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Search Results: 1 - 10 of 28 matches for " Kianoosh Keyhanian "
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Apoptosis inhibition or inflammation: the role of NAIP protein expression in Hodgkin and non-Hodgkin lymphomas compared to non-neoplastic lymph node
Safoura Mazrouei, Amin Ziaei, Amir Tanhaee, Kianoosh Keyhanian, Mahdad Esmaeili, Azar Baradaran, Mansoor Salehi
Journal of Inflammation , 2012, DOI: 10.1186/1476-9255-9-4
Abstract: In this study, we examined NAIP protein expression in 101 Formalin-Fixed Paraffin-Embedded blocks including samples from 39 Hodgkin Lymphoma and 23 Non Hodgkin Lymphoma cases in comparison with 39 control samples (30 normal and 9 Reactive Lymphoid Hyperplasia (RLH) lymph nodes) using semi-quantitative immuno-flourecent Staining.NAIP expression was not statistically different in lymphoma samples neither in HL nor in NHL cases comparing to normal samples. However, we evaluated NAIP expression in normal and RLH lymph nodes. Surprisingly, we have found a statistically significant-difference between the NAIP expression in RLH (M.R of NAIP/GAPDH expression = 0.6365 ± 0.017) and normal lymph node samples (M.R of NAIP/GAPDH expression = 0.5882 ± 0.047) (P < 0.01).These findings show that the regulation of apoptosis could not be the main function of NAIP in the cell, so the pathologic expression of NAIP is not involved in lymphoma. But, we concluded that the over expression of NAIP has more effective role in the inflammatory response. Also, this study clarifies the NAIP expression level in lymphoma which is required for IAPs profiling in order to be used in potential translational applications of IAPs.Apoptosis is a programmed process leading to cell death which controls the development and homeostasis of multicellular organisms [1]. This cell destruction executes when initiator caspases are assemble with adaptor molecules in response to internal or external signal, leading to caspase activation [2-4]. Up to now, numerous literatures have been reported on critical role of apoptosis in different pathological conditions [5]. The loss of apoptosis regulation might proceed in a wide variety of diseases like cancer development and progression while the excess of apoptosis might result in neurodegenerative [6] and immunodeficiency disorders [1]. So, the impaired regulation of apoptosis is considered to be a prominent event in the development and progression of tumor cells [7,8]. T
Effect of intravenous ascorbic acid in hemodialysis patients with anemia and hypeferritinemia
Shahrbanoo Keyhanian,Taziki Omolbanin
Saudi Journal of Kidney Diseases and Transplantation , 2008,
Abstract: Hemodialysis (HD) patients with functional iron deficiency (FID) often develop resistance to recombinant human erythropoietin (Epo). The contributory role of chronic infla-mmation and oxidative stress in its pathogenesis is poorly understood. We assessed the effect of vitamin C, an antioxidant, on Epo-hyporesponsive anemia in hemodialysis patients with un-explained hyperferritinemia levels. Thirty-one of 132 with Hb < 11 g/dL were prospectively fo-llowed up after exclusion of reasons for Epo hyporesponsiveness. Patients were randomly divided into two groups: 15 patients received standard care and 300 mg of intravenous vitamin C with each dialysis session (group 1) and 15 patients received standard care (group 2). After 3 months, Hb and transferrin saturation levels significantly increased in group 1 but not in group 2 (p < 0.05%). Hemoglobin content in reticulocyte and serum ferritin decreased significantly in group 1 but not in control group. In conclusion, hemodialysis patients with refractory anemia and ade-quate iron stores, vitamin C improved responsiveness to Epo by augmenting iron mobilization and possibly via antioxidant effect.
Taping after Rhinoplasty for Asian Noses
Kianoosh Nahid,Chong AW
Iranian Journal of Otorhinolaryngology , 2013,
Fracture resistance of endodontically treated teeth restored by different FRC posts: An in vitro study
Torabi Kianoosh,Fattahi Farnaz
Indian Journal of Dental Research , 2009,
Abstract: Background: Posts and cores are often required for restoration of pulpless teeth and to provide retention and resistance for a complete crown, but conventional posts may increase the root fracture. Objective: This study was performed to compare the root fracture resistance of extracted teeth treated with different fibers reinforced with composite posts and treated teeth with conventional post and core systems. Materials and Methods: Root canal therapy was performed for 50 mandibular first premolars. The coronal portion of each tooth was amputated, and five post and core systems (cast, polyethylene woven, glass, carbon, and quartz fiber posts) were compared. Acrylic resin blocks were used for mounting, using a layer of elastomeric impression material covering the roots. The load was applied axially and measured with a universal testing machine. Results and Conclusion: Significantly, cast posts and cores had a higher failure threshold including teeth fracture; whereas, fiber posts failure was due to core fracture, with or without fractures in coronal portion of posts. Difference in FRC posts did not provide any significant difference in the load failure and the mode of fracture.
Myocardial Infarction in a Patient with Prosthetic Aortic Valve
Seyed Kianoosh Hoseini,Maryam Mehrpooya
Journal of Tehran University Heart Center , 2006,
Abstract: A 45- year old man with a history of Aortic Valve replacement presented with acute chest pain which was diagnosed to be anterior wall myocardial infarction. He received thrombolytic therapy with streptokinase. Echocardiography and fluoroscopy showed normally functioning ball and cage aortic prosthesis. Coronary arteriography showed globular filling defect in midportion of left anterior descending coronary artery, most probably embolized thrombus. The patient underwent medical treatment especially warfarin with higher range of INR without any intervention. He had a smooth in-hospital course and uneventful recovery.
A case with heart failure and skin discoloration
Seyyed Kianoosh Hosseini,Ali Bozorgi
Journal of Tehran University Heart Center , 2007,
Percutaneous Revascularization of Patients with History of Coronary Artery Bypass Grafting
Seyed Kianoosh Hosseini,Fatemeh Behboudi
Journal of Tehran University Heart Center , 2011,
Ear Candling: A Dangerous Pleasure?
Kianoosh Nahid,Prepageran Narayanan,Mohammad Amin Jalaluddin
Iranian Journal of Otorhinolaryngology , 2011,
Abstract: Ear candling is an alternative medicine practice alleged to enhance general health by putting an end of a hollow candle in the ear canal and lighting up the other end of it. It also is advertised for cerumen and debris (bacteria and fungi) removal. Ear candling is claimed to create negative pressure for drawing cerumen from the ear and to benefit the ears in many ways. It is however not free of complications and is now banned. Here we would like to highlight potential complications to this.
Impact of cardiovascular risk factors on the outcome of renal transplantation
Moghimi Mehrdad,Falaknazi Kianoosh,Bagheri Nazila
Saudi Journal of Kidney Diseases and Transplantation , 2010,
Abstract: Cardiovascular diseases are common in renal transplant recipients and renal insuf-ficiency has been shown to be a risk factor for cardiovascular disease. Some studies have reported that cardiovascular risk factors may contribute to the outcome of renal transplantation. This study was performed to determine the impact of cardiovascular risk factors on the outcome of renal transplantation in Iranian subjects. This is a retrospective, observational study including patients of 20-85 years of age who had undergone renal transplantation. Parameters documented and analyzed included demographics, cardiovascular risk factors, past medical history, date of last transplan-tation, the outcome of transplant, last measured serum creatinine, cause of graft failure, rejection, and death. A total of 192 patients were analyzed including 152 in the case group (with identifiable cardiovascular risk factors) and 40 controls (transplant recipients without identifiable risk factors). The mean serum creatinine in the case and control groups were 1.33 ± 0.13 and 1.29 ± 0.36 mg/dL respectively (P= 0.493). Response to transplantation was categorized based on a report from the World Health Organization. Complete response to grafting occurred in the control group more than the case group (P= 0.009), while frequency of partial response to grafting was higher in the case group (0.008). A history of chronic obstructive pulmonary diseases (COPD) could significantly predict the outcome of grafting (P= 0.008) as could the occurrence of renal failure (P= 0.022). Results were consistently reproduced using multivariate cumulative log it model. Our study indicates that the measured cardiovascular risk factors do not significantly influence the outcome of renal transplantation.
Assessment of inflammatory factors and cardiac troponin T in hemodialysis patients
Falaknazi Kianoosh,Bagheri Nazila,Taziki Omolbanin
Saudi Journal of Kidney Diseases and Transplantation , 2009,
Abstract: Hemodialysis (HD) patients suffer from chronic inflammations which make them at increased risk of cardiovascular diseases. The purpose of this study was to see if there is a significant association between inflammatory factors such as ferritin and C-reactive protein (CRP) as well as troponin T in patients on HD. We assessed these serum factors as well as other known cardiac risk factors in 53 patients on HD. The serum ferritin and CRP levels were measured by chemiluminescence′s immune assay while troponin T levels were measured by electrochemist luminescence immune assay. We found that serum concentrations of CRP and ferritin were not significantly higher in patients on HD with known cardiac risk factors (compared with the control group) (p< 0.05). However, the serum troponin T levels in HD patients with cardiovascular risk factors were significantly higher than the control group. Our study suggests that elevated serum troponin T levels can play an important role as a predictor of cardiovascular disease in HD patients. Also, inflammatory factors such as CRP and ferritin may be influenced by chronic inflammation or nutritional status of these patients.
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