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Search Results: 1 - 10 of 215969 matches for " Lídia Moreira; "
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Mutagenicity of New Lead Compounds to Treat Sickle Cell Disease Symptoms in a Salmonella/Microsome Assay
Jean Leandro Dos Santos,Eliana A. Varanda,Lídia Moreira Lima,Chung Man Chin
International Journal of Molecular Sciences , 2010, DOI: 10.3390/ijms11020779
Abstract: A series of phthalimide derivatives planned as drugs candidates to treat the symptoms of sickle cell anemia were evaluated in a mutagenicity test using strains of Salmonella typhimurium TA100 and TA102, without and with addition of S9 mixture, with the aim to identify the best structural requirements for a drug candidate without genotoxic activity. The compounds (1,3-dioxo-1,3-dihydro-2 H-isoindol-2-yl)methyl nitrate ( 1); (1,3-dioxo-1,3-dihydro-2 H-isoindol-2-yl)ethyl nitrate ( 2); 3-(1,3-dioxo-1,3-dihydro-2 H-iso-indol-2-yl)benzyl nitrate ( 3); 4-(1,3-dioxo-1,3-dihydro-2 H-isoindol-2-yl)- N-hydroxy-benzenesulfonamide ( 4); 4-(1,3-dioxo-1,3-dihydro-2 H-isoindol-2-yl)benzyl nitrate ( 5) and 2-[4-(1,3-dioxo-1,3-dihydro-2 H-isoindol-2-yl)phenyl]ethyl nitrate ( 6) presented mutagenic potency ranging between 0-4,803 revertants/μmol. These results allowed us to propose that a methyl spacer linked to a nitrate ester subunit associated to meta aromatic substitution decreases mutagenicity.
Aduba??o nitrogenada em arroz sob irriga??o suplementar por aspers?o
Stone, Luis Fernando;Silveira, Pedro Marques da;Moreira, José Aloísio Alves;Yokoyama, Lídia Pacheco;
Pesquisa Agropecuária Brasileira , 1999, DOI: 10.1590/S0100-204X1999000600002
Abstract: the objective of this study was to determine adequate n level for modern upland rice (oryza sativa l.) cultivars sown at 0.20 m row spacing under supplemental sprinkler irrigation. the effects of n levels (0, 40, 80, 120, and 160 kg of n/ha) on the yield of one cultivar (maravilha) and three favourable upland rice lines (cna7127, cna7730, and ct7/15) were studied during three crop seasons, in santo ant?nio de goiás, go, brazil, in a dark red latosol. according to regression model used, the maximum rice grain yield was 5,523 kg/ha, obtained with 112.9 kg of n/ha. considering the prices of n (r$1.20) and rice (r$ 0.20) practiced in goiania, on june/97, the economical n level was 87.3 kg/ha.
O renascimento de um fármaco: talidomida
Lima, Lídia Moreira;Fraga, Carlos Alberto Manssour;Barreiro, Eliezer J.;
Química Nova , 2001, DOI: 10.1590/S0100-40422001000500016
Abstract: thalidomide, first synthesized in 1953, was widely prescribed for morning sickness of pregnant women from 1957 to 1961, when it was found to be seriously teratogenic, having caused serious birth defect. nowadays, a quarter of a century later, it appears that it may be a miracle drug for such diseases as leprosy, aids, cancer and tuberculosis.
Agentes antiasmáticos modernos: antagonistas de receptores de leucotrienos cisteínicos
Lima, Lídia Moreira;Fraga, Carlos Alberto Manssour;Barreiro, Eliezer J.;
Química Nova , 2002, DOI: 10.1590/S0100-40422002000500019
Abstract: in the early 1990s numerous clinical trials with antileukotriene drugs confirmed the hypothesis that cysteinyl leukotrienes are important bronchoconstrictor agents in asthma. newly released"antiasthmatic medications include antileukotriene agents which function either by blocking the interaction of leukotrienes with receptors or by inhibiting leukotriene synthesis. representatives of cysteinyl leukotriene receptors antagonists are zafirlukast (7), montelukast (8) and pranlukast (9). the bronchodilator efficacy and antiinflammatory property of antileukotriene drugs provided the main impetus behind their introduction as the first novel class of asthma therapy in more than 20 years.
O renascimento de um fármaco: talidomida
Lima Lídia Moreira,Fraga Carlos Alberto Manssour,Barreiro Eliezer J.
Química Nova , 2001,
Abstract: Thalidomide, first synthesized in 1953, was widely prescribed for morning sickness of pregnant women from 1957 to 1961, when it was found to be seriously teratogenic, having caused serious birth defect. Nowadays, a quarter of a century later, it appears that it may be a miracle drug for such diseases as leprosy, AIDS, cancer and tuberculosis.
Agentes antiasmáticos modernos: antagonistas de receptores de leucotrienos cisteínicos
Lima Lídia Moreira,Fraga Carlos Alberto Manssour,Barreiro Eliezer J.
Química Nova , 2002,
Abstract: In the early 1990s numerous clinical trials with antileukotriene drugs confirmed the hypothesis that cysteinyl leukotrienes are important bronchoconstrictor agents in asthma. Newly released"antiasthmatic medications include antileukotriene agents which function either by blocking the interaction of leukotrienes with receptors or by inhibiting leukotriene synthesis. Representatives of cysteinyl leukotriene receptors antagonists are zafirlukast (7), montelukast (8) and pranlukast (9). The bronchodilator efficacy and antiinflammatory property of antileukotriene drugs provided the main impetus behind their introduction as the first novel class of asthma therapy in more than 20 years.
Assessment of the In Vivo Genotoxicity of New Lead Compounds to Treat Sickle Cell Disease
Jean Leandro Dos Santos,Priscila Longhin Bosquesi,Eliana Aparecida Varanda,Lídia Moreira Lima,Man Chin Chung
Molecules , 2011, DOI: 10.3390/molecules16042982
Abstract: The compounds 1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl nitrate (C1), (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl nitrate (C2), 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzyl nitrate (C3), 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-hydroxy-benzenesulfonamide (C4), 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzyl nitrate (C5), and 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]ethyl nitrate (C6) were evaluated with a micronucleus test using mouse peripheral blood to identify new candidate drugs for the treatment of sickle cell disease (SCD) that are safer than hydroxyurea. The compounds induced an average frequency of micronucleated reticulocytes (MNRET) of less than six per 1,000 cells at 12.5, 25, 50, and 100 mg/kg, whereas hydroxyurea induced an average MNRET frequency of 7.8, 9.8, 15, and 33.7 per 1000 cells respectively, at the same concentrations. Compounds C1–C6 are new non-genotoxic in vivo candidate drugs for the treatment of SCD symptoms.
A influência da redu??o do espa?o nasofaringeano na morfologia facial de pré-adolescentes
Santos-Pinto, Ary dos;Paulin, Ricardo Fabris;Melo, Ana Cláudia Moreira;Martins, Lídia Parsekian;
Revista Dental Press de Ortodontia e Ortopedia Facial , 2004, DOI: 10.1590/S1415-54192004000300003
Abstract: the nasopharyngeal reduction consequent to a adenoid obstruction is reponsible to postural adaptions of the head, mandible, tongue and lips and may also lead to facial skeleton pattern alterations. ninety-eight lateral cephalometric x-rays of 7 to 10 years old preadolescents were used considering the nasopharyngeal space width (nsw), that was correspondent to the minor distance between the soft palate and posterior nasopharyngeal wall. the radiographs were divided into 3 groups: group i (narrow), nsw between 1.7 and 5.1mm; group ii (median), nsw between 5.2 and 7.6mm; group iii (extensive) nsw between 7.7 and 12.9mm. two angular and six linear measurements were used to characterize the facial morphology. the means and standard deviations of each measurement were obtained and the anova analysis showed no significant difference among the groups for a-nperp, p = 0.07, pg-nperp, p = 0,058, mandible length, p = 0.98, facial axis, p = 0.96, lower facial height, p = 0.84 and significant difference for mandibular plane, p<0,01. so it can be concluded that the nasopharyngeal space reduction is associated with mandibular plane alterations that presented higher values when there was a nasopharyngeal space reduction.
Avalia??o cefalométrica do tratamento da Classe II, divis?o 1, de Angle com os aparelhos extrabucal de Kloehn e fixo edgewise: influência do padr?o facial
Martins, Lídia Parsekian;Pinto, Ary dos Santos;Gandini Júnior, Luiz Gonzaga;Melo, Ana Claudia Moreira;Martins, Renato Parsekian;
Revista Dental Press de Ortodontia e Ortopedia Facial , 2004, DOI: 10.1590/S1415-54192004000300010
Abstract: the aim of the present study was to evaluate the cephalometric response to kloehn extraoral associated to fixed appliances treatment. initial cephalometric radiographs (t1) and final ones (t2) of two groups composed by 30 patients were selected according to jarabak index as favorable (hypodivergent) and unfavorable (hyperdivergent). the mean age on the beginning of the treatment was 11.03 years and the final mean age was 14.72, with a mean treatment time of 3.6 years for the favorable group. in the unfavorable group, the initial age was of 11.51 years, and the final age of 15.17, with a mean treatment time of 3.4 years. it was used a x and y coordinated system to response analysis, representing the dental and skeletal bases movement. the results and treatment responses were analyzed and the favorable and unfavorable groups compared using the t-student test. there were no statistically significant differences in the cephalometric response of kloehn extraoral associated to fixed appliances treatment between the two groups. the treatment promoted a restriction of the anterior displacement of maxillary base and a lesser mandibular anterior displacement. considering the upper teeth movement, there was restriction of the mesial and extrusive movement of the upper molars in the favorable group while the lower teeth movement was minimum on the anterior and vertical sense.
Therapeutic approaches for tumor necrosis factor inhibition
Barbosa, Maria Letícia de Castro;Fumian, Milla Machado;Miranda, Ana Luísa Palhares de;Barreiro, Eliezer J.;Lima, Lídia Moreira;
Brazilian Journal of Pharmaceutical Sciences , 2011, DOI: 10.1590/S1984-82502011000300002
Abstract: tumor necrosis factor (tnf) consists of an inflammatory cytokine essential for homeostasis and organism defense. despite its physiological relevance, both increased biosynthesis and release of tnf lead to the exacerbation of inflammatory and oxidative responses, which are related to the pathogenesis of a host of diseases of an inflammatory, autoimmune and/or infectious nature. in this context, effective therapeutic approaches for the modulation of tnf have been the focus of research efforts. approximately one million individuals worldwide have been treated with biotechnological inhibitors of this cytokine, the so-called anti-tnf biopharmaceuticals. however, given the high risk of infection and the limitations related to cost and administration routes, new therapeutic approaches aimed at biological targets that directly or indirectly modulate the production and/or activation of tnf appear promising alternatives for the discovery of new anti-inflammatory and immunomodulatory orally active drugs and are therefore discussed in this paper.
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