in some cases and models whereas it increases in others, which implies that a decrease in riming with increasing aerosol load is not a robust result. Furthermore, it is found that neither a decrease in cloud droplet coalescence nor a decrease in riming necessarily implies a decrease in precipitation due to compensation effects by other microphysical pathways. The simulations suggest that mixed-phase conditions play an important role in buffering the effect of aerosol perturbations on cloud microphysics and reducing the overall susceptibility of clouds and precipitation to changes in the aerosol number concentrations. As a consequence the aerosol effect on precipitation is suggested to be less pronounced or even inverted in regions with high terrain (e.g., the Alps or Rocky Mountains) or in regions where mixed-phase microphysics is important for the climatology of orographic precipitation.
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