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Search Results: 1 - 10 of 1437 matches for " Kou Matsuo "
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Primary Neuroendocrine Carcinoma Combined with Squamous Cell Carcinoma of the Soft Palate: A Case Report and Review of Literature  [PDF]
Chatchaphan Udompatanakorn, Naomi Yada, Ayataka Ishikawa, Ikuya Miyamoto, Yukiko Sato, Kou Matsuo
Open Journal of Stomatology (OJST) , 2018, DOI: 10.4236/ojst.2018.83008
Abstract: Background: Neuroendocrine carcinomas (NECs) are rare neoplasms that widely occur in various organs. They are heterogeneous and vary from low to high grade malignant. NEC presenting with a squamous cell carcinoma (SCC) component is referred to as a composite tumor. Thus far, few cases of this composite tumor in the oral cavity have been reported in the literature; thus, the histogenesis remains unclear. ase Presentation: We encountered a rare case of a primary NEC combined with SCC, occurring at the soft palate in a 59-year-old man. A resected specimen of the tumor was composed of two components: NEC and SCC. The NEC area contained small round to oval atypical cells arranged in nests with a glandular-like-pattern, hyperchromatic molded nuclei, a high nuclear-to-cytoplasmic ratio, and a scant eosinophilic cytoplasm. The SCC area was composed of non-keratotic, dysplastic oval to spindle-shaped squamous cells with indistinct cell borders and large nuclei that were hyperchromatic and pleomorphic. Immunohistochemically, the tumor cells of the NEC component were positive for chromagranin A, synaptophysin, CD56, and p16, whereas those of the SCC component were positive for 34βE12, p63, and p16. Conclusion: In consideration of the morphological and immunohistochemical results, the final diagnosis was a primary NEC combined with SCC of the soft palate.
Methylation and Expression Status of SOCS1 and SOCS3 in Oral Lichen Planus  [PDF]
Kurara Yoshimura, Naomi Yada, Kou Matsuo, Hisako Hikiji, Daigo Yoshiga, Manabu Habu, Masaaki Sasaguri, Kazuhiro Tominaga
Open Journal of Stomatology (OJST) , 2018, DOI: 10.4236/ojst.2018.85016
Abstract: Oral lichen planus (OLP) is a disease of unknown etiology affecting oral mucosa by mediated chronic inflammation and is classified as a potentially malignant oral disorder. SOCS1 and SOCS3 in the SOCS family have been identified as negative regulators of the cytokine-activated JAK/STAT pathway responsible for inflammatory reaction. The DNA methylation in the promoter regions of SOCS1 and SOCS3 have been reported to correlate with carcinogenesis. In this study, we performed methylation-specific PCR (MSP) to investigate the methylation status of the promoter regions in SOCS1 and SOCS3 genes using biopsy samples from OLP and oral squamous cell carcinoma (OSCC) patients. SOCS1 was methylated in 14/29 (48.3%) cases with OLP and 7/15 (46.7%) cases with OSCC. At the same time, SOCS3 was methylated in 25/29 (86.2%) cases with OLP and 11/15 (73.3%) cases with OSCC. We didn’t recognize any DNA methylation in SOCS1 or SOCS3 genes from the exfoliated cytological specimens of normal buccal mucosa. Furthermore, mRNA expression level was analyzed using real-time RT-PCR method to evaluate the correlation with DNA methylation status. DNA methylation status of SOCS1 seemed not to affect the expression level of SOCS1 mRNA. At the same time, DNA methylation status of SOCS3 was negatively correlated with the expression level of SOCS3 mRNA (p < 0.05). We posit frequent methylation of the SOCS3 gene promoter, theoretically resulting in the increase of cytokines expression, might be associated with the etiological mechanism of OLP.
Effects of the Chinese Innovation System on Regional Innovation Performance  [PDF]
Kou Kou
Technology and Investment (TI) , 2018, DOI: 10.4236/ti.2018.91003
Abstract: This paper presents the influence of innovation systems on regional innovation performance in China for the period 1998-2008. It places special emphasis on the effects of institutional factors, namely marketization level. The findings indicate that the innovation system contributes greatly to increasing the level of innovation. Among the factors of innovation systems, the openness of the region and government expenditure on education plays key roles. Market-oriented institutional arrangements also increase innovation performance.
On Supersymmetry of the Covariant 3-Algebra Model for M-Theory  [PDF]
Matsuo Sato
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.311226
Abstract: We examine a natural supersymmetric extension of the bosonic covariant 3-algebra model for M-theory proposed in [1]. It possesses manifest SO(1,10) symmetry and is constructed based on the Lorentzian Lie 3-algebra associated with the U(N) Lie algebra. There is no ghost related to the Lorentzian signature in this model. It is invariant under 64 supersymmetry transformations although the supersymmetry algebra does not close. From the model, we derive the BFSS matrix theory and the IIB matrix model in a large N limit by taking appropriate vacua.
Zariski 3-Algebra Model of M-Theory  [PDF]
Matsuo Sato
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.44A006

We review on Zariski 3-algebra model of M-theory. The model is obtained by Zariski quantization of a semi-light-cone supermembrane action. The model has manifest N=1 supersymmetry in eleven dimensions and its relation to the supermembrane action is clear.

Ornithine Decarboxylase Antizyme Induces Hypomethylation of Genome DNA and Histone H3 Lysine 9 Dimethylation (H3K9me2) in Human Oral Cancer Cell Line
Daisuke Yamamoto,Kaori Shima,Kou Matsuo,Takashi Nishioka,Chang Yan Chen,Guo-fu Hu,Akira Sasaki,Takanori Tsuji
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0012554
Abstract: Methylation of CpG islands of genome DNA and lysine residues of histone H3 and H4 tails regulates gene transcription. Inhibition of polyamine synthesis by ornithine decarboxylase antizyme-1 (OAZ) in human oral cancer cell line resulted in accumulation of decarboxylated S-adenosylmethionine (dcSAM), which acts as a competitive inhibitor of methylation reactions. We anticipated that accumulation of dcSAM impaired methylation reactions and resulted in hypomethylation of genome DNA and histone tails.
Effect of Starvation-Refeeding Status on Cholesterol Metabolism in Rats Fed High-Cholesterol Diet  [PDF]
Reiko Inai, Tatsuhiro Matsuo
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.22016
Abstract: The present study investigated the effect of starvation-refeeding status on cholesterol metabolism in rats fed a high-cholesterol diet or a cholesterol-free diet. Twenty male and 20 female Donryu rats (age 5 weeks) were fed a cho-lesterol-free diet for 14 days. Then the male and female rats were each divided into two groups: feeding and starva-tion-refeeding groups. The feeding groups were fed the experimental diet for 3 days, and the starvation-refeeding groups fasted for 2 days followed by 3 days of feeding. Half of each of groups was fed a cholesterol-free diet and the other half was fed a high-cholesterol diet. Starvation-refeeding significantly increased the plasma free cholesterol and HDL-cholesterol concentrations in both the high-cholesterol-diet-fed rats and the cholesterol-free-diet-fed rats. In the female rats, plasma total cholesterol and cholesteryl ester concentrations were significantly higher in the high-cholesterol groups than in the cholesterol-free groups, whereas TG concentration and total cholesterol/TG ratio were not significantly different among all of the groups. Liver total cholesterol and cholesteryl ester were significantly higher in the high-cholesterol groups than in the cholesterol-free groups in both male and female rats. These results suggest that starvation-refeeding affected cholesterol metabolism at least in part. The reactivity of the cholesterol me-tabolism may be different between male and female rats.
Effects of High-Fat Diets Containing Different Fats on Cholesterol Metabolism in Starvation-Refeeding Rats  [PDF]
Reiko Inai, Tatsuhiro Matsuo
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.26090
Abstract: The present study was performed to investegate the effects of high-fat diets containing different fats on cholesterol metabolism in starvation-refeeding rats. Forty female Donryu rats were divided into two groups and then fed high-fat diets containing beef tallow or corn oil without cholesterol for 14 days. Then, 10 rats from each group were divided into high-cholesterol and cholesterol-free groups (Experiment 1). Another 10 rats from beef tallow and corn oil groups were divided into high-cholesterol and high-cholesterol-cholestyramine groups (Experiment 2). All rats were fasted for 2 days followed by 3 days of feeding. In Experiment 1, the high-cholesterol diet caused significant increases in plasma total cholesterol and cholesteryl ester concentrations in the beef tallow diet group. In Experiment 2, dietary cholestyramine markedly decreased plasma and liver cholesterol levels; however, these cholesterol levels were higher in the beef tallow diet group even if cholestyramine was added to the diet. These results suggested that the cholesterol- lowering effect of dietary corn oil may not be due solely to reabsorption of bile acids. This study suggested that high-fat diets containing different fats affected cholesterol metabolism under conditions of starvation-refeeding.
Current Situations and Challenges Concerning Sexual Health among Unmarried Couples Composed of a Mix of Japanese, South Korean Nationals, and Ethnic Koreans Born in Japan (Zainichi): A Qualitative Study  [PDF]
Chie Koh, Hiroya Matsuo
Health (Health) , 2017, DOI: 10.4236/health.2017.91002
Abstract: South Korean nationals are heavily represented in Japan’s foreign population, making up around 20% of all foreign residents in the country. Koreans in Japan can be viewed in two groups: Korean nationals who work or study in Japan, and those of Korean ancestry who were born in Japan or otherwise have historical reasons for residency (commonly called zainichi). There are certain differences seen in gender roles and Confucianism-based traditional culture among Japanese, South Korean nationals, and zainichi. This qualitative study examined consciousness and attitudes about marriage, family planning, and work-life balance in unmarried couples among these three groups. Semi- structured interviews were conducted with five unmarried couples comprising two members from the above three groups (age range: 20 - 35 years), residing in the Kinki region of western Japan. Twelve categories, 25 subcategories, and 79 codes were extracted from 636 contexts. Values regarding sexual health were analyzed from four viewpoints: marriage, family planning, work-life ba- lance, and sexual concerns. The results showed that the couples thought positively about marriage and family planning, while they had several sources of anxiety related to Confucian values and problems stemming from their different nationalities/roots. It is possible that gender roles and Confucian beliefs affect their sexual health. The study underscores that health professionals should provide pertinent knowledge and skills about family planning and child rearing, as well as premarital sexual health counselling, for unmarried couples composed of Japanese, South Korean nationals, and zainichi.
Chitin Based Fuel Cell and Its Proton Conductivity  [PDF]
Takashi Kawabata, Yasumitsu Matsuo
Materials Sciences and Applications (MSA) , 2018, DOI: 10.4236/msa.2018.910056
Abstract: We have fabricated a fuel cell based on the tissue-derived biomaterial “chitin”, and investigated its proton conductivity. It was found that chitin becomes the electrolyte of the fuel cell in the humidified condition, and power density of the fuel cell using chitin electrolyte becomes typically 1.35 mW/cm2 at the 100% relative humidity. This result is the first result showing that the polysaccharide obtained from nature becomes the fuel cell electrolyte. Moreover, this result indicates that chitin is proton conductor in the humidified condition. In the chitin sheet plane, proton conductivity in chitin is observed approximately 0.1 S/m. Further, it was also found that chitin has the anisotropic proton conductivity. The proton conductivity along the chitin fiber direction is higher than that perpendicular to the chitin fiber direction. From these results, it is deduced that the formation of water bridges accompanied by hydration plays an important role in the appearance of proton conductivity in chitin.
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