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Search Results: 1 - 10 of 4789 matches for " Kouichi Shin "
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Risperidone Versus Yokukansan in the Treatment of Severe Alzheimer’s Disease  [PDF]
Yuko Furuhashi, Kouichi Shin
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.22028
Abstract: PURPOSE: Patients with AD commonly exhibit behavioral and psychological symptoms of dementia (BPSD). This study is aimed to compare the efficacy of yokukansan (YKS) and risperidone (RIS) on BPSD in patients with severe Alzheimer’s disease (AD). METHODS: Thirty eight inpatients with AD were investigated. Patients were randomly as-signed to the YKS group (N = 18) or the RIS group (N = 20) and treated for 4 weeks. The primary outcomes were changes in the scores on the Neuropsychiatric Inventory (NPI), the Mini-Mental State Examination (MMSE), the Bar-thel Index, and the Cohen-Mansfield Agitation Inventory (CMAI). The frequency of extrapyramidal symptoms (EPS) and other adverse events were recorded at every visit. RESULTS: All participants in both groups completed the trial. The Barthel Index did not significantly change either in the RIS group or the YKS group. The MMSE scores did not change either in the RIS group or the YKS group. Significant improvements in mean total NPI and CMAI scores showed in both groups. Between the YKS and the RIS groups, there were no significant differences in the NPI or the CMAI scores. EPS and other serious adverse effects were not observed in either group. CONCLUSIONS: In this 4-week trial, YKS treatment significantly improved BPSD in the patients with severe AD. The present study suggests that YKS is as effective as RIS on BPSD with severe AD.
New Airy-type solutions of the ultradiscrete Painleve II equation with parity variables
Hikaru Igarashi,Shin Isojima,Kouichi Takemura
Mathematics , 2015,
Abstract: The q-difference Painleve II equation admits special solutions written in terms of determinant whose entries are the general solution of the q-Airy equation. An ultradiscrete limit of the special solutions is studied by the procedure of ultradiscretization with parity varialbes. Then we obtain new Airy-type solutions of the ultradiscrete Painleve II equation with parity variables, and the solutions have richer structure than the known solutions.
Short term results of endoscopic submucosal dissection in superficial esophageal squamous cell neoplasms
Kouichi Nonaka,Shin Arai,Keiko Ishikawa,Masamitsu Nakao
World Journal of Gastrointestinal Endoscopy , 2010,
Abstract: AIM: To evaluate the efficacy of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms.METHODS: Between July 2007 and March 2009, 27 consecutive superficial esophageal squamous cell neoplasms in 25 enrolled patients were treated by endoscopic submucosal dissection. The therapeutic efficacy, complications, and follow-up results were assessed.RESULTS: The mean size of the lesions was 21 ± 13 mm (range 2-55 mm); the mean size of the resection specimens was 32 ± 12 mm (range 10-70 mm). The en block resection rate was 100% (27/27), and en block resection with tumor-free lateral/basal margins was 88.9% (24/27). Perforation occurred in 1 patient who was managed by conservative medical treatments. None of the patients developed local recurrence or distant metastasis in the follow-up period.CONCLUSION: Endoscopic submucosal dissection is applicable to superficial esophageal squamous cell neoplasms with promising results.
A case of gastric mucosa-associated lymphoid tissue lymphoma in which magnified endoscopy with narrow band imaging was useful in the diagnosis
Kouichi Nonaka,Keiko Ishikawa,Shin Arai,Masamitsu Nakao
World Journal of Gastrointestinal Endoscopy , 2012, DOI: 10.4253/wjge.v4.i4.151
Abstract: Recently, we reported a case of gastric mucosa-associated lymphoid tissue (MALT) lymphoma presenting with unique vascular features. In the report, we defined the tree-like appearance (TLA) on the images of abnormal blood vessels which resembled branches from the trunk of a tree in the shiny mucosa, in which the glandular structure was lost. The 67-year-old female was diagnosed with gastric MALT lymphoma. The patient received eradication therapy for H. pylori. Conventional endoscopy revealed multiple ill-delineated brownish depressions in the stomach and cobblestone-like mucosa was observed at the greater curvature to the posterior wall of the upper gastric body 7 mo after successful eradication. Unsuccessful treatment of gastric MALT lymphoma was suspected on conventional endoscopy. Conventional endoscopic observations found focal depressions and cobblestone-like appearance, and these lesions were subsequently observed using magnified endoscopy combined with narrow band imaging to identify abnormal vessels presenting with a TLA within the lesions. Ten biopsies were taken from the area where abnormal vessels were present within these lesions. Ten biopsies were also taken from the lesions without abnormal vessels as a control. A total of 20 biopsy samples were evaluated to determine whether the diagnosis of MALT lymphoma could be obtained histologically from each sample. A positive diagnosis was obtained in 8/10 TLA (+) sites and in 2/10 TLA(-) sites. Target biopsies of the site with abnormal blood vessels can potentially improve diagnostic accuracy of gastric MALT lymphoma.
Quantum Fluctuation-Induced Phase Transition in S=1/2 XY-like Heisenberg Antiferromagnets on the Triangular Lattice
Shin-ichiro Yoshikawa,Kouichi Okunishi,Makoto Senda,Seiji Miyashita
Physics , 2004, DOI: 10.1143/JPSJ.73.1798
Abstract: The selection of the ground state among nearly degenerate states due to quantum fluctuations is studied for the S=1/2 XY-like Heisenberg antiferromagnets on the triangular lattice in the magnetic field applied along the hard axis, which was first pointed out by Nikuni and Shiba. We find that the selected ground state sensitively depends on the degree of the anisotropy and the magnitude of the magnetic field. This dependence is similar to that in the corresponding classical model at finite temperatures where various types of field induced phases appear due to the entropy effect. It is also found that the similarity of the selected states in the classical and quantum models are not the case in a two-leg ladder lattice, although the lattice consists of triangles locally and the ground state of this lattice in the classical case is the same as that of the triangular lattice.
The origin of ultra-fast outflows in AGN: Monte-Carlo simulations of the wind in PDS 456
Kouichi Hagino,Hirokazu Odaka,Chris Done,Poshak Gandhi,Shin Watanabe,Masao Sako,Tadayuki Takahashi
Physics , 2014, DOI: 10.1093/mnras/stu2095
Abstract: Ultra-fast outflows (UFOs) are seen in many AGN, giving a possible mode for AGN feedback onto the host galaxy. However, the mechanism(s) for the launch and acceleration of these outflows are currently unknown, with UV line driving apparently strongly disfavoured as the material along the line of sight is so highly ionised that it has no UV transitions. We revisit this issue using the Suzaku X-ray data from PDS 456, an AGN with the most powerful UFO seen in the local Universe. We explore conditions in the wind by developing a new 3-D Monte-Carlo code for radiation transport. The code only handles highly ionised ions, but the data show the ionisation state of the wind is high enough that this is appropriate, and this restriction makes it fast enough to explore parameter space. We reproduce the results of earlier work, confirming that the mass loss rate in the wind is around 30% of the inferred inflow rate through the outer disc. We show for the first time that UV line driving is likely to be a major contribution to the wind acceleration. The mass loss rate in the wind matches that predicted from a purely line driven system, and this UV absorption can take place out of the line of sight. Continuum driving should also play a role as the source is close to Eddington. This predicts that the most extreme outflows will be produced from the highest mass accretion rate flows onto high mass black holes, as observed.
A disk wind interpretation of the strong Fe Kα features in 1H 0707-495
Kouichi Hagino,Hirokazu Odaka,Chris Done,Ryota Tomaru,Shin Watanabe,Tadayuki Takahashi
Physics , 2015,
Abstract: 1H 0707-495 is the most convincing example of a supermassive black hole with an X-ray spectrum being dominated by extremely smeared, relativistic reflection. However, here we show that the iron features in its 2--10 keV spectrum are rather similar to the archetypal wind dominated source, PDS 456. We fit all the 2--10 keV spectra from 1H 0707-495 using the same wind model as used for PDS 456, but viewed at higher inclination so that the iron absorption line is broader but not so blueshifted. This gives a good overall fit to the data from 1H 0707-495, and an extrapolation of this model to higher energies also gives a good match to the NuSTAR data. Small remaining residuals may indicate that the emission from the wind is stronger than in PDS 456, consistent with the wider angle wind expected from a continuum driven wind from the super-Eddington mass accretion rate in 1H 0707-495. We suggest that the spectrum of 1H 0707-495 is sculpted more by absorption in a wind than by extreme relativistic effects in strong gravity.
Endoscopic Submucosal Dissection for Early Gastric Cancer  [PDF]
Kouichi Nonaka, Hiroto Kita
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.41A004
Abstract: The field of endoscopy has progressed markedly and become widespread in recent years, and the role of minimally invasive endoscopic treatment has become increasingly more important with the increase in the number of patients in whom gastric cancer is detected at an early stage. In addition, the characteristics of early gastric cancer, which can be curably treated by mucosal resection alone just as by surgical cancer resection, were clarified, and endoscopic submucosal dissection (ESD) was developed as a highly curable, minimally invasive treatment, that is gaining popularity. In this paper, we describe the technical details and complications of ESD for early gastric cancer, including their management.
Magnetic phase diagram of the coupled triangular spin tubes for CsCrF4
Kouichi Seki,Kouichi Okunishi
Physics , 2015, DOI: 10.1103/PhysRevB.91.224403
Abstract: Using Monte Carlo simulations, we explore the magnetic phase diagram of the triangular spin tubes coupled with a ferromagnetic inter-tube interaction for CsCrF4. A planar structure of the coupled tubes is topologically equivalent to the Kagome-triangular lattice, which induces nontrivial frustration effects in the system. We particularly find that, depending on the inter-tube coupling, various ordered phases are actually realized, such as incommensurate order, ferromagnetic order, and Cuboc order, which is characterized by the non-coplanar spin structure of the twelve sublattice accompanying the spin chirality breaking. We also discuss a relevance of the results to recent experiments of CsCrF4.
Status of the Gastric Mucosa with Endoscopically Diagnosed Gastrointestinal Stromal Tumor
Kouichi Nonaka,Shinichi Ban,Yoshimitsu Hiejima,Rei Narita,Michio Shimizu,Masayasu Aikawa,Ken Ohata,Nobuyuki Matsuhashi,Shin Arai,Hiroto Kita
Diagnostic and Therapeutic Endoscopy , 2014, DOI: 10.1155/2014/429761
Abstract: Background. Since gastrointestinal stromal tumor (GIST) is a mesenchymal submucosal tumor, the endosonographic, CT, and MRI features of gastric GISTs have been widely investigated. However, the GIST-bearing gastric mucosa status has not been reported. Objective. To characterize the GIST-bearing gastric mucosa status in terms of the degree of inflammation and atrophy, assessed endoscopically. Subjects and Methods. The subjects were 46 patients with submucosal tumors (histologically proven gastric GISTs) who had undergone upper gastrointestinal endoscopy in our hospital between April 2007 and September 2012. They were retrospectively evaluated regarding clinicopathological features, the endoscopically determined status of the entire gastric mucosa (presence or absence and degree of atrophy), presence or absence and severity of endoscopic gastritis/atrophy (A-B classification) at the GIST site, and presence or absence of H. pylori infection. Results. Twenty-three patients had no mucosal atrophy, but 17 and 6 had closed- and open-type atrophy, respectively. Twenty-six, 5, 12, 1, 1, and 1 patients had grades B0, B1, B2, B3, A0, and A1 gastritis/atrophy at the lesion site, respectively, with no grade A2 gastritis/atrophy. Conclusion. The results suggest that gastric GISTs tend to arise in the stomach wall with H. pylori-negative, nonatrophic mucosa or H. pylori-positive, mildly atrophic mucosa. 1. Introduction Gastric gastrointestinal stromal tumor (GIST) is a mesenchymal tumor arising from the muscularis propria of the gastric wall and is covered with normal mucosa, giving the endoscopic appearance of a submucosal tumor with bridging folds. Since gastric GIST is a submucosal tumor, its endosonographic, CT, and MRI features have been widely investigated [1–4]. However, the status of the GIST-bearing gastric mucosa itself has not been reported. Based on our experience, many GIST patients often show no evidence of H. pylori infection, gastritis, or mucosal atrophy on upper gastrointestinal endoscopy, and even H. pylori-infected patients may show mild gastritis in the background gastric mucosa. We consider that it is necessary to evaluate the GIST-bearing gastric mucosa using available data before testing the validity of this empirical rule and investigate the reason for it, if it is valid. In this study, we retrospectively evaluated patients with submucosal tumors (histologically proven gastric GISTs) regarding the age, gender, site and size of the lesion, risk classification of GISTs, presence or absence and degree of endoscopic atrophy in the entire gastric
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