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Search Results: 1 - 10 of 404152 matches for " Khilan M Shah "
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Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-κB pathway in carcinoma cells by inhibiting IKK phosphorylation
Robert Valentine, Christopher W Dawson, Chunfang Hu, Khilan M Shah, Thomas J Owen, Kathryn L Date, Sonia P Maia, Jianyong Shao, John R Arrand, Lawrence S Young, John D O'Neil
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-1
Abstract: In this report we demonstrate that EBNA1 inhibits the canonical NF-κB pathway in carcinoma lines by inhibiting the phosphorylation of IKKα/β. In agreement with this observation we find a reduction in the phosphorylation of IκBα and reduced phosphorylation and nuclear translocation of p65, resulting in a reduction in the amount of p65 in nuclear NF-κB complexes. Similar effects were also found in carcinoma lines infected with recombinant EBV and in the EBV-positive NPC-derived cell line C666-1. Inhibition of NF-κB was dependent upon regions of EBNA1 essential for gene transactivation whilst the interaction with the deubiquitinating enzyme, USP7, was entirely dispensable. Furthermore, in agreement with EBNA1 inhibiting p65 NF-κB we demonstrate that p65 was exclusively cytoplasmic in 11 out of 11 NPC tumours studied.Inhibition of p65 NF-κB in murine and human epidermis results in tissue hyperplasia and the development of squamous cell carcinoma. In line with this, p65 knockout fibroblasts have a transformed phenotype. Inhibition of p65 NF-κB by EBNA1 may therefore contribute to the development of NPC by inducing tissue hyperplasia. Furthermore, inhibition of NF-κB is employed by viruses as an immune evasion strategy which is also closely linked to oncogenesis during persistent viral infection. Our findings therefore further implicate EBNA1 in playing an important role in the pathogenesis of NPC.Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus that is associated with both lymphoid and epithelial tumours [1], including undifferentiated NPC where there is a near 100% association with EBV infection. Whilst the pattern of EBV latent protein expression varies in different tumour types the EBV nuclear antigen, Epstein-Barr nuclear antigen-1 (EBNA1), is expressed in all EBV-associated malignancies due to its indispensable role in the maintenance and replication of the EBV genome via sequence-specific binding to the viral origin of replication, oriP [2]. Furthermore
Sensitive Spectrofluorimetric Method for Determination of Fluoroquinolones through Charge-Transfer Complex Formation  [PDF]
Jasmin Shah, M. Rasul Jan, Inayat Ullah, Sultan Shah
American Journal of Analytical Chemistry (AJAC) , 2013, DOI: 10.4236/ajac.2013.410066

A sensitive spectrofluorimetric method was developed for determination of ciprofloxacin (CPFX), levofloxacin (LEV), gatifloxacin (GAT) and moxifloxacin (MOX) in pure, commercial formulations, human urine and plasma. The method is based on charge-transfer (CT) complex with chloranilic acid. Fluorescence intensity of the complexes was measured at emission wavelength ranging from 445-492 nm with excitation wavelengths from 285-330 nm. At optimum experimental conditions, a linear calibration plot was obtained in the concentration range of 20-1000 ng·mL-1, 60-320 ng·mL-1, 20-800 ng·mL-1 and 20 -00 ng·mL-1 for CPFX, LEV, MOX and GAT, respectively with good correlation coefficient in the range of 0.9929-1.0 in methanolic medium. The limit of detection and limit of quantification were found to be 5 ng·mL-1

Coconut oil compound ointment
Shah M
Indian Journal of Dermatology, Venereology and Leprology , 2003,
Urea ointment (40%)
Shah M
Indian Journal of Dermatology, Venereology and Leprology , 2003,
Castellani's paint
Shah M
Indian Journal of Dermatology, Venereology and Leprology , 2003,
Inequalities for the Polar Derivative of a Polynomial  [PDF]
Gulshan Singh, W. M. Shah, Yash Paul
Advances in Pure Mathematics (APM) , 2011, DOI: 10.4236/apm.2011.12006
Abstract: If is a polynomial of degree , having all its zeros in |z|≤K, K≥1 , then it was proved by Aziz and Rather [2] that for every real or complex number with |a| ≥K, . In this paper, we sharpen above result for the polynomials p(z) of degree n>3
Increased breath ethane and pentane concentrations in currently unmedicated patients with schizophrenia  [PDF]
Brian M. Ross, Sandeep Shah, Malcolm Peet
Open Journal of Psychiatry (OJPsych) , 2011, DOI: 10.4236/ojpsych.2011.11001
Abstract: Schizophrenia is a common and debilitating mental illness. The disorder is thought to be developmental in origin, with oxidative stress being implicated as possible pathophysiological mechanism. Breath alkanes provide a non-invasive means to assess oxidative stress, with ethane levels reportedly increased in medicated patients with schizophrenia. It is possible, however, that the psychotropic medications used to treat the disorder result in elevated breath ethane levels. We have therefore measured the concentration of ethane and pentane, markers of oxidative stress, in the breath of currently unmedicated patients with schizophrenia. Alveolar breath samples were collected, applied to thermal desorption tubes, and analyzed using a combination of two-stage thermal de-sorption, gas chromatography and mass spectrometry. Compared to healthy controls ethane and pentane levels were found to be elevated in patients with schizophrenia, while levels of butane were normal. Our data support the notion that oxidative stress is increased in schizophrenia and that this is unlikely to be a consequence of antipsychotic medications. In addition, breath alkane analysis may represent a rapid and non-invasive means to monitor oxidative stress occurring in schizophrenia.
Some Edge Product Cordial Graphs in the Context of Duplication of Some Graph Elements  [PDF]
Udayan M. Prajapati, Prakruti D. Shah
Open Journal of Discrete Mathematics (OJDM) , 2016, DOI: 10.4236/ojdm.2016.64021
Abstract: For a graph\"\", a function\"\" is called an edge product cordial labeling of G, if the induced vertex labeling function is defined by the product of the labels of the incident edges as such that the number of edges with label 1 and the number of edges with label 0 differ by at most 1 and the number of vertices with label 1 and the number of vertices with label 0 differ by at most 1. In this paper, we show that the graphs obtained by duplication of a vertex, duplication of a vertex by an edge or duplication of an edge by a vertex in a crown graph are edge product cordial. Moreover, we show that the graph obtained by duplication of each of the vertices of degree three by an edge in a gear graph is edge product cordial. We also show that the graph obtained by duplication of each of the pendent vertices by a new vertex in a helm graph is edge product cordial.
Performance Evaluation of Rectangular Microstrip Patch Antennas Loaded with Plastic and Barium-Titanate Substrates at GSM 1800 MHz Band  [PDF]
Mohammad Ababil Hossain, M. Shah Alam
Open Journal of Antennas and Propagation (OJAPr) , 2018, DOI: 10.4236/ojapr.2018.63004
In this paper, the resonance and radiation characteristics of patch antennas fabricated with two different types of dielectric substrates have been investigated and compared at GSM 1800 MHz band. At first, the above-stated characteristics of a patch antenna loaded with conventional plastic substrate have been investigated. Later a high permittivity dielectric material (barium titanate) has been used as the antenna substrate. The main goal here is to reduce the antenna size with a high permittivity dielectric material and then to compare its resonance and radiation performance with the earlier low permittivity substrate loaded prototype. It is found that with the use of high permittivity substrate the antenna volume gets smaller (about 6% of the plastic substrate prototype) although the gain decreases by around 2.5 dB.
Response of Wheat to Applied Soil Potassium
M. Tariq,M. Shah
Asian Journal of Plant Sciences , 2002,
Abstract: Response of wheat to applied potassium was studied on Peshawar valley soil. Different levels of potassium @ 0, 30, 60, 90, 120 and 150 kg K2O ha -1 along with a basal dose of nitrogen and phosphorus @ 150 kg N and 100 kg P2O5, respectively were applied to wheat. Results showed that yield and yield components of wheat were not significantly affected with potassium fertilization, because the test soil had already sufficient potassium for plant growth and might be some of K+ released from non-exchangeable sources. However, 60 kg K2O ha -1 gave maximum fresh, dry, straw and grain yields and indicated initial level of K2O supplemented with 60 kg K2O ha -1 was sufficient for maximum yields of wheat for the test soil. Potassium uptake by leaves and potassium content of soils at pre heading and post harvesting stages was significantly increased in a linear fashion with increasing applied potassium levels in soil.
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