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Search Results: 1 - 10 of 15005 matches for " Khalid El Akri "
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Using Multiple Linear Regression and Artificial Neural Network Techniques for Predicting CCR5 Binding Affinity of Substituted 1-(3, 3-Diphenylpropyl)-Piperidinyl Amides and Ureas  [PDF]
Rokaya Mouhibi, Mohamed Zahouily, Khalid El Akri, Na?ma Hanafi
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.31002

Quantitative structure–activity relationship (QSAR) models were developed to predict for CCR5 binding affinity of substituted 1-(3, 3-diphenylpropyl)-piperidinyl amides and ureas using multiple linear regression (MLR) and artificial neural network (ANN) techniques. A model with four descriptors, including Hydrogen-bonding donors HBD(R7), the partition coefficient between n-octanol and water logP and logP(R1) and Molecular weight MW(R7), showed good statistics both in the regression and artificial neural network with a configuration of (4-3-1) by using Bayesian and Leven-berg-Marquardt Methods. Comparison of the descriptor’s contribution obtained in MLR and ANN analysis shows that the contribution of some of the descriptors to activity may be non-linear.

Physicochemical 2D-Qsar and 3D Molecular Docking Studies on N-Chlorosulfonyl Isocyanate Analogs as Sterol O-Acyl-Transferase-1 “Soat-1” Inhibitors  [PDF]
Khalid El Akri, Rokaya Mouhibi, Mohamed Zahouily, Na?ma Hanafi, Moulay Abdellah Bahlaoui
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.34013
Abstract: A series of N-carbonyl-functionalized ureas, carbamates and thiocarbamates derivatives (or N-Chloro sulfonyl isocyanate
“N-CSI”) were involved in linear and nonlinear physicochemical quantitative structure-activity relationship
“QSAR” analysis to find out the structural keys to control the inhibition against Sterol O-Acyl-Transferase-1 “SOAT-1”.
The results indicate the important effects of geometrical and chemical descriptors on the inhibitory activity of SOAT-1.
The molecules were also screened for three-dimensional molecular docking on the crystal structure of ACAT-1 (1WL5
for ACAT-1, PDB). A comparison between 2D-QSAR and 3D molecular docking studies shows that the latter confirm
the first results and represent a good prediction of the chemical and physical nature of interactions between our drug
molecules and enzyme SOAT-1.
Bioadsorption of Pb(II) onto Anethum graveolens from Contaminated Wastewater: Equilibrium and Kinetic Studies  [PDF]
Ali Hashem, Khalid El-Khiraigy
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.41012

In the present study we reported the feasibility of the Anethum graveolens as biosorbent to remove Pb(II) from aqueous solutions. Anethum graveolens was characterized by scanning electron microscopy and elemental analysis. The ability of Anethum graveolens to adsorb Pb(II) was investigated by using batch adsorption procedure. The effects such as pH, contact time, adsorbate concentration and biosorbent dosage on the adsorption capacity were studied. The experimental data were analysed using various adsorption kinetic models viz., the pseudo-first and second-order equations, Bangham’s equation, intraparticle diffusion and Elovich models. Results show that the pseudo-second-order equation provides the best correlation for the biosorption process. The equilibrium nature of Pb(II) adsorption at 30 has been described by the Langmuir, Freundlich, Temkin and Redlich-Peterson isotherm models. The equilibrium data fit well on Langmuir isotherm. The monolayer adsorption capacity of Pb(II) onto Anethum graveolens as obtained from Langmuir isotherm at 30 was found to be 303 mg/g. This high adsorption capacity of Anethum graveolens places this biosorbent as one of the best adsorbents for removal of Pb(II) from aqueous effluents.

A Rare Cause of Stomach Gangrene: Necrotizing Gastritis  [PDF]
Hicham El Bouhaddouti, Tarik Souiki, Khalid Mazine, Abdelmalek Ousadden, Khalid Mazaz, Khalid Ait Taleb
Open Journal of Gastroenterology (OJGas) , 2015, DOI: 10.4236/ojgas.2015.52002
Abstract: Necrosis of the stomach is rare. It occurs when there is vascular anomalies, gastric volvulus or her-niation and in infectious gastritis. We report a case in which infectious gastritis leads to a necrotiz-ing gastritis that is treated with urgent gastrectomy.
A Cubic Spline Method for Solving a Unilateral Obstacle Problem  [PDF]
El Bekkey Mermri, Abdelhafid Serghini, Abdelmajid El hajaji, Khalid Hilal
American Journal of Computational Mathematics (AJCM) , 2012, DOI: 10.4236/ajcm.2012.23028
Abstract: This paper, we develop a numerical method for solving a unilateral obstacle problem by using the cubic spline collocation method and the generalized Newton method. This method converges quadratically if a relation-ship between the penalty parameter and the discretization parameter h is satisfied. An error estimate between the penalty solution and the discret penalty solution is provided. To validate the theoretical results, some numerical tests on one dimensional obstacle problem are presented.
Primary breast leiomyosarcoma: case report and literature review  [PDF]
Fatima Zahra EL M’rabet, Hanane El kacemi, Omar El Mesbahi, Khalid El Hassouni, Brahim khalil El Gueddari
Health (Health) , 2011, DOI: 10.4236/health.2011.310104
Abstract: PURPOSE: Leiomyosarcoma of the breast is extremely rare. To date, the factors that are predictive of patient prognosis have not been identified. To clarify the nature of leiomyosarcoma of the breast, and also to establish the proper treatment strategy, we report this case We report this case while discussing The Clinical presentation, diagnosis, therapy and pathologic feature. INTRODUCION: Sarcomas comprise less than 1% of all primary breast neoplasms and only a minority of these are leiomyosarcomas. There were only 35 cases being reported in English literature. The mainstay of treatment is surgical excision with clear margins and longterm followup is essential. Its prognosis is better compared to other breast sarcoma. CASE PRESENTATION: We report a case of primary leiomyosarcoma of the breast occurring in young female patient which was successfully treated by surgery and radiotherapy. CONCLUSION: According to literature data, primary leiomyosarcoma is characterized by a better prognosis compared with other breast sarcomas, To date, the factors that are predictive of patient prognosis have not been identified. .The rarity and diagnostic difficulty imposed a multidisciplinary approach.
Surgical Bypass versus Endoscopic Stenting for Unresectable Head Pancreatic Cancer, Which Palliative Treatment Is Better in Developing Countries, Morocco as an Example  [PDF]
Khalid Mazine, Hamdaoui Mohammed, El Ghazi Karima, Ousadden Abdelmalek, Mazaz Khalid, Ibrahimi Adil, Ait Taleb Khalid, Benajeh Dafrallah, Benjelloun Elbachir
Open Journal of Gastroenterology (OJGas) , 2017, DOI: 10.4236/ojgas.2017.75017
Abstract: Background: Metal stents for unresectable pancreatic cancer are associated with longer patency and superior cost-effectiveness. However, they are too expensive to be recommended routinely in developing countries. Moreover, a debate on outcome results in these patients who receive plastic biliary endoprothesis versus surgical bypass as palliation of obstructive jaundice. We aimed to compare retrospectively the outcomes in patients treated with plastic stent or surgical bypass as a palliative option for these patients. Patients and Methods: We have examined data for patients (n = 86) who received endoscopic stenting (n = 64) or surgical bypass (n = 22), from January 2013 to November 2016, as a palliative treatment for obstructive jaundice from inoperable cancer head pancreas. Results: Serum bilirubin and CA19.9 levels were comparable in age and gender matched patient groups. Moreover, post-operative major complications and 30-days mortality showed no significant differences among patient groups. However, surgical bypass treated patients showed longer initial hospital stay (9 vs. 6 days, p = 0.014), higher cost ($1600 vs. $1088) and longer survival (192 vs. 101 days, p = 0.003) compared to endoscopy-stenting treated patients. Re-hospitalization was required for 5 stented patients (averaged $448). Conclusion: Biliary bypass surgery for unresectable pancreatic cancer may improve patient survival, although prolongs hospital stay. It may be recommended for relatively fit patients with a life expectancy of 6 months and more.
Productivity Improvement Model without Increasing Operation’s Risk and Fatigue  [PDF]
Adel Al-Shayea, Abdulaziz El-Tamimi, Khalid Al-Saleh, Khalid Al-Yami
Engineering (ENG) , 2011, DOI: 10.4236/eng.2011.311140
Abstract: Productivity improvement of an operation without increasing operation risk and operation fatigue that increase the needed relaxation allowance is an important subject in process design. This research subject stimulates researchers to focus on improving the productivity of the whole production process by changing the technique of performing significant operations in the process. However, two important issues that affect the implementation of any new technique were not considered in the pervious research works. These are the risk magnitude of the new technique on the workplace environment and the fatigue level that affect human's health. In this paper, a model was developed that maximize the productivity of the production process by selecting the best technique to perform significant process operations among proper candidate techniques that improve these operations productivity while minimizing these operations risk and fatigue.
Annular pancreas producing duodenal obstruction: A case report  [PDF]
Abdesslam Bouassria, Hicham Elbouhaddouti, Ouadii Mouaqit, El Bachir Benjelloun, Abdelmalek Ousadden, Khalid Mazaz, Khalid Ait Taleb
Open Journal of Gastroenterology (OJGas) , 2013, DOI: 10.4236/ojgas.2013.33032

Annular pancreas is a rare congenital anomaly characterized by the presence of ectopic pancreatic tissue surrounding the duodenum. This malformation is usually asymptomatic in adults, but can manifests as pancreatitis, duodenal stenosis, or duodenal or gastric ulceration. We report the case of a young patient of 18 years old hospitalized for epigastric pain and vomiting, in whom radiological investigations showed an annular pancreas. At operation, a complete obstruction of the duodenum between its first and second parts was found, caused by an annular pancreas. No other congenital anomaly of the intra abdominal organs was noted. A gastroenterostomy was performed. Both the rarity of this congenital abnormality and its successful correction by surgical means have prompted us to make the following presentation.

Hemobilia Due to an Iatrogenic Arteriobiliary Fistula Complicating Laparoscopic Cholecystectomy: A Case Report  [PDF]
Hicham El Bouhaddouti, Khalid Mazine, Abdesslam Bouassria, Ouadii Mouaqit, Elbachir Benjelloun, Abdelmalek Ousadden, Khalid Ait Taleb
Open Journal of Gastroenterology (OJGas) , 2014, DOI: 10.4236/ojgas.2014.46040
Abstract: Hemobilia is the result of a pathological communication between bile duct and intra or extrahepatic vessel. 40% to 60% of the haemobilia cases are Iatrogenic, and the other causes are either vascular malformations or hepatic blunt trauma. We describe the case history of a patient in which laparoscopic cholecystectomy was complicated 3 months later by massive hemobilia. The cause of haemorrhage was a fistula between the principal bil duct and the right hepatic artery. This complication was successfully managed by surgery and angiographic embolization with full recovery of the patient.
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