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Search Results: 1 - 10 of 663 matches for " Kouichi Ozaki "
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Prediction model for knee osteoarthritis based on genetic and clinical information
Hiroshi Takahashi, Masahiro Nakajima, Kouichi Ozaki, Toshihiro Tanaka, Naoyuki Kamatani, Shiro Ikegawa
Arthritis Research & Therapy , 2010, DOI: 10.1186/ar3157
Abstract: We genotyped risk alleles of the three susceptibility genes, asporin (ASPN), growth differentiation factor 5 (GDF5), and double von Willebrand factor A domains (DVWA) for a total of 2,158 Japanese subjects (933 OA and 1,225 controls) and statistically analyzed their effects. After that, we constructed prediction models by using the logistic regression analysis.When the effects of each allele were assumed to be the same and multiplicative, each additional risk allele increased the odds ratio (OR) by a factor of 1.23 (95% confidence interval (CI), 1.12 to 1.34). Individuals with five or six risk alleles showed significantly higher susceptibility when compared with those with zero or one, with an OR of 2.67 (95% CI, 1.46 to 4.87; P = 0.0020). Statistical evaluation of the prediction power of models showed that a model using only genotyping data had poor predictability. We obtained a model with good predictability by incorporating clinical data, which was further improved by rigorous age adjustment.Our results showed that consideration of adjusted clinical information, as well as increases in the number of risk alleles to be integrated, is critical for OA prediction by using data from case-control studies. To the authors' knowledge, this is the first report of the OA-prediction model combining both genetic and clinical information.Osteoarthritis (OA) is the most common bone and joint disease and is characterized by progressive cartilage degeneration. OA is a polygenic disease caused by genetic and environmental factors [1]. Epidemiologic studies have suggested that genetic factors strongly affect the onset and development of OA [2]. Genetic association studies are now uncovering the genetic factors responsible for of OA, that is, its susceptibility genes. Candidate-gene approaches have identified several genes associated with OA, and genome-wide association studies have recently found several promising OA-susceptibility genes [1,3].Identification of OA-susceptibility ge
Risperidone Versus Yokukansan in the Treatment of Severe Alzheimer’s Disease  [PDF]
Yuko Furuhashi, Kouichi Shin
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.22028
Abstract: PURPOSE: Patients with AD commonly exhibit behavioral and psychological symptoms of dementia (BPSD). This study is aimed to compare the efficacy of yokukansan (YKS) and risperidone (RIS) on BPSD in patients with severe Alzheimer’s disease (AD). METHODS: Thirty eight inpatients with AD were investigated. Patients were randomly as-signed to the YKS group (N = 18) or the RIS group (N = 20) and treated for 4 weeks. The primary outcomes were changes in the scores on the Neuropsychiatric Inventory (NPI), the Mini-Mental State Examination (MMSE), the Bar-thel Index, and the Cohen-Mansfield Agitation Inventory (CMAI). The frequency of extrapyramidal symptoms (EPS) and other adverse events were recorded at every visit. RESULTS: All participants in both groups completed the trial. The Barthel Index did not significantly change either in the RIS group or the YKS group. The MMSE scores did not change either in the RIS group or the YKS group. Significant improvements in mean total NPI and CMAI scores showed in both groups. Between the YKS and the RIS groups, there were no significant differences in the NPI or the CMAI scores. EPS and other serious adverse effects were not observed in either group. CONCLUSIONS: In this 4-week trial, YKS treatment significantly improved BPSD in the patients with severe AD. The present study suggests that YKS is as effective as RIS on BPSD with severe AD.
Endoscopic Submucosal Dissection for Early Gastric Cancer  [PDF]
Kouichi Nonaka, Hiroto Kita
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.41A004
Abstract: The field of endoscopy has progressed markedly and become widespread in recent years, and the role of minimally invasive endoscopic treatment has become increasingly more important with the increase in the number of patients in whom gastric cancer is detected at an early stage. In addition, the characteristics of early gastric cancer, which can be curably treated by mucosal resection alone just as by surgical cancer resection, were clarified, and endoscopic submucosal dissection (ESD) was developed as a highly curable, minimally invasive treatment, that is gaining popularity. In this paper, we describe the technical details and complications of ESD for early gastric cancer, including their management.
Haplotypes with Copy Number and Single Nucleotide Polymorphisms in CYP2A6 Locus Are Associated with Smoking Quantity in a Japanese Population
Natsuhiko Kumasaka, Masayuki Aoki, Yukinori Okada, Atsushi Takahashi, Kouichi Ozaki, Taisei Mushiroda, Tomomitsu Hirota, Mayumi Tamari, Toshihiro Tanaka, Yusuke Nakamura, Naoyuki Kamatani, Michiaki Kubo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044507
Abstract: Smoking is a major public health problem, but the genetic factors associated with smoking behaviors are not fully elucidated. Here, we have conducted an integrated genome-wide association study to identify common copy number polymorphisms (CNPs) and single nucleotide polymorphisms (SNPs) associated with the number of cigarettes smoked per day (CPD) in Japanese smokers ( = 17,158). Our analysis identified a common CNP with a strong effect on CPD (rs8102683; ) in the 19q13 region, encompassing the CYP2A6 locus. After adjustment for the associated CNP, we found an additional associated SNP (rs11878604; ) located 30 kb downstream of the CYP2A6 gene. Imputation of the CYP2A6 locus revealed that haplotypes underlying the CNP and the SNP corresponded to classical, functional alleles of CYP2A6 gene that regulate nicotine metabolism and explained 2% of the phenotypic variance of CPD (ANOVA -test ). These haplotypes were also associated with smoking-related diseases, including lung cancer, chronic obstructive pulmonary disease and arteriosclerosis obliterans.
Effects of Bank Branch Competition on Rural Firm Entry and Exit: Evidence from Hokkaido, Japan  [PDF]
Kozo Harimaya, Yasufumi Ozaki
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.83028
Abstract: This paper investigates the effects of bank branch competition on rural firm entry and exit in Hokkaido, the largest and northernmost prefecture in Japan. Using a panel dataset of 188 municipalities, we run a two-stage least squares regression to examine whether banking competition affects firm entry and exit, respectively. Although the empirical evidence does not strongly support the notion of simultaneously linked firm entry and exit, banking competition has a negative effect on firm exit rates. Furthermore, consistent results are obtained when running a seemingly unrelated regression. Our findings suggest that fierce competition among banks does not contribute to firm survival and region-based relationship banking in less competitive areas can deter firm exit.
Magnetic phase diagram of the coupled triangular spin tubes for CsCrF4
Kouichi Seki,Kouichi Okunishi
Physics , 2015, DOI: 10.1103/PhysRevB.91.224403
Abstract: Using Monte Carlo simulations, we explore the magnetic phase diagram of the triangular spin tubes coupled with a ferromagnetic inter-tube interaction for CsCrF4. A planar structure of the coupled tubes is topologically equivalent to the Kagome-triangular lattice, which induces nontrivial frustration effects in the system. We particularly find that, depending on the inter-tube coupling, various ordered phases are actually realized, such as incommensurate order, ferromagnetic order, and Cuboc order, which is characterized by the non-coplanar spin structure of the twelve sublattice accompanying the spin chirality breaking. We also discuss a relevance of the results to recent experiments of CsCrF4.
On Gap Functions for Quasi-Variational Inequalities
Kouichi Taji
Abstract and Applied Analysis , 2008, DOI: 10.1155/2008/531361
Abstract: For variational inequalities, various merit functions, such as the gap function, the regularized gap function, the D-gap function and so on, have been proposed. These functions lead to equivalent optimization formulations and are used to optimization-based methods for solving variational inequalities. In this paper, we extend the regularized gap function and the D-gap functions for a quasi-variational inequality, which is a generalization of the variational inequality and is used to formulate generalized equilibrium problems. These extensions are shown to formulate equivalent optimization problems for quasi-variational inequalities and are shown to be continuous and directionally differentiable.
Middle Convolution and Heun's Equation
Kouichi Takemura
Symmetry, Integrability and Geometry : Methods and Applications , 2009,
Abstract: Heun's equation naturally appears as special cases of Fuchsian system of differential equations of rank two with four singularities by introducing the space of initial conditions of the sixth Painlevé equation. Middle convolutions of the Fuchsian system are related with an integral transformation of Heun's equation.
Towards Finite-Gap Integration of the Inozemtsev Model
Kouichi Takemura
Symmetry, Integrability and Geometry : Methods and Applications , 2007,
Abstract: The Inozemtsev model is considered to be a multivaluable generalization of Heun's equation. We review results on Heun's equation, the elliptic Calogero-Moser-Sutherland model and the Inozemtsev model, and discuss some approaches to the finite-gap integration for multivariable models.
The Heun equation and the Calogero-Moser-Sutherland system II: Perturbation and algebraic solution
Kouichi Takemura
Electronic Journal of Differential Equations , 2004,
Abstract: We apply a method of perturbation for the $BC_1$ Inozemtsev model from the trigonometric model and show the holomorphy of perturbation. Consequently, the convergence of eigenvalues and eigenfuncions which are expressed as formal power series is proved. We investigate also the relationship between $L^2$ space and some finite dimensional space of elliptic functions.
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