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Search Results: 1 - 10 of 40555 matches for " Kuan-Chia Lin "
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Classification and regression tree analysis in acute coronary syndrome patients  [PDF]
Heng-Hsin Tung, Chiang-Yi Chen, Kuan-Chia Lin, Nai-Kuan Chou, Jyun-Yi Lee, Daniel L. Clinciu, Ru-Yu Lien
World Journal of Cardiovascular Diseases (WJCD) , 2012, DOI: 10.4236/wjcd.2012.23030
Abstract: Objectives: The objectives of this study are to use CART (Classification and regression tree) and step-wise regression to 1) define the predictors of quality of life in ACS (acute coronary syndrome) patients, using demographics, ACS symptoms, and anxiety as independent variables; and 2) discuss and compare the results of these two statistical approaches. Back- ground: In outcome studies of ACS, CART is a good alternative approach to linear regression; however, CART is rarely used. Methods: A descriptive survey design was used with 100 samples recruited. Result and Conclusions: Anxiety is the most significant predictor and also a stronger predictor than symptoms of ACS for the quality of life. The anxiety level patients experienced at the time heart attack occurred can be used to predict quality of life a month later. Furthermore, the majority of ACS patients experienced a moderate to high level of anxiety during a heart attack.
Effectiveness of Traditional Chinese Medicine for Liver Protection and Chemotherapy Completion among Cancer Patients
Mei-Ling Liu,Li-Yin Chien,Cheng-Jeng Tai,Kuan-Chia Lin,Chen-Jei Tai
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep185
Abstract: While traditional Chinese medicine (TCM) is widely used among Chinese patients with cancer, studies evaluating the effectiveness of TCM using objective indicators are rare. We examined the effectiveness of TCM for liver protection and completion of chemotherapy among patients with cancer receiving chemotherapy. We used a case-control design to examine the medical records of patients with cancer who received chemotherapy in a teaching hospital in Taipei in 2004. A total of 184 courses of chemotherapy among 89 patients were studied. Of the 184 courses, 42 used TCM jointly with chemotherapy served as cases, while the remaining 142 courses served as controls. Outcome variables included counts of cancelled or delayed chemotherapies and liver function (aspartate aminotransferase, AST and alanine aminotransferase, ALT) 1 week before, during and 2 weeks after chemotherapy. Generalized estimating equations were used to analyze the data. Patients who had concomitant TCM with chemotherapy had lower serum ALT and AST during chemotherapy than the controls given that the age, sex, cancer stage, radiotherapy sites, cancer diagnosis and potential hepatotoxicity of the chemotherapeutic drugs were controlled for in the model [β  = ?3.48, 95% confidence interval (CI) ?10.08 to 3.11 for AST; β  = ?5.95, 95% CI: ?11.47 to ?0.44 for ALT]. There was no significant difference between the case and control groups for odds of completing one course of chemotherapy. Use of TCM with chemotherapy resulted in protection of the liver during chemotherapy, as manifested by lower serum AST and ALT levels.
Morbidity at elementary school entry differs by sex and level of residence urbanization: a comparative cross-sectional study
Rea-Jeng Yang, Jiunn-Jye Sheu, Huey-Shys Chen, Kuan-Chia Lin, Hsiu-Li Huang
BMC Public Health , 2007, DOI: 10.1186/1471-2458-7-358
Abstract: This is a comparative descriptive study. Data from the 2002 Student Entry Physical Examination (SEPE) and Student Medical History Inventory (SMHI) were obtained from 203 public and private elementary schools in northern Taiwan where a population of 53,053 students was included. Frequencies, independent sample t test, one-way ANOVA along with Scheff's post hoc test, and Pearson's correlation were conducted using SPSS.This study showed that 13.7% of students had at least one diagnosed disease from the SMHI reported by parents. Moreover, the SEPE indicated that 79.5% students had at least one health concern. Dental caries, myopia, and obesity were the most prevalent health problems among the first-graders (69.6%, 27.1%, and 9.5%, respectively). Research results show that there were significant differences in the prevalence of dental caries, myopia, and obesity between different sexes and among levels of urbanization. However, the quantity of available medical resources made no significant difference.Elementary school entry physical examination is an important way to detect students' health problems. It is suggested that school health interventions consider students' health profiles along with their sex and level of urbanization in planning. More research is needed to find the risk factors of the health problems. Additionally, the creation of a school health committee is suggested to implement and evaluate the entry health examination program.Health is vital to a child's ability to learn and to succeed in life [1]. Diseases or health problems can prevent a child from fully engaged in learning activities. For instance, studies found that childhood asthma is associated with an increased risk for school problems, including grade failure and learning disability [2,3]. As a means of primary prevention, many studies suggested that physical examination can identify high risk groups among school-aged children and also provide clues for secondary prevention [4,5]. Physical exami
Auricular Acupressure for Managing Postoperative Pain and Knee Motion in Patients with Total Knee Replacement: A Randomized Sham Control Study
Ling-hua Chang,Chung-Hua Hsu,Gwo-Ping Jong,Shungtai Ho,Shiow-luan Tsay,Kuan-Chia Lin
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/528452
Abstract: Background. Postoperative pain management remains a significant challenge for all healthcare providers. A randomized controlled trial was conducted to examine the adjuvant effects of auricular acupressure on relieving postoperative pain and improving the passive range of motion in patients with total knee replacement (TKR). Method. Sixty-two patients who had undergone a TKR were randomly assigned to the acupressure group and the sham control group. The intervention was delivered three times a day for 3 days. A visual analog scale (VAS) and the Short-Form McGill Pain Questionnaire were used to assess pain intensity. Pain medication consumption was recorded, and the knee motion was measured using a goniometer. Results. The patients experienced a moderately severe level of pain postoperatively (VAS 58.66 ± 20.35) while being on the routine PCA. No differences were found in pain scores between the groups at all points. However, analgesic drug usage in the acupressure group patients was significantly lower than in the sham control group (<0.05), controlling for BMI, age, and pain score. On the 3rd day after surgery, the passive knee motion in the acupressure group patients was significantly better than in the sham control group patients (<0.05), controlling for BMI. Conclusion. The application of auricular acupressure at specific therapeutic points significantly reduces the opioid analgesia requirement and improves the knee motion in patients with TKR.
Chun-Ting Yeh,Hsin-Kuan Liu,Chia-Jing Lin,Chia-Her Lin
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810035907
Abstract: The title complex, [Mg3(CHO2)3(C9H3O6)(C3H7NO)3]n, exhibits a two-dimensional structure parallel to (001), which is built up from the MgII atoms and bridging carboxylate ligands (3 symmetry). The MgII atom is six-coordinated by one O atom from a dimethylformamide molecule, two O atoms from two μ6-benzene-1,3,5-tricarboxylate ligands and three O atoms from three μ3-formate ligands in a distorted octahedral geometry.
N-Acetylglucosamine: Production and Applications
Jeen-Kuan Chen,Chia-Rui Shen,Chao-Lin Liu
Marine Drugs , 2010, DOI: 10.3390/md8092493
Abstract: N-Acetylglucosamine (GlcNAc) is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin, the second most abundant carbohydrate after cellulose. In addition to serving as a component of this homogeneous polysaccharide, GlcNAc is also a basic component of hyaluronic acid and keratin sulfate on the cell surface. In this review, we discuss the industrial production of GlcNAc, using chitin as a substrate, by chemical, enzymatic and biotransformation methods. Also, newly developed methods to obtain GlcNAc using glucose as a substrate in genetically modified microorganisms are introduced. Moreover, GlcNAc has generated interest not only as an underutilized resource but also as a new functional material with high potential in various fields. Here we also take a closer look at the current applications of GlcNAc, and several new and cutting edge approaches in this fascinating area are thoroughly discussed.
Hsin-Kuan Liu,Xiang-Wen Peng,Chia-Her Lin
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809002864
Abstract: The solvothermal reaction of magnesium nitrate with biphenyl-4,4′-dicarboxylic acid in N,N-dimethylformamide and water leads to the formation of crystals of the title complex, [Mg(C14H8O4)(H2O)2]n. In the crystal structure, the Mg cations are coordinated by six O atoms from two water molecules and four symmetry-related biphenyl-4,4′-dicarboxylate anions within slightly distorted octahedra. The Mg cations are located on a center of inversion, the biphenyl-4,4′-dicarboxylate anions around a twofold rotation axis and the water molecule in a general position. The Mg cations are linked by the anions into a three-dimensional framework.
The Identification and Characterization of Chitotriosidase Activity in Pancreatin from Porcine Pancreas
Chia-Rui Shen,Chao-Lin Liu,Hsiao-Ping Lee,Jeen-Kuan Chen
Molecules , 2013, DOI: 10.3390/molecules18032978
Abstract: The versatile oligosaccharide biopolymers, chitin and chitosan, are typically produced using enzymatic processes. However, these processes are usually costly because chitinases and chitosanases are available in limited quantities. Fortunately, a number of commercial enzymes can hydrolyze chitin and chitosan to produce long chain chitin or chitosan oligosaccharides. Here, a platform to screen for enzymes with chitinase and chitosanase activities using a single gel with glycol chitin or glycol chitosan as a substrate was applied. SDS-resistant chitinase and chitosanase activities were observed for pancreatin. Its chitotriosidase had an optimal hydrolysis pH of 4 in the substrate specificity assay. This activity was thermally unstable, but independent of 2-mercaptoethanol. This is the first time a chitotriosidase has been identified in the hog. This finding suggests that oligochitosaccharides can be mass-produced inexpensively using pancreatin.
Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression
Chia-Hsin Chan,Szu-Wei Lee,Jing Wang,Hui-Kuan Lin
The Scientific World Journal , 2010, DOI: 10.1100/tsw.2010.89
Timing of tracheostomy as a determinant of weaning success in critically ill patients: a retrospective study
Chia-Lin Hsu, Kuan-Yu Chen, Chia-Hsuin Chang, Jih-Shuin Jerng, Chong-Jen Yu, Pan-Chyr Yang
Critical Care , 2004, DOI: 10.1186/cc3018
Abstract: The medical records of patients who underwent tracheostomy in the medical intensive care unit (ICU) of a tertiary medical centre from July 1998 to June 2001 were reviewed. Clinical characteristics, length of stay in the ICU, rates of post-tracheostomy pneumonia, weaning from mechanical ventilation and mortality rates were analyzed.A total of 163 patients (93 men and 70 women) were included; their mean age was 70 years. Patients were classified into two groups: successful weaning (n = 78) and failure to wean (n = 85). Shorter intubation periods (P = 0.02), length of ICU stay (P = 0.001) and post-tracheostomy ICU stay (P = 0.005) were noted in patients in the successful weaning group. Patients who underwent tracheostomy more than 3 weeks after intubation had higher ICU mortality rates and rates of weaning failure. The length of intubation correlated with the length of ICU stay in the successful weaning group (r = 0.70; P < 0.001). Multivariate analysis revealed that tracheostomy after 3 weeks of intubation, poor oxygenation before tracheostomy (arterial oxygen tension/fractional inspired oxygen ratio <250) and occurrence of nosocomial pneumonia after tracheostomy were independent predictors of weaning failure.The study suggests that tracheostomy after 21 days of intubation is associated with a higher rate of failure to wean from mechanical ventilation, longer ICU stay and higher ICU mortality.Tracheostomy is among the most frequently performed procedures in critically ill patients, being done in about 24% of patients in medical intensive care units (ICUs) [1]. The most common indication for tracheostomy in the ICU is need for prolonged mechanical ventilation [2,3]. Tracheostomy has several advantages over endotracheal intubation, including lower airway resistance, smaller dead space, less movement of the tube within the trachea, greater patient comfort and more efficient suction [4,5]. Although recent studies have suggested that tracheostomy can be a safe procedure in
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