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Search Results: 1 - 10 of 1876 matches for " Koji Ohara "
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Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent
Tomohisa Horibe, Masayuki Kohno, Mari Haramoto, Koji Ohara, Koji Kawakami
Journal of Translational Medicine , 2011, DOI: 10.1186/1479-5876-9-8
Abstract: We focused on the interaction of Hsp90 with its cofactor protein p60/Hop, and engineered a cell-permeable peptidomimetic, termed "hybrid Antp-TPR peptide", modeled on the binding interface between the molecular chaperone Hsp90 and the TPR2A domain of Hop.It was demonstrated that this designed hybrid Antp-TPR peptide inhibited the interaction of Hsp90 with the TPR2A domain, inducing cell death of breast, pancreatic, renal, lung, prostate, and gastric cancer cell lines in vitro. In contrast, Antp-TPR peptide did not affect the viability of normal cells. Moreover, analysis in vivo revealed that Antp-TPR peptide displayed a significant antitumor activity in a xenograft model of human pancreatic cancer in mice.These results indicate that Antp-TPR peptide would provide a potent and selective anticancer therapy to cancer patients.Heat-shock protein 90 (Hsp90) is a molecular chaperone [1] that participates in the quality control of protein folding. The mechanism of action of Hsp90 includes sequential ATPase cycles and the stepwise recruitment of cochaperones, including Hsp70, CDC37, p60/Hsp-organizing protein (Hop), and p23 [2,3]. In particular, Hsp90 and Hsp70 interact with numerous cofactors containing so-called tetratricopeptide repeat (TPR) domains. TPR domains are composed of loosely conserved 34-amino acid sequence motifs that are repeated between one and 16 times per domain. Originally identified in components of the anaphase-promoting complex [4,5], TPR domains are now known to mediate specific protein interactions in numerous cellular contexts [6-8]. Moreover, apart from serving mere anchoring functions, TPR domains of the chaperone cofactors Hip and p60/Hop also are able to regulate the ATPase activities of Hsp70 and Hsp90, respectively [9,10]. Each 34-amino acid motif forms a pair of antiparallel α-helices. These motifs are arranged in a tandem array into a superhelical structure that encloses a central groove. The TPR-domain-containing cofactors of the Hsp70/Hsp
Computer-aided differential diagnosis system for Alzheimer’s disease based on machine learning with functional and morphological image features in magnetic resonance imaging  [PDF]
Yasuo Yamashita, Hidetaka Arimura, Takashi Yoshiura, Chiaki Tokunaga, Ohara Tomoyuki, Koji Kobayashi, Yasuhiko Nakamura, Nobuyoshi Ohya, Hiroshi Honda, Fukai Toyofuku
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.611137

Alzheimer’s disease (AD) is a dementing disorder and one of the major public health problems in countries with greater longevity. The cerebral cortical thickness and cerebral blood flow (CBF), which are considered as morphological and functional image features, respectively, could be decreased in specific cerebral regions of patients with dementia of Alzheimer type. Therefore, the aim of this study was to develop a computer-aided classification system for AD patients based on machine learning with the morphological and functional image features derived from a magnetic resonance (MR) imaging system. The cortical thicknesses in ten cerebral regions were derived as morphological features by using gradient vector trajectories in fuzzy membership images. Functional CBF maps were measured with an arterial spin labeling technique, and ten regional CBF values were obtained by registration between the CBF map and Talairach atlas using an affine transformation and a free form deformation. We applied two systems based on an arterial neural network (ANN) and a support vector machine (SVM), which were trained with 4 morphological and 6 functional image features, to 15 AD patients and 15 clinically normal (CN) subjects for classification of AD. The area under the receiver operating characteristic curve (AUC) values for the two systems based on the ANN and SVM with both image features were 0.901 and 0.915, respectively. The AUC values for the ANN-and SVM-based systems with the morphological features were 0.710 and 0.660, respectively, and those with the functional features were 0.878 and 0.903, respectively. Our preliminary results suggest that the proposed method may have potential for assisting radiologists in the differential diagnosis of AD patients by using morphological and functional image features.

Local Structure of Superionic Glass Agx(GeSe3)1-x, x=0.565
Kumara L.S.R.,Ohara Koji,Kawakita Yukinobu,Jóvári Pál
EPJ Web of Conferences , 2011, DOI: 10.1051/epjconf/20111502007
Abstract: To investigate relation between inhomogeneous structure of Agx(GeSe3)1-x superionic glass and conduction path formation, x-ray diffraction, neutron diffraction and EXAFS measurements on K-edges for each constituent were performed. Reverse Monte Carlo structural modelling based on these experimental data revealed that Ag conduction paths are formed in random glass media of GeSe4 tetrahedral network. The first sharp diffraction peak (FSDP) located at 1.1 -1 is mainly contributed by GeSe4 network, while an observed intense small angle scattering is contributed also by Ag-Ag as well as GeSe4 network.
Geometric study for the Legendre duality of generalized entropies and its application to the porous medium equation
Atsumi Ohara
Physics , 2009, DOI: 10.1140/epjb/e2009-00170-y
Abstract: We geometrically study the Legendre duality relation that plays an important role in statistical physics with the standard or generalized entropies. For this purpose, we introduce dualistic structure defined by information geometry, and discuss concepts arising in generalized thermostatistics, such as relative entropies, escort distributions and modified expectations. Further, a possible generalization of these concepts in a certain direction is also considered. Finally, as an application of such a geometric viewpoint, we briefly demonstrate several new results on a behavior of the solution to the nonlinear diffusion equation called the {\em porous medium equation}.
Algebraic K-theory of projective modules over spectral affine schemes and the representation
Mariko Ohara
Mathematics , 2014,
Abstract: Recently, the $\mathcal{G}$-structured $\infty$-topoi and the concept of the spectral schemes are developed by Lurie in his textbook and papers. In this paper, we study K-theory of spectral schemes by using quasi-coherent sheaves. When we regard the K-theory as a functor $K$ on the affine spectral schemes, we prove that the group completion $\Omega B (BGL)$ represents the sheafification of $K$ with respect to Zariski (resp. Nisnevich) topology, where we define $BGL$ by a classifying space of a colimit of affine spectral scheme $GL_n$. It gives a generalization of the consequence of Elmendorf-Kriz-Mandell-May to the algebraic K-theory sheaf in certain $\infty$-topos. We also prove the theorem of heart for the K-theory for finitely generated projective modules which has only finitely many non-zero homotopy groups.
Comparison of Discharge Duration Curves from Two Adjacent Forested Catchments—Effect of Forest Age and Dominant Tree Species  [PDF]
Koji Tamai
Journal of Water Resource and Protection (JWARP) , 2010, DOI: 10.4236/jwarp.2010.28086
Abstract: The effects of forest age and dominant tree species on the water discharge volume have been analyzed by a paired-watershed experiment in two adjacent catchments in Tatsunokuchi-yama Experimental Forest, western Japan. The control period is 1937-1943. The treated periods are 1948-1953, 1968-1977, and 1996-2003. In these treated periods, the forest age or the dominant tree species were different between two adjacent periods. Differences in the discharge duration curves from the two catchments are compared for the control and the treated periods. A significant change in the discharge duration curves is seen in the third treated period (1996-2003) on days with low water, when the forest age difference between the adjacent catchments was 35 years. This is believed to be the result of differences in forest age and forest treatment just after the occurrence of pine wilt disease.
Diagnosis of occult fractures of the ischiopubic rami  [PDF]
Koji Suzuki
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.63A049
Introduction: Recently, the diagnosis of occult frac- tures has been facilitated due to increased availability and utilization of MRI. Diagnosing a fracture of the ischiopubic rami from a proximal femoral fracture, in particular, is difficult using physical exam alone and can be facilitated by having access to an MRI. Here we report both physical exam findings and MRI findings that help in differentiating occult fractures of the iliopubic rami. Materials and Methods: From April 2010 to December 2012, we identified 30 pa- tients (5 male and 25 female; aged 43 - 93 years old). We recorded if a traumatic episode occurred, ambu- latory status at the initial visit (bed ridden, standing up with an aid, walking with an aid). We also re- corded if imaging was used in determining the final diagnosis (radiographs, MRI or CT). Results: Twenty- one patients had a fracture as a result of a traumatic episode. In the remaining 9 cases, no trauma oc- curred and therefore the fractures were insufficiency fractures. Ten patients were bed ridden at the initial visit, eight patients were able to stand only with a walking aid, and the remaining twelve patients were able to walk with an aid. Occasional radiographs were used to confirm the presence of a fracture in 4 cases, MRI in 11 cases, and CT scan in 15 cases. Dis- cussion and Conclusions: Occult fractures of the is- chiopubic rami can occur without trauma and it can be difficult to differentiate these fractures from occult proximal femoral fractures. In these cases, MRI is useful to definitively obtain a diagnosis. In cases of pacemaker, bullet implantation or artificial hip joints, CT or occasional radiographs are also useful to diag- nose occult fractures of the ischiopubic rami.
Reply to “Comments on ‘There Is No Axiomatic System for the Quantum Theory’”  [PDF]
Koji Nagata
Journal of Quantum Information Science (JQIS) , 2014, DOI: 10.4236/jqis.2014.44018
Abstract: Barros discusses that [Jose Acacio de Barros, Int. J. Theor. Phys. 50, 1828 (2011)] Nagata derives inconsistencies from quantum mechanics [K. Nagata, Int. J. Theor. Phys. 48, 3532 (2009)]. Barros considers that the inconsistencies do not come from quantum mechanics, but from extra assumptions about the reality of observables. Here we discuss the fact that there is a contradiction within the quantum theory. We discuss the fact that only one expected value in a spin-1/2 pure state 〈σxrules out the reality of the observable. We do not accept extra assumptions about the reality of observables. We use the actually measured results of quantum measurements (raw data). We use a single Pauli observable. We stress that we can use the quantum theory even if we give up the axiomatic system for the quantum theory.
A Geometric Approach to Temptation and Self-Control  [PDF]
Koji Abe
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.63060
Abstract: By making use of a geometry of preferences, Abe (2012) proves the Gul and Pesendorfer’s utility representation theorem about temptation without self-control. This companion paper provides a similar proof for the Gul and Pesendorfer's utility representation theorem about temptation and costly self-control. As a result, the both theorems are proved in the unified way.
Introduction of the Tensor Which Satisfied Binary Law  [PDF]
Koji Ichidayama
Journal of Modern Physics (JMP) , 2017, DOI: 10.4236/jmp.2017.81011
Abstract: P: For every coordinate system, there is no immediate reason for preferring certain systems of co-ordinates to others. If we don’t recognize that P is establishment, we must recognize to existence of the absolute coordinate system. Therefore, we must recognize that P is establishment. Nevertheless, I got conclusion that P isn’t es-tablishment for all coordinate systems \"\". If P is establishment, this is the trouble. As against, I got conclusion that if we consider “Binary Law” for all coordinate systems \"\", P is establishment for all coordinate systems \"\". If we consider Binary Law for all coordinate systems \"\", we must consider Binary Law for the coordinate systems using into Tensor, too. So, I decided to report for the Tensor which satisfied Binary Law.
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