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Klebsiella pneumoniae liver abscess (KPLA) has been described as an invasive syndrome with extrahepatic
complications. The majority of KPLA is caused by capsular serotype K1 and K2 isolates. We report a case of carbapenem resistant Klebsiella pneumoniae liver abscess. The patient initially presented with
infected right above-the-knee amputation and was later found with a
large liver abscess.
Initial antimicrobial susceptibility showed carbapenem resistant K. pneumoniae (CRKP). Further molecular workup
revealed that the isolate
was a less virulent non-K1/K2 serotype, and both rmpA and kfu genes were negative. The lack of outer membrane porins likely contributed to the carbapenem
our knowledge, this is a first reported case of carbapenem resistant, non-K1/K2 serotype K. pneumoniae liver abscess in the United States.
By the end of the
21st century, mean sea surface temperatures are expected to increase
4?C, while atmospheric CO2 concentrations are predicted to triple
causing seawater to become acidic. These compounding effects will undoubtedly
have major consequences for the organisms and processes in the oceans.
Bacterioplankton play a vital role in the marine carbon cycle and the oceans’
ability to sequester CO2. We utilized pCO2 perturbation experiments to investigate the effects of ocean acidity and
elevated temperature on bacterioplankton community structure and metabolism.
Terminal-restriction fragment length polymorphism (T-RFLP) of small subunit
ribosomal (SSU) genes revealed that bacterioplankton incubated in lower pH
conditions exhibited a reduction of species richness, evenness, and overall
diversity, relative to those incubated in ambient pH conditions. Non-metric
multidimensional scaling (MDS) of T-RFLP data resulted in clustering by pH
suggesting that pH influenced the structure of these communities. Shifts in the
dominant members of bacterioplankton communities incubated under different pH
were observed in both T-RFLP and SSU clone library analyses. Both ambient and low
pH communities were dominated by Gammaproteobacteria and Alphaproteobacteria,
although abundance of Alphaproteobacteria increased in communities incubated at
lower pH. This was expressed by the gamma to alpha ratio dropping from ~9 to 4,
respectively. In general, the representative taxa from these two classes were
distinctly different between the treatments, with a few taxa found to be
persistent in both treatments. Changes in