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Search Results: 1 - 10 of 238 matches for " Kumiko Nakahira "
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The Expression of Surfactant Proteins A and D in the Intestines and Pancreas of Murine Fetuses  [PDF]
Ryuta Saka, Hiroomi Okuyama, Kaoru Uchida, Kumiko Nakahira, Takashi Sasaki, Satoko Nose, Masahiro Nakayama, Masahiro Fukuzawa, Itaru Yanagihara
Open Journal of Pediatrics (OJPed) , 2014, DOI: 10.4236/ojped.2014.41002

Purpose: Surfactant proteins exist in the digestive tract and may play an important role in the host defense. However, the expression of surfactant proteins in the premature digestive system remains unclear. The aim of this study was to investigate the expression of surfactant proteins in the intes-tines and pancreas of murine fetuses. Methods: Immunostaining for SP-A and SP-D was assessed in the small intestine and pancreas of ICR murine fetuses on days 15, 16, 17 and 18 of gestation (normal duration of pregnancy: 19 - 21 days). RT-PCR was performed to detect the expression of spa and spd mRNA in the small intestine and pancreas on day 16, 17 and 18 of gestation. Results: Immunoreactivity for SP-A and SP-D in the

Phosphorylation of FOXP3 by LCK Downregulates MMP9 Expression and Represses Cell Invasion
Kumiko Nakahira, Akihiro Morita, Nam-Soon Kim, Itaru Yanagihara
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0077099
Abstract: Forkhead Box P3 (FOXP3) is a member of the forkhead/winged helix family of the transcription factors and plays an important role not only as a master gene in T-regulatory cells, but also as a tumor suppressor. In this study, we identified lymphocyte-specific protein tyrosine kinase (LCK), which correlates with cancer malignancy, as a binding partner of FOXP3. FOXP3 downregulated LCK-induced MMP9, SKP2, and VEGF-A expression. We observed that LCK phosphorylated Tyr-342 of FOXP3 by immunoprecipitation and in vitro kinase assay, and the replacement of Tyr-342 with phenylalanine (Y342F) abolished the ability to suppress MMP9 expression. Although FOXP3 decreased the invasive ability induced by LCK in MCF-7 cells, Y342F mutation in FOXP3 diminished this suppressive effect. Thus we demonstrate for the first time that LCK upregulates FOXP3 by tyrosine phosphorylation, resulting in decreased MMP9, SKP2, and VEGF-A expression, and suppressed cellular invasion. We consider that further clarification of transcriptional mechanism of FOXP3 may facilitate the development of novel therapeutic approaches to suppress cancer malignancy.
MAXI/GSC Discovery of the Black Hole Candidate MAXI J1305-704
Kumiko Morihana,Mutsumi Sugizaki,Satoshi Nakahira,Megumi Shidatsu,Yoshihiro Ueda,Motoko Serino,Tatehiro Mihara,Masaru Matsuoka,Hitoshi Negoro,Nobuyuki Kawai
Physics , 2013, DOI: 10.1093/pasj/65.5.L10
Abstract: We present the first results on the new black hole candidate, MAXI J1305-704, observed by MAXI/GSC. The new X-ray transient, named as MAXI J1305-704, was first detected by the MAXI-GSC all-sky survey on 2012 April 9 in the direction to the outer Galactic bulge at (l,b)=(304.2deg,-7.6deg). The Swift/XRT follow-up observation confirmed the uncatalogued point source and localized to the position at (13h06m56s.44,-70d27'4".91). The source continued the activity for about five months until 2012 August. The MAXI/GSC light curve in the 2--10 keV band and the variation of the hardness ratio of the 4-10 keV to the 2-4 keV flux revealed the hard-to-soft state transition on the the sixth day (April 15) in the brightening phase and the soft-to-hard transition on the ~60th day (June 15) in the decay phase. The luminosity at the initial hard-to-soft transition was significantly higher than that at the soft-to-hard transition in the decay phase. The X-ray spectra in the hard state are represented by a single power-law model with a photon index of ~2.0, while those in the soft state need such an additional soft component as represented by a multi-color disk blackbody emission with an inner disk temperature ~0.5--1.2 keV. All the obtained features support the source identification of a Galactic black-hole binary located in the Galactic bulge.
Structure Refinement of Mn-Substituted LiMnxFe1-xPO4  [PDF]
Masakazu Togo, Atsushi Nakahira
Materials Sciences and Applications (MSA) , 2018, DOI: 10.4236/msa.2018.96039
Abstract: For Mn substituted LiMnxFe1-xPO4 synthesized by hydrothermal process, the structural differences caused by Mn substitution were characterized by SEM, ICP, XRD, XAFS, and FT-IR. In this study, by using XAFS advantageous to the atomic selectivity, the local structure of MeO6 octahedral was investigated. From ICP, Mn composition in the products was similar to Mn addition amount, and the peak shifts of XRD patterns with increasing Mn addition were observed. The lattice constants refined by Rietveld analysis were a = 1.0338 ± 5 nm, b = 0.5995 ± 4 nm and c = 0.4696 ± 1 nm in LiFePO4, and it was expanded linearly with increasing Mn addition. Fe-O bond distance, which was calculated by curve fitting of the radius distribution function of LiMnxFe1-xPO4, was 0.208 nm smaller than 0.214 nm of Mn-O bond. In addition, MeO6 octahedral expansion was affected to PO4 vibrational structure from FT-IR spectra.
Social Context Representation in Product-Service Systems with Internet of Things  [PDF]
Yongse Kim, Kumiko Suzuki
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.37030

A Product-Service Systems (PSS) is composed of service and product element to provide values for relevant stakeholders. A typical service interaction involves providers and receivers, and respective values are provided in a social interaction. When service channel is supported by physical touchpoints, receivers will interact with products, which may interact with providers. Thus, in PSS, various kinds of interactions occur in diverse social contexts. These social contexts can be repre- sented using graphs where nodes represent stakeholders and product touchpoints and attributed edges represent the interaction. Interaction among products as well as that of human stakeholders and that of human and product touchpoint can be described using such a graph-based representation. In designing and operating PSS with internet of things, social context representations could be used in analyzing and comparing key aspects of social interaction types to retrieve similar cases to exploit related interaction design strategies and operation know-hows.

Capacity of the Pectoralis Major Muscle May Be a Prognostic Factor for Aspiration Pneumonia  [PDF]
Kumiko Sakaguchi, Shuichi Hara
Advances in Aging Research (AAR) , 2017, DOI: 10.4236/aar.2017.66011
Objective: Aspiration pneumonia is thought to be caused by a decline in respiratory and swallowing function. We aimed to clarify whether the pectoralis major muscle and the rectus abdominis muscles are prognostic factors for aspiration pneumonia and to investigate the relationships between these muscles and nutritional status, swallowing function and sarcopenia, Methods: Medical records of 139 Japanese patients hospitalized for aspiration pneumonia between December 2010 and December 2014 were reviewed retrospectively. The volume and thickness of the pectoralis major muscle, the crosssectional area and thickness of the rectus abdominis muscles, and cross-sectional area of the psoas major muscle were measured using computed tomography. Swallowing function, nutritional status, activities of daily living, and prognosis also were evaluated. Results: The volume [Median: (left) 4713.2 mm3 vs. 4232.6 mm3 (right) 4981.7 mm3 vs. 4362.6 mm3 p < 0.05] and thickness [Median: (left) 6.9 mm vs. 4.6 mm (right) 7.3 mm vs. 5.7 mm p < 0.01] of the pectoralis major muscle and thickness of the right rectus abdominis muscles [Median: 7.3 mm vs. 5.8 mm p < 0.05] were significantly larger, while Mini-Nutritional Assessment Short Form (MNA-SF) [Median: 6.0 vs. 4.0 p < 0.01] and Functional Oral Intake Scale (FOIS) [Median: 3 vs. 1 p < 0.01] scores were significantly higher in patients who survived. The volume [Median: (left) 5789.1 mm3 vs. 3706.5 mm3 (right) 5650.3 mm3 vs. 4003.7 mm3 p < 0.01] and thickness [Median: (left) 7.1 mm vs. 5.9 mm p < 0.05] of the pectoralis major muscle and cross-sectional area of the psoas major muscle (left and right) [Median: (left) 500.1 mm2 vs. 432.0 mm2 (right) 563.5 mm2 vs. 446.3 mm2 p < 0.01] were significantly larger, while albumin levels [Median: 3.8 g/dl vs. 3.4g/dl p < 0.01] and MNA-SF [Median: 6.0 vs. 5.0 p < 0.01] and FOIS [Median: 4 vs. 1 p < 0.01] scores were significantly higher in patients with coexisting diseases. Conclusion: The capacity of the pectoralis major muscle may be an independent factor in the prognosis of elderly patients with aspiration pneumonia as a primary disease.
Accretion disk and ionized absorber of the 9.7-hour dipping black hole binary MAXI J1305-704
Megumi Shidatsu,Yoshihiro Ueda,Satoshi Nakahira,Chris Done,Kumiko Morihana,Mutsumi Sugizaki,Tatehiro Mihara,Takafumi Hori,Hitoshi Negoro,Nobuyuki Kawai,Kazutaka Yamaoka,Ken Ebisawa,Masaru Matsuoka,Motoko Serino,Tatsuhito Yoshikawa,Takahiro Nagayama,Noriyuki Matsunaga
Physics , 2013, DOI: 10.1088/0004-637X/779/1/26
Abstract: We report the results from X-ray studies of the newly discovered black hole candidate MAXI J1305-704 based on Suzaku and Swift observations in the low/hard and high/soft states, respectively. The long Suzaku observation shows two types of clear absorption dips, both of which recur on a dip interval of 9.74 +- 0.04 hours, which we identify with the orbital period. There is also partially ionized absorption in the non-dip (persistent) emission in both the high/soft state and, very unusually, the low/hard state. However, this absorption (in both states) has substantially lower ionization than that seen in other high inclination systems, where the material forms a homogeneous disk wind. Here instead the absorption is most probably associated with clumpy, compact structures associated with the dipping material, which we see uniquely in this source likely because we view it at a very large inclination angle. A large inclination angle is also favored, together with a low black hole mass, to explain the high disk temperature seen in the fairly low luminosity high/soft state, as Doppler boosting enhances the disk temperature at high inclination. The disk radius inferred from these data is significantly smaller than that of the soft component seen in the low/hard state, supporting models where the disk is truncated at low luminosities. We find, however, that the lack of variability power on time scales of ~50 sec in the Suzaku low/hard state data is difficult to explain, even with a low mass black hole.
Japanese Higher Education Institutions in the 21st Century: The Challenge of Globalization and Internationalization
AOKI, Kumiko
Electronic Journal of Contemporary Japanese Studies , 2005,
Abstract: Higher education institutions in Japan are facing unprecedented challenges today due to the following three factors:the decrease in the size of college age cohorts in the coming years; heightened expectations in the modes of instructional delivery through the advances of information and communication technologies (ICT); global competition for college students worldwide especially from English-speaking countries. This paper examines internationalization of higher education in Japan in terms of:foreign faculty members in Japan, foreign tertiary students in Japan, Japanese students studying abroad, branch campuses of foreign colleges and universities in Japan, off-shore campuses of Japanese colleges and universities, and cross-border higher education through e-learning.
Ultrahigh energy cosmic ray acceleration in newly born magnetars and their associated gravitational wave signatures
Kumiko Kotera
Physics , 2011, DOI: 10.1103/PhysRevD.84.023002
Abstract: Newly born magnetars are good candidate sources of ultrahigh energy cosmic rays. These objects can in principle easily accelerate particles to the highest energies required to satisfy the ultrahigh energy cosmic ray scenario (E~10^{20-21} eV), thanks to their important rotational and magnetic energy reservoirs. Their acceleration mechanism, based on unipolar induction, predicts however a hard particle injection that does not fit the observed ultrahigh energy cosmic ray spectrum. Here we show that an adequate distribution of initial voltages among magnetar winds can be found to soften the spectrum. We discuss the effect of these distributions for the stochastic gravitational wave background signature produced by magnetars. The magnetar population characteristics needed to fit the ultrahigh energy cosmic ray spectrum could lead in most optimistic cases to gravitational wave background signals enhanced of up to four orders of magnitudes in the range of frequency 1-100 Hz, compared to the standard predictions. These signals could reach the sensitivities of future detectors such as DECIGO or BBO.
Fluctuation-dissipation relations outside the linear response regime in a two-dimensional driven lattice gas along the direction transverse to the driving force
Kumiko Hayashi
Physics , 2005, DOI: 10.1103/PhysRevE.72.047105
Abstract: We performed numerical experiments on a two-dimensional driven lattice gas, which constitutes a simple stochastic nonequilibrium many-body model. In this model, focusing on the behavior along the direction transverse to the external driving force, we numerically measure transport coefficients and dynamical fluctuations outside the linear response regime far from equilibrium. Using these quantities, we find the validity of the Einstein relation, the Green-Kubo relation and the fluctuation-response relation.
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