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Search Results: 1 - 10 of 541090 matches for " Lídia M.;Ormelli "
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New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole
Lima, Lídia M.;Ormelli, Claudia B.;Fraga, Carlos A.M.;Miranda, Ana L.P.;Barreiro, Eliezer J.;
Journal of the Brazilian Chemical Society , 1999, DOI: 10.1590/S0103-50531999000500013
Abstract: as part of a research program aiming at the synthesis and pharmacological evaluation of novel lead-compounds exploring brazilian abundant natural products, we describe herein the synthesis and the antithrombotic profile of new aryl-sulfonylsemicarbazides and aryl-sulfonylthiosemicarbazides (10a-d). the new derivatives, designed with basis on the molecular hybridization concept, were prepared in good yields from natural safrole (9), isolated from sassafras oil. the anti-aggregating activity of these new derivatives (10a-d) on platelet aggregation induced by adp, collagen, arachidonic acid and u-46619, indicates an important antithrombotic profile for the 6-methyl-3,4-methylenedioxyphenyl-sulfonyl-n-phenylthiosemicarbazide derivative (10d), acting at the arachidonic acid cascade and representing a new lead-compound with antithrombotic activity.
New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole
Lima Lídia M.,Ormelli Claudia B.,Fraga Carlos A.M.,Miranda Ana L.P.
Journal of the Brazilian Chemical Society , 1999,
Abstract: As part of a research program aiming at the synthesis and pharmacological evaluation of novel lead-compounds exploring Brazilian abundant natural products, we describe herein the synthesis and the antithrombotic profile of new aryl-sulfonylsemicarbazides and aryl-sulfonylthiosemicarbazides (10a-d). The new derivatives, designed with basis on the molecular hybridization concept, were prepared in good yields from natural safrole (9), isolated from sassafras oil. The anti-aggregating activity of these new derivatives (10a-d) on platelet aggregation induced by ADP, collagen, arachidonic acid and U-46619, indicates an important antithrombotic profile for the 6-methyl-3,4-methylenedioxyphenyl-sulfonyl-N-phenylthiosemicarbazide derivative (10d), acting at the arachidonic acid cascade and representing a new lead-compound with antithrombotic activity.
Química Medicinal Moderna: desafios e contribui??o brasileira
Lima, Lídia M.;
Química Nova , 2007, DOI: 10.1590/S0100-40422007000600015
Abstract: the main aspects of the modern medicinal chemistry, among the classic and industrial paradigms, used in the drug discovery process will be treated. the contribution of the brazilian science in the knowledge generation in medicinal chemistry will be demonstrated, with base in searches accomplished in the portal web of science? 7.10 and in the directory of groups of research of cnpq.
Observa??es sobre a ocorrência de Pilumnus floridanus Stimpson (Decapoda, Brachyura, Pilumnidae) na costa do Rio de Janeiro, Brasil
Oliveira, Lydia M. S.;Oshiro, Lídia M. Y.;
Revista Brasileira de Zoologia , 2006, DOI: 10.1590/S0101-81752006000400037
Abstract: the specimens were collected in sepetiba bay during the winter. their distribution was formerly known from off cape lookout, north carolina until florida, gulf of mexico, yucatan channel, honduras, antilles, venezuela and brazil (alagoas, sergipe and bahia).
Crescimento somático do caranguejo-u?á Ucides cordatus (Crustacea, Brachyura, Ocypodidae) em laboratório
Lima, Giovana V.;Oshiro, Lídia M. Y.;
Iheringia. Série Zoologia , 2006, DOI: 10.1590/S0073-47212006000400011
Abstract: in crustaceans, size increase occurs only immediately after molting when the animal is in the soft-shelled condition. the growth of ucides cordatus (linnaeus, 1763) was observed in laboratory, through its occurrence of molt, percentual increment of size and intermolt period. the study was realized from october/2000 to march/2002 and a total of 91 crabs (15 males, 33 females and 43 juveniles) were sampled in itacuru?á - coroa grande mangrove, state of rio de janeiro, brazil. the animals were maintained in two types of containers: adult crabs were kept in containers of 1000 l capacity, during eighteen months; while the juveniles were kept in plastic containers of 20 l capacity during eight months. the crabs were maintained in flowing seawater and fed on frozen leaves of rhizophora mangle (l.) (rhizophoraceae) and laguncularia racemosa (gaertn.) (combretaceae), twice a week. the carapace width ranged from 50.1 to 70.0 mm in males, 40.2 to 80.0 mm to females and 1.1 to 40.1 mm to juveniles. the survival rate of the specimens studied was of 46.7% for males, 39.4% for females after eighteen months and 67.4% for juveniles after eight months. the males and females molted up to three times during the experiment, while the juveniles molted up twice. molts occurred between august and april, showing more frequency during spring and summer. the increment of carapace width decreased with size, with mean was 2.21 ± 1.39% for males, 1.28 ± 0.84% for females and 2.89 ± 2.13% for juveniles. the relationship between the percentual increment and the carapace width can be expressed by the equation im = -0.0707lc + 4.645 (r2= 0.40). the intermolt period was 191 ± 140 days for males, 216 ± 76.2 days for females and 54 ± 1.41 days for juveniles. the percentual increment of size was statistically significant (p<0,05) when compared males and females, and adults and juveniles.
Trabalho e atividade: categorias de análise na psicologia histórico-cultural do desenvolvimento
Martins, Lígia Márcia;Eidt,dia Mara;
Psicologia em Estudo , 2010, DOI: 10.1590/S1413-73722010000400003
Abstract: this article is the result of theoretical studies and intends to show some contributions to the development historical-cultural psychology, more specifically, regarding to the relationship between the work and activity categories. these studies show to be relevant to the psychologists, pedagogues and other professionals involved directly or indirectly with the educational practice, in the quest to understand the problem of development periodization in a non-naturalistic perspective. in this way, the main activity category shows up as a central driving force of human development process and, therefore, it is closely linked to the place which each individual takes up in the class society as well as the objective conditions of his material existence. the development study matches with the study of specific person, immersed in a web of social relations; in a political and economic system; and finally, something else is nothing , but the study of the history objectified in each particular individual.
Avalia??o e Acompanhamento Psicológico Pré e Pós-Transplante Hepático
Abrunheiro,Lídia M. Matias; Perdigoto,Rui; Sendas,Sandra;
Psicologia, Saúde & Doen?as , 2005,
Abstract: this work has the objective of show, what a psychologist can do in a hospital, particularly in the liver transplantation unit. the work of this professional has the objective of evaluate and give psychological support to these patients, giving them a space where they can receive more information about the transplantation. therefore they will be prepared emotional and psychological about some problems, which can show up resulting from the treatment before and after the liver transplant. all this process of psychological support and evaluation has the objective of improving their quality of life.
Parti??o ambiental de Potimirim glabra (Kingsley) e Potimirim potimirim (Müller) (Crustacea, Decapoda, Atyidae) no rio Sahy, Mangaratiba, Rio de Janeiro, Brasil
Lima, Giovana V.;Oshiro, Lídia M. Y.;
Revista Brasileira de Zoologia , 2002, DOI: 10.1590/S0101-81752002000600017
Abstract: this work aims to determinate the spatial distribution of two sympatric freshwater shrimp species, potimirim glabra (kingsley, 1878) and potimirim potimirim (müller, 1881) in sahy river, municipality of mangaratiba. the populations were collected from september, 1997 to february, 1999. the animals were collected monthly by sieving the marginal vegetation, on rocky surface and among litter on river bottom. the animals were sorted sexed. their carapace length measured and total length measured. a total of 4,889 animals were collected in sahy river: 3,281 p. glabra and 1,608 p. potimirim. the spatial distribution of p. glabra and p. potimirim showed an environmental partition. potimirim glabra occurred in abundance at the farthest stations from the beach, wilst and p. potimirim, at the nearest stations from the sea.
Maturidade sexual do caranguejo Armases rubripes (Rathbun) (Crustacea, Brachyura, Sesarmidae) na Baía de Sepetiba, Rio de Janeiro, Brasil
Lima, Giovana V.;Oshiro, Lídia M. Y.;
Revista Brasileira de Zoologia , 2006, DOI: 10.1590/S0101-81752006000400014
Abstract: the present study analyzed the sexual maturity of armases rubripes (rathbun, 1897) in three populations from different environmental conditions (river, beach and mangrove) in the southeastern brazilian coast. crabs were sampled monthly from july 2002 to february 2004; they were captured with sieves at sahy river, during the high tides, and by hand at beach and mangrove areas, during low tides. animals were captured by establishing a catch effort of two collectors during 15 minutes for each station. at laboratory, all individuals were sexed and the carapace width measured. the gonads, gonopods and abdomen morphology were observed according to shape and macroscopic aspects. a total of 4,051 specimens were sampled (1,067males, 1,563 females and 1,421 juveniles). there were recognized five morphotypes: juveniles, immature males, immature females, mature males and mature females. the onset of physiological and morphological sexual maturity was asynchronous within sexes, of which, males reaching the ability to produce gametes earlier than females. the size at the onset of sexual maturity was significantly different among populations different coming from areas, except for mangrove area. the individuals obtained from mangrove showed the shortest size at the onset of sexual maturity. therefore, estimates of males and females sizes at morphological sexual maturity the allometric growth analyses are inadequate in this species.
Distribui??o espacial, sazonal e estrutura populacional do caranguejo Aratus pisonii (H. Milne Edwards) (Crustacea, Decapoda, Sesarmidae) do manguezal de Itacuru?á, Rio de Janeiro, Brasil
Nicolau, Cristiane F.;Oshiro, Lídia M. Y.;
Revista Brasileira de Zoologia , 2007, DOI: 10.1590/S0101-81752007000200026
Abstract: this work was performed by monthly sampling from june 2000 to may 2001 for population structure studies and by seasonal sampling from january to october 2002 for space and seasonal distribution studies, dividing the mangrove in three different areas. on the space-seasonal distribution study, 694 crabs were caught, where 45% was captured in area 1,36% in area 2 and 19% in area 3. there were significant differences between the number of individuals between area 2 and 3. for the population structure study a total of 742 crabs were captured, being 59% male, 32.7% female and 8.3% ovigerous females. the sex ratio was 1:0.69 (male:female), and the carapace width ranged from 9.6 to 25.0 mm cw in males and from 5.5 to 24.9 mm cw in females. the size class distribution was unimodal and the males were more frequent between 19.1 to 21.0 mm cw, while females between 17.1 to 19 mm cw. the sex ratio along each size class showed the male predominance in almost all classes except between the classes of 5.1 to 7.0 and 7.1 to 9.0 mm cw.
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