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Search Results: 1 - 10 of 152370 matches for " Koang H Lim "
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Intracisternal administration of NR2 subunit antagonists attenuates the nociceptive behavior and p-p38 MAPK expression produced by compression of the trigeminal nerve root
Hye J Jeon, Seung R Han, Koang H Lim, Kyoung A Won, Yong C Bae, Dong K Ahn
Molecular Pain , 2011, DOI: 10.1186/1744-8069-7-46
Abstract: Experiments were carried out using male Sprague-Dawley rats weighing (200-230 g). Compression of the trigeminal nerve root was performed under pentobarbital sodium (40 mg/kg) anesthesia. Compression of the trigeminal nerve root produced distinct nociceptive behavior such as mechanical allodynia and hyperalgesia. Intracisternal administration of 10 or 20 μg of D-AP5 significantly increased the air-puff threshold and decreased the pin-prick scores in a dose-dependent manner. The intracisternal administration of PPPA (1, 10 μg), or PPDA (5, 10 μg) increased the air-puff threshold and decreased the pin-prick scores ipsilateral as well as contralateral to the compression of the trigeminal root. Compression of the trigeminal nerve root upregulated the expression of p-p38 MAPK in the ipsilateral medullary dorsal horn which was diminished by D-AP5, PPPA, PPDA, but not Ro25-6981.Our findings suggest that central NMDA receptor NR2 subunits play an important role in the central processing of trigeminal neuralgia-like nociception in rats with compression of the trigeminal nerve root. Our data further indicate that the targeted blockade of NR2 subunits is a potentially important new treatments strategy for trigeminal neuralgia-like nociception.N-Methyl-D-aspartate (NMDA) receptors, which are among the major mediators of fast excitatory neurotransmission in the central nervous system, have an important role in long-term potentiation and depression, synaptogenesis, synaptic plasticity, and neuronal death [1,2]. The NMDA receptor (NR) family is composed of seven subunits, NR1, NR2A-D and NR3A and B, which are all products of separate genes [3]. Distinct NMDA receptor subtypes differ in their sensitivity to a variety of ligands, kinetic properties, and interactions with intracellular proteins [4]. Expression of functional recombinant NMDA receptors in mammalian cells requires the co-expression of at least one NR1 subunit, an essential channel-forming subunit, and one NR2 subunit [1,
Flash Learning Games Wow Students and Instructors: Moving Toward An Academic Gaming Portal
Dan H Lim
Journal of Systemics, Cybernetics and Informatics , 2003,
Abstract: This paper describes and discusses the rationale, background, design, and implementation of Flash learning games. The paper explains why Macromedia Flash has been selected as the authoring tool in the development of highly interactive learning games for online learning. The background evolutionary process of developing the learning games points out why it has been a daunting task to create compelling learning games that impact learning. Designing learning game objects that allow other educators to customize game content is the core of this paper. The author envisions this academic gaming project will evolve into an academic gaming portal, developed in conjunction with other major institutional partners.
Transplacental Passage of Interleukins 4 and 13?
Robert H. Lim, Lester Kobzik
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004660
Abstract: The mechanisms by which prenatal events affect development of adult disease are incompletely characterized. Based on findings in a murine model of maternal transmission of asthma risk, we sought to test the role of the pro-asthmatic cytokines interleukin IL-4 and -13. To assess transplacental passage of functional cytokines, we assayed phosphorylation of STAT-6, a marker of IL-4 and -13 signaling via heterodimeric receptor complexes which require an IL-4 receptor alpha subunit. IL-4 receptor alpha?/? females were mated to wild-type males, and pregnant females were injected with supraphysiologic doses of IL-4 or 13. One hour after injection, the receptor heterozygotic embryos were harvested and tissue nuclear proteins extracts assayed for phosphorylation of STAT-6 by Western blot. While direct injection of embryos produced a robust positive control, no phosphorylation was seen after maternal injection with either IL-4 or -13, indicating that neither crossed the placenta in detectable amounts. The data demonstrate a useful approach to assay for transplacental passage of functional maternal molecules, and indicate that molecules other than IL-4 and IL-13 may mediate transplacental effects in maternal transmission of asthma risk.
A Natural Explanation of All Solar Neutrino Data by Resonant Spin-Flavor Precession Scenario
C. S. Lim,H. Nunokawa
Physics , 1994, DOI: 10.1016/0927-6505(95)00011-5
Abstract: It is emphasized that the $E_{\nu}$ (neutrino energy) spectrum of the $\nu_e$ survival probability in the Resonant Spin-Flavor Precession (RSFP) scenario has very desirable shape to reconcile all existing solar neutrino data. As the result, the RSFP scenario is shown to have rather broad allowed region to reconcile the data in the ($B,\ \Delta m^2$) plane, with $B$ being the magnetic field strength inside the Sun. The sensitivity of the allowed region on the different choices of the $B$ profile, and the time variations of the solar neutrino event rates in the RSFP scenario are also discussed in some detail.
Inflammation in Diabetic Nephropathy
Andy K. H. Lim,Gregory H. Tesch
Mediators of Inflammation , 2012, DOI: 10.1155/2012/146154
Abstract: Diabetic nephropathy is the leading cause of end-stage kidney disease worldwide but current treatments remain suboptimal. This review examines the evidence for inflammation in the development and progression of diabetic nephropathy in both experimental and human diabetes, and provides an update on recent novel experimental approaches targeting inflammation and the lessons we have learned from these approaches. We highlight the important role of inflammatory cells in the kidney, particularly infiltrating macrophages, T-lymphocytes and the subpopulation of regulatory T cells. The possible link between immune deposition and diabetic nephropathy is explored, along with the recently described immune complexes of anti-oxidized low-density lipoproteins. We also briefly discuss some of the major inflammatory cytokines involved in the pathogenesis of diabetic nephropathy, including the role of adipokines. Lastly, we present the latest data on the pathogenic role of the stress-activated protein kinases in diabetic nephropathy, from studies on the p38 mitogen activated protein kinase and the c-Jun amino terminal kinase cell signalling pathways. The genetic and pharmacological approaches which reduce inflammation in diabetic nephropathy have not only enhanced our understanding of the pathophysiology of the disease but shown promise as potential therapeutic strategies. 1. Introduction Diabetic nephropathy (DN) has not been traditionally considered an inflammatory disease. However, recent studies have shown that kidney inflammation is crucial in promoting the development and progression of DN. Inflammation may be a key factor which is activated by the metabolic, biochemical, and haemodynamic derangements known to exist in the diabetic kidney. In this paper, we discuss the evidence for inflammation in DN and the lessons we have learned from novel experimental anti-inflammatory therapies. The main areas covered include the role of immune and inflammatory cells, inflammatory cytokines, and stress-activated protein kinases. We also briefly review the controversy around the role of immune complexes and immune deposition in DN. 2. Inflammatory Cells In human DN, macrophages and T cells accumulate in the glomeruli and interstitium, even in the early stages of the disease. Recruitment of leukocytes involves three steps: (a) selectin-dependent leukocyte rolling on the endothelium, (b) chemokine-dependent integrin activation and leukocyte adhesion, and (c) transmigration of leukocytes across the endothelium [1]. Proinflammatory cytokines produced by leukocytes such as
Limits on the neutrino magnetic moment from the MUNU experiment
Z. Daraktchieva,J. Lamblin,O. Link,C. Amsler,M. Avenier,C. Broggini,J. Busto,C. Cerna,G. Gervasio,P. Jeanneret,G. Jonkmans,D. H. Koang,D. Lebrun,F. Ould-Saada,G. Puglierin,A. Stutz,A. Tadsen,J. -L. Vuilleumier
Physics , 2003, DOI: 10.1016/S0370-2693(03)00707-X
Abstract: The MUNU experiment was carried out at the Bugey nuclear power reactor. The aim was the study of electron antineutrino-electron elastic scattering at low energy. The recoil electrons were recorded in a gas time projection chamber, immersed in a tank filled with liquid scintillator serving as veto detector, suppressing in particular Compton electrons. The measured electron recoil spectrum is presented. Upper limits on the neutrino magnetic moment were derived and are discussed.
Low energy tracking and particles identification in the MUNU Time Projection Chamber at 1 bar. Possible application in low energy solar neutrino spectroscopy
Z. Daraktchieva,C. Amsler,M. Avenier,C. Broggini,J. Busto,C. Cerna,F. Juget,D. H. Koang,J. Lamblin,D. Lebrun,O. Link,G. Puglierin,A. Stutz,A. Tadsen,J. -L. Vuilleumier,J. -M. Vuilleumier,V. Zacek
Physics , 2007, DOI: 10.1088/0954-3899/35/12/125107
Abstract: In this paper we present the results from the measurements made with the MUNU TPC at 1bar pressure of CF4 in the energy region below 1 MeV. Electron events down to 80 keV are successfully measured. The electron energy and direction are reconstructed for every contained single electron above 200 keV. As test the 137Cs photopeak is reconstructed by measuring both the energy and direction of the Compton electrons in the TPC.
Sub MeV Particles Detection and Identification in the MUNU detector ((1)ISN, IN2P3/CNRS-UJF, Grenoble, France, (2)Institut de Physique, Neuchatel, Switzerland, (3) INFN, Padova Italy, (4) Physik-Institut, Zürich, Switzerland)
M. Avenier,C. Broggini,J. Busto,C. Cerna,V. Chazal,P. Jeanneret,G. Jonkmans,D. H. Koang,J. Lamblin,D. Lebrun,O. Link,R. Lüescher,F. Ouldsada,G. Puglierin,A. Stutz,A. Tadsen,J. -L. Vuilleumier
Physics , 2001, DOI: 10.1016/S0168-9002(01)01520-0
Abstract: We report on the performance of a 1 m$^{3}$ TPC filled with CF$_{4}$ at 3 bar, immersed in liquid scintillator and viewed by photomultipliers. Particle detection, event identification and localization achieved by measuring both the current signal and the scintillation light are presented. Particular features of $\alpha$ particle detection are also discussed. Finally, the ${54}$Mn photopeak, reconstructed from the Compton scattering and recoil angle is shown.
Final results on the neutrino magnetic moment from the MUNU experiment
The MUNU collaboration,Z. Daraktchieva,C. Amsler,M. Avenier,C. Broggini,J. Busto,C. Cerna,F. Juget,D. H. Koang,J. Lamblin,D. Lebrun,O. Link,G. Puglierin,A. Stutz,A. Tadsen,J. -L. Vuilleumier,V. Zacek
Physics , 2005, DOI: 10.1016/j.physletb.2005.04.030
Abstract: The MUNU detector was designed to study neutrino-electron elastic scattering at low energy. The central component is a Time Projection Chamber filled with CF4 gas, surrounded by an anti-Compton detector. The experiment was carried out at the Bugey (France) nuclear reactor. In this paper we present the final analysis of the data recorded at 3 bar and 1 bar pressure. Both the energy and the scattering angle of the recoil electron are measured. From the 3 bar data a new upper limit on the neutrino magnetic moment was derived. At 1 bar electron tracks down to 150 keV were reconstructed, demonstrating the potentiality of the experimental technique for future applications in low energy neutrino physics.
Risk for Asthma in Offspring of Asthmatic Mothers versus Fathers: A Meta-Analysis
Robert H. Lim,Lester Kobzik,Morten Dahl
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010134
Abstract: Many human epidemiologic studies demonstrate that maternal asthma confers greater risk of asthma to offspring than does paternal disease. However, a handful have shown the opposite. Given this disparity, a meta-analysis is necessary to determine the veracity and magnitude of the “maternal effect.”
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