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Search Results: 1 - 10 of 1883 matches for " Kiyoshi Fujita "
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Effects of Depth of Needle Insertion with Risperidone Long-Acting Injectable in Persons with Schizophrenia: A Randomized Double-Blind Study  [PDF]
Yueren Zhao, Tetsuya Tanioka, Yuko Yasuhara, Kensaku Takase, Soji Tsuboi, Kiyoshi Fujita, Rozzano C. Locsin, Nakao Iwata
Open Journal of Psychiatry (OJPsych) , 2017, DOI: 10.4236/ojpsych.2017.74031
Abstract: In some cases, if the insertion depth is shallower than expected, intramuscular (IM) injection of risperidone long-acting injectable (RLAI) may not penetrate the muscle fascia. However, if needle insertion depth is deeper than anticipated, needle penetration may cause damage to nerves, arteries and veins. Few clinical studies were done to evaluate the depth of needle length insertion reaching the intended gluteal muscle. The aim of this study was to evaluate the suitable depth of injecting RLAI. Twenty-six patients with schizophrenia were treated with RLAI, and randomly divided into two groups: 50 mm needle inserted group (Group-D, deep insertion, n = 13) and 20 mm needle insertion group (Group-S, shallow insertion, n = 13). For Group-S, the needle length was marked with a spacer at exactly 20 mm. Injections were performed by the psychiatrist or nurse, alternating between the two gluteal sites by double-cross method every two weeks. Clinical psychotic symptoms and injection site reactions were recorded throughout the study period. Experienced psychologists who were blinded from the needle-length experimental variable evaluated patients’ psychotic symptoms using the Positive and Negative Syndrome Scale (PANSS) every two weeks. The plasma 9-hydroxyrisperidone (9-OH-RIS) concentrations were measured every two weeks; comparison data were determined on the 8th week and the 14th week. No significant difference was observed in 9-OH-RIS concentrations, psychotic symptoms, injection site skin reactions of subjects in both groups. However, in Group-D, injection site adverse reactions were confirmed in two subjects (15%). In Group-S, injection site reactions were confirmed in six subjects (46%). Although effective 9-OH-RIS concentrations were obtained with the insertion using both depth, it was concluded that the 50 mm insertion length was more suitable for dorsogluteal IM injections in adult patients with schizophrenia as demonstrated by the incidence of local adverse skin reactions.
Usefulness of Infrared Thermal Imaging Camera for Screening of Postoperative Surgical Site Infection after the Nuss Procedure
Kenya Fujita,Masahiko Noguchi,Shunsuke Yuzuriha,Daisuke Yanagisawa,Kiyoshi Matsuo
Case Reports in Surgery , 2013, DOI: 10.1155/2013/946156
Abstract: Introduction and Objective. The Nuss procedure is widely used in the treatment of pectus excavatum worldwide. Postoperative pectus bar infection is one of the most serious complications associated with this procedure. Therefore, early detection of signs of implant infection is very important. However, this is difficult, and effective methods have yet to be established. Methods. We use a handheld infrared thermal imaging camera to screen patients for postoperative infection following the Nuss procedure. Here, we report a 28-year-old man with recurrent postoperative (Ravitch procedure) pectus excavatum. Results. Infrared thermography camera clearly indicated slight cellulitis in the right chest. Conclusion. Our technique may assist in preventing postoperative bar infection and removal caused by severe bar infection. Furthermore, this camera is potentially suitable for many situations in infection monitoring following subcutaneous implant surgery. 1. Introduction The Nuss procedure is a well-established method for minimally invasive repair of pectus excavatum, which is both safe and shows good cosmetic results [1]. However, there have been reports of severe intraoperative and postoperative complications, among which postoperative pectus bar infection is one of the most serious complications. We use a handheld infrared thermal imaging camera (FLIR B60; FLIR Systems Inc., Wilsonville, OR, USA) to screen for postoperative infections in patients following the Nuss procedure. 2. Case Presentation A 28-year-old man with recurrent pectus excavatum following the Ravitch procedure was treated with the Nuss procedure. Implantation of three bars was required to correct his chest deformity. At 5 weeks postoperatively, he complained of slight sluggishness. His serum C-reactive protein level was simultaneously elevated to 1.5?mg/L from 0.1?mg/L (3 weeks after operation), and the rate of neutrophilic leukocytes had increased from 54% to 78%. However, clinical infectious signs and symptoms were mostly absent, and we could not determine whether these observations were due to infection at the surgical site or another site, for example, upper respiratory inflammation (e.g., common cold). However, infrared thermal imaging clearly indicated a hot spot in the operated anterolateral chest wall (Figures 1(a) and 1(b)). The patient immediately received intravenous antibiotic therapy (meropenem) with hospitalization for 1 week, followed by oral administration of minocycline. His symptoms improved, and surgical debridement was not required. Figure 1: The figure shows clinical (a)
Suzaku Observation of the Diffuse X-Ray Emission from the Open Cluster Westerlund 2: a Hypernova Remnant?
Yutaka Fujita,Kiyoshi Hayashida,Hiroaki Takahashi,Fumio Takahara
Physics , 2009, DOI: 10.1093/pasj/61.6.1229
Abstract: We present the analysis of Suzaku observations of the young open cluster Westerlund 2, which is filled with diffuse X-ray emission. We found that the emission consists of three thermal components or two thermal and one non-thermal components. The upper limit of the energy flux of the non-thermal component is smaller than that in the TeV band observed with H.E.S.S. This may indicate that active particle acceleration has stopped in this cluster, and that the accelerated electrons have already cooled. The gamma-ray emission observed with H.E.S.S. is likely to come from high-energy protons, which hardly cool in contrast with electrons. Metal abundances of the diffuse X-ray gas may indicate the explosion of a massive star in the past.
Properties of the Brightest Cluster Galaxy and Its Host Cluster
Haruyoshi Katayama,Kiyoshi Hayashida,Fumio Takahara,Yutaka Fujita
Physics , 2002, DOI: 10.1086/346126
Abstract: We investigate the relation between the properties of Brightest Cluster Galaxies (BCGs) and those of their host clusters. To quantify the properties of cluster hot gas, we employ the parameter $Z$ of the fundamental plane of X-ray clusters. It is found that the offset of the BCG from the peak of cluster X-ray emission is larger for smaller $Z$ clusters. The parameter $Z$ (not the redshift {\it z}), which mainly depends on virial density $\rho_{\rm {vir}}$, is considered to represent the formation epoch of a cluster. We thus consider that the offset of the BCG is correlated with the dynamical equilibrium state of its host cluster. On the contrary, no significant correlation is found between the absolute optical magnitude of the BCG and the parameter $Z$. If the extreme brightness of the BCG is mainly acquired in the course of cluster evolution by environmental effect, BCGs are expected to be brighter in large $Z$ clusters. Our result is not consistent with this simplified view. On the contrary, it is possible that the extreme brightness of the BCG is likely to be determined in the early history of cluster collapse.
Two Distinct Pathways to Development of Squamous Cell Carcinoma of the Vulva
Yutaka Ueda,Takayuki Enomoto,Toshihiro Kimura,Kiyoshi Yoshino,Masami Fujita,Tadashi Kimura
Journal of Skin Cancer , 2011, DOI: 10.1155/2011/951250
Abstract: Squamous cell carcinoma (SCC) accounts for approximately 95% of the malignant tumors of the vaginal vulva and is mostly found in elderly women. The future numbers of patients with vulvar SCC is expected to rise, mainly because of the proportional increase in the average age of the general population. Two different pathways for vulvar SCC have been put forth. The first pathway is triggered by infection with a high-risk-type Human Papillomavirus (HPV). Integration of the HPV DNA into the host genome leads to the development of a typical vulvar intraepithelial neoplasia (VIN), accompanied with overexpression of and . This lesion subsequently forms a warty- or basaloid-type SCC. The HPV vaccine is a promising new tool for prevention of this HPV related SCC of the vulva. The second pathway is HPV-independent. Keratinizing SCC develops within a background of lichen sclerosus (LS) through a differentiated VIN. It has a different set of genetic alterations than those in the first pathway, including p53 mutations, allelic imbalances (AI), and microsatellite instability (MSI). Further clinical and basic research is still required to understand and prevent vulvar SCC. Capsule. Two pathway for pathogenesis of squamous cell carcinoma of the value are reviewed. 1. Introduction Squamous cell carcinoma (SCC) accounts for only 5% of the malignant tumors of the female genital tract, but it represents 95% of vaginal vulvar tumors [1]. The incidence of malignant vulvar tumors in the United States is 1.5?per 100,000 women per year, and this incidence increases with age. The average age at diagnosis is in the 7th to 8th decades of life, with a future rise in absolute numbers of vulvar SCC expected, mainly due to the proportional increase in the average age of the general population [2]. Two different types of vulvar SCC have been delineated, each with their own precursors. The first type is associated with an infection with one of the high-risk types of Human Papillomaviruses (HPV), and it primarily affects younger women. The other type is associated with a lichen sclerosus (LS) condition, and it occurs predominantly in elderly patients independent of any HPV infection [2]. Although the pathogenesis of vulvar SCC has been investigated, it has not been documented nearly as well as the pathogenesis of the more common cervical SCC. We herein give an overview, focusing on the molecular events of these two distinct HPV-associated and independent pathways for the development of vulvar SCC. 2. Clinical and Pathological Features of SCC and Its Precursors 2.1. SCC Vulvar SCC accounts
Serum Biomarkers for Early Detection of Gynecologic Cancers
Yutaka Ueda,Takayuki Enomoto,Toshihiro Kimura,Takashi Miyatake,Kiyoshi Yoshino,Masami Fujita,Tadashi Kimura
Cancers , 2010, DOI: 10.3390/cancers2021312
Abstract: Ovarian, endometrial, and cervical cancers are three of the most common malignancies of the female reproductive organs. CA 125, historically the most reliable serum marker for ovarian cancer, is elevated in 50% of early-stage ovarian tumors. For endometrial cancers, there are no established serum markers. SCC, which is the best studied serum marker for squamous cell carcinomas, has been unreliable; SCC is elevated in cervical squamous cell carcinomas ranging from 28–85% of the time. Recent proteomics-based analyses show great promise for the discovery of new and more useful biomarkers. In this review, we will discuss the currently utilized serum tumor markers for gynecologic cancers and the novel biomarkers that are now under investigation.
A randomized, double-blind, placebo-controlled study of rapid-acting intramuscular olanzapine in Japanese patients for schizophrenia with acute agitation
Hideaki Katagiri, Shinji Fujikoshi, Takuya Suzuki, Kiyoshi Fujita, Naoya Sugiyama, Michihiro Takahashi, Juan-Carlos Gomez
BMC Psychiatry , 2013, DOI: 10.1186/1471-244x-13-20
Abstract: We conducted a placebo-controlled, randomized, double-blind, parallel-group study in Japanese patients diagnosed with schizophrenia according to the diagnostic criteria specified in the DSM-IV-TR. Patients were randomized to 2 treatment groups: IM olanzapine (10 mg) or IM placebo. The primary efficacy outcome was the change in PANSS-EC from baseline to 2 hours after the first IM injection. Treatment groups were compared with an analysis of variance model which included treatment and site as factors. During the 24-hour treatment period, safety was assessed by clinical examination and laboratory investigations, electrocardiograms, extrapyramidal symptoms scales, and recording spontaneously reported adverse events.Of the 91 randomized patients, 90 patients (45 IM olanzapine-group; 45 IM placebo-group) were in the full analysis set. The mean change of PANSS-EC total score from baseline to 2 hours after the first IM injection (mean±standard deviation) was ?9.2±4.5 for the IM olanzapine group and ?2.8±5.6 for the IM placebo group. The difference between treatment groups was statistically significant (p<.001). There were no deaths, serious adverse events, treatment-emergent adverse events (TEAEs) leading to discontinuation, severe TEAEs, or instances of oversedation in this study. There were no statistically significant differences between treatment groups in the proportion of patients with potentially clinically significant changes in laboratory tests, vital signs (blood pressure and pulse rate), electrocardiograms, and treatment-emergent extrapyramidal symptoms.The efficacy of IM olanzapine 10 mg in patients with exacerbation of schizophrenia with acute psychotic agitation was greater than IM placebo in the primary efficacy measure, PANSS-EC. Intramuscular olanzapine 10 mg was shown to be generally safe and tolerable, and could be a new option for treatment of schizophrenia in Japan.NCT00970281Schizophrenia is a chronic disease, but in the acute phase agitation is common
A Radiotherapy Treatment Margin Formula When Systematic Positioning Errors are Relatively Small Compared to Random Positioning Errors: A First-Order Approximation  [PDF]
Kiyoshi Yoda
International Journal of Medical Physics,Clinical Engineering and Radiation Oncology (IJMPCERO) , 2017, DOI: 10.4236/ijmpcero.2017.62017
Abstract: A radiotherapy treatment margin formula has been analytically derived when a standard deviation (SD) of systematic positioning errors Ʃ is relatively small compared to an SD of random positioning errors σ. The margin formula for 0 Ʃ σ was calculated by linearly interpolating two boundaries at Ʃ = 0 and Ʃ = σ, assuming that the van Herk margin approximation of k1Ʃ + k2σ is valid at Ʃ = σ. It was shown that a margin formula for 0 Ʃ σ may be approximated by k1σ + k2Ʃ, leading to a more general form of k1 max(Ʃ,σ) + k2 min(Ʃ,σ) which is a piecewise linear approximation for any values of Ʃ and σ.
Development of Charging Infrastructure and Subsidies for Promoting Electric Vehicles  [PDF]
Kiyoshi Arakawa
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.811131
Abstract: This paper clarifies an effect of policy on the development of charging infrastructure and subsidies for promoting electric vehicles (EVs). Due to the long-term function of charging infrastructure, this paper constructs a multiple-period model to analyze policy effects on the diffusion of EVs from a long-term perspective. This paper shows that charging infrastructure and subsidy encourage innovation on increasing the battery capacity of EVs. Because intertemporal cost allocation can be executed in the development of a charging infrastructure with a subsidy, a policy with a long-term perspective can enhance the charging infrastructure and promote EVs effectively.
Optimal Amount and Timing of Investment in a Stochastic Dynamic Cournot Competition  [PDF]
Yasunori Fujita
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.61001
Abstract: By making use of the optimal stopping theory, we construct a multi-stage stochastic Cournot model to examine the effect of increase in uncertainty and number of entrants on the amount and timing of strategic cost reduction investment. It is revealed that firms should enlarge and postpone the investment if 1) the market is more uncertain, or 2) there exist more firms in the market.
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