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Search Results: 1 - 10 of 7724 matches for " Kyong Park "
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Design of Korean Standard Modular Buoy Body Using Polyethylene Polymer Material for Ship Safety  [PDF]
Young Whan Park, Tae Wan Kim, Jae Sub Kwak, In Kwan Kim, Ji Eon Park, Kyong Ho Ha
Journal of Materials Science and Chemical Engineering (MSCE) , 2016, DOI: 10.4236/msce.2016.41011
Abstract:

Buoy is the structure which is floated on sea surface in order to indicate the presenting obstacle such as reef and shallow sea and to show the direction of sea route to ship during sailing. Generally, the conventional material of buoy is steel and it has some problems. Firstly this steel light buoy has safety risk in case of collision between ship and steel buoy. Secondly steel buoy revealed high corrosion environment of salted water and oxide and corrosion of steel can lead to marine pollution. Thirdly it needs too much maintain cost because of its heavy weight. In this study, in order to overcome these problems we changed the buoy material from conventional steel body to polyethylene body. Polymer buoy body was designed with module type part and it can reduce total weight up to 43.12%. To evaluate the strength of that part, the structure analysis simulation was carried out with respect to stress, displacement, and strain. Maximum stress was 1.667 × 107 N/m2 and it was 25% of yielding stress of base material. Maximum displacement and strain were 3.164 mm and 0.00433353 and they are too small value and in safe range with comparing to total length of body. The stability of polymer buoy body was compared with conventional buoy with respect to center of gravity, center of buoyancy, metacenter, oscillation period, and tilt angle by wind, tidal current, and wave. Every value was improved comparing conventional one and we can get more stable buoy. Therefore the new polymer buoy body could prove its safety and stability.

Apoptotic Phosphorylation of Histone H3 on Ser-10 by Protein Kinase Cδ
Choon-Ho Park, Kyong-Tai Kim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044307
Abstract: Phosphorylation of histone H3 on Ser-10 is regarded as an epigenetic mitotic marker and is tightly correlated with chromosome condensation during both mitosis and meiosis. However, it was also reported that histone H3 Ser-10 phosphorylation occurs when cells are exposed to various death stimuli, suggesting a potential role in the regulation of apoptosis. Here we report that histone H3 Ser-10 phosphorylation is mediated by the pro-apoptotic kinase protein kinase C (PKC) δ during apoptosis. We observed that PKCδ robustly phosphorylates histone H3 on Ser-10 both in vitro and in vivo. Ectopic expression of catalytically active PKCδ efficiently induces condensed chromatin structure in the nucleus. We also discovered that activation of PKCδ is required for histone H3 Ser-10 phosphorylation after treatment with DNA damaging agents during apoptosis. Collectively, these findings suggest that PKCδ is the kinase responsible for histone H3 Ser-10 phosphoryation during apoptosis and thus contributes to chromatin condensation together with other apoptosis-related histone modifications. As a result, histone H3 Ser-10 phosphorylation can be designated a new ‘apoptotic histone code’ mediated by PKCδ.
Task-related modulation of anterior theta and posterior alpha EEG reflects top-down preparation
Byoung-Kyong Min, Hae-Jeong Park
BMC Neuroscience , 2010, DOI: 10.1186/1471-2202-11-79
Abstract: We recorded EEG data from 15 healthy controls performing a color and shape discrimination task, and used the wavelet transformation to investigate the time course and power of oscillatory activity in the signals. We observed a relationship between both anterior theta and posterior alpha power in the prestimulus period and the type of subsequent task.Since task-differences were reflected in both theta and alpha activities prior to stimulus onset, both prestimulus theta (particularly around the anterior region) and prestimulus alpha (particularly around the posterior region) activities may reflect prestimulus top-down preparation for the performance of subsequent tasks.When people identify an object, they have to match what they sense against their knowledge. In general, people accomplish recognition by a combination of two information processing pathways: top-down and bottom-up. Bottom-up processing (i.e. sensation) occurs when the sensory input information induces perceptual representation, whereas top-down processing (i.e. identification) occurs when the perceptual representation is influenced by some higher mental function such as previous knowledge, motivation, or expectation.To facilitate perceptual identification, one may use subjective expectations of the stimulus to come. Accordingly, a cognitive intention (e.g. expectation, mental readiness, active redirection of attention), embedded in a top-down process, may precede an event or stimulus. Bottom-up sensory processing is then guided by such top-down processing as a specific reallocation of attention relevant to the type of stimulus to follow or task to be performed. In this way, top-down intentional processing can increase the speed and efficiency of perceptual identification.In this regard, the influence of prestimulus mental activity on the subsequent poststimulus responses (or task-performances) is worth investigating. Indeed, some studies showed the relationship between the prestimulus alpha activity and
Unresectable gastric cancer with gastric outlet obstruction and distant metastasis responding to intraperitoneal and folfox chemotherapy after palliative laparoscopic gastrojejunostomy: report of a case
Joong-Min Park, Kyong-Choun Chi
World Journal of Surgical Oncology , 2010, DOI: 10.1186/1477-7819-8-109
Abstract: We report a case of 55-year-old man who was diagnosed with a poorly differentiated adenocarcinoma in the pre-pyloric antrum with GOO by gastroscopy. An abdominal computed tomography (CT) scan revealed thickening of the gastric wall and adjacent fat infiltration, and a large amount of food in the stomach suggesting a passage disturbance, enlarged lymph nodes along the common hepatic and left gastric arteries, and multiple hepatic metastases. The serum carcinoembryonic antigen (CEA) level was 343 ng/ml and the carbohydrate antigen (CA) 19-9 level was within normal limits. The patient underwent a laparoscopic gastrojejunostomy for palliation of the GOO. On the 3rd and 12th days after surgery, he received intraperitoneal chemotherapy with 40 mg of docetaxel and 150 mg of carboplatin. Simultaneously, combined chemotherapy with 85 mg/m2 of oxaliplatin for the 1st day and 600 mg/m2 of 5-FU for 2 days (FOLFOX regimen) was administered from the 8th post-operative day. After completion of nine courses of FOLFOX, the patient achieved a complete response (CR) with complete disappearance of the primary tumor and the metastatic foci. He underwent a radical subtotal gastrectomy with D3 lymph node dissection 4 months after the initial palliative surgery. The pathologic results revealed no residual primary tumor and no lymph node metastasis in 43 dissected lymph nodes. He has maintained a CR for 18 months since the last operation.Combination chemotherapy with systemic and intraperitoneal chemotherapy following laparoscopic bypass surgery showed marked efficacy in the treatment for unresectable advanced gastric cancer with GOO.Although survival of patients with gastric cancer after surgery has been improved by early detection and curative surgery, the prognosis of patients with highly advanced gastric cancer, especially with distant metastasis such as peritoneal dissemination or hematogenous metastasis, is usually very poor. Chemotherapy is the treatment of choice for metastatic adva
RPC Gap Production and Performance for CMS RE4 Upgrade
Sung Keun Park,Min Ho Kang,Kyong Sei Lee
Physics , 2014, DOI: 10.1088/1748-0221/9/11/C11009
Abstract: CMS experiment constructed the fourth Resistive Plate Chamber (RPC) trigger station composed of 144 RPCs to enhance the high momentum muon trigger efficiency at both endcap regions. All new CMS endcap RPC gaps are produced in accordance with QA and QC at the Korea Detector Laboratory (KODEL) in Korea. All qualified gaps have been delivered to three assembly sites: CERN in Switzerland, BARC in India, and Ghent University in Belgium for the RPC detector assembly. In this paper, we present the detailed procedures used in the production of RPC gaps adopted for the CMS upgrade.
Development and Characterization of New Microsatellite Markers for Perilla frutescens (L.) Britton  [PDF]
Kyu Jin Sa, Su Eun Lim, Ik-Young Choi, Kyong-Cheul Park, Ju Kyong Lee
American Journal of Plant Sciences (AJPS) , 2019, DOI: 10.4236/ajps.2019.109115
Abstract: Based on RNA sequences using transcriptome analysis, 37 new simple sequence repeat (SSR) primer sets were developed for Perilla species. These new SSR markers were applied to analyze the genetic diversity among 15 accessions of Perilla species. A total of 182 alleles were confirmed in 37 loci, with an average of 4.9 alleles per locus and from 2 to 9 alleles per locus. The MAF (major allele frequency) per locus varied from 0.200 to 0.733, with an average of 0.463. The gene diversity (GD) ranged from 0.391 to 0.853, with an average of 0.670. The average polymorphic information content (PIC) was 0.624, ranging from 0.315 to 0.838. The new SSR markers of Perilla species reported in this study may provide potential markers to analyze the genetic diversity and genetic relationships of Perilla species. In addition, new Perilla SSR markers developed from transcriptome analysis can be useful for the identification of cultivars, conservation of Perilla germplasm resources, and genetic mapping and designating of important genes/QTLs for future Perilla crop breeding programs.
Effects of Chemosignals from Sad Tears and Postprandial Plasma on Appetite and Food Intake in Humans
Tae Jung Oh, Min Young Kim, Kyong Soo Park, Young Min Cho
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042352
Abstract: Chemosignals from human body fluids may modulate biological functions in humans. The objective of this study was to examine whether chemosignals from human sad tears and postprandial plasma modulate appetite. We obtained fasting and postprandial plasma from male participants and sad tears and saline, which was trickled below the eyelids, from female volunteers. These samples were then randomly distributed to male participants to sniff with a band-aid containing 100 μl of each fluid on four consecutive days in a double-blind fashion. We checked appetite by a visual analogue scale (VAS) and food intake by measuring the consumption of a test meal. In addition, the serum levels of total testosterone and LH were measured. Twenty men (mean age 26.3±4.6 years) were enrolled in this study. They could not discriminate between the smell of fasting and postprandial plasma and the smell of sad tears and trickled saline. Appetite and the amount of food intake were not different between the groups. Although the VAS ratings of appetite correlated with the food intake upon sniffing fasting plasma, postprandial plasma, and trickled saline, there was no such correlation upon sniffing sad tears. In addition, the decrease in serum testosterone levels from the baseline was greater with sad tears than with the trickled saline (?28.6±3.3% vs. ?14.0±5.2%; P = 0.019). These data suggest that chemosignals from human sad tears and postprandial plasma do not appear to reduce appetite and food intake. However, further studies are necessary to examine whether sad tears may alter the appetite-eating behavior relation.
Correlation of the Rates of Solvolysis of i-Butyl Fluoroformate and a Consideration of Leaving-Group Effects
Yelin Lee,Kyoung-Ho Park,Mi Hye Seong,Jin Burm Kyong,Dennis N. Kevill
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12117806
Abstract: The specific rates of solvolysis of isobutyl fluoroformate ( 1) have been measured at 40.0 °C in 22 pure and binary solvents. These results correlated well with the extended Grunwald-Winstein (G-W) equation, which incorporated the N T solvent nucleophilicity scale and the Y Cl solvent ionizing power scale. The sensitivities ( l and m-values) to changes in solvent nucleophilicity and solvent ionizing power, and the kF/kCl values are very similar to those observed previously for solvolyses of n-octyl fluoroformate, consistent with the additional step of an addition-elimination pathway being rate-determining. The solvent deuterium isotope effect value ( kMeOH/kMeOD) for methanolysis of 1 was determined, and for solvolyses in ethanol, methanol, 80% ethanol, and 70% TFE, the values of the enthalpy and the entropy of activation for the solvolysis of 1 were also determined. The results are compared with those reported earlier for isobutyl chloroformate ( 2) and other alkyl haloformate esters and mechanistic conclusions are drawn.
Simple Sequence Repeat Polymorphisms (SSRPs) for Evaluation of Molecular Diversity and Germplasm Classification of Minor Crops
Yong-Jin Park,Ju Kyong Lee,Nam-Soo Kim
Molecules , 2009, DOI: 10.3390/molecules14114546
Abstract: Evaluation of the genetic diversity among populations is an essential prerequisite for the preservation of endangered species. Thousands of new accessions are introduced into germplasm institutes each year, thereby necessitating assessment of their molecular diversity before elimination of the redundant genotypes. Of the protocols that facilitate the assessment of molecular diversity, SSRPs (simple sequence repeat polymorphisms) or microsatellite variation is the preferred system since it detects a large number of DNA polymorphisms with relatively simple technical complexity. The paucity of information on DNA sequences has limited their widespread utilization in the assessment of genetic diversity of minor or neglected crop species. However, recent advancements in DNA sequencing and PCR technologies in conjunction with sophisticated computer software have facilitated the development of SSRP markers in minor crops. This review examines the development and molecular nature of SSR markers, and their utilization in many aspects of plant genetics and ecology.
The genetic polymorphisms of HER-2 and the risk of lung cancer in a Korean population
Uk Jo, Sle Han, Jae Seo, Kyong Park, Jae Lee, Hyo Lee, Jeong Ryu, Yeul Kim
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-359
Abstract: The frequencies of 4 polymorphisms of the HER-2 gene were examined by the polymerase chain reaction-restriction fragment length polymorphism or the single-nucleotide polymorphism-identification technology assay in the 407 lung cancer patients and 407 healthy controls.The frequencies of the 4 polymorphisms were not significantly different between patient and control groups in overall subjects. However, in the subgroup analysis, the 3 single nucleotide polymorphisms (-3444C>T, -1985G>T and P1170A C>G) showed statistically significant differences in the subgroups of females, non-smokers, and non-drinkers (p < 0.05). Additionally, we found the association between the risk of lung cancer and the polymorphisms of HER-2 gene in non-smoker subgroups with adenocarcinoma (p < 0.05).Our results suggest that the polymorphisms of the HER-2 gene are associated with an increased susceptibility to lung cancer in females, non-smokers and non-drinkers subgroups in the Korean population.Lung cancer is the worldwide leading cause of cancer-related death [1]. During the past decades, the rate of incidence and mortality of lung cancer in Korea have been increasing significantly and constantly[2]. Although lung cancer has been considered as a disease caused by smoking and environmental/occupational exposure, previous studies suggest that genetic factors may also contribute to the risk of lung cancer [3].Single nucleotide polymorphisms (SNPs) are the most common form of human genetic variation, and they may contribute to an individual's susceptibility to cancer [4,5]. Many previous studies have demonstrated that some polymorphisms of certain genes are associated with the risk of lung cancer, affecting either the gene expression or activities of enzymes [6-8].The HER-2 (also known as erbB-2 or neu and a member of the epidermal growth factor receptor family), proto-oncogene is located at chromosome 17q21 and encodes a transmembrane glycoprotein (p185) with tyrosine kinase activity [9,10]. So
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