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Search Results: 1 - 10 of 328416 matches for " Lúcio Fábio Caldas;Steinmetz "
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Deficiência de 5alfa-redutase tipo 2: experiências de Campinas (SP) e Salvador (BA)
Hackel, Christine;Oliveira, Luiz Eduardo C. de;Toralles, Maria Betania;Nunes-Silva, Daniela;Tonini, Maria Manuela O.;Ferraz, Lúcio Fábio Caldas;Steinmetz, Leandra;Damiani, Durval;Oliveira, Laurione Candido de;Maciel-Guerra, Andréa T.;Stuchi-Perez, Eliana Gabas;Guerra-Júnior, Gil;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2005, DOI: 10.1590/S0004-27302005000100014
Abstract: objective: to report the experience regarding patients with steroid 5a-reductase type 2 deficiency from three different clinical services in brazil. casuistic and methods: twenty five patients with clinical and hormonal features of 5a-reductase deficiency from 23 families (15 from bahia, 7 from s?o paulo and 1 from minas gerais) were included in this study. clinical, hormonal and molecular data were evaluated. the molecular analysis of the five exons of the srd5a2 gene was done by automatic or manual sequencing of pcr products. results: in ten families, srd5a2 mutations were found in homozygosis (5 with g183s, 2 with r246w, 1 with g196s, 1 with del642t, 1 with 217_218insc), in three in compound heterozygosis (1 with q126r/ivs3+1g>a, 1 with q126r/del418t, 1 with q126r/g158r) while other three were heterozygous, with only one deleterious mutation (1 with g196s, 1 with a207d, and 1 with r246w). in seven cases, no sequencing abnormalities were detected. the g183s substitution was the most frequently found among miscigenated patients (afro-euro-brazilians) from bahia. hormonal and clinical findings did not differ between patients with or without mutations, exception made to a higher frequency of consanguinity and greater severity of genital ambiguity in the first group. conclusion: our results reinforce the importance of molecular investigation for the diagnosis of this disease and point out to the finding of a very frequent mutation (g183s) in our series, especially in patients with mixed ethnic background from bahia, and the description of mutations that have only been reported in brazilian patients so far.
Apparent mineralocorticoid excess syndrome in a Brazilian boy caused by the homozygous missense mutation p.R186C in the HSD11B2 gene
Coeli, Fernanda Borchers;Ferraz, Lúcio Fábio Caldas;Lemos-Marini, Sofia H. V. de;Rigatto, Sumara Zuanazi Pinto;Belangero, Vera Maria Santoro;de-Mello, Maricilda Palandi;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2008, DOI: 10.1590/S0004-27302008000800012
Abstract: the apparent mineralocorticoid excess syndrome (ame) is a rare autosomal recessive disorder due to the deficiency of 11β-hydroxysteroid dehydrogenase type 2 enzyme (11beta-hsd2). the 11beta-hsd2 enzyme, encoded by hsd11b2 gene, metabolizes active cortisol in cortisone. mutations on hsd11b2 gene affect the enzyme activity by leading to an excess of cortisol, which causes its inappropriate access to mineralocorticoid receptor. therefore, cortisol will bind mineralocorticoid receptor. the human hsd11b2 gene maps to chromosome 16q22 and consists of five exons encoding a protein of 405 amino acids. we present here clinical and molecular studies on a brazilian boy who was born pre-term after an oligodramnious pregnancy. he was diagnosed as having ame at the age of 26 months. his parents are second cousins. molecular characterization of the hsd11b2 gene revealed the homozygous mutation p.r186c. the patient described here is the second case of hds11b2 gene mutation reported in brazilian patients with ame.
Fábio Lúcio Santos
Acta Scientiarum : Technology , 2009,
Abstract: This paper deals with an analytical model of a rigid rotor supported by hydrodynamic journal bearings where the plane separation technique together with the Artificial Neural Network (ANN) is used to predict the location and magnitude of the correction masses for balancing the rotor bearing system. The rotating system is modeled by applying the rigid shaft Stodola-Green model, in which the shaft gyroscopic moments and rotatory inertia are accountedfor, in conjunction with the hydrodynamic cylindrical journal bearing model based on theclassical Reynolds equation. A linearized perturbation procedure is employed to render the lubrication equations from the Reynolds equation, which allows predicting the eight linear forcecoefficients associated with the bearing direct and cross-coupled stiffness and damping coefficients. The results show that the methodology presented is efficient for balancing rotorsystems. This paper gives a step further in the monitoring process, since Artificial Neural Network is normally used to predict, not to correct the mass unbalance. The procedure presentedcan be used in turbo machinery industry to balance rotating machinery that require continuous inspections. Some simulated results will be used in order to clarify the methodology presented. Este trabalho foi desenvolvido com o objetivo de empregara técnica de balanceamento de separa o de planos juntamente com Redes Neurais Artificiais (RNA) para a predi o da localiza o e massas de corre o para o balanceamento de um sistema rotor-mancal, para tal, foi empregado um modelo analítico consitituído por um rotor rígido apoiado em mancais hidrodinamicos. O sistema rotativo foi modelado com base no modelo de eixo rígidos de Stodola-Green, no qual foram considerados o efeito girocópico e a inércia rotatória, além de um modelo de mancal hidrodinamico cilíndrico baseado nas equa es deReynolds que permitiu a determina o de oito coeficientes lineares de for a associados com os coeficientes de rigidez e amortecimento diretos e cruzados do mancal. Os resultados mostraram que a metodologia apresentada foi eficiente para o balanceamento de rotores. Este trabalho fornece grande contribui o para o processo de monitoramento, uma vez que Redes Neurais Artificiais normalmente s o empregadas para identifica o, e n o para a corre o dodesbalanceamento. O procedimento apresentado pode ser empregado no balanceamento de turbomáquinas industriais, as quais necessitam de contínuas avalia es. Resultados simulados s o apresentados com o objetivo de ilustrar metodologia de balanceamento proposta.
Using Virtualization to Provide Interdomain QoS-enabled Routing
Fábio L. Verdi,Maurício F. Magalh?es,Edmundo Madeira,Annikki Welin
Journal of Networks , 2007, DOI: 10.4304/jnw.2.2.23-32
Abstract: Today, the most important aspect related with the Internet architecture is its ossification representing the difficulties to introduce evolutions in the architecture as a way to meet the demands posed by the new requirements as mobility, security, heterogeneity, etc. In this paper we discuss how the network virtualization can be used to support the interdomain QoS-enabled routing. We present the Virtual Topology Service (VTS), a new approach to provide interdomain services taking into account QoS and Traffic Engineering (TE) constraints. We advocate in favor of a service layer that offers new mechanisms for interdomain routing without affecting the underlying Internet infrastructure. The VTS abstracts the physical network details of each Autonomous System (AS) and is totally integrated with BGP. Two models to obtain VTs were defined, the Push Model and the Pull Model. The latter one uses the Internet hierarchy to get more alternative routes towards a destination. We will show how the VTS and other services such as the end-toend negotiation service work together to provide a complete mechanism for provisioning of interdomain QoS- enabled routes in IP networks. Preliminary evaluation results are also presented.
Peroxidases ativadas por fra??es protéicas de extrato biológico eficaz na prote??o do tomateiro contra a mancha bacteriana
Cavalcanti, Fábio R.;Resende, Mário Lúcio V.;Oliveira, José Tadeu A.;
Fitopatologia Brasileira , 2007, DOI: 10.1590/S0100-41582007000600010
Abstract: a crude formulation (vlaf) of an aqueous cold extract obtained from solanum lycocarpum necrotic tissue infected by crinipellis perniciosa was showed capable of reducing disease progress of tomato bacterial leaf spot, when previously sprayed on tomato plants. the fractions f0/30 and f30/60 were achieved by saline precipitation and they showed highest amounts of proteins from vlaf. the fractions were submitted to cationic exchange chromatography for protein scanning. non-retained peaks from this first chromatography were submitted to an anionic exchange chromatography. both retained and non-retained peaks from both ion exchanges were sampled and sprayed on cv. santa cruz kada tomatoes. contrasting peroxidase activities were observed 14 hours after sprayings. the samples that produced the highest peroxidase increases were the retained peak in cationic exchange from f0/30 (f0-30cmr) and the retained peak in anionic exchange chromatography from f30/60 (f30-60deaer). our results indicate the viability of searching for protein- or carbohydrate-derived molecules from vlaf aqueous extract.
Multímetro interfaceado de baixo custo para aquisi??o de dados
Richter, Eduardo M.;Rocha, Fábio R. P.;Angnes, Lúcio;
Química Nova , 2004, DOI: 10.1590/S0100-40422004000200023
Abstract: a digital multimeter (~u$ 240.00 on the national market) connected to a microcomputer by a rs-232 serial interface is proposed for data acquisition in equipment with analog output. data are measured at the rate of 2 points per second and stored in text files by the software that accompanies the device, running in a windows environment. the performance of the multimeter was verified by monitoring the transient signals generated in flow injection systems associated with fluorimetric, spectrophotometric and flame photometric detection. in addition, the performance of the proposed device was similar to that attained by employing an interface card with a 12-bit analog-to-digital converter for acquisition of the signals generated by a capillary electrophoresis equipment with oscillometric detection.
Predicting the revolving door phenomenon among patients with schizophrenic, affective disorders and non-organic psychoses
Gastal Fábio L,Andreoli Sérgio B,Quintana Maria Inês S,Gameiro Maurício Almeida
Revista de Saúde Pública , 2000,
Abstract: OBJECTIVE: The aim of the study was to identify the variables that predict the revolving door phenomenon in psychiatric hospital at the moment of a second admission. METHODS: The sample consisted of 3,093 patients who have been followed during 5 to 24 years after their first hospital admission due to schizophrenia, and affective or psychotic disorders. Those who had had four or more admissions during the study period were considered as revolving door patients. Logistic regression analyses were used to assess the impact of gender, age, marital status, urban conditions, diagnosis, mean period of stay on the first admission, interval between the first and second admissions on the patterns of hospitalization. RESULTS: The variables with the highest predictive power for readmission were the interval between first and second admissions, and the length of stay in the first admission. CONCLUSIONS: These data may help public health planners in providing optimal care to a small group of patients with more effective utilization of the available services.
Multímetro interfaceado de baixo custo para aquisi o de dados
Richter Eduardo M.,Rocha Fábio R. P.,Angnes Lúcio
Química Nova , 2004,
Abstract: A digital multimeter (~U$ 240.00 on the national market) connected to a microcomputer by a RS-232 serial interface is proposed for data acquisition in equipment with analog output. Data are measured at the rate of 2 points per second and stored in text files by the software that accompanies the device, running in a Windows environment. The performance of the multimeter was verified by monitoring the transient signals generated in flow injection systems associated with fluorimetric, spectrophotometric and flame photometric detection. In addition, the performance of the proposed device was similar to that attained by employing an interface card with a 12-bit analog-to-digital converter for acquisition of the signals generated by a capillary electrophoresis equipment with oscillometric detection.
Produ o in vitro de embri es bovinos com soro de égua ou de vaca em estro com ou sem a adi o de LH/FSH
Figueiró Giuliano Moraes,Leivas Fábio Galas,Rauber Lúcio Pereira,Sá Filho Manoel Francisco de
Ciência Rural , 2004,
Abstract: Mil duzentos e setenta e um oócitos foram divididos em 4 tratamentos com a finalidade de se avaliar a influência da adi o de LH e FSH na produ o in vitro de embri es bovinos com soro de vaca em estro (SVE) ou soro de éguas obtido no 1masculine dia do estro (SE). Independente do tratamento os oócitos foram maturados com TCM199 + 5,95mg/ml de Hepes, 0,025mg/ml de piruvato de sódio e 2,2mg/ml de bicarbonato de sódio, sendo adicionado 10% de soro de égua (ES), 10% de SVE (VS), 10% de soro de égua + 0,5mg/ml de horm nio luteinizante bovino (LHb) + 0,01UI/ml de horm nio folículo estimulante recombinante humano-rFSHh (EH) e 10% SVE + LHb + rFSHh (VH). Os oócitos assim tratados, foram maturados em estufa com 5% de CO2 a 39masculineC sob umidade saturada por 22-24h. Depois, foram fecundados em TALP-FERT por 18-20h e cultivados por 8 dias em meio SOF + 5% de SE (ES e EH) ou SVE (VS e VH). As taxas de clivagem de 72% obtidas no grupo VH (229/316) e 61% no grupo VS (193/315) foram significativamente menores (p<0,05) que as dos grupos ES (80% - 254/317) e EH (80% - 257/323). A produ o de embri es (blastocistos iniciais, blastocistos, blastocistos expandidos e eclodidos) no D7 após a insemina o para os grupos ES (32%), EH (28%) e VH (27%), foi significativamente superior aos 20% obtidos no VS (p<0,05). No D9, verificou-se uma diferen a significativa (p<0,05) entre os grupos ES (31%) e EH (29%) quando comparados com o grupo VS (22%), mas n o houve diferen a quando comparamos com o VH (24%). A taxa de eclos o em D9 foi de 11% (ES), 11% (EH), 10% (VS) e 5% (VH). N o houve diferen a entre as médias do número de células dos embri es (Blastocistos expandidos e eclodidos) obtidos no D9. Conclui-se, com estes resultados que, para a obten o de taxas regulares de blastocistos, n o seja necessária a adi o de horm nios quando se utilize o soro de égua, e que os horm nios devam ser adicionados quando se utilize soro de vaca.
Efeito das fontes de amido e nitrogênio de diferentes degradabilidades ruminais.1. Digestibilidades parcial e total
Fregadolli, Fábio Luiz;Zeoula, Lúcia Maria;Prado, Ivanor Nunes do;Branco, Ant?nio Ferriani;Caldas Neto, Saul Ferreira;Kassies, Marcos Paulo;Dalponte, Augusto Ortega;
Revista Brasileira de Zootecnia , 2001, DOI: 10.1590/S1516-35982001000300035
Abstract: total and partial digestibility of diets combining the starch sources of high degradability (dried cassava hulls) and low degradability (corn), with nitrogen sources of high (yeast) and low (cottonseed meal and meat and bone meal) degradability, in a 2 x 2 factorial arrangement, were evaluated. four holstein steers (334 kg) fitted with ruminal and duodenal cannulas, in a 4 x 4 latin square were used. chromic oxide was used as a marker for drying matter flow. interactions of starch and n sources on apparent digestibility coefficient (adc) of crude protein (cp) and neutral detergent fiber (ndf) was detected. diets of corn and yeast, cassava hulls and cottonseed meal + meat and bone meal showed higher adc of cp than diets of corn and meat and bone meal and with cassava hulls and yeast. the diet of starch and n with high ruminal degradability showed lower value than others diets, that was not different. ruminal digestion of ndf was higher when starch source was corn compared with cassava hulls. the highest digestion of starch was higher in diets with cassava hulls than in diets of corn, in all segments of digestive system. negative values for ruminal digestion of cp to experimental diets were observed. the n source influenced ruminal and intestinal digestion of energy. the ruminal digestion was higher in diets with yeast e intestinal digestion was higher in diets with cottonseed meal + meat and bone meal.
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