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Search Results: 1 - 10 of 916 matches for " Kerstin Borgmann "
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Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy
Annette Raabe, Katharina Derda, Sebastian Reuther, Silke Symczak, Kerstin Borgmann, Ulrike Hoeller, Andreas Ziegler, Cordula Petersen, Ekkehard Dikomey
Radiation Oncology , 2012, DOI: 10.1186/1748-717x-7-65
Abstract: Retrospective analysis of 83 breast cancer patients treated with breast conserving radiotherapy. A total dose of 50.4?Gy was administered, applying 1.8?Gy/fraction within 42?days. Erythema was evaluated according to the Radiation Therapy Oncology Group (RTOG) score. DNA was extracted from blood samples and polymorphisms were determined using either the Polymerase Chain Reaction based Restriction-Fragment-Length-Polymorphism (PCR-RFL) technique or Matrix-Assisted-Laser-Desorption/Ionization –Time-Of-Flight-Mass-Spectrometry (MALDI-TOF). Relative excess heterozygosity (REH) was investigated to check compatibility of genotype frequencies with Hardy-Weinberg equilibrium (HWE). In addition, p-values from the standard exact HWE lack of fit test were calculated using 100,000 permutations. HWE analyses were performed using R.Fifty-six percent (46/83) of all patients developed erythema of grade 2 or 3, with this risk being higher for patients with large breast volume (odds ratio, OR?=?2.55, 95% confidence interval, CI: 1.03–6.31, p?=?0.041). No significant association between SNPs and risk of erythema was found when all patients were considered. However, in patients with small breast volume the TGFB1 SNP was associated with erythema (p?=?0.028), whereas the SNP in XPD showed an association in patients with large breast volume (p?=?0.046). A risk score based on all risk alleles was neither significant in all patients nor in patients with small or large breast volume. Risk alleles of most SNPs were different compared to a previously identified risk profile for fibrosis.The genetic risk profile for erythema appears to be different for patients with small and larger breast volume. This risk profile seems to be specific for erythema as compared to a risk profile for fibrosis.
La tecnología y la búsqueda de la felicidad
Revista iberoamericana de ciencia tecnolog?-a y sociedad , 2005,
Abstract: the connection between technology and happiness is a challenge to philosophy. it can be met if we understand technology as the process of commodification that is guided by a characteristic pattern-the device paradigm, and if we distinguish between happiness as the consumption of pleasures and moral excellence as the devotion to focal things and practices. these clarifications and distinctions allow us relocate and redeem pleasure and to envision a life wherein pleasure and virtue are joined to yield genuine happiness.
La tecnología y la búsqueda de la felicidad
Albert Borgmann
Revista iberoamericana de ciencia tecnolog?-a y sociedad , 2005,
Abstract: La conexión entre tecnología y felicidad es un desafío para la filosofía. Este desafío puede enfrentarse si entendemos la tecnología como un proceso de mercantilización que es guiado por un patrón característico- el paradigma del dispositivo, y si diferenciamos entre la felicidad como el consumo de placeres y la excelencia moral como la devoción de cosas y prácticas focales. Estas clarificaciones y distinciones nos permiten reubicar y redimir el placer y avizorar una vida donde el placer y la virtud se encuentren reunidos para dar lugar a una genuina felicidad. The connection between technology and happiness is a challenge to philosophy. It can be met if we understand technology as the process of commodification that is guided by a characteristic pattern-the device paradigm, and if we distinguish between happiness as the consumption of pleasures and moral excellence as the devotion to focal things and practices. These clarifications and distinctions allow us relocate and redeem pleasure and to envision a life wherein pleasure and virtue are joined to yield genuine happiness.
Biomarkers and Mechanisms of FANCD2 Function
Henning Willers,Lisa A. Kachnic,Chen-Mei Luo,Li Li,Martin Purschke,Kerstin Borgmann,Kathryn D. Held,Simon N. Powell
Journal of Biomedicine and Biotechnology , 2008, DOI: 10.1155/2008/821529
Abstract: Genetic or epigenetic inactivation of the pathway formed by the Fanconi anemia (FA) and BRCA1 proteins occurs in several cancer types, making the affected tumors potentially hypersensitive to DNA cross-linkers and other chemotherapeutic agents. It has been proposed that the inability of FA/BRCA-defective cells to form subnuclear foci of effector proteins, such as FANCD2, can be used as a biomarker to aid individualization of chemotherapy. We show that FANCD2 inactivation not only renders cells sensitive to cross-links, but also oxidative stress, a common effect of cancer therapeutics. Oxidative stress sensitivity does not correlate with FANCD2 or RAD51 foci formation, but associates with increased H2AX foci levels and apoptosis. Therefore, FANCD2 may protect cells against cross-links and oxidative stress through distinct mechanisms, consistent with the growing notion that the pathway is not linear. Our data emphasize the need for multiple biomarkers, such as H2AX, FANCD2, and RAD51, to capture all pathway activities.
Active and Healthy Ageing at Work—A Qualitative Study with Employees 55 - 63 Years and Their Managers  [PDF]
Kerstin Nilsson
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.57002
Abstract: The proportion of elderly individuals in the population is increasing in most industrial countries. This demographic change increases the need of more people who work until an older age to maintain the welfare in the states. However, it is not clear if older employees are interested to in generally extend the working life to an older age. It is also not stated if managers in organizations are interested of extending their older employees working life. The overall aim of this study was to examine older employees own experience of their work situation and ageing at work. The aim was also to investigate their managers’ attitude to them as older employees. The investigation was conducted by focusing group interviews with employees aged 55 - 63 years, and with their mangers aged 40 - 63 years. The findings stated that the older employees’ consideration for an extend working life seemed to be based on their health and health problems in relation to their work situation; their personal economy; their managers attitude to them as elderly and the possibility to social inclusion at work; and their possibilities for self-crediting activities at work despite their age. The managers seem to have a positive attitude to some of the older employees’ experience knowledge, if that was in the same direction as their own interest. Otherwise the mangers saw the older employees as problem and obsoleted. The managers were also negative to older employees who got health problems which effect the work production negatively. The older workers in this study described managers’ importance to if they want to work in an extended working life. However, the managers seem not to understand their own importance in this and were not interested to keep all elderly in an extended working life.
The Influence of Work Environmental and Motivation Factors on Seniors’ Attitudes to an Extended Working Life or to Retire. A Cross Sectional Study with Employees 55 - 74 Years of Age  [PDF]
Kerstin Nilsson
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.57003
Abstract: Aim: The aim of this study was to investigate difference between whether individuals think they can work, and want to work until 65 years or not. Methods: A cross/sectional study including survey of 1949 employees aged 55 - 74 years. Results: Working environments were the most significant differences between the groups associated to if the respondents think they can work beyond 65 years or not. Motivation factors were the most significant differences between the groups associated with if the respondents want to work beyond 65 years or not. Conclusions: A satisfying work environment is important to whether people think they can work or not. Nevertheless, whether people want to work is depending on whether the employees are satisfied with the factors that promote their motivation for work. If society wants more people to work until an upper age, it is important to improve both work environmental factors and motivation factors in their work situation.
An internet-based intervention program for supporting families with prematurely born infants  [PDF]
Birgitta Lindberg, Kerstin ?hrling
Open Journal of Nursing (OJN) , 2012, DOI: 10.4236/ojn.2012.22012
Abstract: The purpose of this paper was to describe the development, planning and implementing of an internet-based intervention program for providing support to families with prematurely born infants. During the families initial stay at home with their infant; families were given access to use of videoconference system from their home to have contact with staff at the neonatal unit, via direct link, throughout twenty-four hours. This program successfully ended, and video-conferencing is incorporated as a tool to support families after coming home. Probably, a variety of factors has contributed to make this program successful, as for example user friendliness and the close collaboration between researchers and staff at the neonatal unit. In conclusion, Information and Communication Technology (ICT) must be taken into consideration in developing upcoming care, thereby making possible a program to extend accessibility to health care.
The Transfer of Knowledge between Younger and Older Employees in the Health and Medical Care: An Intervention Study  [PDF]
Emma Nilsson, Kerstin Nilsson
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.57006
Abstract: In the ageing society more old employees need to stay in working life for longer. However, the society also needs to take care of the increased amount of elderly in a more effective and respectful way. To take care of older employees experience knowledge to make the elderly care and the care employees work situation better and self-crediting to go on in an extended working life, new methods and measures are needed to be developed and evaluated. The overall purpose of this article was to evaluate how the participant in the intervention project experienced the project and its methodology. The intervention project followed three different methods: i) through interviews of the participants and the supervisor; ii) through participant observation; and iii) through an evaluation questionnaire to participants after the project was completed. The intervention project did transfer knowledge between different fields, that are, between generations, between different departments and between the municipality and county. The participation was described as not only a place for reflection and knowledge, but also a protected zone where participants could talk about the kind of problems they would ponder over. Several participants felt that it was important to develop and continue the work that the intervention project set in motion. The participants’ experience was made to be visible and their professional competence has been strengthened. They indicated that there had been an exchange of knowledge and between not only the generations but also the different kinds of work. The organisations also seem to have gained from the project by allowing the participants to unload, become more positive, develop more knowledge of experience, increase their propensity for reflection and get a better consensus between the municipality and county. The intervention project seems to have fulfilled the stated purpose and also the expectations of the participants.
Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports
Georg Seifert, Hanno Riess, Karl Seeger, Guenter Henze, Anja Borgmann
BMC Cancer , 2006, DOI: 10.1186/1471-2407-6-103
Abstract: As a therapeutic proof of principle, we demonstrate that the use of r-UK and autologous plasma effectively reestablishes the function of occluded central venous ports (CVP) resistant to routine management of catheter occlusion. Five patients with occluded ports resistant to the routine management were treated.All patients were successfully treated with thrombolytic therapy using intraluminal instillation of r-UK and autologous plasma.Instillation of r-UK and autologous plasma is a safe and effective method for management of CVP occlusion.Regular application of plasma products or chemotherapy is often complicated by catheter-related problems such as blockage. Especially in children, an effective and simple reestablishment of catheter patency is important. Maintenance of catheter function is usually achieved with flushing (sodium chloride and/or heparin) or urokinase instillation [1,2]. In the majority of cases low-dose urokinase therapy is a safe and efficacious treatment for catheter occlusion, frequently obviating the need for catheter removal. However, in some cases of occluded central venous ports (CVP), r-UK instillation is not effective. Because effective therapeutic function of r-UK requires the presence of plasminogen (see Figure 1) contained in human plasma, we combined autologous plasma and r-UK for treatment of occluded CVP in adult and paediatric patients.Five patients with occluded CVP were treated. Patient characteristics are given in Table 1. After up to eight attempts every 15 minutes with drawing and pressing to remove the CVP occlusion with sodium chloride and/or heparin and subsequently with 10 mg recombinant tissue plasminogen activator (r-tPA) and 5.000 IU r-UK, we used a combination of 2 ml of the patient's plasma and 10.000 IU r-UK (Medac GmbH, Germany) dissolved in 1 ml sodium chloride. The plasma was obtained by centrifugation at 1100 g for 10 minutes in a sterile syringe. Next, the combination of autologous plasma and r-UK were slowly mixed
Breeding Phenology of Birds: Mechanisms Underlying Seasonal Declines in the Risk of Nest Predation
Kathi L. Borgmann, Courtney J. Conway, Michael L. Morrison
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065909
Abstract: Seasonal declines in avian clutch size are well documented, but seasonal variation in other reproductive parameters has received less attention. For example, the probability of complete brood mortality typically explains much of the variation in reproductive success and often varies seasonally, but we know little about the underlying cause of that variation. This oversight is surprising given that nest predation influences many other life-history traits and varies throughout the breeding season in many songbirds. To determine the underlying causes of observed seasonal decreases in risk of nest predation, we modeled nest predation of Dusky Flycatchers (Empidonax oberholseri) in northern California as a function of foliage phenology, energetic demand, developmental stage, conspecific nest density, food availability for nest predators, and nest predator abundance. Seasonal variation in the risk of nest predation was not associated with seasonal changes in energetic demand, conspecific nest density, or predator abundance. Instead, seasonal variation in the risk of nest predation was associated with foliage density (early, but not late, in the breeding season) and seasonal changes in food available to nest predators. Supplemental food provided to nest predators resulted in a numerical response by nest predators, increasing the risk of nest predation at nests that were near supplemental feeders. Our results suggest that seasonal changes in foliage density and factors associated with changes in food availability for nest predators are important drivers of temporal patterns in risk of avian nest predation.
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