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Search Results: 1 - 10 of 601851 matches for " Léa Carolina deLima;Maníglia "
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Avalia??o da influência da nulidade dos genótipos GSTT1 e GSTM1 na carcinogênese em cabe?a e pesco?o
Goloni-Bertollo, Eny Maria;Biselli, Joice Matos;Corrêa, Léa Carolina deLima;Maníglia, José Victor;Rossit, Andréa Regina Baptista;Ruiz, Mariangela Torreglosa;Pavarino-Bertelli, érika Cristina;
Revista da Associa??o Médica Brasileira , 2006, DOI: 10.1590/S0104-42302006000500028
Abstract: background: to evaluate the influence of gstm1 and gstt1 null genotypes in head and neck carcinogenesis. methods: the frequencies of gstm1 and gstt1 null genotypes were evaluated by multiplex polymerase chain reaction (pcr) in 45 patients with head and neck squamous cell carcinoma and in 45 control group individuals. both groups were composed of smokers paired by gender, age and race. results: the gstt1 null genotype was found in 24.4% of the patients and 17.7% of the control group (p= 0.606), while 44.4% of the patients and 48.8% of the control group were bearers of the gstm1 null genotype (p=0.832). no associations between gstt1 and gstmi null genotypes and primary tumor sites were found. conclusion: in our study, it was impossible to establish the influence of the gstt1 and gstm1 null genotypes in head and neck carcinogenesis.
Cancer de cabe a e pesco o: causas, preven o e tratamento Head and neck cancer: causes, prevention and treatment
Ana Lívia Silva Galbiatti,Jo?o Armando Padovani-Junior,José Victor Maníglia,Cléa Dometilde Soares Rodrigues
Brazilian Journal of Otorhinolaryngology , 2013,
Abstract: Cancer de cabe a e pesco o é o quinto tipo de cancer mais comum e a taxa de sobrevivência n o tem mudado nos últimos anos. OBJETIVO: Determinar os fatores de risco, causas, tratamento e preven o do cancer de cabe a e pesco o. MéTODO: Nós detalhamos os fatores de risco, causas, tratamento e preven o da doen a por meio de pesquisa nos bancos de dados PUBMED, MEDLINE e SciELO. RESULTADOS: álcool e fumo ainda s o os principais fatores de risco. Outros fatores podem influenciar o desenvolvimento do carcinoma de cabe a e pesco o. A op o de tratamento principal é terapia cirúrgica e sua utiliza o seguida por radioterapia é uma prática comum de tratamento em fases iniciais da doen a. Existem terapias que visam agir em componentes moleculares genéticos específicos para o desenvolvimento do tumor. A cessa o do cigarro, limita o de ingest o de álcool, evitar a exposi o à fuma a do cigarro, a carcinogênicos ambientais, detec o precoce de infec o por HPV, manuten o da saúde bucal, bons hábitos alimentares e controle do stress podem ser medidas de preven o da doen a. CONCLUS O: Investiga es adicionais s o necessárias para completa compreens o do desenvolvimento do carcinoma de cabe a e pesco o e isso irá fornecer novos caminhos e melhora na interven o e abordagens terapêuticas. Although head and neck carcinoma ranks fifth among cancer types, patient survival rates have not changed significantly over the past years. OBJECTIVE: To determine the risk factors, causes, therapies, and prevention measures for head and neck cancer. METHOD: Risk factors, causes, therapies, and preventive measures for this disease were searched on databases PUBMED, MEDLINE, and SCIELO. RESULTS: Alcohol and tobacco are still atop risk factors. Other factors may influence the development of head and neck carcinoma. Surgery is the main treatment option, and the addition of radiotherapy following surgery is frequent for patients in the early stages of the disease. Other therapies target specific genetic molecular components connected to tumor development. Disease preventive measures include smoking cessation, limiting alcohol intake, preventing exposure to tobacco smoke and environmental carcinogenic agents, early detection of infection by HPV, maintaining oral health, good eating habits, and managing stress. CONCLUSION: Additional research is needed for a more thorough understanding of the development of head and neck carcinomas and to shed light on new ways to improve therapeutic approaches and interventions.
A new peridural needle-the ′LOLO′ needle.
Delima L,Delima D
Journal of Postgraduate Medicine , 1989,
Abstract: Peridural needles in present day use have a compromised function because of their circular cross section. An ideal peridural needle must be sharp to cut the spinal ligaments and at the same time blunt enough to ensure prevention of dural perforation. This ideal function is only possible if the bevel and tip of the needle are not inversely related as is the case in circular cross section needles. The ′LOLO′ peridural needle developed by us is free of this compromise. It has a square cross section with a long, sharp eccentric tip. The bevel is flat and rectangular. The side opening is 4 mms from the tip of the needle through which the catheter is deflected out. Such a design is sharp to traverse the spinal ligaments and also effectively ensures dural tenting and prevent perforation. These properties have been proved by a myelographic study and compared to other conventional needles.
Análise proliferativa nas células trofoblásticas em bovinos
Rici, Rose Eli G.;Facciotti, Patrícia R.;Franciolli, André L.R.;Man?anares, Ana Carolina F.;Pastori, Jamila;Maria, Durvanei A.;Miglino, Maria Angélica;
Pesquisa Veterinária Brasileira , 2011, DOI: 10.1590/S0100-736X2011000600014
Abstract: the aim of the present study was to evaluate the cell proliferative activity, by agnors number, in different regions of bovine placenta throughout gestation. a total of 28 bovine placentas were separated into four groups: group i (60 to 120 days), group ii (121 to 170 days), group iii (171 to 220 days), and group iv (221 to 290 days). it was found a greater number of agnors in giant trophoblastic cells (gtc) when compared with mononuclear trophoblastic cells (mtc) (p<0,001) in all regions and gestational groups analyzed, that confirms their intensive synthesis activity in trophoblast epithelium. the central region of the placentome begins an intense proliferative activity in group ii, observed by clusters, while placentomes edges showed a higher number of clusters on group iii. these data suggest that the central region of the placentomes began an intense proliferative activity prior to its edge, both declines at the end of pregnancy. interplacentomal area showed a higher number of agnors in the group iv, suggesting a higher proliferative activity of these cells at the end of pregnancy. the results of this study indicate that the proliferative activity, as determined by the amount of intranuclear agnors, exhibits patterns that are not only specific to each type of trophoblastic cells, but also for each specific region of bovine placenta throughout pregnancy.
Polimorfismos GSTT1 e GSTM1 em indivíduos tabagistas com carcinoma espinocelular de cabe?a e pesco?o
Biselli, Joice Matos;Leal, Renata Cristina de Angelo Calsaverini;Ruiz, Mariangela Torreglosa;Goloni-Bertollo, Eny Maria;Maníglia, José Victor;Rossit, Andréa Regina Baptista;Pavarino-Bertelli, érika Cristina;
Revista Brasileira de Otorrinolaringologia , 2006, DOI: 10.1590/S0034-72992006000500012
Abstract: gene variability related to carcinogen activation and detoxification may interfere with susceptibility to head and neck cancer. aim: to investigate the relation between gstt1 and gstm1 null polymorphisms and the risk of head and neck squamous cell carcinoma in cigarette smokers. material and method: a case-control study conducted at the sao jose do rio preto medical school, brazil. gstm1 and gstt1 null genotype frequencies were evaluated by multiplex pcr in 45 cigarette smokers with head and neck squamous cell carcinomas and 45 cigarette smokers without this disease. results: the oral cavity was the most prevalent tumor site for squamous cell carcinoma. the gstt1 null genotype was found in 33.3% of the experimental group and 23.3% of the control group (p= 0.311). experimental and control groups had gstm1 null genotype frequencies of 35% and 48.3% (p=0.582). no association between alcohol consumption and gstt1 and gstmi null genotypes was found in these groups (p-values>0.05). there were more men, and alcohol consumption was prevalent in both groups. conclusion: in this study we were unable to show a correlation between gstm1 and gstt1 genotypes and the development of head and neck squamous cell carcinomas in cigarette smokers.
García L.,Carolina;
Boletín de Ciencias de la Tierra , 2006,
Abstract: surface formations of the aburra valley include several successive genetically similar series of extensive fluvial and slope deposits, possibly generated by events of intense tectonic activity. these deposits display a typical stepped structure, in which older deposits are located in the upper part of slopes and the recent ones, sometimes derivated form the older, are located in the lower part of the slope. although in the last two decades several works emphasize the importance of these deposits in the evolution of the aburra valley, few are those with chronological relations sustained in ages obtained by absolute dating which would allow to confirm the relations of the deposits with important orogenic events. the absolut ages until the moment are 3,12 ma (rendón et al., in press) for the older deposits and 0,19 ma (aristizabal, 2004) to 0,62 (ortiz, 2002) for the recent deposits of the serie.
Entropic inequalities and properties of some special functions
V. I. Man'ko,L. A. Markovich
Physics , 2014, DOI: 10.1007/s10946-014-9414-7
Abstract: Using known entropic and information inequalities new inequalities for some classical polynomials are obtained. Examples of Jacobi and Legendre polynomials are considered.
Ge condensation under SiGe oxidization: from Molecular Dynamics simulation to one-dimensional analytic modeling
Patrick Ganster,Andrès Saúl,Guy Tréglia
Physics , 2012,
Abstract: Oxidization of a dilute Si(Ge) alloy is modeled using an original protocol based on molecular dynamics simulation and rules for the oxygen insertions. These rules, deduced from ab-initio calculations, favor the formation of SiO_2 against GeO_2 oxide which leads to segregation of Ge atoms into the alloy during the oxidization front advance. Ge condensation is then observed close to the SiO_2/Ge interface due to the strain induced by oxydization in this region. From the analysis of the simulation process, we propose a one-dimensional description of Ge condensation wich perfectly reproduces the evolution of the Ge concentration during oxidization of the SiGe alloy.
Altera??o da temperatura radicular externa durante o preparo para conten??o intra-radicular
FERREIRA, Cláudio Maníglia;ORSI, Iara Augusta;FR?NER, Izabel Cristina;
Revista de Odontologia da Universidade de S?o Paulo , 1999, DOI: 10.1590/S0103-06631999000300013
Abstract: the objective of the present study was to compare the change in temperature on the external surface of the root in vitro during post and core preparation using 4 different techniques. forty lower single-root premolars instrumented and filled with gutta-percha and stored in 10% formalin were divided into 4 groups according to the technique of gutta-percha removal employed, using heated endodontic pluggers and peeso, largo and gates-glidden burs. the experiment was performed in a chamber with controlled temperature maintained at about 26°c. for gutta-percha removal from the canals, 2/3 of the root length was calculated and approximately 4 mm of apical filling was left. the temperature of the external surface of the root was measured with a thermo-couple connected to a multimeter and measurements were made in 3 regions: cervical (about 3 mm below the cementum-enamel junction), middle and apical regions of a predetermined measurent. analysis of variance indicated significant differences (p < 0.01) between regions and techniques. the complementary tukey test indicated that the heated endodontic pluggers produced the greatest increased in temperature among the three techniques, and the peeso bur produced the greatest increase in temperature among the burs used. among regions, the apical one presented the greatest change in temperature for all the techniques evaluated.
Altera o da temperatura radicular externa durante o preparo para conten o intra-radicular
FERREIRA Cláudio Maníglia,ORSI Iara Augusta,FR?NER Izabel Cristina
Revista de Odontologia da Universidade de S?o Paulo , 1999,
Abstract: O objetivo deste trabalho foi comparar in vitro a altera o de temperatura na superfície radicular externa durante o preparo para conten o intra-radicular utilizando 4 técnicas de remo o da guta-percha: condensadores aquecidos, brocas de Peeso, Gates-Glidden e Largo, em 40 dentes pré-molares inferiores (unirradiculares) tratados endodonticamente. O experimento foi realizado em uma camara com temperatura controlada em torno de 26°C. Para a remo o da guta-percha do interior dos canais, foram calculados dois ter os do comprimento da raiz, deixando em torno de 4 mm de obtura o apical. As medi es da temperatura radicular externa foram realizadas com um termopar acoplado a um multímetro e efetuadas em 3 regi es: cervical (em torno de 3 mm abaixo da jun o cemento-esmalte), média e apical. A análise de variancia indicou diferen as significantes (p < 0,01) entre as regi es e as técnicas utilizadas. O teste complementar de Tukey indicou que os condensadores aquecidos produziram o maior aumento de temperatura dentre as técnicas, e a broca de Peeso dentre as brocas, seguida pela de Largo e de Gates-Glidden. Dentre as regi es, a apical apresentou a maior altera o de temperatura em todas as técnicas avaliadas.
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