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Search Results: 1 - 10 of 144327 matches for " Krizzia B Albanez "
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Molecular characteristics and chromatin texture features in acute promyelocytic leukemia
Mariana R B De Mello, Dulcineia M Albuquerque, Fernanda Pereira-Cunha, Krizzia B Albanez, Katia B B Pagnano, Fernando F Costa, Konradin Metze, Irene Lorand-Metze
Diagnostic Pathology , 2012, DOI: 10.1186/1746-1596-7-75
Abstract: In a prospective study, we analyzed peripheral (PB) leukocyte count, immunophenotype, methylation status of CDKN2B, CDKN2A and TP73; FLT3 and NPM1 mutations besides nuclear chromatin texture characteristics of the leukemic cells. We also examined the relation of these features with patient’s outcome.Among 19 cases, 4 had a microgranular morphology, 7 presented PB leukocytes >10x109/l, 2 had FLT3-ITD and 3 had FLT3-TKD (all three presenting a methylated CDKN2B). NPM1 mutation was not observed. PB leukocyte count showed an inverse relation with standard deviation of gray levels, contrast, cluster prominence, and chromatin fractal dimension (FD). Cases with FLT3-ITD presented a microgranular morphology, PB leukocytosis and expression of HLA-DR, CD34 and CD11b. Concerning nuclear chromatin texture variables, these cases had a lower entropy, contrast, cluster prominence and FD, but higher local homogeneity, and R245, in keeping with more homogeneously distributed chromatin. In the univariate Cox analysis, a higher leukocyte count, FLT3-ITD mutation, microgranular morphology, methylation of CDKN2B, besides a higher local homogeneity of nuclear chromatin, a lower chromatin entropy and FD were associated to a worse outcome. All these features lost significance when the cases were stratified for FLT3-ITD mutation. Methylation status of CDNK2A and TP73 showed no relation to patient’s survival.in APL, patients with FLT3-ITD mutation show different clinical characteristics and have blasts with a more homogeneous chromatin texture. Texture analysis demonstrated that FLTD-ITD was accompanied not only by different cytoplasmic features, but also by a change in chromatin structure in routine cytologic preparations. Yet we were not able to detect chromatin changes by nuclear texture analysis of patients with the FTLD-TKD or methylation of specific genes.Acute promyelocytic leukemia (APL) is a well characterized subtype of acute myeloid leukemia (AML) defined by a specific cytogenetic
17-Acetoxymulinic acid
Iván Brito,Jorge Bórquez,Joselyn Albanez,Michael Bolte
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810032952
Abstract: The title compound, [systematic name: 5a-acetoxymethyl-3-isopropyl-8-methyl-1,2,3,3a,4,5,5a,6,7,10,10a,10b-dodecahydro-7,10-endo-epidioxycyclohepta[e]indene-3a-carboxylic acid], C22H32O6 (I), is closely related to methyl 5a-acetoxymethyl-3-isopropyl-8-methyl-1,2,3,3a,4,5,5a,6,7,10,10a,10b-dodecahydro-7,10-endo-epidioxycyclohepta[e]indene-3a-carboxylate, (II) [Brito et al., (2008). Acta Cryst. E64, o1209]. There are two molecules in the asymmetric unit, which are linked by two strong intramolecular O—H...O hydrogen bonds with graph-set motif R22(8). In both (I) and (II), the conformation of the three fused rings are almost identical. The five-membered ring has an envelope conformation, the six-membered ring has a chair conformation and the seven-membered ring has a boat conformation. The most obvious differences between the two compounds is the observed disorder of the acetoxymethyl fragments in both molecules of the asymmetric unit of (I). This disorder is not observed in (II). The crystal structure and the molecular conformation is stabilized by intermolecular C—H...O hydrogen bonds. The ability to form hydrogen bonds is different in the two compounds. The crystal studied was a non-merohedral twin, the ratio of the twin components being 0.28 (1):0.72 (1)
Impactos da assimetria de informa??o na estrutura de capital de empresas brasileiras abertas
Albanez, Tatiana;Valle, Maurício Ribeiro do;
Revista Contabilidade & Finan?as , 2009, DOI: 10.1590/S1519-70772009000300002
Abstract: several theories try to explain what determines the financing policy firms adopt. one of the existent approaches, pecking order theory, focuses on information asymmetry as an important determinant of the capital structure. in the present work, we try to analyze the central presumption of the referred theory and to verify if the information asymmetry influences the financing decisions of brazilian open capital firms in the period 1997-2007. in order to do so, proxy variables are used for information asymmetry, besides control variables that represent firms' characteristics. panel data analysis is the technique used. as the main result, it was found that companies considered to have the lowest degree of information asymmetry are higher leveraged than the others when analyzing the level of total debt. that result is contrary to the pecking order theory, where these companies would have the opportunity to raise resources by emitting shares, due to the low probability of occurring problems derived from information asymmetry. however, this result supports the expected alternative relation, where companies with lower asymmetric information make it easier for their debt holders to evaluate their risk, what could increase the credit offer, favoring the use of debt by reducing the adverse selection costs and increasing the debt capacity of these companies. in doing so, it becomes important to also analyze the role of the risk when establishing a hierarchy of preferences adopted by brazilian firms regarding alternative financing sources.
Tatiana Albanez,Maurício Ribeiro do Valle
Revista Universo Contábil , 2009,
Abstract: This paper analyzes the debt composition of sugar and ethanol companies from the center-south area of the country in five year-harvest (01/02, 02/03, 03/04, 04/05 and 05/06). It is tried to incorporate institutional factors to the capital structure analysis of the companies, such as the access to different sources, as well as to know the importance of those resources in the capital structure of the analyzed companies. Thus, it is tried to understand the participation of different financing lines used by the firms in their indebtedness, which are grouped in four categories: differentiated lines in national currency, differentiated lines in foreign currency, market lines in national currency and market lines in foreign currency. The research also tries to identify whether the companies used, in the analyzed period, the strategies of low debt and/or high liquidity to compensate the high interest rates of the national market. The sample is composed by 35 companies that process around 33% of the sugar cane of the country. The main results showed that the companies used mainly resources from differentiated lines in national currency and from market lines in foreign currency. It is also verified that, on average, the companies presented a debt level around 30%, in which prevails the use of long-term debt, and high liquidity levels through the period. It is noticed that the access to differentiated financing lines have influenced the financing decisions taken by the companies, since the use of these lines prevailed in all of the years, which ratifies the importance of including institutional factors in the capital structure analysis of the companies. Este artigo analisa a composi o do endividamento de usinas de a úcar e álcool da regi o centro-sul do país em cinco anos-safra (01/02, 02/03, 03/04, 04/05 e 05/06). Procura-se incorporar fatores institucionais à análise da estrutura de capital das empresas, como o acesso a diferentes fontes de recursos, bem como conhecer qual a importancia desses recursos na estrutura de capital das usinas analisadas. Para tanto, busca-se conhecer qual a participa o no endividamento das diferentes linhas de financiamento utilizadas pelas usinas, as quais s o agrupadas em quatro categorias: linhas diferenciadas em moeda nacional, linhas diferenciadas em moeda estrangeira, linhas de mercado em moeda nacional e linhas de mercado em moeda estrangeira. A pesquisa também procura identificar se as usinas utilizaram, no período analisado, as estratégias de baixo endividamento e/ou alta liquidez para compensar as altas taxas de juros a qu
Trithiacyanuric acid: a second triclinic polymorph
Iván Brito,Joselyn Albanez,Michael Bolte
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810033234
Abstract: The title compound, C3H3N3S3, is a triclinic modification. The other reported modification crystallizes with just one molecule in the asymmetric unit, [Guo et al. (2006). Cryst. Growth Des. 6, 846–848] and was solved by power X-ray diffraction data. The present modification has Z′ = 2. In the crystal, molecules are linked by strong intramolecular N—H...S hydrogen bonds with set graph-motif R22(8). In both molecules, all of the N atoms and two of the S atoms are involved in hydrogen bonding, with an average H...S distance of 2.58 and N—H...S angles in the range 163–167°. π–π stacking interactions are not observed. In the solid state, the molecules exist in the thione form. The molecular and supramolecular properties are similar in both polymorphs.
Journal of the Chilean Chemical Society , 2010, DOI: 10.4067/S0717-97072010000300027
Abstract: two new dicationic ionic liquids 1,7-bis(3-methylimidazolium-1-yl)heptane bromide (i) and 1,8-bis(3-methylimidazolium-1-yl)octane bromide (ii) have been synthesized and characterized by elemental analysis, ft-ir, 1h and 13c nmr, and tg-dsc techniques. the compound (i) is liquid at room temperature, whereas (ii) is liquid at 42.7°c.
Fatores institucionais e assimetria informacional: influência na estrutura de capital de empresas brasileiras
Albanez, Tatiana;Valle, Maurício Ribeiro do;Corrar, Luiz Jo?o;
RAM. Revista de Administra??o Mackenzie , 2012, DOI: 10.1590/S1678-69712012000200004
Abstract: the main objective of this paper is to analyze if the presence of important brazilian institutional factors, such as the access to sources and different financing lines of credit, affects the economic and statistical significance of the information asymmetry, main assumption of the pecking order theory, in the determination of brazilian firms' capital structure. in order to do so we used control variables, variables representing institutional factors and information asymmetry in a panel data regarding brazilian firms in industrial sectors traded in bovespa, in the period 1997-2007. the most important result found is that the variables size, tangibility, profitability and risk are important determinants of capital structure of the analyzed firms, also the significant participation of different lines in the indebtedness of these firms. in response to the objective of the research, it is observed that the information asymmetry does not lose economic and statistical significance in the proposed model, after inclusion of variables representing institutional factors, which highlights the importance of information asymmetry in determining the capital structure of brazilian firms. the negative sign found supports the pecking order theory, where these companies would be less in debt due to the possibility of raising funds by issuing shares. it is emphasized that the proxies used to represent the attribute information asymmetry constitute a limitation of the research, being suggested, for future works, the use of other variables, to check consistency of the results found, as well as the analysis of the influence of information asymmetry on the cost of brazilian firms' capital, in order to verify if companies considered with less information asymmetry can borrow resources at more attractive interest rate.
Iván Brito,Alejandro Cárdenas,Joselyn Albanez,Michael Bolte
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809044870
Abstract: There are two independent molecules in the asymmetric unit of the title compound, C19H24S2. In both molecules, the aliphatic segment of the ligand is in an all-trans conformation: the –S–(CH2)5–S–bridging chain is almost planar (r.m.s. deviation for all non-H atoms = 0.0393 and 0.0796 in the two molecules) and maximally extended. Their mean planes form dihedral angles of 4.08 (6)/20.47 (6) and 2.22 (6)/58.19 (6)° with the aromatic rings in the two molecules. The crystal packing is purely governed by weak intermolecular forces.
Dimethyl 2,2′-[butane-1,4-diylbis(sulfanediyl)]dibenzoate
Iván Brito,Alejandro Cárdenas,Joselyn Albanez,Michael Bolte
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809042846
Abstract: The title compound, C20H22O4S2, was synthesized by the reaction of 1,4-dibromobutene with methyl thiosalicylate. The aliphatic segment of this ligand is in an all-trans conformation. The bridging chain, –S-(CH2)4-S–, is almost planar (r.m.s. deviation for all non-H atoms: 0.056 ) and its mean plane forms dihedral angles of 16.60 (7) and 5.80 (2)° with the aromatic rings. In the crystal, the molecules are linked by weak C—H...O interactions into chains with graph-set notation C(14) along [0 0 1]. The crystal studied was a racemic twin, the ratio of the twin components being 0.27 (9):0.73 (9).
2-Phenylethyl 1-thio-β-d-galactopyranoside hemihydrate
Iván Brito,László Szilágyi,Ambati Ashok Kumar,Joselyn Albanez
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811031667
Abstract: The title compound, C14H20O5S·0.5H2O, crystallizes with two organic molecules and a solvent water molecule in the asymmetric unit. In both molecules, the hexapyranosyl rings adopt a slightly distorted chair conformation (5C2) with four substituents in equatorial positions and one substituent in an axial position. The main difference between the organic molecules is the dihedral angle between the phenyl ring and the best plane defined by the O—C1—C2—C3 atoms (r.m.s deviations = 0.003 and 0.043 ) of the hexapyranosyl rings [47.4 (4) and 86.5 (4)°]. In the asymmetric unit, molecules are linked by two strong O—H...O hydrogen bonds. In the crystal, the components are linked by a total of 10 distinct O—H...O hydrogen bonds, resulting in the formation of a two-dimensional network parallel to the ab plane.
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