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Search Results: 1 - 10 of 2464 matches for " King "
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Quinquennial Terror: Machiavelli’s Understanding of the Political Sublime  [PDF]
Ed King
Open Journal of Political Science (OJPS) , 2013, DOI: 10.4236/ojps.2013.32010
Abstract:

This paper argues that far from advocating fear of violence as a continuous source of civic provocation Machiavelli’s ideal ruler employs an aesthetic approach to civic violence; one that actually harms few citizens and moderates their fear with admiration through carefully considered psychological imperatives similar to those articulated two hundred years later in theories of the sublime. Such violence as there was would occur half a decade at a time in between which the citizens and the patria would enjoy stability, wealth and honor. It had a proven Medici provenance, having been developed through Cosimo de Medici’s intuitive genius for governance and was maintained by Piero and Lorenzo the Magnificent. The insight was empirically confirmed by Niccolò’s observations of similarly intuitive political savants; namely Cesare Borgia and Julius II. It was not given a technical title by Machiavelli, who unhelpfully referred to it as crudeltà bene usate (cruelty well used) but we might call it “the politics of the sublime”. Despite its most dramatic (and consequentially disproportionate) evocation in the Prince, Machiavelli’s reliance on the political sublime waned throughout his literary career, until he rejected it in a stunning critique of Cosimo’s reign in the Florentine Histories.

Categorizing HIV-1 subtypes using an ant-based clustering algorithm  [PDF]
David King, Wei Hu
Journal of Biomedical Science and Engineering (JBiSE) , 2010, DOI: 10.4236/jbise.2010.38104
Abstract: Human Immunodeficiency Virus (HIV) is especially difficult to treat due to its rapid mutation rate. There are currently eleven different genomic subtypes of HIV-1, as well as a number of recombinant subtypes. An area of study in bioinformatics is the development of algorithms to identify the subtypes of HIV-1 genomes. Ant-based algorithms have the ability to find global solutions in optimizations problems, and are also able to process complex data efficiently. We proposed a new technique named Ant Colony Anchor Algorithm (ACAA), using anchors of training data on a topographic map to categorize HIV-1 sequences based on ant-based clustering. We used three sets of sequences from the POL region of the HIV-1 genome. We categorized these three dataset with the Subtype Analyzer (STAR), a current HIV-1 categorization algorithm, and the ACAA. We found that the ACAA returned higher accuracy values of 83.2%, 67.1%, and 53.5% for our three datasets respectively, than the STAR’s 47.3%, 49.4% and 18%. The results of the ACAA are the average results of 20 runs of the algorithm. We also observed the performance of the algorithm on specific subtypes, and observed that while the STAR and ACAA performed with similar accuracy on several subtypes (A, B, and C in particular), the ACAA had a significant advantage over the STAR in others, especially in categorizing recombinant subtypes.
Interest-Rate Setting at the ECB Following the Financial and Sovereign Debt Crises, in Real-Time  [PDF]
Florence Bouvet, Sharmila King
Modern Economy (ME) , 2011, DOI: 10.4236/me.2011.25083
Abstract: We analyse European Central Bank (ECB) policy by estimating a forward-looking, augmented Taylor rule using expectations data. Specifically, we investigate the impact of the financial and sovereign debt crises on ECB policy. We find the European Overnight Index Average (EONIA) rises when expected economic activity is strong. Regardless of the inflation measure, inflation is not associated with the EONIA. Using a recursive estimation and a Chow test, we identify a policy shift in December 2008. The more generally accepted starting date of the crisis, August 2007, does not correspond to a statistically significant shift in the ECB policy. Using December 2008 for a policy shift, general financial market sentiment, as measured by VSTOXX, is not significant in explaining EONIA movements. The ECB’s response to a shock to economic activity has been more moderate since the crises. However, the EONIA increases as Greek sovereign risk rises, possibly from increasing demand for liquidity by banks.
Computation of Local Fractal Dimension Values of the Human Cerebral Cortex  [PDF]
Richard D. King
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.512166
Abstract:

Objectives: The purpose of this paper is to describe a technique for computing the local fractal dimension of the human cerebral cortex as extracted from high-resolution magnetic resonance imaging scans. Methods: 3D models of the human cerebral cortex were extracted from high resolution magnetic resonance images of 10 healthy adult volunteers using FreeSurfer. The local fractal dimension of the cortex was computed using a custom-written cube-counting algorithm. The effect of constraining the maximum region size on the measured value of local fractal dimension was examined. A proof of principle was demonstrated by comparing an individual with Alzheimer’s disease to a healthy individual. Results: Local values of cortical fractal dimension can be obtained by constraining the size of the region over which the cube counting is performed. Cubic regions of intermediate size (30 × 30 × 30 mm) yielded a profile that demonstrated greater regional variability compared to smaller (15 × 15 × 15 mm) or larger (60 × 60 × 60 mm) region sizes. Conclusions: Local fractal dimension of the cerebral cortex is a novel measure that may yield additional, quantitative insight into the clinical meaning of cortical shape changes.

The Prince of Pine Avenue and the Père de la Patrie: A Machiavellian Analysis of Pierre Trudeau and Rene Lévesque  [PDF]
Ed King, Charles Sancy
Open Journal of Political Science (OJPS) , 2015, DOI: 10.4236/ojps.2015.54024
Abstract: This study was inspired by the remarkable number of Machiavellian references we noted in journalistic and scholarly accounts of the 1970 War Measures Act and the Québec Referendum that followed a decade later. The notion that Machiavelli’s insights in the sixteenth century might have utility for a critique of 20th century Quebecois political life seemed outrageous and we wanted to explore the validity of such associations. There’s nothing wrong with this. We wanted to see if there was more to them than the shorthand of short-cycle journalism or if they actually possessed enough analytical force to usefully illustrate aspects of that period of Quebec’s history. We discovered that the Machiavellian lens was remarkably illuminating, especially with respect to the clash of two of Quebec’s most influential personalities, Pierre Trudeau and Rene Lévesque although, with the notable exception of Denis Arcand, the connections made at the time failed to extend much beyond attempts to make ad hominum slurs against the principle actors in the drama.
Personal Tacit Knowledge and Global Learning Professional Competencies—Multi-Dimensional Relationships  [PDF]
Rosalind R. King
Journal of Computer and Communications (JCC) , 2017, DOI: 10.4236/jcc.2017.513003
Abstract: Global learning professional competencies (GLPCs) are essential for college students to be able to address the impact of globalization in the 21st century. Organizations and society-at-large look to higher education to prepare college students with GLPCs. In addition, there is a body of literature that suggest personal tacit knowledge enhance GLPCs. However, researchers have done little from an empirical perspective to determine the relationship between the use of P-T K and enhancement of GLPCs, hence the purpose of this study. The statistical results revealed significant correlations, p < 0.001. From the findings of this research, faculty can teach different GLPCs to help students affect social positive change in the 21st century knowledge society through use of P-T K.
Entropy Generation through the Interaction of Laminar Boundary-Layer Flows: Sensitivity to Initial Conditions  [PDF]
LaVar King Isaacson
Journal of Modern Physics (JMP) , 2018, DOI: 10.4236/jmp.2018.98104
Abstract: A modified form of the Townsend equations for the fluctuating velocity wave vectors is applied to the interaction of a longitudinal vortex with a laminar boundary-layer flow. These three-dimensional equations are cast into a Lorenz-format system of equations for the spectral velocity component solutions. Tsallis-form empirical entropic indices are obtained from the solutions of the modified Lorenz equations. These solutions are sensitive to the initial conditions applied to the time-dependent coupled, non-linear differential equations for the spectral velocity components. Eighteen sets of initial conditions for these solutions are examined. The empirical entropic indices yield corresponding intermittency exponents which then yield the entropy generation rates for each set of initial conditions. The flow environment consists of the flow of hydrogen gas with impurities at a given temperature and pressure in the interaction of a longitudinal vortex with a laminar boundary layer flow. Results are presented that indicate a strong correlation of predicted entropy generation rates and the corresponding applied initial conditions. These initial conditions may be ascribed to the turbulence levels in the boundary layer, thus indicating a source for the subsequent entropy generation rates by the interactive instabilities.
Potential Inbreeding in a Small Population of a Mass Flowering Species, Xanthorrhoea johnsonii (Xanthorrhoeaceae): Is Your Mother My Father?  [PDF]
Rachel King, Jacinta M. Zalucki
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.33036
Abstract: Xanthorrhoea johnsonii is a long lived slow growing perennial understorey species, that produces a large quantity of passively dispersed seed every 3 - 5 years. Reproductive maturity is not reached until 20 - 30 years of age. The temporal asynchrony of the flowering event in this population was analogous to geographic isolation through fragmentation. A small population of plants flowering in isolation provided the opportunity to examine outcrossing rates, genetic diversity and the paternity of progeny at a small spatial scale (0.2 ha). The geographic location and physical characteristics of the adult plants were recorded, and both adults and their seed were sampled for genetic analysis. Four microsatellite loci were screened for genetic diversity and spatial structure analysis. A population outcrossing rate was estimated, as well as the number of paternal parents required to resolve the progeny multilocus genotypes. High genetic diversity was found in both adults and progeny with an estimated 97% outcrossing rate. All maternal lines required several paternal contributors, with no evidence of dominant paternal genotypes. Pollen transfer occurred between both geographically close and distant plants.
A Wee Lesson in Science Communication
Emma King
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0020122
Abstract:
Haemophilus influenzae and the lung (Haemophilus and the lung)
Paul King
Clinical and Translational Medicine , 2012, DOI: 10.1186/2001-1326-1-10
Abstract: Haemophilus influenzae was first identified by Pfeiffer in 1892, who (incorrectly) believed it was the cause of influenza [1]. It is an exclusively human pathogen and was the first bacterium to have its genome completely sequenced. This served as a precursor to the sequencing of the human genome.H. influenzae is a component of the normal upper respiratory tract flora and is well recognized to be an important cause of systemic infection. It is also a major cause of a variety of respiratory conditions and has had a relatively low profile in this respect in comparison to some other pathogens; such as Mycobacterium tuberculosisand Streptococcuspneumoniae.Recently there has been increasing recognition that this bacterium has a role in chronic lower respiratory tract inflammation. However the interaction between H. influenzae and the lung is still not well defined. A combination of bacterial pathogenic features and deficiency of host defense may permit this bacterium to establish infection in the lower respiratory tract resulting in inflammation and clinical disease. This review will discuss the role of H. influenzae in the lower respiratory tract in particular its role in bronchitis.Haemophilus influenzae is a gram-negative coccobacillus with a variable shape (pleomorphic). It grows both aerobically and anaerobically. Aerobic growth requires the presence of X (hemin) and V (nicotinamide adenine dinucleotide (NAD)) factors. In the laboratory it is classically grown on chocolate agar (Figure?1).Haemophilus influenzae is divided into typeable and nontypeable strains on the presence or absence of a polysaccharide capsule. The typeable strains which have this capsule are classified into six serotypes (designated a to f) based on their ability to react with antisera against recognized polysaccharide capsules [2,3]. The type b form of H. influenzae (designated as Hib) is the most prominent typeable form and its capsule is composed of a linear ribosyl and ribotol phosphage polym
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