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Search Results: 1 - 10 of 9359 matches for " Keum-Soo Park "
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9G DNAChip Technology: Self-Assembled Monolayer (SAM) of ssDNA for Ultra-Sensitive Detection of Biomarkers
Satish Balasaheb Nimse,Keum-Soo Song,Junghoon Kim,Danishmalik Rafiq Sayyed,Taisun Kim
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14035723
Abstract: A 9G DNAChip obtained by allowing the formation of a self-assembled monolayer (SAM) of oligonucleotides appended with nine consecutive guanines on the chip surface has been applied in the detection of biomarkers. Using a 9G DNAChip, biomarker in the concentration range of 4 pg/mL to 40 fg/mL can be easily differentiated in the buffer matrix. Moreover, it is the first time that a biomarker with a concentration of 40 fg/mL has been detected in a mixture of proteins without use of any signal amplification technique.
HPV Genotyping 9G Membrane Test
Danishmalik Rafiq Sayyed,Keum-Soo Song,Satish Balasaheb Nimse,Heejung An,Junghoon Kim,Taisun Kim
Viruses , 2013, DOI: 10.3390/v5112840
Abstract: The results of the genital human papillomavirus (HPV) detection in 439 cervical samples by cervical cytology were compared with sequencing analysis and a newly developed HPV genotyping 9G membrane test. The excellent sensitivity and specificity of the HPV genotyping 9G membrane test was assured by a signal to noise ratio of more than 300 and a target hybridization to non-target hybridization ratio of 300 ~ 400 at 25 °C. The final results can be obtained in 29 min by simple loading of the hybridization and washing solutions and scanning the membranes without any drying steps or special handling. The 100% identical results of the HPV genotyping 9G membrane test with sequencing results in 439 clinical samples demonstrate significant clinical application for this test. HPV genotyping 9G membrane tests can identify and discriminate five HR-HPV genotypes which are prevalent in almost 87% of cervical cancer cases. Its simple handling makes the HPV genotyping 9G membrane test a very convenient platform for accurate HPV genotyping.
Efficacies of the new Paclitaxel-eluting Coroflex Please? Stent in percutaneous coronary intervention; comparison of efficacy between Coroflex Please? and Taxus? (ECO-PLEASANT) trial: study rationale and design
Jae-Bin Seo, Hui-Kyung Jeon, Kyung-Woo Park, Jong-Seon Park, Jang-Ho Bae, Sang-Wook Kim, Keon-Woong Moon, Jae-Woong Choi, Sang-Gon Lee, Woo-Young Chung, Tae-Jin Youn, Soo-Joong Kim, Doo-Il Kim, Byung-Ok Kim, Min-Su Hyon, Keum-Soo Park, Tae-Joon Cha, Hweung-Kon Hwang, Seung-Ho Hur, Hyo-Soo Kim
Trials , 2009, DOI: 10.1186/1745-6215-10-98
Abstract: In the comparison of Efficacy between COroflex PLEASe? ANd Taxus? stent(ECO-PLEASANT) trial, approximately 900 patients are being prospectively and randomly assigned to the either type of Coroflex Please? stent and Taxus Liberte? stent via web-based randomization. The primary endpoint is clinically driven target vessel revascularization at 9 months. The secondary endpoints include major cardiac adverse events, target vessel failure, stent thrombosis and angiographic efficacy endpoints.The ECO-PLEASANT trial is the study not yet performed to directly compare the efficacy and safety of the Coroflex Please? versus Taxus Liberte? stent. On the basis of this trial, we will be able to find out whether the Coroflex Please? stent is non-inferior to Taxus Liberte? stent or not.ClinicalTrials.gov number, NCT00699543.Previous randomized trials have shown the efficacy of a slow-release polymeric sirolimus-eluting stent (Cypher?, Cordis, Warren, NJ, USA), paclitaxel-eluting stent (Taxus?, Boston Scientific, Natick, MA, USA), and zotarolimus-eluting stent (Endeavor?, Medtronic, Minneapolis, MN, USA) over bare metal stents in reducing neointimal hyperplasia, late luminal loss, and angiographic restenosis leading to decreased target lesion revascularization [1-11] The Paclitaxel-eluting Coroflex Please? stent is a newly developed drug eluting stent using the Coroflex? stent platform combined with the drug paclitaxel contained in a polymer coating[12]In the PECOPS I, which was one-arm observational study, the results of Coroflex Please? stent were within the range of other Paclitaxel-eluting coronary stents [12,13] Compared with binary restenosis rate of 7.9% in Taxus IV trial, Coroflex? Please stent showed 7.8% of restenosis rate[7] The 3.1% of 30 day MACE rate is within the range of other trials with stents eluting Paclitaxel or Sirolimus. The 6 month MACE rates in PECOPS I were 8.0%, which was similar to 7.8%, and 8.5% in Taxus II MR and SR, respectively[6] In Taxus IV, 9 month f
Correlation between Coating Adhesion and Damage Threshold: Simple Method of Reliability Assessment for Optoelectronic Applications  [PDF]
Jongwoo Park, Dong-Soo Shin
Optics and Photonics Journal (OPJ) , 2015, DOI: 10.4236/opj.2015.54011
Abstract: It is demonstrated that inherent coating adhesion and damage threshold are correlated for Ta2O5 and HfO2 coatings widely used in optoelectronic devices. By utilizing a newly proposed 1-h boiling water test combined with the optical aging under high-power laser irradiation, we show that an optical coating that survives the 1-h boiling water test withstands the damage threshold, ensuring the field service life even in harsh environments. Besides the standard evaluation methods, which may have limitations for applications required in harsh environments, the 1-h boiling water test can serve as an alternative method of reliability assessment for optical coatings. A heuristics herein can be used as a gating item for qualification of optical coatings for various applications.
Atmospheric Dispersion and Deposition of Radionuclides (137Cs and 131I) Released from the Fukushima Dai-ichi Nuclear Power Plant  [PDF]
Soon-Ung Park, Anna Choe, Moon-Soo Park
Computational Water, Energy, and Environmental Engineering (CWEEE) , 2013, DOI: 10.4236/cweee.2013.22B011
Abstract: The Lagrangian Particle Dispersion Model (LPDM) in the 594 km× 594 km model domain with the horizontal grid scale of 3 km×3 km centered at a power plant and the Eulerian Transport Model (ETM) modified from the Asian Dust Aerosol Model 2 (ADAM2) in the domain of 70° LAT × 140° LON with the horizontal grid scale of 27 km×27 km have been developed. These models have been implemented to simulate the concentration and deposition of radionuclides (137Cs and 131I) released from the accident of the Fukushima Dai-ichi nuclear power plant. It is found that both models are able to simulate quite reasonably the observed concentrations of 137Cs and 131I near the power plant. However, the LPDM model is more useful for the estimation of concentration near the power plant site in details whereas the ETM model is good for the long-range transport processes of the radionuclide plume. The estimated maximum mean surface concentration, column integrated mean concentration and the total deposition (wet+dry) by LPDM for the period from 12 March to 30 April 2011 are, respectively found to be 2.975 × 102 Bq m-3, 3.7 × 107 Bq m-2, and 1.78 × 1014 Bq m-2 for 137Cs and 1.96 × 104 Bq m-3, 2.24 × 109 Bq m-2 and 5.96 × 1014 Bq m-2 for 131I. The radionuclide plumes released from the accident power plant are found to spread wide regions not only the whole model domain of downwind regions but the upwind regions of Russia, Mongolia, Korea, eastern China, Philippines and Vietnam within the analysis period.
Evaluation of the Shear Strength of Perfobond Rib Connectors in Ultra High Performance Concrete  [PDF]
Jae Yoon Kang, Jong Sup Park, Woo Tai Jung, Moon Seoung Keum
Engineering (ENG) , 2014, DOI: 10.4236/eng.2014.613089
Abstract: Since the previous strength prediction models for the perfobond rib connector were proposed based upon the results of push-out tests conducted on concretes with compressive strength below 50 MPa, push-out test is performed on perfobond shear connectors applying ultra high performance concretes with compressive strength higher than 80 MPa to evaluate their shear resistance. The test variables are chosen to be the diameter and number of dowel holes and, the change in the shear strength of the perfobond rib connector is examined with respect to the strength of two types of UHPC: steel fiber-reinforced concrete with compressive strength of 180 MPa and concrete without steel fiber with compressive strength of 80 MPa. The test results reveal that higher concrete strength and larger number of holes increased the shear strength, and that higher increase rate in the shear strength was achieved by the dowel action. The comparison with the predictions obtained by the previous models shows that the experimental results are close to the values given by the model proposed by Oguejiofor and Hosain [1].
Connection between Concrete Layers with Different Strengths  [PDF]
Jae Yoon Kang, Jong Sup Park, Woo Tai Jung, Moon Seoung Keum
Engineering (ENG) , 2015, DOI: 10.4236/eng.2015.77032
Abstract: As part of a research intending to develop steel-concrete hybrid girder using ultra high performance concrete with compressive strength of 80 MPa, this study conducts loading test on this girder to investigate the methods for its composition with a slab using 30 MPa-concrete and the corresponding interfacial behavior. Prior to the loading test, the design formula of the Eurocode for the shear resistance developed in concrete-to-concrete interface is examined for the interface between concrete layers of different strengths. The effect of the surface roughness on the shear resistance is examined using this formula and finite element analysis to verify the applicability of the formula. Based upon the results, loading test is conducted on girder specimens to evaluate the actual behavior with respect to the interfacial surface condition. The test results reveal that the specimen with rough interface could not develop perfectly composite behavior and experienced adhesive failure. In case of simultaneous action of flexure and shear, it appears that conservative design should be applied without consideration of the interfacial condition when determining the arrangement of shear reinforcement.
Construction of surfaces of general type from elliptic surfaces via Q-Gorenstein smoothing
JongHae Keum,Yongnam Lee,Heesang Park
Mathematics , 2010,
Abstract: We present methods to construct interesting surfaces of general type via $\mathbb{Q}$-Gorenstein smoothing of a singular surface obtained from an elliptic surface. By applying our methods to special Enriques surfaces, we construct new examples of a minimal surface of general type with $p_g=0$, $\pi_1=\mathbb{Z}/2\mathbb{Z}$, and $K^2\le 4$.
Shear Behavior in Indented Concrete Layers with Different Strengths  [PDF]
Jae-Yoon Kang, Jong-Sup Park, Woo-Tai Jung, Moon-Seoung Keum
Engineering (ENG) , 2016, DOI: 10.4236/eng.2016.87039
Abstract: This paper investigates the design formula for the shear strength at the concrete-to-concrete interface proposed in Eurocode with regard to concrete layers with different strengths. Based upon the results of the study on the applicability of the design formula, push-off test is conducted on specimens with various indented interfaces to evaluate the actual behavior with respect to the surface roughness. The experimental results reveal that the interfacial shear strength increases with higher compressive strength of the concrete layers presenting different strengths and that the shear strength at the indented interface differs by 20% to 50% compared to the value predicted by the design formula. Especially, the shear strength developed between the concrete layers with different strengths appears to be different from the prediction of the design formula as much as the layers present larger difference in their compressive strengths.
Effects of Thermal and Solvent Aging on Breakdown Voltage of TPE, PBT/PET Alloy, and PBT Insulated Low Voltage Electric Wire
Eun-Soo Park
Journal of Polymers , 2013, DOI: 10.1155/2013/493731
Abstract: Tests were performed to evaluate the effects of thermal and solvent aging on the mechanical and dielectric breakdown properties of four types of polyester resins, namely, the insulation layer of poly(butylene terephthalat) (PBT)- based thermoplastic elastomer (TPE, TPE1), poly(butylene 2,6-naphthalate)-based TPE (TPE2), PBT/poly(ethylene terephthalate) alloy (Alloy), and PBT extruded onto a copper conductor of low voltage electric wire. The tensile specimens used in this series were prepared from the same extruded resins. The prepared electric wires and tensile specimens were thermally aged in air and in toluene, xylene, TCB, and NMP. When Alloy and PBT were thermally aged in toluene, xylene and TCB at 120°C for 6?h, the tensile properties were significantly decreased compared to TPE1 and TPE2 at the same condition. The reduction of elongation at break of Alloy was more discernible than that of PBT. This result indicated that Alloy is more affected by thermal and solvent ageing. Among them, TPE2 showed the highest breakdown voltage (BDV), and it has also the highest BDV after thermal and solvent aging. 1. Introduction The service life of electric wire is determined by the condition of the insulating material. Insulations are commonly used as a flexible polymer coating on electric wire. Defects such as voids, contaminants, and scratches in the insulation structure lead to electrical failure in polymer insulted wires [1–4]. Thermoplastic polyesters, enclosing poly(ethylene terephthalate) (PET), poly(butylene terephthalate) (PBT), copolymers, and blends, are widely used for electrical and electronic applications such as switching transformers, inverters, and information and telecommunications equipment due to their good electrical insulation and dielectric properties. Many manufacturers of transformers get electrical insulating varnishes for secondary insulation and have to apply and transform them using a chemical curing process. The insulating varnish is applied to coils of polyester insulated wire, in the process of which it fills the gaps and micropores, and after curing it forms into a continuous resin film. It is important for mechanical stability and protection of coiled wire against dust, moisture, and chemicals which might cause insulation deterioration. Thereby, leakage currents or short circuits can be avoided so that safe and reliable electrical products can be produced [5]. However, the insulating varnishes, which are provided for this purpose, are highly reactive materials. They are usually included in one or more solvents, such as toluene,
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