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Search Results: 1 - 10 of 5526 matches for " Kyung Ran Im "
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Trapa japonica Flerov Extract Attenuates Lipid Accumulation through Downregulation of Adipogenic Transcription Factors in 3T3-L1 Cells  [PDF]
Mi Jin Kim, Kyung Ran Im, Kyung-Sup Yoon
American Journal of Molecular Biology (AJMB) , 2015, DOI: 10.4236/ajmb.2015.52004
Abstract: Obesity is a major human health problem associated with various diseases, including cardiac injury and type 2 diabetes. Trapa japonica Flerov (TJF) has been used in traditional oriental medicine to treat diabetes. In this study, we evaluated the inhibitory effect of and the mechanism underlying the effect of TJF extract on adipogenesis in 3T3-L1 cells. The effects of TJF extract on cell viability were analyzed using a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay, and the anti-adipogenic effect was measured by oil red O staining. The expression of peroxisomal proliferator activated receptor (PPAR)γ, CCAAT/enhancer-binding protein-α (C/EBP)α, adenosine monophosphate-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACC), adiponectin, and fatty acid binding protein (FABP)4 involved in adipogenesis was determined by western blot analysis. TJF extract effectively inhibited lipid accumulation and the expression of PPARγ and C/EBPα in 3T3-L1 cells. TJF also increased the phosphorylation of AMPK and ACC, and decreased the expression of adiponectin and FABP4. These results indicate that TJF extract exerts its anti-obesity effect through the downregulation of adipogenic transcription factors and adipogenic marker genes.
Thrombocytosis Accompanying Renal Abscess: A Case Report and Review of the Literature  [PDF]
Mustafa Burak Ho?can, Ye?im Ho?can, Ahmet Tun?k?ran
Open Journal of Urology (OJU) , 2012, DOI: 10.4236/oju.2012.22015
Abstract: Reactive thrombocytosis can be seen in patients with various kinds of infections, including upper urinary tract infection. Thrombocytosis in patients with upper urinary tract infection is a response of the bone marrow to the infection and is therefore classified as secondary thrombocytosis. We report a case of thrombocytosis accompanying renal abscess. In this case report, we present that thrombocytosis in a patient with upper urinary tract infection is not a random condition and is associated with renal abscess which is a complication of disease.
Synergistic effect between cryptotanshinone and antibiotics in oral pathogenic bacteria  [PDF]
Jeong-Dan Cha, Mi-Ran Jeong, Kyung-Min Choi, Jeong-Hye Park, Su-Mi Cha, Kyung-Yeol Lee
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.42A039
Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacterial activity against all oral bacteria tested in this experiment. The antibacterial activities of CT against oral bacteria were assessed using the checkerboard and time-kill methods to evaluate the synergistic effects of treatment with ampicillin or gentamicin. The CT was determined against oral pathogenic bacteria with MIC and MBC values ranging from 0.5 to 16 and 1 to 64 μg/mL; for am- picillin from 0.0313 to 16 and 0.125 to 32 μg/mL; for gentamicin from 2 to 256 and 4 to 512 μg/mL respectively. The range of MIC50 and MIC90 were 0.0625 - 8 μg/mL and 1 - 64 μg/mL, respectively. The combination effects of CT with antibiotics were synergistic (FIC index < 0.5) against tested oral bacteria except additive, Streptococcus sobrinus, S. criceti, and Actinobacillus actinomycetemcomitans (FIC index < 0.75 - 1.0). The MBCs were shown reducing ≥4 - 8-fold, indicating a synergistic effect as defined by a FBCI of ≤0.5. Furthermore, a time-kill study showed that the growth of the tested bacteria was completely attenuated after 3 - 6 h of treatment with the 1/2 MIC of CT, regardless of whether it was administered alone or with ampicillin or
Adenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing mice
Kyung-Sun Hwang, Won-Kyung Cho, Jinsang Yoo, Hwan-Jung Yun, Samyong Kim, Dong-Soo Im
BMC Cancer , 2005, DOI: 10.1186/1471-2407-5-51
Abstract: Adenoviral vectors were constructed encoding one or both subunits of murine IL-12 (Ad.p35, Ad.p40 and Ad.IL-12) or cytosine deaminase (Ad.CD). The functionality of the IL-12 or CD gene products expressed from these vectors was validated by splenic interferon (IFN)-γ production or viability assays in cultured cells. Ad.p35 plus Ad.p40, or Ad.IL-12, with or without Ad.CD, were administered (single-dose) intratumorally to Renca tumor-bearing mice. The animals injected with Ad.CD also received 5-FC intraperitoneally. The antitumor effects were then evaluated by measuring tumor regression, mean animal survival time, splenic natural killer (NK) cell activity and IFN-γ production.The inhibition of tumor growth in mice treated with Ad.p35 plus Ad.p40 and Ad.CD, followed by injection of 5-FC, was significantly greater than that in mice treated with Ad.CD/5-FC, a mixture of Ad.p35 plus Ad.p40, or Ad.GFP (control). The combined gene transfer increased splenic NK cell activity and IFN-γ production by splenocytes. Ad.CD/5-FC treatment significantly increased the antitumor effect of Ad.IL-12 in terms of tumor growth inhibition and mean animal survival time.The results suggest that adenovirus-mediated IL-12 gene transfer combined with Ad.CD followed by 5-FC treatment may be useful for treating cancers.Gene therapy for treating cancers has been intensively investigated. Therapeutic gene transfer using viral or nonviral vectors has been shown to be clinically feasible and safe. However, the therapeutic outcome appears not to be high as expected, presumably because the in vivo gene delivery efficiency is low. In this sense, a more effective modality is needed to improve the therapeutic benefit. Combined transfer of genes with different mechanisms of action may potentate the therapeutic outcome. Indeed, combination cancer gene therapy using cytokine and suicide genes has been shown to be more effective than single gene transfer in animal models [1-9].Interleukin (IL)-12 is a heterodim
Mathematical Issues in the Inference of Causal Interactions among Multichannel Neural Signals
Young-Jin Jung,Kyung Hwan Kim,Chang-Hwan Im
Journal of Applied Mathematics , 2012, DOI: 10.1155/2012/472036
Abstract: Within the last few decades, attempts have been made to characterize the underlying mechanisms of brain activity by analyzing neural signals recorded, directly or indirectly, from the human brain. Accordingly, inference of functional connectivity among neural signals has become an indispensable research tool in modern neuroscience studies aiming to explore how different brain areas are interacting with each other. Indeed, remarkable advances in computational sciences and applied mathematics even allow the estimation of causal interactions among multichannel neural signals. Here, we introduce the brief mathematical background of the use of causality inference in neuroscience and discuss the relevant mathematical issues, with the ultimate goal of providing applied mathematicians with the current state-of-the-art knowledge on this promising multidisciplinary topic.
Association of Epidermal Growth Factor Receptor Mutations with Metastatic Presentations in Non-Small Cell Lung Cancer
Im Il Na,Jong Heon Park,Du Hwan Choe,Jin Kyung Lee
ISRN Oncology , 2011, DOI: 10.5402/2011/756265
A New Angle-Based Location Method Using a Forward-Link Signal
Seung-Hun Song,Hyun-Ja Im,Ji-Won Park,Tae-Kyung Sung
EURASIP Journal on Advances in Signal Processing , 2009, DOI: 10.1155/2009/407893
Abstract: With conventional AOA positioning using a reverse-link signal, each sensor is equipped with an array antenna to measure the incident angle of the signal emitting by a mobile source. In order to perform the complicated array processing for angle measurements, both the sensor size and the power consumed by the sensor can increase in RLAOA (reverse-link AOA) positioning. In some applications such as mobile vehicle localization, the vehicle has fewer limitations in terms of size or power consumption. Rather, it is desirable to make the sensor as light as possible. This paper presents a new angle-based positioning scheme using a forward-link signal. Under the assumption that a ground vehicle moves on a horizontal surface, a measurement equation for the FLAOA (forward-link AOA) is initially derived. Using the measurement equation, a closed-form solution for FLAOA positioning is proposed. With the proposed method, it is also possible to estimate the azimuth of the vehicle as well as its position. The performance of the proposed method is compared to that of RLAOA positioning in a computer simulation. The simulation results show that the proposed method is potentially suitable for applications involving the localization and guidance of mobile vehicles.
Integrative Genomics: Quantifying Significance of Phenotype-Genotype Relationships from Multiple Sources of High-Throughput Data
Eric R. Gamazon,R. Stephanie Huang,M. Eileen Dolan,Nancy J. Cox,Hae Kyung Im
Frontiers in Genetics , 2013, DOI: 10.3389/fgene.2012.00202
Abstract: Given recent advances in the generation of high-throughput data such as whole-genome genetic variation and transcriptome expression, it is critical to come up with novel methods to integrate these heterogeneous datasets and to assess the significance of identified phenotype-genotype relationships. Recent studies show that genome-wide association findings are likely to fall in loci with gene regulatory effects such as expression quantitative trait loci (eQTLs), demonstrating the utility of such integrative approaches. When genotype and gene expression data are available on the same individuals, we and others developed methods wherein top phenotype-associated genetic variants are prioritized if they are associated, as eQTLs, with gene expression traits that are themselves associated with the phenotype. Yet there has been no method to determine an overall p-value for the findings that arise specifically from the integrative nature of the approach. We propose a computationally feasible permutation method that accounts for the assimilative nature of the method and the correlation structure among gene expression traits and among genotypes. We apply the method to data from a study of cellular sensitivity to etoposide, one of the most widely used chemotherapeutic drugs. To our knowledge, this study is the first statistically sound quantification of the overall significance of the genotype-phenotype relationships resulting from applying an integrative approach. This method can be easily extended to cases in which gene expression data are replaced by other molecular phenotypes of interest, e.g., microRNA or proteomic data. This study has important implications for studies seeking to expand on genetic association studies by the use of omics data. Finally, we provide an R code to compute the empirical false discovery rate when p-values for the observed and simulated phenotypes are available.
Medium Resolution Near-Infrared Spectra of the Host Galaxies of Nearby Quasars
Huynh Anh N. Le,Soojong Pak,Myungshin Im,Minjin Kim,Chae Kyung Sim,Luis C. Ho
Physics , 2014, DOI: 10.1016/j.asr.2014.05.023
Abstract: We present medium resolution near-infrared host galaxy spectra of low redshift quasars, PG 0844 + 349 (z=0.064), PG 1226 + 023 (z=0.158), and PG 1426+015 (z=0.086). The observations were done by using the Infrared Camera and Spectrograph (IRCS) at the Subaru 8.2 m telescope. The full width at half maximum of the point spread function was about 0.3 arcsec by operations of an adaptive optics system, which can effectively resolve the quasar spectra from the host galaxy spectra. We spent up to several hours per target and developed data reduction methods to reduce the systematic noises of the telluric emissions and absorptions. From the obtained spectra, we identified absorption features of Mg I (1.503 um), Si I (1.589 um) and CO (6-3) (1.619 um), and measured the velocity dispersions of PG 0844 + 349 to be 132+/-110 km s-1 and PG 1426 + 015 to be 264+/-215 km s-1. By using an M_BH-sigma relation of elliptical galaxies, we derived the black hole (BH) mass of PG 0844+349, log(M_BH/M_SUN) = 7.7+/-5.5 and PG 1426+015, log(M_BH/M_SUN) = 9.0+/-7.5. These values are consistent with the BH mass values from broad emission lines with an assumption of a virial factor of 5.5.
Yusuf Temiz,Ferruh ?im?ek,Salih Güran,Rengin Ah?skal?
Marmara Medical Journal , 2007,
Abstract: Ectopic ureter draining a poorly functioning renal moiety can be missed by classical radiological methods such as ultrasonography, voiding cystourethrogram and intravenous pyelogram. In such conditions, use of computerize tomography and magnetic resonance imaging have been advocated to diagnose poorly functioning, abnormal duplex collecting system and ectopic ureter. A case of a 16-year old girl with continuous dribbling incontinence and normal IVP and cystoscopy findings whose ectopic ureter and duplicated system could only be diagnosed by MRU is presented in this case report.
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