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Search Results: 1 - 10 of 92 matches for " Kiyoko Umene "
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Oncofertility in Gynecologic Malignant Tumors  [PDF]
Masataka Adachi, Kouji Banno, Iori Kisu, Megumi Yanokura, Moito Iijima, Takashi Takeda, Kiyoko Umene, Yuya Nogami, Eiichiro Tominaga, Daisuke Aoki
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.614128
Abstract: Long-term survival is the priority in treatment of patients with malignant tumors. In the field of gynecology, fertility preservation has also recently become an important objective due to improved treatment outcomes and different needs of patients. Methods for fertility preservation include cervical conization, ovarian protection against radiation or chemotherapy for ovarian cancer since the ovary is hypersensitive to cancer therapies, treatment of gynecological cancer during pregnancy, and cryopreservation of oocytes, embryos or ovarian tissue before treatment of malignant tumors. Radical trachelectomy for early cervical cancer and treatment with medroxy progesterone acetate for early endometrial carcinoma are also options for fertility preservation, but the efficacy and risk of recurrence have yet to be fully evaluated. The first childbirth following uterine transplantation was also achieved last year and this success has expanded the potential for pregnancy and delivery among cancer survivors.
Candidate Biomarkers for Genetic and Clinicopathological Diagnosis of Endometrial Cancer
Kouji Banno,Yuya Nogami,Iori Kisu,Megumi Yanokura,Kiyoko Umene,Kenta Masuda,Yusuke Kobayashi,Wataru Yamagami,Nobuyuki Susumu,Daisuke Aoki
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms140612123
Abstract: The recent increase in the frequency of endometrial cancer has emphasized the need for accurate diagnosis and improved treatment. The current diagnosis is still based on conventional pathological indicators, such as clinical stage, tumor differentiation, invasion depth and vascular invasion. However, the genetic mechanisms underlying endometrial cancer have gradually been determined, due to developments in molecular biology, leading to the possibility of new methods of diagnosis and treatment planning. New candidate biomarkers for endometrial cancer include those for molecular epigenetic mutations, such as microRNAs. These biomarkers may permit earlier detection of endometrial cancer and prediction of outcomes and are likely to contribute to future personalized therapy for endometrial cancer.
Acute Stress Symptoms in Families of Patients Admitted to the Intensive Care Unit during the First 24 Hours Following Admission in Japan  [PDF]
Miyuki Komachi, Kiyoko Kamibeppu
Open Journal of Nursing (OJN) , 2015, DOI: 10.4236/ojn.2015.54035
Abstract: Families of patients in the intensive care unit often experience sever stress. Understanding their experience is important for providing family-centered care during this difficult period. Little is known about the experience of families of patients admitted to the intensive care unit (ICU). To evaluate the prevalence and factors associated with acute stress symptoms among families of patients admitted to the ICU, we carried out a cross-sectional study at a teaching and advanced treatment hospital. The mean total Impact of Event Scale-Revised (IES-R) score differed significantly between planned and unplanned ICU admissions (t = 4.03, p < 0.05), indicating a main effect of admission type (F = 18.5, p < 0.05). There was no significant main effect of relationship (F = 0.05, p = 0.82) or interaction effect of admission type and relationship (F = 0.54, p = 0.47). Multiple regression analysis indicated that admission type was significantly associated with acute stress symptoms (B = 18.09, β = 0.47, p < 0.01), and explained 22% of the variance in total IES-R score. Whether a patient had a planned or unplanned admission to the ICU influenced symptoms associated with acute stress symptoms of family members more than did getting support from nurses, being the patient’s spouse, or the severity of illness of the patient.
Evaluating Sleeping and Waking States of Infants: Consistency of Actigraph and Observational Data  [PDF]
Rie Nakamura Ikeda, Kiyoko Fukai
Creative Education (CE) , 2015, DOI: 10.4236/ce.2015.65053
Abstract: The objective was to evaluate sleeping and waking states of infants <6 months old. The design of study was comparing video-recorded and actigraphic data. Participants were thirteen healthy 3- to 5-month-old infants. At their homes, subjects wore an ankle actigraph for 1 h and were videotaped simultaneously. We performed per-minute analysis of video data using the method for observing newborns developed by Brazelton. Video and actigraphic data were compared each minute. The total concordance rate was 93.5%. Sleep/wake identification by actigraphy and visual observation correspond closely for infants.
The Experience of Postpartum Depression among Mothers with Withdrawn Attachment Style during Pregnancy and the First Postnatal Month  [PDF]
Mari Ikeda, Momoko Hayashi, Kiyoko Kamibeppu
Open Journal of Depression (OJD) , 2015, DOI: 10.4236/ojd.2015.44008
Abstract: Approximately 19% of women experience minor or major depression in the first three months following childbirth. Most research suggests that women with withdrawn attachment styles are less likely to be depressed. However, unlike mothers in Western culture, mothers in Japan with withdrawn attachment styles are reported to have greater potential to become depressed. Thus, the aim of this study was to describe the behaviors and situational awareness of Japanese mothers’ with withdrawn attachment styles during pregnancy in order to reveal the specific dynamics underlying the withdrawn style. Interview data were analyzed using qualitative thematic content analysis. Of the 84 women assessed, 12 were determined to have a withdrawn style, and based on the Mini-International Neuropsychiatric Interview, five demonstrated the onset of postpartum depression (PPD). Two themes regarding relationships with partners emerged including: 1) confiding behavior: the importance of what is shared; and 2) need to be heard: wanting sympathy rather than criticism. Additionally, three themes describing mothers’ experiences during the first postnatal month emerged: 1) overwhelming experiences: the childbirth experience; 2) seeking help: behavior changes altered relationships; and 3) experience with the baby. Withdrawn style mothers keep distance from crisis, avoid closeness with others, and opt to manage problems by themselves. However, childbirth and infant care are not easily managed in this style. Mothers who used childbirth to confide in their partners may have reduced the severity of insecurity or developed a more secure style. Healthcare professionals are in the best position to develop good relationships with new mothers and provide support that focuses more on emotional factors and self-esteem levels.
The Inter Relationship of Mental State between Antepartum and Postpartum Assessed by Depression and Bonding Scales in Mothers  [PDF]
Kafumi Sugishita, Kiyoko Kamibeppu, Hiroya Matsuo
Health (Health) , 2016, DOI: 10.4236/health.2016.812126
Abstract: The number of deaths caused by child abuse is increasing, which is one of social concerns. The mental health of mothers might be related to child abuse. The aim of this study was to examine and compare the mental state of mothers in both the antepartum and postpartum period assessed by the Edinburgh Postnatal Depression Scale (EPDS) and Mother-Infant-Bonding-Scale (MIBS), and compare the results. Participants (n = 134) were recruited twice in antepartum medical checkups (20 to 36 weeks of gestation) and postpartum medical checkups (1 month after birth). Information on characteristics of participants was collected from medical records in both periods. Family function and ante-postpartum mental health were assessed by Family APGAR, EPDS, and MIBS. Antepartum depressive state was related to postpartum depressive state (p = 0.015), antepartum bonding was related to bonding in postpartum bonding (p = 0.0001), and antepartum bonding disorder was related to postpartum depressive state (relative risk = 11.7). Worries about costs and poor of family function were related to the mental health of mothers in both the antepartum and postpartum periods. Antepartum depressive state is an indicator of postpartum depression. We suggested that health professionals conduct an evaluation of mother’s mental health and related factors in the antepartum period. The present findings emphasize the importance of antepartum mental health as a predictor of postpartum depression and bonding disorder.
Characterization of macrophage mutants established by their resistance to LPS and cycloheximide-induced apopotic cell death  [PDF]
Fumio Amano, Shoko Tsukabe, Reiko Teshima, Keiko Waku, Kiyoko Kohama
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.326097
Abstract: Macrophages are activated by bacterial lipopolysaccharide (LPS) to produce inflammatory cytokines such as TNF-α or reactive oxygen species such as nitric oxide or superoxide anion. However, in the presence of an inhibitor of protein synthesis, cyclohex-imide (CHX), at 10 μg/mL, LPS at 100 ng/mL induced macrophage apoptosis rapidly without producing phenotypes of activated macrophages. In order to understand the mechanism underlying LPS-induced cytotoxicity toward macrophages, we isolated mutant cells from a macrophage-like cell line, J774.1, as clones resistant against the cytotoxic effects of LPS + CHX by using a somatic cell genetics protocol. All of the mutant clones, designated as LCR mutants, showed resistance to the cell death induced by LPS + CHX as well as to that induced by higher doses of LPS alone, as did the LPS1916 mutant cell line, which had been previously established by its resistance to 100 μg/mL LPS. Characterization of the activated macrophage phenotypes revealed that these mutants showed reduced production of TNF-α and nitric oxide in response to LPS. Further analysis showed a much reduced amount of [125I]LPS-binding and lower CD14 expression on the cell surface, in spite of an adequate intracellular expression of CD14 molecules. Besides, the molecular weight of CD14 on these mutants was around 40-48 kDa, smaller than that of the wild-type JA-4 cells (around 50-55 kDa), suggesting impaired CD14 maturation in these mutants. However, expression of Toll-like receptor 4 (TLR4) and Myd 88 on the cell surface was not different between the wild type and the mutant cells. These results suggest that LCR mutants have common phenotypes of mal-expression of CD14 molecules on the macrophage cell surface, leading to not only reduced responses to LPS-mediated macrophage activation but acquisition of resistance to LPS-induced apoptotic cell death in the presence of CHX.
Approach to perinatal mental health and child abuse prevention in Japanese prefectural health centers  [PDF]
Kafumi Sugishita, Kayoko Kurihara, Shiho Murayama, Kiyoko Kamibeppu
Health (Health) , 2013, DOI: 10.4236/health.2013.54097

The aim of this study was to conduct a nationwide survey in Japan of prefectural health centers, which were responsible for providing guidance to municipalities. The survey was performed in order to clarify the following issues: 1) the current level of support provided by prefectural centers for pre-and post-natal mental health; 2) the structures in place for providing consultation services for an “unwanted pregnancy” and the support available for high-risk cases; and 3) the advice available on postpartum maternal psychological screening, and interpretation of results of such screening. Questionnaires were sent by post to 394 prefectural health centers, of which 277 (70.3%) responded. A total of 32% of prefectural health centers confirmed that they had offered support to high-risk cases during pregnancy, and 72% had offered support post-partum. Regarding offering support to high-risk mothers, those prefectural health centers that did provide consultation services (n = 59) reported providing introductions and information about available facilities (P < 0.001) and conducting case conferences (P < 0.002). This was significantly different than prefectural health centers that did not provide consultation services (n = 198). At the prefectural health centers that “follow up on” the results of the mental health screening, psychiatry consultations were reported twice as often as the prefectural health centers that did “not follow up on” the results of mental health screening. These findings indicate that childcare support systems for postpartum mental health and the prevention of child abuse were established. However, the lack of prenatal health and support systems for the prenatal period remains an issue.

Factors influencing self-efficacy in breastfeeding support among public health nurses in Japan  [PDF]
Noriko Toyama, Kayoko Kurihara, Mineko Muranaka, Kiyoko Kamibeppu
Health (Health) , 2013, DOI: 10.4236/health.2013.512278

This study investigated self-efficacy in breastfeeding support among public health nurses (PHNs) working at maternal and child health (MCH) services in Japanese municipalities, and its related factors such as education, working experience, breastfeeding experience, and postgraduate/continuous education. Directors of the MCH divisions were requested to select one PHN to answer the self-report questionnaires sent. The questionnaires were collected from October 2010 to January 2011. Of the 1750 questionnaires sent, 831 were returned (response rate: 47.5%); 102 were excluded from analysis because of missing data (valid response rate: 41.7%). After adjusting the weights of PHN sampling and collection rates by prefecture and population size, Model 1 of the multiple regression analysis showed that the self-efficacy in breastfeeding support was significantly higher in large/urban municipalities (β = 0.13) and in the Kanto district. Model 2 revealed that self-efficacy was significantly associated with working experience (β = 0.13) and breastfeeding experience (β = 0.22) but not with educational background. Model 3 showed that self-efficacy was significantly associated with postgraduate education (β = 0.14) and continuous education (β = 0.12). This suggested that PHNs’ self-efficacy increased through self-enrichment. It is necessary to create training opportunities about breastfeeding support for PHNs—especially those working in remote and/or small municipalities— and to provide them with new and important information.


Relationship among Subjective Satisfaction with Verbal Communication, Dental Status, and Health-Related Quality of Life in Japanese Community-Residing Elderly Individuals  [PDF]
Shuichi Hara, Hiroko Miura, Kiyoko Yamasaki, Naoko Morisaki, Ken Osaka
Advances in Applied Sociology (AASoci) , 2015, DOI: 10.4236/aasoci.2015.51004
Abstract: Aim: We aimed to explore factors related to improving health-related quality of life (HRQOL) among Japanese community-residing elderly individuals. Using a questionnaire, we investigated subjective satisfaction with verbal communication, dental status, and HRQOL in community-residing elderly people. Methods: Subjects were 454 independent elderly individuals, with a mean age of 76.1 ± 6.8 years, living in Japan. The Japanese version of the SF-8 Health Survey was used to evaluate HRQOL. Subjective satisfaction with verbal communication was investigated using a five-point scale. Multiple regression analysis was conducted to identify determinants affecting HRQOL. Covariance structure analysis was conducted to investigate any mutual association between age, presence of natural teeth, satisfaction with verbal communication, and HRQOL. Results: The HRQOL scores of subjects who answered that they were “very satisfied” or “satisfied” with verbal communication were significantly higher than those of subjects in the groups of “neither satisfied nor unsatisfied”, the “unsatisfied”, and the “very unsatisfied” in physical component summary (PCS) scores or mental component summary (MCS) scores of SF-8 (P < 0.001). In multiple regression analysis, age, gender, and satisfaction with verbal communication were independent predictors of PCS scores. Furthermore, age and subjective satisfaction with verbal communication were also independent predictors of MCS scores. There was a significant positive correlation between subjective satisfaction with verbal communication and PCS (r = 0.307, P < 0.001) or MCS (r = 0.435, P < 0.001) in covariance structure analysis. Conclusions: Satisfaction with verbal communication is significantly related to HRQOL among Japanese community-dwelling elderly individuals.
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