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Search Results: 1 - 10 of 1245 matches for " Kowalski ML "
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A direct comparison of efficacy between desloratadine and rupatadine in seasonal allergic rhinoconjunctivitis: a randomized, double-blind, placebo-controlled study
Lukat KF,Rivas P,Roger A,Kowalski ML
Journal of Asthma and Allergy , 2013,
Abstract: KF Lukat,1 P Rivas,2 A Roger,3 ML Kowalski,4 U Botzen,5 F Wessel,6 F Sanquer,7 I Agache,8 I Izquierdo9Investigators working group clinical trial 1Institute Respiratory Science, Dusseldorf, Germany; 2Hospital Viladecans, ENT Department, Barcelona, Spain; 3Hospital Universitario “German Trias i Pujol,” Badalona, Spain; 4Medical University of Lodz, Immunology, Rheumatology, and Allergy, Lodz, Poland; 5ENT, private consult, Solingen, Germany; 6Allergologist, Private Practice, Nantes, France; 7Allergologist, Private Practice, Bordeaux, France; 8Medical Clinical SC Radoi Mariana SRL, Brasov, Romania; 9Clinical Research and Development, J Uriach y Compa ia, SA Barcelona, SpainBackground: H1-antihistamines are recommended as the first-line symptomatic treatment of allergic rhinitis. The objective of this study was to evaluate the effects of rupatadine (RUP) versus desloratadine (DES) in subjects with seasonal allergic rhinitis (SAR).Method: To assess the efficacy and safety of RUP in SAR in comparison with placebo (PL) and DES. A randomized, double-blind, multicenter, international, and PL-controlled study was carried out. The main selection criteria included SAR patients over 12 years old with a positive prick test to a relevant seasonal allergen for the geographic area. Symptomatic patients at screening with a nasal symptom sum score of ≥6 points (nasal discharge, nasal obstruction, sneezing, and nasal pruritus), a non-nasal score of ≥3 points (ocular pruritus, ocular redness, and tearing eyes), and a rhinorrhea score of ≥2 points with laboratory test results and electrocardiography within acceptable limits were included in the study. Change from baseline in the total symptom-score (T7SS) over the 4-week treatment period (reflective evaluation) was considered the primary efficacy variable. Secondary efficacy measures included total nasal symptom score (T4NSS) and conjunctival symptom score (T3NNSS), both of which are reflective and instantaneous evaluations. Furthermore questions related to quality of life (eg, sleep disturbances or impairment of daily activities) have also been evaluated. Safety was assessed according to adverse events reported, as well as laboratory and electrocardiography controls.Results: A total of 379 patients were randomized, of which 356 were included and allocated to PL (n = 122), RUP (n = 117), or DES (n = 117). Mean change of T7SS over the 4-week treatment period was significantly reduced in the RUP ( 46.1%, P = 0.03) and DES ( 48.9%, P = 0.01) groups, compared with PL. Similarly, RUP and DES were comparable and significantly super
A direct comparison of efficacy between desloratadine and rupatadine in seasonal allergic rhinoconjunctivitis: a randomized, double-blind, placebo-controlled study
Lukat KF, Rivas P, Roger A, Kowalski ML, Botzen U, Wessel F, Sanquer F, Agache I, Izquierdo I
Journal of Asthma and Allergy , 2013, DOI: http://dx.doi.org/10.2147/JAA.S39496
Abstract: direct comparison of efficacy between desloratadine and rupatadine in seasonal allergic rhinoconjunctivitis: a randomized, double-blind, placebo-controlled study Original Research (766) Total Article Views Authors: Lukat KF, Rivas P, Roger A, Kowalski ML, Botzen U, Wessel F, Sanquer F, Agache I, Izquierdo I Published Date February 2013 Volume 2013:6 Pages 31 - 39 DOI: http://dx.doi.org/10.2147/JAA.S39496 Received: 23 October 2012 Accepted: 06 December 2012 Published: 22 February 2013 KF Lukat,1 P Rivas,2 A Roger,3 ML Kowalski,4 U Botzen,5 F Wessel,6 F Sanquer,7 I Agache,8 I Izquierdo9 Investigators working group clinical trial 1Institute Respiratory Science, Dusseldorf, Germany; 2Hospital Viladecans, ENT Department, Barcelona, Spain; 3Hospital Universitario “German Trias i Pujol,” Badalona, Spain; 4Medical University of Lodz, Immunology, Rheumatology, and Allergy, Lodz, Poland; 5ENT, private consult, Solingen, Germany; 6Allergologist, Private Practice, Nantes, France; 7Allergologist, Private Practice, Bordeaux, France; 8Medical Clinical SC Radoi Mariana SRL, Brasov, Romania; 9Clinical Research and Development, J Uriach y Compa ia, SA Barcelona, Spain Background: H1-antihistamines are recommended as the first-line symptomatic treatment of allergic rhinitis. The objective of this study was to evaluate the effects of rupatadine (RUP) versus desloratadine (DES) in subjects with seasonal allergic rhinitis (SAR). Method: To assess the efficacy and safety of RUP in SAR in comparison with placebo (PL) and DES. A randomized, double-blind, multicenter, international, and PL-controlled study was carried out. The main selection criteria included SAR patients over 12 years old with a positive prick test to a relevant seasonal allergen for the geographic area. Symptomatic patients at screening with a nasal symptom sum score of ≥6 points (nasal discharge, nasal obstruction, sneezing, and nasal pruritus), a non-nasal score of ≥3 points (ocular pruritus, ocular redness, and tearing eyes), and a rhinorrhea score of ≥2 points with laboratory test results and electrocardiography within acceptable limits were included in the study. Change from baseline in the total symptom-score (T7SS) over the 4-week treatment period (reflective evaluation) was considered the primary efficacy variable. Secondary efficacy measures included total nasal symptom score (T4NSS) and conjunctival symptom score (T3NNSS), both of which are reflective and instantaneous evaluations. Furthermore questions related to quality of life (eg, sleep disturbances or impairment of daily activities) have also been evaluated. Safety was assessed according to adverse events reported, as well as laboratory and electrocardiography controls. Results: A total of 379 patients were randomized, of which 356 were included and allocated to PL (n = 122), RUP (n = 117), or DES (n = 117). Mean change of T7SS over the 4-week treatment period was significantly reduced in the RUP ( 46.1%, P = 0.03) and DES ( 48.9%, P = 0.
On the Quadratic Transportation Problem  [PDF]
Veena Adlakha, Krzysztof Kowalski
Open Journal of Optimization (OJOp) , 2013, DOI: 10.4236/ojop.2013.23012
Abstract:

We present a direct analytical algorithm for solving transportation problems with quadratic function cost coefficients. The algorithm uses the concept of absolute points developed by the authors in earlier works. The versatility of the proposed algorithm is evidenced by the fact that quadratic functions are often used as approximations for other functions, as in, for example, regression analysis. As compared with the earlier international methods for quadratic transportation problem (QTP) which are based on the Lagrangian relaxation approach, the proposed algorithm helps to understand the structure of the QTP better and can guide in managerial decisions. We present a numerical example to illustrate the application of the proposed method.

A survey of European primitive breeds of sheep
ML Ryder
Genetics Selection Evolution , 1981, DOI: 10.1186/1297-9686-13-4-381
Abstract:
Social Wellbeing Predictor of illness behavior among HIV seropositive individuals
ML Imasiku
Medical Journal of Zambia , 2009,
Abstract: Objective: The objective of the present study was to compare the social wellbeing of HIV seropositive individuals and individuals the normative population who are not HIV positive to find out how social support affects physical well-being. Design: Amultiple group design was used to assess the intensity and impact of social support on HIV seropositive individuals, and individuals from the normative population. The study utilized a cohort method which lasted a period of four years. Main outcome measure: Social support and physical wellbeing Results: Totals of 120 subjects - drawn from different organizations/institutions in Zambia and India were enrolled into the study. The descriptive analysis of Indian participants shows that HIV seropositive who received inadequate social support obtained 65% on somatic symptoms while individuals from the normative population obtained 43.3% From Zambia 67% of the HIV seropositive individuals who received inadequate social support experienced somatic symptoms in the recent past as against 50% individuals from the normative population. Regarding social support from friends and family, the 'F' ratio for diagnosis and nationality was significant at 0.01 revealing that HIV+ individuals obtained the least social support. Correlation between the level of physical illness behavior [somatic symptoms] and social support from friends was found to be -0.389 while that for social support from family was - 0.307. This indicated that physical illness behavior is negatively and significantly correlated with perceived social support from friends and family. Conclusion: When the level of social support is perceived to be high by an individual, then it's likely that physical illness behavior will be low because those who had adequate social support from either their friends or families had less illness behaviour. The results therefore illustrate that less levels of social support and physical illness behavior seem to co-exist. Therefore provision of adequate social support should be included in the management and treatment of HIVseropositive individuals in order to enhance their quality of life.
Prevalence & characteristics of mothers with multiple pregnancies and associated labour complications at Muhimbili National Hospital, September 2005
ML Sikosana
Dar Es Salaam Medical Students' Journal , 2006,
Abstract: Objective: To determine the prevalence & characteristics of mothers with multiple pregnancies and associated labour complications at Muhimbili National Hospital Design: Retrospective Case control Study Subjects/Materials: A hospital based retrospective study. All women who delivered (live and still births) at Muhimbili National Hospital between January 2005 and June 2005 only. The required information was obtained from the record books of the Department of Obstetrics & Gynaecology. Results: Revealed incidence of multiple pregnancies was 30.1 per 1000 deliveries and a significant difference between the gestational ages at delivery between multiple pregnancies and controls. The twin pregnancies approximately 3 times more likely to deliver prematurely (odd ratio 3.90 {1.08
Therapeutic Potential of Statins in Age-related Macular Degeneration
ML Shahsuvaryan
Sierra Leone Journal of Biomedical Research , 2011,
Abstract: Age-related macular degeneration (ARMD) is the leading cause of irreversible vision loss, affecting one in three people aged 75 and above. Although exciting new pharmaceuticals to treat ARMD such as endothelial growth factor (VEGF) inhibitors, are now available, they are effective only in selected group of patients, and can be used only during a narrow time window. Monthly intravitreal anti-VEGF injections with systemic exposure to anti-VEGF could be replaced by new drugs taken in a non-invasive way. Statins are the most commonly used lipid lowering drugs. The objective of this review is therefore to evaluate the evidence and discuss the rationale behind the recent suggestions that statins may be useful in the prevention and the treatment of age-related macular degeneration. This review recognised that there are potentially multiple biological bases for the protective effect of statins on the risk of ARMD. Thus, it is time to conduct a randomised controlled trial to provide direct evidence of the effectiveness of specific type statin in lowering the incidence and progression of ARMD. New intervention as statins usage to prevent the development of age-related macular degeneration and its progression remain an important strategy to limit the morbidity due to this significant public health problem.
A comparative study of anxiety among HIV seropositive individuals, cancer patients and individuals from the normative population
ML Imasiku
Medical Journal of Zambia , 2008,
Abstract: Excessive anxiety contributes to a sense of helplessness in which a person feels little control over the present or future and continues maladaptive behaviour patterns. In view of the negative influence of long standing anxiety, the present study attempts to find an answer regarding the possible differences between the prevalence and impact of anxiety in HIV seropositive individuals, cancer patients and individuals from the normative population. Anxiety is a major health harzard in HIV seropositive individuals. This is so because it is probably one of the factors responsible for the quick progression of their HIV seropositive status to AIDS. Method: The sample consisted of 180 subjects. Half of these individuals (90) came from Zambia and the remaining 90 came from India. Out of each group of 90 individuals, 30 were HIV seropositive individuals, 30 were HIV negative but with cancer and 30 were individuals from the normative population (having none of the above two mentioned conditions i.e. HIV or Cancer). In Zambia, the sample was drawn from the University Teaching Hospital (UTH), Kara Counseling - Hope house, Mother Theresa Hospice and Network of Zambian people living with HIV (NZP+). In India the sample was drawn from Snehandan, Karnataka network for people living with HIV (KNP+), and Kidwai Hospital. The technique of assessment used was the Symptoms Questionnaire developed 1 used to assess anxiety and physical illness behavior (somatic symptoms). The data obtained was analyzed using‘t’ tests and analysis of covariance. In the present investigation an attempt was made to explore the intensity of anxiety in HIV+ individuals, Cancer patients and individuals from the normative population. Conclusion: The findings of the present study reveal that HIV+ individuals and cancer patients have higher levels of anxiety than individuals from the normative population. Anxiety is also found to be positively correlated with physical illness behavior. This indicates that high level of anxiety and physical illness behavior seem to co- exist. It’s therefore likely that a high level of anxiety is a core factor that might be responsible for the quick progression of HIV infection into AIDS.
Oral glycopyrrolate for the treatment of chronic severe drooling caused by neurological disorders in children
Evatt ML
Neuropsychiatric Disease and Treatment , 2011,
Abstract: Marian L EvattDepartment of Neurology, Atlanta Veterans Administration Hospital and Emory University School of Medicine, Atlanta, GA, USAAbstract: Excessive drooling may complicate the care of children with chronic neurological conditions by socially isolating both patients and families and by causing secondary dermatitis and infection. Normal control of saliva requires normal integrity of oral structures, normal oropharyngeal sensation, and motor functioning, as well as normal cognitive awareness and rate of salivary production. Glycopyrrolate is an anticholinergic medication with a quaternary structure that recently received Food and Drug Administration approval to treat sialorrhea due to neurological problems in children ages 3–16 years. This review summarizes the few published studies of safety and efficacy of glycopyrrolate for drooling in children with chronic neurological conditions.Keywords: drooling, sialorrhoea, sialorrhea, children, glycopyrrolate
Role of Pancreatic Stents in Prevention of Post-ERCP Pancreatitis
Freeman ML
JOP Journal of the Pancreas , 2004,
Abstract:
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