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Search Results: 1 - 10 of 369569 matches for " Lúcia Porto Fonseca de; "
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diagnóstico da infec??o pelo HPV em les?es do colo do útero em mulheres HIV+: acuidade da histopatologia
Souza, Néli Sueli Teixeira de;Melo, Victor Hugo do;Castro, Lúcia Porto Fonseca de;
Revista Brasileira de Ginecologia e Obstetrícia , 2001, DOI: 10.1590/S0100-72032001000600003
Abstract: purpose: to compare histopathology and polymerase chain reaction (pcr) for the diagnosis of human papillomavirus (hpv) in cervical lesions of human immunodeficiency virus (hiv)-seropositive women. methods: fifty-two hiv-seropositive women with suspected hpv cervical lesions were studied. cervical scrapes were collected for pcr and colposcopy-guided biopsy was made for the histopathologic study. three samples were disqualified for pcr, leaving a study population of 49 women. results: the prevalence of hpv was 53% by histopathology and 85.7% by pcr. among the 42 patients in whom hpv was detected by pcr, 26 were confirmed by histopathology (sensitivity = 61.9%). this method gave no false-positives (specificity = 100%), with 100% of positive prediction. compared to pcr, the histopathology had: positive predcitive value = 100% and negative predcitive value = 30.4%. among the 26 patients with hpv-positive biopsy, 15 (57.7%) had cervical intraepithelial neoplasia (cin); relative risk = 13.3. conclusion: histopathology was 100% correct for hpv-infection diagnosis. it means that when the biopsy is positive, hpv will be present, confirming the clinical suspicion. however, the low sensitivity excludes histopathology as a screening examination in this group of women.
diagnóstico da infec o pelo HPV em les es do colo do útero em mulheres HIV+: acuidade da histopatologia
Souza Néli Sueli Teixeira de,Melo Victor Hugo do,Castro Lúcia Porto Fonseca de
Revista Brasileira de Ginecologia e Obstetrícia , 2001,
Abstract: Objetivo: comparar a acurácia do estudo histopatológico e da rea o em cadeia por polimerase (PCR) no diagnóstico da infec o pelo papilomavírus humano (HPV) em les es do colo uterino de mulheres infectadas pelo vírus da imunodeficiência humana (HIV). Métodos: foram estudadas 52 mulheres soropositivas para o HIV com les es cervicais clinicamente suspeitas de HPV nas quais se realizou raspado ectocervical para a PCR e biópsia dirigida pela colposcopia, para o estudo histopatológico. As amostras de três pacientes se mostraram sem qualidade para a PCR, reduzindo a popula o estudada para 49. Resultados: a prevalência de HPV foi de 53% pela histopatologia e de 85,7% pela PCR. Dentre as 42 pacientes com HPV detectado pela PCR, 26 foram confirmadas pela histopatologia (sensibilidade = 61,9%). Esta, por sua vez, n o demonstrou nenhum resultado falso-positivo (especificidade = 100%), com predi o positiva de 100%. Comparando-se os dois resultados, encontrou-se para a histopatologia: valor preditivo positivo = 100% e valor preditivo negativo = 30,4%. Das 26 pacientes com histopatologia positiva para HPV, 15 (57,6%) apresentaram neoplasias intra-epiteliais cervicais (NIC). O risco relativo de uma paciente com HPV apresentar NIC foi de 13,3. Conclus o: a histopatologia mostrou 100% de acerto para o diagnóstico de HPV, o que significa dizer que, quando a biópsia for positiva o HPV certamente estará presente, confirmando a suspeita clínica. No entanto, a baixa sensibilidade retira da histopatologia o valor como exame de rastreamento nesse grupo de mulheres.
Achados histológicos em 48 pacientes transplantados do fígado: biópsias do enxerto pós-reperfus o (tempo zero) e de três a 15 dias pós-transplante
Castro Alexandre Fonseca de,Castro Lúcia Porto Fonseca de,Leite Virginia Hora Rios,Paulino Júnior Eduardo
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2002,
Abstract: Introdu o: As rela es entre a morfologia do enxerto transplantado e a do período pós-transplante s o importantes no acompanhamento dos pacientes e no direcionamento dos tratamentos instituídos. Objetivo: Analisar os achados histológicos do enxerto hepático em biópsiasrealizadas pós-reperfus o (tempo zero) e naquelas realizadas de três a 15 dias pós-transplante. Materiais e métodos: Noventa e seis biópsias de 48 pacientes foram selecionadas por terem sido colhidas no tempo zero (pós-reperfus o) e no período compreendido entre o terceiro e o 15o dia pós-transplante, com identifica o das les es hepatocitárias degenerativas, necrose e atividadeinflamatória. As biópsias pós-transplante foram ainda graduadas quanto ao índice de atividade de rejei o (IAR), segundo o consenso de Banff. Resultados: Osachados histopatológicos mais freqüentes nas biópsias pós-reperfus o foram de degenera o hidrópica discreta (acometimento de até 50% dos hepatócitos) em 87,5% dos casos e necrose focal intralobular (lítica, apoptose) presente em 75% dos pacientes, em graus variáveis. Nas biópsiasrealizadas pós-transplante encontrou-se degenera o hidrópica discreta também em 87,5% dos casos e rejei o aguda em 38 (79,2%) pacientes. Nestas biópsias com rejei o aguda, chamou aten o a intensidade da agress o a ductos biliares em graus moderado (2) e acentuado (3) presentes em 42,1% dos casos, enquanto a endotelialite portal, nestas mesmas intensidades, ocorreu em 21,05%. Conclus o: Nossos dados evidenciaram les es relacionadas à preserva o (les es do tipo harvesting) nas biópsias pós-reperfus o. As biópsias pós-transplante revelaram índice de rejei o morfológica na maioria dos casos, como evidenciado na literatura, destacando-se aqui a intensidade da agress o a ductos biliares.
Associa??o timoma e estrongiloidíase intestinal grave
Godoy, Pérsio;Campos, Christian Marcellus Camargos;Costa, Guilherme;Castro, Lúcia Porto Fonseca de;
Revista da Sociedade Brasileira de Medicina Tropical , 1998, DOI: 10.1590/S0037-86821998000500009
Abstract: a 59-years-old man with thymoma and severe intestinal strongyloidiasis is reported. the authors pointed out a possible influence of immunological response related with thymoma in the development of hyperinfection by strongyloides stercoralis.
Associa o timoma e estrongiloidíase intestinal grave
Godoy Pérsio,Campos Christian Marcellus Camargos,Costa Guilherme,Castro Lúcia Porto Fonseca de
Revista da Sociedade Brasileira de Medicina Tropical , 1998,
Abstract: Os autores relatam o caso de um homem de 59 anos de idade com timoma e estrongiloidíase intestinal grave. S o revistos aspectos da resposta imunitária relacionados ao tumor e, possivelmente, implicados no desenvolvimento da hiperinfec o pelo Strongyloides stercoralis.
Avalia??o endócrina e morfológica de transplante ovariano homógeno
Petroianu, Andy;Alberti, Luiz Ronaldo;Vasconcellos, Leonardo de Souza;Leite, Juliana Moysés;Castro, Lúcia Porto Fonseca de;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2004, DOI: 10.1590/S1676-24442004000300012
Abstract: introduction: ovarian failure may be due to bilateral oophorectomy on several ovarian diseases, such as infection and neoplasm; chemo and radiotherapy as well as factors related to age led to endocrine disturbances followed by systemic complications. objectives: to assess endocrine and histological ovarian aspects following allogeneic ovarian transplantation without vascular pedicle and immunosupressed by cyclosporine. material and method: twelve female new zealand white and california rabbits were divided into 2 groups: group 1 (n = 4), sham operation; and group 2 (n = 8), submitted to a laparotomy and ovarian bilateral transplantation between pairs of animals. in one side the ovary was intact and in the other side the ovary was sliced. at the end of the follow-up period, blood samples were studied for estradiol, progesterone, fsh and lh. at the end of the experiment, histological studies of ovaries, uterus and tubes were carried out. results: the ovary implants were surrounded by connective tissue; they were well vascularized, and presented follicles in different stages of development. hormonal values were normal in all rabbits. conclusions: allogeneic orthotopic ovarian transplantation without vascular pedicle and immunosupressed by cyclosporine was effective to preserve normal level of ovarian hormone.
Gesta??o obtida em coelha após ooforectomia bilateral e transplante ovariano homógeno
Petroianu, Andy;Vasconcellos, Leonardo de Souza;Leite, Juliana Moysés;Alberti, Luiz Ronaldo;Castro, Lúcia Porto Fonseca de;
Revista do Colégio Brasileiro de Cirurgi?es , 2003, DOI: 10.1590/S0100-69912003000400003
Abstract: objetivo: to verify the fertility of rabbits submitted to allogenic ovarian transplantation without vascular pedicle and immunosupressed by cyclosporine. methods: ten new zealand white and california female rabbits were submitted to ovaries exchanging between pairs of animals. in one side the ovary was intact and in the other side the ovary was sliced. cyclosporine was administered through a 12 fr orogastric tube, every day during six months. three months later, the animals were daily paired with sexually mature new zealand white males during other six months. at the end of the follow-up period, blood samples were withdrawn for estradiol, progesterone, follicle stimulating hormone and luteinizing hormone assessment. then, all animals were killed. hystological studies of uterus, ovaries and tubes were carried out. results: pregnancy occurred in five rabbits, and four of them had live litters. hormones levels were normal in all animals. transplanted ovaries were surrounded by connective tissue, they were well vascularized and contained follicles in different stages of development. conclusions: rabbits submitted to allogeneic ovarian transplantation without vascular pedicle and immunosupressed by cyclosporine maintain fertility and female hormone function.
Histopatologia da seromiotomia dupla e sutura seromuscular no cólon descendente de ratos
Silva Júnior, Aldérico Luiz da;Silva, Alcino Lázaro da;Castro, Lúcia Porto Fonseca de;
Revista do Colégio Brasileiro de Cirurgi?es , 1999, DOI: 10.1590/S0100-69911999000600009
Abstract: experiments were carried out on mice, aiming to retard bowel movement in the descending colon. the microscopic alterations in the stools and the histopathological changes in the large intestine were observed. fifteen male mice and fifteen female mice have been operated on and divided into three groups named 30, 60 and 90 days, according to the time set for the relaparotomy. all mice have been submitted to two extramucous seromytomies in the descending colon with circunferential incisions (360). one of them was located one centimeter; and the other two centimeters, above the peritoneal reflection. after the seromytomias, a seromuscular suture surrouding all over the colon area was performed. we observed visceral and perineal adherence in the three groups, the majority without organic repercurssion. however a mouse from the 60 days group had partial obstructive manifestation that resulted in death on the 40th pos-surgical day. there were complications with total colon obstruction for stools impact in the operated area of two female mice that also developed into death on the 2nd pos - surgical week. a mouse showed deiscence and evisceration of the abdominal suture, dying on the 10th day pos- surgical. therefore, there were therefore four deaths (13,33%) due to a total, parcial and evisceration obstruction. in the three groups inflamatory reaction was observed, in all the coatings, which was greater in the 30 days groups. 1n the groups 60 and 90 days, sectionalized tissues were repaired by fibrous conjunctive tissue. our results did not show that the procedure hasn't produced clinics and radiological repercussions, in the distal from the operated site intestine. there were histopathlogical alterations that assured inflamatory process with reaction of strange body type in the sutured colon. this inflamatory process on a same transversal and circunferencial plane, provided a concentrica partial stenose resulting intestine transit delay confirmed by the shape, shine and st
Hepatite auto-imune tipo 1 em crian?as e adolescentes: avalia??o da suspens?o do tratamento imunossupressor
Ferreira, Alexandre Rodrigues;Roquete, Mariza Leit?o Valadares;Penna, Francisco José;Toppa, Nivaldo H.;Castro, Lúcia Porto Fonseca de;
Jornal de Pediatria , 2005, DOI: 10.1590/S0021-75572005000500014
Abstract: objective: to assess treatment withdrawal in children and adolescents with autoimmune hepatitis, with clinical and laboratory remission for a minimum period of 24 months, determining the relapse rate after treatment withdrawal. method: this is a descriptive, retrospective and partially prospective study of 21 children and adolescents with type 1 autoimmune hepatitis treated at the outpatient division of pediatric hepatology, teaching hospital of universidade federal de minas gerais (ufmg), belo horizonte, brazil, between january 1986 and december 2001. results: we assessed 54 patients and selected 21, of whom 19 were female subjects (90.5%), aged between 5.7 and 17.6 years (median = 13.8 years), with a mean follow-up of 5.1±2.4 years (median = 4.4 years) and an average clinical and laboratory remission of 4.1±1.5 years (median = 4.1 years). out of the 21 patients studied, 10 (47.6%) manifested some inflammatory activity that prevented the discontinuation of treatment, which was withdrawn in 11 patients (52.4%). out of these, six patients (54.5%) presented reactivation of the disease and five maintained clinical and laboratory remission with a mean follow-up of 4±1 years (median = 3.9 years). the time interval between discontinuation of treatment and reactivation of the disease ranged from 29 days to 40.3 months (median = 2.2 months). conclusions: we observed a high relapse rate (54.5%) in this group of patients with autoimmune hepatitis, which was more frequent within the first 12 months after treatment withdrawal, in addition to a high number of patients that presented some degree of inflammatory activity despite the long period of clinical and laboratory remission.
Achados histológicos em 48 pacientes transplantados do fígado: biópsias do enxerto pós-reperfus?o (tempo zero) e de três a 15 dias pós-transplante
Castro, Alexandre Fonseca de;Castro, Lúcia Porto Fonseca de;Leite, Virginia Hora Rios;Paulino Júnior, Eduardo;Lima, Agnaldo Soares;Gazzola, Luciana;Toppa, Nivaldo Hartung;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2002, DOI: 10.1590/S1676-24442002000400009
Abstract: introduction: the morphology of the donor graft and of the post-transplant period are important in the follow-up and management of liver transplanted patients. objective: analyse the morphological findings of the liver graft in post-reperfusional biopsies (time zero) and in biopsies taken three to 15 days after transplantation. materials and methods: ninety six (96) biopsies of forty eight (48) patients were selected for being performed in time zero (after reperfusion) and in the period between the 3rd and the 15th day after transplantation, with identification of degenerative findings, necrosis and inflamatory activity. the post-transplantation specimens were also graduated using the rejection activity index (rai), according to the banff consensus. results: the most common findings in time-zero biopsies were discrete hepatocyte ballooning (up to 50% of hepatocytes) in 87.5% of cases and intralobular focal necrosis (lytic, apoptosis) seen in 75% of the patients. in biopsies taken after transplantation mild hepatocyte ballooning was also seen in 87.5% of the cases. acute rejection was seen in 38 (79.2%) of these biopsies. moderate (2) and intense (3) bile-duct damage was present in 42.10% of the post-transplant biopsies with acute rejection, while portal endotelialitis at the same degree of intensity was present in 21.05% of these cases. conclusion: our findings reveal preservation related findings ("harvesting") in time zero biopsies. acute rejection was seen in most cases of post-transplant specimens, according to the literature, with emphasis to the intensity of bile-duct damage.
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