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Search Results: 1 - 10 of 30994 matches for " Kurien Thomas "
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Simultaneous Multicomponent Spectrophotometric analysis of Ampicillin and Probenecid in Pharmaceutical formulation by Derivative spectroscopy
Thomas Kurian,Jose Kurien
Hygeia : Journal for Drugs and Medicines , 2011,
Abstract: Asimple, fast and precise simultaneous multicomponent derivative spectrophotometricmethod has been developed for simultaneous determination of Ampicillin and Probenecidin pharmaceutical formulation. The first derivative spectra has absorptionmaxima at 222.2nm for Ampicillin and 288 nm for Probenecid in 0.1N NaOHused as solvent. The peak with good absorption at different concentrations, obeyed BeerLambert law only was chosen. Both Ampicillin and Probenecidshowed linearity in the range of 10 to 50 μg/ml concentration.
Theoretical Framework and Empirical Modeling for Time Required to Vaccinate a Population in an Epidemic
Arni S. R. Srinivasa Rao,Thomas Kurien
Quantitative Biology , 2011,
Abstract: The paper describes a method to understand time required to vaccinate against viruses in total as well as subpopulations. As a demonstration, a model based estimate for time required to vaccinate H1N1 in India, given its administrative difficulties is provided. We have proved novel theorems for the time functions defined in the paper. Such results are useful in planning for future epidemics. The number of days required to vaccinate entire high risk population in three subpopulations (villages, tehsils and towns) are noted to be 84, 89 and 88 respectively. There exists state wise disparities in the health infrastructure and capacities to deliver vaccines and hence national estimates need to be re-evaluated based on individual performances in the states.
Simple Spectrofluorimetric determination of Buspirone hydrochloride in Bulk drug and Pharmaceutical dosage forms.
Jose Kurien,,Thomas Kurian,,Helen William,Bijumol C.
Hygeia : Journal for Drugs and Medicines , 2012,
Abstract: Plan: An analytical method for estimation of Buspirone HCl in bulk drug and pharmaceutical dosage forms by spectrofluorimetric is described.Prologue: The method is simple, fast and accurate and can be used for routine analysis of commercial Buspirone HCl tablets.Methodology: The developed method is based on the determination of fluorescence intensity of the solutions in water at 379nm after excitation at 238nm. Different experimental parameters affecting the fluorescence were carefully studied. The fluorescence intensity of the solution was stable for 5 hours. The calibration curve was linear from 50-1500ng/ml. The limit of detection (LOD) and limit of quantification (LOQ) were 20ng/ml and 45ng/ml respectively. Outcome: The proposed method has been applied successfully for the determination of Buspirone HCl in pharmaceutical dosage forms. No significant interference was observed from excipients, coloring and flavoring agents commonly used in the formulation. The mean recovery of drug from tablets was 99.89%.
Simultaneous Multicomponent Analysis of Ampicillin and Probenecid in Pharmaceutical formulation by Reverse Phase High Performance Liquid Chromatography
Thomas Kurian*, Jose Kurien, Helen William and Bijumol C.
Hygeia : Journal for Drugs and Medicines , 2012,
Abstract: Plan: Reverse Phase High Performance Liquid Chromatographic method for Ampicillin and Probenecid describedPrologue: Ampicillin trihydrate is an antibiotic active against mainly gram positive bacteria and some gram negative bacteria. Probenecid is a uricosuric agent used in gout therapy. The present study aims at the development of Reverse phase High Performance Liquid Chromatography method for simultaneous estimation of Ampicillin and Probenecid in combined dosage formulations.Methodology: The HPLC system used consists of Waters 501 pump and a Waters 486 tunable wave length UV-visible detector. The data station was computer controlled using base line 810 software which includes an integrator and a recorder. The mobile phase used was sodium acetate solution (50mm): acetonitrile (75:25). The UV response was measured at 235nm. The column used was Reverse phase(5 micron) 25cm x4.6mm. Outcome: The method provided adequate accuracy and precision .The developed RP-HPLC method can be used for the routine analysis of Ampicillin and Probenecid in combination.
Formulation and Evaluation of Floating tablets of Theophylline
C.Bijumol,Helen William,Jose Kurien and Thomas Kurian
Hygeia : Journal for Drugs and Medicines , 2013,
Abstract: Plan: Formulation of oral gastro retentive floating tablets ofTheophylline.Prologue: The primary aim of the present study is to design a sustainedrelease gastro retentive oral dosage form using intra gastric floating asformulation strategy. Theophylline, an antiasthmatic is used as the model drug.Methodology: Oral gastro retentivefloating tablets of Theophylline was formulated using gel-forming hydrophilicpolymers, HPMCK4M, HPMCK100M and HPMC 15cps. The work also focused on in vivoevaluation of buoyancy by x-ray imaging. Suitable In vitro methods forestimating the drug release from the tablet as a function of time weredeveloped and compared with marketed product (TheoSR200mg)Outcome: The prepared Tablets exhibited satisfactory physicochemicalcharacteristics. All the prepared batches showed good in vitro buoyancy. Thetablets with HPMCK4M and HPMCK100M floated for longer duration and had morematrix integrity as compared to formulations containing HPMC 15cps. Formulationswith HPMCK100M & HPMCK4M showed better control of drug release and the drugrelease was similar to that of marketed product.
Simple Spectrophotometric determination of Tegaserod Maleate in Pharmaceutical dosage forms
Helen William,Bijumol C,Jose Kurien and Thomas Kurian
Hygeia : Journal for Drugs and Medicines , 2013,
Abstract: Plan: An analytical method for the estimation of Tegaserod Maleatein bulk drugs and pharmaceutical dosage forms is described.Prologue: Tegaserod Maleate is the first selective serotonin 5-HT4receptor partial agonist to improve symptoms of constipation-predominantIrritable Bowel syndrome. The present study aims at the development of simpleSpectrophotometric method for the estimation of Tegaserod in dosage forms.Methodology: The developed method is based on the formation of a purplecoloured complex due to the reaction of Tegaserod Maleate withp-Dimethylaminobenzaldehyde reagent, which gave a maximum absorbance at 515nm.Beer’s law is obeyed over the concentration range of 5-50μg/ml. All thevariables were studied to optimize the reaction conditions.Outcome: The proposed method is simple, fast, accurate and economical and can be used for the routine analysis of Tegaserod in dosage forms.
Increasing invasive disease due to penicillin resistant S. pneumoniae in India
Balaji Veeraraghavan,Thomas Kurien,Joshi Hari,Beall Bernard
Indian Journal of Medical Sciences , 2008,
Abstract: S. pneumoniae continues to be a major cause of invasive disease worldwide with considerable mortality and morbidity. Here we report the emergence of penicillin intermediate resistance to S. pneumoniae in India, which may predispose for an increased incidence of invasive pneumococcal disease in both children and adults with multi-drug resistance profile resulting in clinical failure.
Malaria treatment, compliance and cure in Gandhinagar, Gujarat  [PDF]
Mamta Dattani, George Kurien
Health (Health) , 2014, DOI: 10.4236/health.2014.61002

Early diagnosis and complete treatment are the most important components of the malaria control program, which have a direct bearing on prevention of mortality and reduction in the morbidity, therefore, follow-up of the patient treatment is an important aspect of monitoring disease in the community. Aims: To assess treatment compliance among confirmed malaria cases in Gandhinagar District and to determine the proportion of cure rate with complete treatment as per the national drug policy. Study Variables: Exploratory-rural and urban areas; outcome-compliance, cure rate. Analysis: Percentage, proportions. Results: Compliance among 192 subjects under the study conducted in 2008 i.e. confirmed that malaria cases were 88% even after the introduction of 14 day therapy for “Plasmodium vivax” cases, while 100% cure rate was observed on the follow-up till the 28th day among “P. vivax” and “P. falciparum” cases which helped in reducing malaria incidence in the rural area by 50% as compared to the preceding year of the study. Conclusion: Follow-up of the treatment given to malaria patients has enhanced compliance and cure rate, which in turn contributed towards interruption of transmission. Therefore, a better cure rate through the administration of effective antimalarial drugs as per the drug policy in combination with other containment measures is the right strategy to keep morbidity and mortality due to malaria under effective

A Sensitive Spectrophotometric method for the Quantitative Determination of Buspirone Hydrochloride in Pharmaceutical Formulations
Jose Kurien*
Hygeia : Journal for Drugs and Medicines , 2012,
Abstract: Plan: An analytical method forthe estimation of Buspirone hydrochloride in bulk drug and tablet formulationis described.Methodology: Thedeveloped method is based on the formation of red colored chromogen due to thereaction of Buspirone hydrochloride with Thiobarbituric acid reagent, whichexhibits λmax at 531nm against reagent blank. The color was stable for morethan 6 hrs for method. Beer’s law is obeyed over the concentration range of 10-100μg /ml. All the variables were studied to optimize the reaction conditions. Thecalculated molar absorptivity value is 2.29 × 106 lit.mol-1.cm-1.Outcome: Theproposed method was successfully applied to the determination of Buspironehydrochloride in formulations. Good recoveries were obtained and the resultswere statistically compared with the official method, showed good agreement andindicated no significant difference in precision. No interference was observedin the presence of common pharmaceutical excipients. The proposed method doesnot require any extraction.
Scaling of high-wavenumber energy spectra in the unit aspect-ratio rotating Boussinesq system
Susan Kurien
Physics , 2010,
Abstract: Phenomenological and numerical studies of the small scale spectra of energy are presented for high Reynolds number rotating Boussinesq flows in unit aspect-ratio domains. We introduce a non-dimensional parameter Gamma such that when the potential vorticity is nearly linear in the dynamical variables, we deduce that for Gamma much less than 1, the potential enstrophy suppresses the transfer of horizontal kinetic energy into wavemodes with large horizontal component k_h while forcing it to become independent of vertical wavevector component k_z, scaling as k_h^{-5}. When Gamma much greater than 1, the potential enstrophy suppresses the transfer of potential energy into the wavemodes with large vertical component k_z while forcing it to become independent of k_h, scaling as k_z^{-5) power. Spectra computed from high-resolution simulations of the Boussinesq equations with isotropic low-wavenumber forcing are used to explore such anisotropic constraints on the energy and provide a posteriori justification for the joint flux ansatz used to obtain the (-5) scaling exponent. In all cases the empirical evidence points to both energy and potential enstrophy being jointly transferred downscale with the spectral scaling of the the former constrained by the latter.
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