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Search Results: 1 - 10 of 904 matches for " Kerstin Sollerbrant "
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Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs
Christian A Shaw, Paul C Holland, Michael Sinnreich, Carol Allen, Kerstin Sollerbrant, George Karpati, Josephine Nalbantoglu
BMC Cell Biology , 2004, DOI: 10.1186/1471-2121-5-42
Abstract: Using antibodies directed against the extracellular and the cytoplasmic domains of CAR, we show CAR in normal human and mouse skeletal muscle to be a novel component of the neuromuscular junction. In cardiac muscle, CAR immunoreactivity is observed at the level of intercalated discs. We demonstrate a single isoform of CAR to be expressed exclusively at the human neuromuscular junction whereas both predominant CAR isoforms are expressed at the intercalated discs of non-diseased human heart.The localization of CAR to these important junctional complexes suggests that CAR may play both a structural and a regulatory role in skeletal and cardiac muscle, and that these complexes may serve as a point of entry for Coxsackie B virus.The Coxsackie and adenovirus receptor (CAR) [1,2], a transmembrane protein of the immunoglobulin super-family, serves as a receptor for adenovirus (Ad) subgroups A, C, D, E and F [3] as well as Coxsackie B viruses (CVB) [4]. CAR is a highly conserved protein with two predominant isoforms, produced through differential splicing, and having cytoplasmic domains of either 107 residues (ending in SIV) or 94 residues (ending in TVV) [2,5]. The extracellular domain mediates homophilic cell adhesion [6-8] and ectopically-expressed CAR localizes to homotypic intercellular contacts [8]. The expression of CAR is regulated developmentally [6,9-12] as well as in a tissue-specific manner [2,5]. To date, most studies on CAR expression in the adult have resorted to analysis of transcript levels. These have revealed that the pattern of tissue-specific expression differs between humans and mice. In humans, a predominant transcript of ~6 – 6.5 kb is observed in heart, testis, prostate and pancreas while much less expression is detected in liver, brain, colon and small intestine. In the mouse on the other hand, the most abundant expression is in liver, kidney, lung and heart.Interest in CAR stems from its function as the primary high affinity receptor for Ad serotyp
Essential Role of the Coxsackie - and Adenovirus Receptor (CAR) in Development of the Lymphatic System in Mice
Momina Mirza, Mei-Fong Pang, Mohamad Amr Zaini, Paula Haiko, Tuomas Tammela, Kari Alitalo, Lennart Philipson, Jonas Fuxe, Kerstin Sollerbrant
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037523
Abstract: The coxsackie- and adenovirus receptor (CAR) is a cell adhesion molecule predominantly associated with epithelial tight junctions in adult tissues. CAR is also expressed in cardiomyocytes and essential for heart development up to embryonic day 11.5, but not thereafter. CAR is not expressed in vascular endothelial cells but was recently detected in neonatal lymphatic vessels, suggesting that CAR could play a role in the development of the lymphatic system. To address this, we generated mice carrying a conditional deletion of the CAR gene (Cxadr) and knocked out CAR in the mouse embryo at different time points during post-cardiac development. Deletion of Cxadr from E12.5, but not from E13.5, resulted in subcutaneous edema, hemorrhage and embryonic death. Subcutaneous lymphatic vessels were dilated and structurally abnormal with gaps and holes present at lymphatic endothelial cell-cell junctions. Furthermore, lymphatic vessels were filled with erythrocytes showing a defect in the separation between the blood and lymphatic systems. Regionally, erythrocytes leaked out into the interstitium from leaky lymphatic vessels explaining the hemorrhage detected in CAR-deficient mouse embryos. The results show that CAR plays an essential role in development of the lymphatic vasculature in the mouse embryo by promoting appropriate formation of lymphatic endothelial cell-cell junctions.
Multiple Phenotypes in Adult Mice following Inactivation of the Coxsackievirus and Adenovirus Receptor (Car) Gene
Ahmad Pazirandeh, Taranum Sultana, Momina Mirza, Bj?rn Rozell, Kjell Hultenby, Karin Wallis, Bj?rn Vennstr?m, Ben Davis, Anders Arner, Rainer Heuchel, Matthias L?hr, Lennart Philipson, Kerstin Sollerbrant
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0020203
Abstract: To determine the normal function of the Coxsackievirus and Adenovirus Receptor (CAR), a protein found in tight junctions and other intercellular complexes, we constructed a mouse line in which the CAR gene could be disrupted at any chosen time point in a broad spectrum of cell types and tissues. All knockouts examined displayed a dilated intestinal tract and atrophy of the exocrine pancreas with appearance of tubular complexes characteristic of acinar-to-ductal metaplasia. The mice also exhibited a complete atrio-ventricular block and abnormal thymopoiesis. These results demonstrate that CAR exerts important functions in the physiology of several organs in vivo.
Active and Healthy Ageing at Work—A Qualitative Study with Employees 55 - 63 Years and Their Managers  [PDF]
Kerstin Nilsson
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.57002
Abstract: The proportion of elderly individuals in the population is increasing in most industrial countries. This demographic change increases the need of more people who work until an older age to maintain the welfare in the states. However, it is not clear if older employees are interested to in generally extend the working life to an older age. It is also not stated if managers in organizations are interested of extending their older employees working life. The overall aim of this study was to examine older employees own experience of their work situation and ageing at work. The aim was also to investigate their managers’ attitude to them as older employees. The investigation was conducted by focusing group interviews with employees aged 55 - 63 years, and with their mangers aged 40 - 63 years. The findings stated that the older employees’ consideration for an extend working life seemed to be based on their health and health problems in relation to their work situation; their personal economy; their managers attitude to them as elderly and the possibility to social inclusion at work; and their possibilities for self-crediting activities at work despite their age. The managers seem to have a positive attitude to some of the older employees’ experience knowledge, if that was in the same direction as their own interest. Otherwise the mangers saw the older employees as problem and obsoleted. The managers were also negative to older employees who got health problems which effect the work production negatively. The older workers in this study described managers’ importance to if they want to work in an extended working life. However, the managers seem not to understand their own importance in this and were not interested to keep all elderly in an extended working life.
The Influence of Work Environmental and Motivation Factors on Seniors’ Attitudes to an Extended Working Life or to Retire. A Cross Sectional Study with Employees 55 - 74 Years of Age  [PDF]
Kerstin Nilsson
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.57003
Abstract: Aim: The aim of this study was to investigate difference between whether individuals think they can work, and want to work until 65 years or not. Methods: A cross/sectional study including survey of 1949 employees aged 55 - 74 years. Results: Working environments were the most significant differences between the groups associated to if the respondents think they can work beyond 65 years or not. Motivation factors were the most significant differences between the groups associated with if the respondents want to work beyond 65 years or not. Conclusions: A satisfying work environment is important to whether people think they can work or not. Nevertheless, whether people want to work is depending on whether the employees are satisfied with the factors that promote their motivation for work. If society wants more people to work until an upper age, it is important to improve both work environmental factors and motivation factors in their work situation.
An internet-based intervention program for supporting families with prematurely born infants  [PDF]
Birgitta Lindberg, Kerstin ?hrling
Open Journal of Nursing (OJN) , 2012, DOI: 10.4236/ojn.2012.22012
Abstract: The purpose of this paper was to describe the development, planning and implementing of an internet-based intervention program for providing support to families with prematurely born infants. During the families initial stay at home with their infant; families were given access to use of videoconference system from their home to have contact with staff at the neonatal unit, via direct link, throughout twenty-four hours. This program successfully ended, and video-conferencing is incorporated as a tool to support families after coming home. Probably, a variety of factors has contributed to make this program successful, as for example user friendliness and the close collaboration between researchers and staff at the neonatal unit. In conclusion, Information and Communication Technology (ICT) must be taken into consideration in developing upcoming care, thereby making possible a program to extend accessibility to health care.
The Transfer of Knowledge between Younger and Older Employees in the Health and Medical Care: An Intervention Study  [PDF]
Emma Nilsson, Kerstin Nilsson
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.57006
Abstract: In the ageing society more old employees need to stay in working life for longer. However, the society also needs to take care of the increased amount of elderly in a more effective and respectful way. To take care of older employees experience knowledge to make the elderly care and the care employees work situation better and self-crediting to go on in an extended working life, new methods and measures are needed to be developed and evaluated. The overall purpose of this article was to evaluate how the participant in the intervention project experienced the project and its methodology. The intervention project followed three different methods: i) through interviews of the participants and the supervisor; ii) through participant observation; and iii) through an evaluation questionnaire to participants after the project was completed. The intervention project did transfer knowledge between different fields, that are, between generations, between different departments and between the municipality and county. The participation was described as not only a place for reflection and knowledge, but also a protected zone where participants could talk about the kind of problems they would ponder over. Several participants felt that it was important to develop and continue the work that the intervention project set in motion. The participants’ experience was made to be visible and their professional competence has been strengthened. They indicated that there had been an exchange of knowledge and between not only the generations but also the different kinds of work. The organisations also seem to have gained from the project by allowing the participants to unload, become more positive, develop more knowledge of experience, increase their propensity for reflection and get a better consensus between the municipality and county. The intervention project seems to have fulfilled the stated purpose and also the expectations of the participants.
Undeserving men and patronised women
Kerstin Stenius
Nordic Studies on Alcohol and Drugs , 2011, DOI: 10.2478/v10199-011-0019-y
Problematising survey measures of harms and risks of illicit drug use
Kerstin Stenius
Nordic Studies on Alcohol and Drugs , 2011, DOI: 10.2478/v10199-011-0011-6
Different liberalisms and alcohol policies
Kerstin Stenius
Nordic Studies on Alcohol and Drugs , 2012, DOI: 10.2478/v10199-012-0014-y
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