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Search Results: 1 - 10 of 23540 matches for " Kuo-Sheng Hung "
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The Liquid Sensor Using Thin Film Bulk Acoustic Resonator with C-Axis Tilted AlN Films
Ying-Chung Chen,Wei-Tsai Chang,Kuo-Sheng Kao,Chun-Hung Yang,Chien-Chuan Cheng
Journal of Nanomaterials , 2013, DOI: 10.1155/2013/245095
Abstract: Dual-mode thin film bulk acoustic resonator (TFBAR) devices are fabricated with c-axis tilted AlN films. To fabricate dual-mode TFBAR devices, the off-axis RF magnetron sputtering method for the growth of tilted piezoelectric AlN thin films is adopted. In this report, the AlN thin films are deposited with tilting angles of 15° and 23°. The frequency response of the TFBAR device with 23° tilted AlN thin film is measured to reveal its ability to provide dual-mode resonance. The sensitivities of the longitudinal and shear modes to mass loading are calculated to be 2295?Hz?cm2/ng and 1363?Hz?cm2/ng with the mechanical quality factors of 480 and 287, respectively. The sensitivities of the longitudinal and shear modes are calculated to be 0 and 15?Hz?cm2/μg for liquid loading. 1. Introduction Surface and bulk acoustic resonator devices are attracting increasing attention owning to their use in various novel sensors, including UV sensors, mass sensors, biosensors, and others [1–3]. Surface acoustic resonators have been developed and examined for potential sensor applications because they are cheap and small. However, surface acoustic resonators suffer from high insertion loss and poor power handling. Therefore, thin film bulk acoustic resonator (TFBAR) devices have been studied globally; they have a low insertion loss, a high power handling capability, small size, and high sensitivity [4–6]. Lakin classified FBAR devices into three types, which were via-isolated resonators, air gap-isolated resonators, and solidly mounted resonators [7]. The general purpose of these structures is to form a free or clamped interface beneath the resonance zone. This work develops a dual-mode TFBAR device based on an adapted via-isolated resonator with piezoelectric thin film whose c-axis is tilted. The back-etched cavity is used as the sensing area. Despite the use of various piezoelectric films in TFBAR devices, including PZT, ZnO, and AlN thin films [8–12], most of the many studies of piezoelectric thin films have focused on PZT piezoelectric materials. However, the use of PZT is limited for environmental reasons [13, 14]. Hence, ZnO and AlN thin films have become the most promising materials for piezoelectric applications. This study concerns piezoelectric thin films of AlN, whose high quality factor makes them useful for elucidating the sensing properties of TFBAR for liquids. TFBAR has two major resonance modes longitudinal and shear. The longitudinal mode is typically used when TFBAR is utilized as a communication device at high operating frequencies. For biosensor
Ltcc Fold-Back Bandpass Filter Designed with Capacitively Loaded Stubs
Kuo-Sheng Chin;Jian-Luen Hung;Chun-Wei Huang;Shu-Peng Huang;Yung-An Kao;Shuh-Han Chao
PIER C , 2011, DOI: 10.2528/PIERC11062704
Abstract: This study presents a design of a compact stub-type bandpass filter with capacitively loaded stubs and a fold-back structure. This paper employed the fabrication process of low-temperature co-fired ceramic (LTCC) for filter realization of a multi-layer structure. The proposed filter structure required adding end capacitors to stubs to extend their electrical length, while achieving a length reduction of 30%. This study provided design curves to determine the dimensions of the end capacitor for reaching maximum electrical length extension. In addition, a fold-back configuration was applied to halve the filter size. An experimental filter operating at 5.8 GHz was fabricated and measured to validate the design concept, achieving a highly compact size of 14.3×8.2×0.76 mm.
Bioaerosols from a Food Waste Composting Plant Affect Human Airway Epithelial Cell Remodeling Genes
Ming-Wei Chang,Chung-Ru Lee,Hsueh-Fen Hung,Kuo-Sheng Teng,Hsin Huang,Chun-Yu Chuang
International Journal of Environmental Research and Public Health , 2014, DOI: 10.3390/ijerph110100337
Abstract: The composting procedure in food waste plants generates airborne bioaerosols that have the potential to damage human airway epithelial cells. Persistent inflammation and repair responses induce airway remodeling and damage to the respiratory system. This study elucidated the expression changes of airway remodeling genes in human lung mucoepidermoid NCI-H292 cells exposed to bioaerosols from a composting plant. Different types of microorganisms were detectable in the composting plant, using the agar culture method. Real-time polymerase chain reaction was used to quantify the level of Aspergillus fumigatus and the profile of remodeling genes. The real-time PCR results indicated that the amount of A. fumigatus in the composting hall was less than 10 2 conidia. The endotoxins in the field bioaerosols were determined using a limulus amebocyte lysate test. The endotoxin levels depended on the type of particulate matter (PM), with coarse particles (2.5–10 μm) having higher endotoxin levels than did fine particles (0.5–2.5 μm). After exposure to the conditioned medium of field bioaerosol samples, NCI-H292 cells showed increased pro-inflammatory interleukin (IL)-6 release and activated epidermal growth factor receptor (EGFR), transforming growth factor (TGF)-β1 and cyclin-dependent kinase inhibitor 1 (p21 WAF1/CIP1) gene expression, but not of matrix metallopeptidase (MMP)-9. Airborne endotoxin levels were higher inside the composting hall than they were in other areas, and they were associated with PM. This suggested that airborne bioaerosols in the composting plant contained endotoxins and microorganisms besides A. fumigatus that cause the inflammatory cytokine secretion and augment the expression of remodeling genes in NCI-H292 cells. It is thus necessary to monitor potentially hazardous materials from bioaerosols in food composting plants, which could affect the health of workers.
Cell Type-Specific Dependency on the PI3K/Akt Signaling Pathway for the Endogenous Epo and VEGF Induction by Baicalein in Neurons versus Astrocytes
Yu-Yo Sun, Shang-Hsuan Lin, Hung-Cheng Lin, Chia-Chi Hung, Chen-Yu Wang, Yen-Chu Lin, Kuo-Sheng Hung, Cheng-Chang Lien, Chia-Yi Kuan, Yi-Hsuan Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069019
Abstract: The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-α (HIF1α) through inhibition of prolyl hydrolase 2 (PHD2) and activation of the phosphatidylinositide-3 kinase (PI3K)/Akt signaling pathway. Yet, the significance and regulation of prosurvival cytokines erythropoietin (Epo) and vascular endothelial growth factor (VEGF), two transcriptional targets of HIF1α, in baicalein-mediated neuroprotection in neurons and astrocytes remains unknown. Here we investigated the causal relationship between the PI3K/Akt signaling pathway and Epo/VEGF expression in baicalein-mediated neuroprotection in primary rat cortical neurons and astrocytes. Our results show that baicalein induced Epo and VEGF expression in a HIF1α- and PI3K/Akt-dependent manner in neurons. Baicalein also protected neurons against excitotoxicity in a PI3K- and Epo/VEGF-dependent manner without affecting neuronal excitability. In contrast, at least a 10-fold higher concentration of baicalein was needed to induce Epo/VEGF production and PI3K/Akt activity in astrocytes for protection of neurons. Moreover, only baicalein-induced astrocytic VEGF, but not Epo expression requires HIF1α, while PI3K/Akt signaling had little role in baicalein-induced astrocytic Epo/VEGF expression. These results suggest distinct mechanisms of baicalein-mediated Epo/VEGF production in neurons and astrocytes for neuroprotection, and provide new insights into the mechanisms and potential of baicalein in treating brain injury in vivo.
Population-Based 5-Year Follow-Up Study in Taiwan of Dementia and Risk of Stroke
Mu-En Liu, Shih-Jen Tsai, Wei-Chiao Chang, Chun-Hung Hsu, Ti Lu, Kuo-Sheng Hung, Wen-Ta Chiu, Wei-Pin Chang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061771
Abstract: Background This study estimates the risk of stroke within 5 years of newly diagnosed dementia among elderly persons aged 65 and above. We examined the relationship between antipsychotic usage and development of stroke in patients with dementia. Methods We conducted a nationwide 5-year population-based study using data retrieved from the Longitudinal Health Insurance Database 2005 (LHID2005) in Taiwan. The study cohort comprised 2243 patients with dementia aged ≥65 years who had at least one inpatient service claim or at least 2 ambulatory care claims, whereas the comparison cohort consisted of 6714 randomly selected subjects (3 for every dementia patient) and were matched with the study group according to sex, age, and index year. We further classified dementia patients into 2 groups based on their history of antipsychotic usage. A total of 1450 patients were classified into the antipsychotic usage group and the remaining 793 patients were classified into the non-antipsychotic usage group. Cox proportional-hazards regressions were performed to compute the 5-year stroke-free survival rates after adjusting for potentially confounding factors. Results The dementia patients have a 2-fold greater risk of developing stroke within 5 years of diagnosis compared to non-dementia age- and sex-matched subjects, after adjusting for other risk factors (95% confidence interval (CI) = 2.58–3.08; P<.001). Antipsychotic usage among patients with dementia increases risk of stroke 1.17-fold compared to patients without antipsychotic treatment (95% CI = 1.01–1.40; P<.05). Conclusions Dementia may be an independent risk factor for stroke, and the use of antipsychotics may further increase the risk of stroke in dementia patients.
Genetic Polymorphisms of Stromal Interaction Molecule 1 Associated with the Erythrocyte Sedimentation Rate and C-Reactive Protein in HLA-B27 Positive Ankylosing Spondylitis Patients
James Cheng-Chung Wei, Kuo-Sheng Hung, Yu-Wen Hsu, Ruey-Hong Wong, Chun-Huang Huang, Ming-Shiou Jan, Shyh-Jong Wu, Yung-Shun Juan, Wei-Chiao Chang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0049698
Abstract: Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. The development of ankylosing spondylitis is still unclear. Genetics factors such as human leukocyte antigen HLA-B27 and ERAP1 have been widely reported to associate to AS susceptibility. In this study, we enrolled 361 AS patients and selected four tagging single nucleotides polymorphisms (tSNPs) at STIM1 gene. The correlation between STIM1 genetic polymorphisms and AS activity index (BASDAI, BASFI, BAS-G) as well as laboratory parameters of inflammation (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)) were tested. Our results indicated that HLA-B27 positive AS patients who are carrying the minor allele homozygous G/G genotype of SNP rs3750996 significantly associated with a higher level of ESR in serum. Furthermore, rs3750996/rs3750994 pairwise allele analysis indicated that G-C haplotypes also significantly correlated with higher level of ESR as well as CRP. These findings provide a better understanding of STIM1 genetic contribution to the pathogenesis of AS.
Association Study of Polymorphisms rs4552569 and rs17095830 and the Risk of Ankylosing Spondylitis in a Taiwanese Population
James Cheng-Chung Wei, Yu-Wen Hsu, Kuo-Sheng Hung, Ruey-Hong Wong, Chun-Huang Huang, Yi-Tzu Liu, Yuh-Cherng Guo, Shiro Ikegawa, Wei-Chiao Chang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0052801
Abstract: Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. However, the development of anklosing spondylitis is unclear. Human leukocyte antigens HLA-B27 and ERAP1 have been widely reported to be associated with AS susceptibility. A recent genome-wide association study (GWAS) showed that two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569) and within ANO6 at 12q12 (rs17095830) contribute to the risk of AS in Han Chinese. In this study, we enrolled 475 AS patients and 475 healthy subjects to assess whether these genetic variations contribute to the susceptibility and the severity of AS in the Taiwanese population. The correlation between genetic polymorphisms, AS activity indexes, (namely, BASDAI, BASFI and BAS-G) and AS complications (uveitis and inflammatory bowel disease) were tested using the markers, rs4552569 and rs17095830. Although no association between rs4552569/rs17095830 genetic polymorphisms and AS susceptibility/severity was found, a significant association between rs17095830 and inflammatory bowel disease was observed in a Taiwanese population.
Miniaturized Microstrip Dual-Band Bandstop Filters Using Tri-Section Stepped-Impedance Resonators
Kuo-Sheng Chin;Chih-Kang Lung
PIER C , 2009, DOI: 10.2528/PIERC09080306
Abstract: A novel circuit structure of dual-band bandstop filters is proposed in this paper. This structure comprises two shunt-connected tri-section stepped impedance resonators with a transmission line in between. Theoretical analysis and design procedures are described. The derived synthesis equations have two degrees of freedom which provide more design flexibility in filter synthesis. Notably, three advantages of the proposed filter structure lie in the fact of its increased nonuniform impedances, resulting in a compact size, wide range of realizable frequency ratio, and more realizable impedances. Three experimental dual-band bandstop filters with various frequency ratios were fabricated to demonstrate the feasibility of the new filter structure.
Ltcc Vertically-Stacked Cross-Coupled Bandpass Filter for Lmds Band Applications
Kuo-Sheng Chin;Cheng Hua Chen;Chih Chun Chang
PIER C , 2011, DOI: 10.2528/PIERC11051101
Abstract: This study develops a compact 28 GHz bandpass filter on a low-temperature co-fired ceramic substrate for applications in LMDS (Local Multipoint Distribution Service) bands. The filter comprises two pairs of verticallystacked cross-coupled open loops with vertical interconnection structures, achieving compactness, high integration, and superior frequency selectivity. Attaining selective response with two transmission zeros requires adjusting the couplings of adjacent resonators and external quality factor. The open loops are fed by using the three-via vertical interconnections to prevent any electrical effect on the filter. Measurements correlate closely with the simulation results: this study achieved a bandwidth of 2.1 GHz (27.6-29.7 GHz) with two zeros located at 25.8 GHz and 31.1 GHz, and a compact size of 2.69 x 2.66 x 0.4 mm.
Novel Microstrip Bandpass Filters Using Direct-Coupled Triangular Stepped-Impedance Resonators for Spurious Suppression
Kuo-Sheng Chin;Deng-Jun Chen
PIER Letters , 2009, DOI: 10.2528/PIERL09090602
Abstract: This paper presents a novel spurious suppressed bandpass filter designed with triangular stepped-impedance resonators. The proposed resonators are folded for a triangular schematic, which creates two transmission zeros. By varying the line width of resonators, one of the zeros is tuned to suppress the first and second spurious responses, and the other is used to improve skirt selectivity. The current study analytically derives explicit design equations and fabricates a three-pole Chebyshev bandpass filter centered at 1.5 GHz based on the direct-coupled structure. The experimental results show spurious suppression improvement more than 20 dB up to 5.6 .
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