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Search Results: 1 - 10 of 106 matches for " Kiyoko Nagura "
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The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer
Hiroko Natsume, Kazuya Shinmura, Hong Tao, Hisaki Igarashi, Masaya Suzuki, Kiyoko Nagura, Masanori Goto, Hidetaka Yamada, Matsuyoshi Maeda, Hiroyuki Konno, Satoki Nakamura, Haruhiko Sugimura
Journal of Translational Medicine , 2012, DOI: 10.1186/1479-5876-10-97
Abstract: A genome-wide single nucleotide polymorphism microarray analysis was performed using three cell lines of differentiated gastric cancers, and 22 genes (including ERBB2) in five highly amplified chromosome regions (with a copy number of more than 6) were identified. Particular attention was paid to the CRKL gene, the product of which is an adaptor protein containing Src homology 2 and 3 (SH2/SH3) domains. An extremely high CRKL copy number was confirmed in the MKN74 gastric cancer cell line using fluorescence in situ hybridization (FISH), and a high level of CRKL expression was also observed in the cells. The RNA-interference-mediated knockdown of CRKL in MKN74 disclosed the ability of CRKL to upregulate gastric cell proliferation. An immunohistochemical analysis revealed that CRKL protein was overexpressed in 24.4% (88/360) of the primary gastric cancers that were analyzed. The CRKL copy number was also examined in 360 primary gastric cancers using a FISH analysis, and CRKL amplification was found to be associated with CRKL overexpression. Finally, we showed that MKN74 cells with CRKL amplification were responsive to the dual Src/BCR-ABL kinase inhibitor BMS354825, likely via the inhibition of CRKL phosphorylation, and that the proliferation of MKN74 cells was suppressed by treatment with a CRKL-targeting peptide.These results suggested that CRKL protein is overexpressed in a subset of gastric cancers and is associated with CRKL amplification in gastric cancer. Furthermore, our results suggested that CRKL protein has the ability to regulate gastric cell proliferation and has the potential to serve as a molecular therapy target for gastric cancer.Although the overall incidence of gastric cancer is decreasing in many countries, the high incidence of gastric cancer remains a serious health problem, and gastric cancer continues to be the second-leading cause of cancer-related death worldwide [1,2]. Gastric carcinogenesis is a multi-step process in which environmental and
Mirror Symmetry on Arbitrary Dimensional Calabi-Yau Manifold with a few moduli
Masaru Nagura
Physics , 1994, DOI: 10.1142/S0217732395001794
Abstract: We calculate the B-model on the mirror pair of $X_{2N-2}(2,2,\cdots,2,1,1)$ , which is an $(N-2)$-dimensional Calabi-Yau manifold and has two marginal operators i.e. $h^{1,1}(X_{2N-2}(2,2,\cdots,2,1,1))=2$. In \cite{nagandjin} we have discussed about mirror symmetry on $X_N(1,1,\cdots,1)$ and its mirror pair. However, $X_N(1,1,\cdots,1)$ had only one moduli. In this paper we extend its methods to the case with a few moduli using toric geometry.
Seifert matrices of Brunnian links
Maki Nagura
Mathematics , 2006,
Abstract: We show some properties of a Seifert matrix of an $n$-component Brunnian link. In particular, we give a necessary and sufficient condition for a matrix to be a Seifert matrix of a 2-component Brunnian link up to S-equivalence.
Acute Stress Symptoms in Families of Patients Admitted to the Intensive Care Unit during the First 24 Hours Following Admission in Japan  [PDF]
Miyuki Komachi, Kiyoko Kamibeppu
Open Journal of Nursing (OJN) , 2015, DOI: 10.4236/ojn.2015.54035
Abstract: Families of patients in the intensive care unit often experience sever stress. Understanding their experience is important for providing family-centered care during this difficult period. Little is known about the experience of families of patients admitted to the intensive care unit (ICU). To evaluate the prevalence and factors associated with acute stress symptoms among families of patients admitted to the ICU, we carried out a cross-sectional study at a teaching and advanced treatment hospital. The mean total Impact of Event Scale-Revised (IES-R) score differed significantly between planned and unplanned ICU admissions (t = 4.03, p < 0.05), indicating a main effect of admission type (F = 18.5, p < 0.05). There was no significant main effect of relationship (F = 0.05, p = 0.82) or interaction effect of admission type and relationship (F = 0.54, p = 0.47). Multiple regression analysis indicated that admission type was significantly associated with acute stress symptoms (B = 18.09, β = 0.47, p < 0.01), and explained 22% of the variance in total IES-R score. Whether a patient had a planned or unplanned admission to the ICU influenced symptoms associated with acute stress symptoms of family members more than did getting support from nurses, being the patient’s spouse, or the severity of illness of the patient.
Evaluating Sleeping and Waking States of Infants: Consistency of Actigraph and Observational Data  [PDF]
Rie Nakamura Ikeda, Kiyoko Fukai
Creative Education (CE) , 2015, DOI: 10.4236/ce.2015.65053
Abstract: The objective was to evaluate sleeping and waking states of infants <6 months old. The design of study was comparing video-recorded and actigraphic data. Participants were thirteen healthy 3- to 5-month-old infants. At their homes, subjects wore an ankle actigraph for 1 h and were videotaped simultaneously. We performed per-minute analysis of video data using the method for observing newborns developed by Brazelton. Video and actigraphic data were compared each minute. The total concordance rate was 93.5%. Sleep/wake identification by actigraphy and visual observation correspond closely for infants.
Adaptive Ant Colony Optimization Considering Intensification and Diversification
Masaya Yoshikawa,Tomohiro Nagura
Lecture Notes in Engineering and Computer Science , 2009,
Mirror Symmetry of K3 and Torus
Masaru Nagura,Katsuyuki Sugiyama
Physics , 1993, DOI: 10.1142/S0217751X95000115
Abstract: We discuss a K3 and torus from view point of "mirror symmetry". We calculate the periods of the K3 surface and obtain the mirror map, the two-point correlation function, and the prepotential. Then we find there is no instanton correction on K3 (also torus), which is expected from view point of Algebraic geometry.
Mirror Symmetry and An Exact Calculation of N-2 Point Correlation Function on Calabi-Yau Manifold embedded in CP^{N-1}
Masao Jinzenji,Masaru Nagura
Physics , 1994, DOI: 10.1142/S0217751X96000559
Abstract: We consider an (N-2)-dimensional Calabi-Yau manifold which is defined as the zero locus of the polynomial of degree N (of Fermat type) in CP^{N-1} and its mirror manifold. We introduce the (N-2)-point correlation function (generalized Yukawa coupling) and evaluate it both by solving the Picard-Fuchs equation for period integrals in the mirror manifold and also by explicitly calculating the contribution of holomorphic maps of degree 1 to the Yukawa coupling in the Calabi-Yau manifold using the method of Algebraic geometry...
The Experience of Postpartum Depression among Mothers with Withdrawn Attachment Style during Pregnancy and the First Postnatal Month  [PDF]
Mari Ikeda, Momoko Hayashi, Kiyoko Kamibeppu
Open Journal of Depression (OJD) , 2015, DOI: 10.4236/ojd.2015.44008
Abstract: Approximately 19% of women experience minor or major depression in the first three months following childbirth. Most research suggests that women with withdrawn attachment styles are less likely to be depressed. However, unlike mothers in Western culture, mothers in Japan with withdrawn attachment styles are reported to have greater potential to become depressed. Thus, the aim of this study was to describe the behaviors and situational awareness of Japanese mothers’ with withdrawn attachment styles during pregnancy in order to reveal the specific dynamics underlying the withdrawn style. Interview data were analyzed using qualitative thematic content analysis. Of the 84 women assessed, 12 were determined to have a withdrawn style, and based on the Mini-International Neuropsychiatric Interview, five demonstrated the onset of postpartum depression (PPD). Two themes regarding relationships with partners emerged including: 1) confiding behavior: the importance of what is shared; and 2) need to be heard: wanting sympathy rather than criticism. Additionally, three themes describing mothers’ experiences during the first postnatal month emerged: 1) overwhelming experiences: the childbirth experience; 2) seeking help: behavior changes altered relationships; and 3) experience with the baby. Withdrawn style mothers keep distance from crisis, avoid closeness with others, and opt to manage problems by themselves. However, childbirth and infant care are not easily managed in this style. Mothers who used childbirth to confide in their partners may have reduced the severity of insecurity or developed a more secure style. Healthcare professionals are in the best position to develop good relationships with new mothers and provide support that focuses more on emotional factors and self-esteem levels.
The Inter Relationship of Mental State between Antepartum and Postpartum Assessed by Depression and Bonding Scales in Mothers  [PDF]
Kafumi Sugishita, Kiyoko Kamibeppu, Hiroya Matsuo
Health (Health) , 2016, DOI: 10.4236/health.2016.812126
Abstract: The number of deaths caused by child abuse is increasing, which is one of social concerns. The mental health of mothers might be related to child abuse. The aim of this study was to examine and compare the mental state of mothers in both the antepartum and postpartum period assessed by the Edinburgh Postnatal Depression Scale (EPDS) and Mother-Infant-Bonding-Scale (MIBS), and compare the results. Participants (n = 134) were recruited twice in antepartum medical checkups (20 to 36 weeks of gestation) and postpartum medical checkups (1 month after birth). Information on characteristics of participants was collected from medical records in both periods. Family function and ante-postpartum mental health were assessed by Family APGAR, EPDS, and MIBS. Antepartum depressive state was related to postpartum depressive state (p = 0.015), antepartum bonding was related to bonding in postpartum bonding (p = 0.0001), and antepartum bonding disorder was related to postpartum depressive state (relative risk = 11.7). Worries about costs and poor of family function were related to the mental health of mothers in both the antepartum and postpartum periods. Antepartum depressive state is an indicator of postpartum depression. We suggested that health professionals conduct an evaluation of mother’s mental health and related factors in the antepartum period. The present findings emphasize the importance of antepartum mental health as a predictor of postpartum depression and bonding disorder.
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