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Search Results: 1 - 10 of 7272 matches for " Ki-Suck Jung "
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Mild hypoglycemia is independently associated with increased risk of mortality in patients with sepsis: a 3-year retrospective observational study
Sunghoon Park, Dong-Gyu Kim, Gee Suh, Jun Kang, Young-Su Ju, Yong-Jae Lee, Ji Park, Seok Lee, Ki-Suck Jung
Critical Care , 2012, DOI: 10.1186/cc11674
Abstract: Patients admitted to a medical ICU for sepsis, as defined by the Surviving Sepsis Campaign guidelines, during a 3-year period were enrolled retrospectively. Data on blood glucose (BG) control parameters and patient outcomes were collected. The primary outcome was the relationship of mild hypoglycemia (defined as minimum BG of 40 to 69 mg/dl during ICU stay) to hospital mortality, and the secondary outcomes were ICU-acquired complication rates, ICU and 1-year mortality rates. A relationship between glucose variability and hypoglycemic events was also investigated.Three-hundred and thirteen consecutive patients with sepsis were enrolled (mean age, 71.8 ± 11.3 years; male, n = 166; diabetics, n = 102). A total of 14,249 (5.6/day/patient) BG tests were performed, and 175 hypoglycemic events (spontaneous, n = 71; iatrogenic, n = 104) occurred in 80 (25.6%) patients during the ICU stay; severe hypoglycemia (minimum BG level < 40 mg/dl) occurred in 24 (7.7%) patients, and mild hypoglycemia (minimum BG level 40 to 69 mg/dl) was found in 56 (17.9%) patients. The frequency of hypoglycemic events increased with higher glucose variability, and patients with mild hypoglycemia had higher rates of ICU-acquired complications than did those with no hypoglycemia (renal, 36.2% vs. 15.6%, P = 0.003; cardiac, 31.9% vs. 14.3%, P = 0.008; hepatic, 34.0% vs. 18.2%, P = 0.024; bacteremia, 14.9% vs. 4.5%, P = 0.021). Multivariate analysis revealed that mild hypoglycemia was independently associated with increased hospital mortality (odds ratio, 3.43; 95% confidence interval, 1.51 to 7.82), and even a single event was an independent risk factor (odds ratio, 2.98; 95% confidence interval, 1.10 to 8.09). Kaplan-Meier analysis demonstrated that mild hypoglycemia was significantly associated with a lower 1-year cumulative survival rate among patients with sepsis (P < 0.001).Mild hypoglycemia was associated with increased risk of hospital and 1-year mortality, as well as the occurrence of ICU-acqu
Synthesis, Characterization, and Photovoltaic Properties of Soluble TiOPc Derivatives
Young-Keun Kim,Hyo-Jin Kang,Young-Wook Jang,Su-Bin Lee,Seung-Min Lee,Ki-Suck Jung,Jin-Kook Lee,Mi-Ra Kim
International Journal of Molecular Sciences , 2008, DOI: 10.3390/ijms9122745
Abstract: We have synthesized soluble TiOPc derivatives containing alkoxy groups for use as additives in dye-sensitized solar cells (DSSCs). The DSSC devices containing these TiOPc derivatives exhibited short-circuit current densities of 8.49~10.04 mA/cm2 and power conversion efficiencies of 2.73~3.62 % under AM 1.5 illumination and 100 mW/cm2 irradiation.
Brain natriuretic peptide levels have diagnostic and prognostic capability for cardio-renal syndrome type 4 in intensive care unit patients
Sunghoon Park, Goo-Yeong Cho, Sung Kim, Yong Hwang, Hye-Ryun Kang, Seung Jang, Dong-Gyu Kim, Young Song, Young-A Bae, Ki-Suck Jung
Critical Care , 2009, DOI: 10.1186/cc7878
Abstract: All patients with CKD and a serum creatinine (Cr) of 2.0 mg/dl or higher admitted to the ICU between January 2006 and September 2007 were enrolled in this study. The CKD group was divided according to the presence or absence of acute decompensated heart failure (ADHF) into CKD + ADHF and CKD - ADHF groups, respectively. Other patients with ADHF having low Cr (<1.2 mg/dl) in the coronary care unit were also recruited as a control group during the same period. BNP levels at the time of admission (admission BNP) were compared amongst these groups. We then sought to determine whether BNP levels could predict the outcome in patients with CKD.Of 136 patients with CKD for whom data were available, including 58 on dialysis (42.6%), 81 (59.6%) had ADHF and their estimated glomerular filtration rate (eGFR) was 12.8 ± 7.3 ml/min/1.73 m2. BNP levels at admission were 2708.6 ± 1246.9, 567.9 ± 491.7 and 1418.9 ± 1126.5 pg/ml in the CKD + ADHF, CKD - ADHF and control groups (n = 33), respectively (P = 0.000). The optimal cutoff level in patients with CKD was 1020.5 pg/ml (area under the curve = 0.944) to detect ADHF from the receiver operating characteristic (ROC) curve. This level was not associated with in-hospital mortality, all-cause death or a composite event (all-cause death and/or new cardiac event). However, a borderline significant association was observed with new cardiac events (hazard ratio (HR) = 4.551; P = 0.078) during the follow-up period (521.1 ± 44.7 days). Furthermore, continuous variables of BNP and BNP quartiles were significantly associated with new cardiac events in the multivariate Cox model (HR = 1.001, P = 0.041; HR = 2.212, P = 0.018).The findings suggest that the level of BNP at the time of admission may be a useful marker for detecting ADHF and predicting cardiac events in patients with CKD in the ICU setting.Cardiovascular disease is a leading cause of death in patients with chronic kidney disease (CKD), for whom the cardiovascular mortality rate is 1
A promoter SNP rs4073T>A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode
Mi-Hyun Ahn, Byung-Lae Park, Shin-Hwa Lee, Sung-Woo Park, Jong-Sook Park, Do-Jin Kim, An-Soo Jang, Jai-Soung Park, Hwa-Kyun Shin, Soo-Taek Uh, Yang-Ki Kim, Young Kim, Sung Han, Ki-Suck Jung, Kye Lee, Sung Jeong, Jeong Park, Byoung Choi, In Park, Man Chung, Hyoung Shin, Jin Song, Dong Kim, Choon-Sik Park, Young-Soo Shim
Respiratory Research , 2011, DOI: 10.1186/1465-9921-12-73
Abstract: One promoter (rs4073T>A) and two intronic SNPs (rs2227307T>G and rs2227306C>T) of the IL-8 genes were genotyped in 237 subjects with IPF and 456 normal controls. Logistic regression analysis was applied to evaluate the association of these SNPs with IPF. IL-8 in BAL fluids was measured using a quantitative sandwich enzyme immunoassay, and promoter activity was assessed using the luciferase reporter assay.The minor allele frequencies of rs4073T>A and rs2227307T>G were significantly lower in the 162 subjects with surgical biopsy-proven IPF and 75 subjects with clinical IPF compared with normal controls in the recessive model (OR = 0.46 and 0.48, p = 0.006 and 0.007, respectively). The IL-8 protein concentration in BAL fluids significantly increased in 24 subjects with IPF compared with 14 controls (p = 0.009). Nine IPF subjects homozygous for the rs4073 T>A common allele exhibited higher levels of the IL-8 protein compared with six subjects homozygous for the minor allele (p = 0.024). The luciferase activity of the rs4073T>A common allele was significantly higher than that of the rs4073T>A minor allele (p = 0.002).The common allele of a promoter SNP, rs4073T>A, may increase susceptibility to the development of IPF via up-regulation of IL-8.Idiopathic pulmonary fibrosis (IPF) is a devastating disease of the idiopathic interstitial pneumonia family. It predominantly affects the lung parenchyma and is characterized by progressive dyspnea and worsening lung function [1]. Although the pathogenesis of IPF is largely unknown, a current hypothesis suggests aberrant wound healing of ongoing alveolar epithelial injury and repair associated with the formation of patchy fibroblast-myofibroblast foci, which evolve to fibrosis [2,3]. The processes of inflammation and fibrosis likely involve an interaction between environmental triggers and genetic background [2]. Supporting evidence for the genetic background for pulmonary fibrosis is the familial occurrence, as seen in familial IP
Influence of initial molecular substance on the diffusion flux across cell membranes  [PDF]
Bum Joon Jung, Dae-Han Ki
Advances in Bioscience and Biotechnology (ABB) , 2014, DOI: 10.4236/abb.2014.53021
Abstract:

The influence of initial placement of molecular or ion substance is investigated on the diffusion fluxes across the cell membrane. The diffusion fluxes and recovery curves are obtained by considering both the singlespot and double-spot concentrations inside the cell membrane. The results show that the additional concentration inside the membrane reduces the net fluxes at the cell interior as well as the exterior. In addition, it is found that the change in diffusion flux at the two outer walls of the membrane by the two-spot concentrations in the cell membrane is weaker than that of the single-spot concentration at the center. The variation of the influence of initial locations of the molecular concentrations inside the cell membrane on the diffusion fluxes is also discussed. This result can be applied to the diffusion process in avascular collagenous tissues.

Increased Corticomuscular Coherence in Idiopathic REM Sleep Behavior Disorder
Ki-Young Jung
Frontiers in Neurology , 2012, DOI: 10.3389/fneur.2012.00060
Abstract: The authors hypothesized that if locomotor drive increases along with rapid eye movement (REM) sleep without atonia in idiopathic REM sleep behavior disorder (RBD), then RBD patients would have greater corticomuscular coherence (CMC) values during REM sleep than at other sleep stages and than in healthy control subjects during REM sleep. To explore this hypothesis, we analyzed beta frequency range CMC between sensorimotor cortex electroencephalography (EEG) and chin/limb muscle EMG in idiopathic RBD patients. Eleven drug naive idiopathic RBD patients and 11 age-matched healthy control subjects were included in the present study. All participants completed subjective sleep questionnaires and underwent polysomnography for one night. The CMC value between EEGs recorded at central electrodes and EMGs acquired at leg and chin muscles were computed and compared by repeated measures analysis of variance (ANOVA). Sleep stages and muscle (i.e., chin vs. leg) served as within-subject factors, and group served as the between-subject factor. Repeated measures ANOVA revealed no significant main effect of group (F1,20 = 0.571, p = 0.458) or muscle (F1,20 = 1.283, p = 0.271). However, sleep stage was found to have a significant main effect (F2.067,41.332 = 20.912, p < 0.001). The interaction between group and sleep stage was significant (F2.067,41.332 = 3.438, p = 0.040). RBD patients had a significantly higher CMC value than controls during REM sleep (0.047 ± 0.00 vs. 0.052 ± 0.00, respectively, p = 0.007). This study reveals increased CMC during REM sleep in patients with RBD, which indicates increased cortical locomotor drive. Furthermore, this study supports the hypothesis that sufficient locomotor drive plays a role in the pathophysiology of RBD in addition to REM sleep without atonia.
Data Hiding Method with Quality Control for Binary Images  [PDF]
Ki-Hyun Jung, Kee-Young Yoo
Journal of Software Engineering and Applications (JSEA) , 2009, DOI: 10.4236/jsea.2009.21003
Abstract: Secret data hiding in binary images is more difficult than other formats since binary images require only one bit repre-sentation to indicate black and white. This study proposes a new method for data hiding in binary images using opti-mized bit position to replace a secret bit. This method manipulates blocks, which are sub-divided. The parity bit for a specified block decides whether to change or not, to embed a secret bit. By finding the best position to insert a secret bit for each divided block, the image quality of the resulting stego-image can be improved, while maintaining low computational complexity. The experimental results show that the proposed method has an improvement with respect to a previous work.
Rescue endoscopic band ligation of iatrogenic gastric perforations following failed endoclip closure
Joung-Ho Han,Tae Hoon Lee,Yunho Jung,Suck-Ho Lee
World Journal of Gastroenterology , 2013, DOI: 10.3748/wjg.v19.i6.955
Abstract: Iatrogenic gastric perforation is one of the most serious complications during therapeutic endoscopy, despite significant advances in endoscopic techniques and devices. This case study evaluated the clinical efficacy and safety of the rescue endoscopic band ligation (EBL) technique in iatrogenic gastric wall perforation following the failure of primary endoclip closure. Five patients were enrolled in this study. These patients underwent emergency endoscopy following the onset of acute gastric wall perforation during endoscopic procedures. The outcome measurements were primary technical success and immediate or delayed procedure-related complications. Successful endoscopic closure using band ligation was reported in all patients, with no complication occurring. We conclude that EBL may be a feasible and safe alternate technique for the management of acute gastric perforation, especially in cases where closure is difficult with endoclips.
The Performance Improvement of BASK System for Giga-Bit MODEM Using the Fuzzy System  [PDF]
Ki-Hwan Eom, Kyo-Hwan Hyun, Kyung-Kwon Jung
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2010, DOI: 10.4236/ijcns.2010.35058
Abstract: In this paper we propose an automatic bandwidth control method for the performance improvement of Binary Amplitude Shift Keying (BASK) system for Giga-bit Modem in millimeter band. To improve the performance of the BASK system with a fixed bandwidth, the proposed method is to adjust a bandwidth of low pass filter in receiver using the fuzzy system. The BASK system consists of a high speed shutter of the transmitter and a counter and a repeater of receiver. The repeater consists of four stage converters, and a converter is constructed with a low pass filter and a limiter. The inputs to the fuzzy system are the reminder and integral of remainder of counter, and output is a bandwidth. We used a Viterbi algorithm to find the optimum detection from output of the counter. Simulation results show that the proposed system improves the performance compared to the fixed bandwidth.
Optimizing of Iterative Turbo Equalizer for Underwater Sensor Communication
Ji Won Jung,Ki Man Kim
International Journal of Distributed Sensor Networks , 2013, DOI: 10.1155/2013/129781
Abstract: We presented an iterative turbo equalization to cope with intersymbol interference induced by reflection of sea level and sea bottom for underwater sensor communication channel. Iterative turbo equalizer consists of inner codes and outer codes; we employ decision feedback equalizer as an outer code and turbo codes as an inner code. Equalizer and decoder are connected through the interleaving and deinterleaving that update each other's information repeatedly. At the receiver side, we resort to powerful turbo equalization algorithms that iteratively exchange probabilistic information between inner decoder and outer decoder, thereby reducing the error rates significantly. Furthermore, we expand iterative turbo equalizer techniques for single-input-single-output (SISO) system to multiple-input-multiple-output (MIMO) system in order to increase data rates for underwater sensor communication channel. Based on experimental channel response, we confirmed that the performance is improved as iteration number is increased. The performance is improved by 3.5?[dB] compared to noniteration for SISO channel and by 1?[dB] for MIMO channel, respectively. We also decided that optimal iterations are 3. Very important for a successful decoding is the channel estimation, which is also discussed. 1. Introduction The excessive multipath encountered in underwater sensor communication (USC) channel is creating intersymbol interference (ISI), which is limiting factor to achieve a high data rate and bit error rate (BER) performance. Various different methods to cope with multipath situation have been developed. In addition to ISI, cochannel interference (CoI) is also occurred resulting from the use of multiple transmitters in UW communication. Removal of both CoI and ISI is a challenging problem in view of difficult channel conditions. The optimal detector is a maximum likelihood detector (MLD), which can be realized, for example, by the soft Viterbi algorithm. Due to the length of the impulse response in the UW channel, the number of states in the decoder will be increased. One well-proven method to counteract ISI is the decision feedback equalized (DFE), which has been used in many UW communication links [1, 2]. However, the use of DFE has difficulties when a multipath with a number of arrivals has equal strength or low SNR [3]. The other way to cope with ISI, iterative equalizer which constitutes an outer loop is used in the receiver. An inner loop consists of iterative decoder. The assembly utilizes the error correcting power of the iterative codes to get an efficient
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