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Search Results: 1 - 10 of 154456 matches for " Kerina H Jones "
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A Large-Scale Study of Anxiety and Depression in People with Multiple Sclerosis: A Survey via the Web Portal of the UK MS Register
Kerina H. Jones,David V. Ford,Philip A. Jones,Ann John,Rodden M. Middleton,Hazel Lockhart-Jones,Lisa A. Osborne,J. Gareth Noble
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041910
Abstract: Studies have found that people with Multiple Sclerosis experience relatively high rates of anxiety and depression. Although methodologically robust, many of these studies had access to only modest sample sizes (N<200). The aims of this study were to use responses gained via the web portal of the UK MS Register (N>4000) to: describe the depression and anxiety profiles of people with MS; to determine if anxiety and depression are related to age or disease duration; and to assess whether the levels of anxiety and depression differ between genders and types of MS.
How People with Multiple Sclerosis Rate Their Quality of Life: An EQ-5D Survey via the UK MS Register
Kerina H. Jones, David V. Ford, Philip A. Jones, Ann John, Rodden M. Middleton, Hazel Lockhart-Jones, Jeffrey Peng, Lisa A. Osborne, J. Gareth Noble
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065640
Abstract: Introduction The EQ-5D is a widely-used, standardised, quality of life measure producing health profiles, indices and states. The aims of this study were to assess the role of various factors in how people with Multiple Sclerosis rate their quality of life, based on responses to the EQ-5D received via the web portal of the UK MS Register. Methods The 4516 responses to the EQ-5D (between May 2011 and April 2012) were collated with basic demographic and descriptive MS data and the resulting dataset was analysed in SPSS (v.20). Results The mean health state for people with MS was 59.73 (SD 22.4, median 61), compared to the UK population mean of 82.48 (which is approximately 1SD above the cohort mean). The characteristics of respondents with high health states (at or above +1SD) were: better health profiles (most predictive dimension: Usual Activities), higher health indices, younger age, shorter durations of MS, female gender, relapsing-remitting MS, higher educational attainment and being in paid employment (all p-values<0.001). Conversely, the characteristics of respondents with low health states (at or below -1SD) were: poorer health profiles (most predictive dimension: Mobility), lower health indices, older age, longer durations of MS, male gender, progressive MS, lower educational attainment and having an employment status of sick/disabled (p = 0.0014 for age, all other p-values<0.001). Particular living arrangements were not associated with either the high or low health status groups. Conclusions This large-scale study has enabled in-depth analyses on how people with MS rate their quality of life, and it provides new knowledge on the various factors that contribute to their self-assessed health status. These findings demonstrate the impact of MS on quality of life, and they can be used to inform care provision and further research, to work towards enhancing the quality of life of people with MS.
The Physical and Psychological Impact of Multiple Sclerosis Using the MSIS-29 via the Web Portal of the UK MS Register
Kerina H. Jones, David V. Ford, Philip A. Jones, Ann John, Rodden M. Middleton, Hazel Lockhart-Jones, Jeffrey Peng, Lisa A. Osborne, J. Gareth Noble
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0055422
Abstract: Introduction The MSIS-29 was developed to assess the physical and psychological impact of MS. The aims of this study were to use the responses to the MSIS-29 via the web portal of the UK MS Register to: examine the internal properties of the scale delivered via the internet, profile the cohort, and assess how well the scale measures impact of disability on the potential workforce. Methods Between May 2011 and April 2012, 4558 people with MS completed the MSIS-29(v.1). The responses were collated with basic demographic and descriptive MS data and the resulting dataset was analysed in SPSS(v.20). Results Internal consistency was high (Cronbach's alpha 0.97 MSIS-29-PHYS, 0.92 MSIS-29-PSYCH). The mean MSIS-29-PHYS score was 60.5 (50.6%) with a median of 62 and the mean MSIS-29-PSYCH score was 24.8 (43.8%) with a median of 24. Physical scores increased with age and disease duration (p<0.001, p<0.001), but there was a weak negative relationship between psychological scores and age (p<0.001). The odds of people having an employment status of sick/disabled were 7.2 (CI 5.5, 9.4, p<0.001) for people with a moderate physical score, and 22.3 (CI 17.0, 29.3, p<0.001) for people with a high physical score (relative to having a low physical score). Conclusions This largest known study of its kind has demonstrated how the MSIS-29 can be administered via the internet to characterise a cohort, and to predict the likely impact of disability on taking an active part in the workforce, as a reasonable proxy for the effects of MS on general activities. The findings examining MSIS-29-PHYS and MSIS-29-PSYCH scores against age support the use of two sub-scales, not a combined score. These results underline the importance of using a scale such as this to monitor disability levels regularly in guiding MS care to enable people to be as active as possible.
The feasibility of collecting information from people with Multiple Sclerosis for the UK MS Register via a web portal: characterising a cohort of people with MS
David V Ford, Kerina H Jones, Rod M Middleton, Hazel Lockhart-Jones, Inocencio DC Maramba, Gareth J Noble, Lisa A Osborne, Ronan A Lyons
BMC Medical Informatics and Decision Making , 2012, DOI: 10.1186/1472-6947-12-73
Abstract: The web portal was developed using VB.net and JQuery with a Microsoft SQL 2008 database. UK adults with MS can self-register and enter data about themselves by completing validated questionnaires. Descriptive statistics were used to characterise the respondents.The web portal was launched in May 2011, and in first three months 7,279 individuals registered on the portal. The ratio of men to women was 1:2.4 (n?=?5,899), the mean self-reported age at first symptoms was 33.8 (SD 10.5) years, and at diagnosis 39.6 (SD 10.3) years (n?=?4,401). The reported types of MS were: 15% primary progressive, 63% relapsing-remitting, 8% secondary progressive, and 14% unknown (n?=?5,400). These characteristics are similar to those of the prevalent MS population. Employment rates, sickness/disability rates, ethnicity and educational qualifications were compared with the general UK population. Information about the respondents’ experience of early symptoms and the process of diagnosis, plus living arrangements are also reported.These initial findings from the MS Register portal demonstrate the feasibility of collecting data about people with MS via a web platform, and show that sufficient information can be gathered to characterise a cohort of people with MS. The innovative design of the UK MS register, bringing together three disparate sources of data, is creating a rich resource for research into this condition.
The SAIL Databank: building a national architecture for e-health research and evaluation
David V Ford, Kerina H Jones, Jean-Philippe Verplancke, Ronan A Lyons, Gareth John, Ginevra Brown, Caroline J Brooks, Simon Thompson, Owen Bodger, Tony Couch, Ken Leake
BMC Health Services Research , 2009, DOI: 10.1186/1472-6963-9-157
Abstract: A set of objectives was identified to address the challenges and establish the Secure Anonymised Information Linkage (SAIL) system in accordance with Information Governance. These were to: 1) ensure data transportation is secure; 2) operate a reliable record matching technique to enable accurate record linkage across datasets; 3) anonymise and encrypt the data to prevent re-identification of individuals; 4) apply measures to address disclosure risk in data views created for researchers; 5) ensure data access is controlled and authorised; 6) establish methods for scrutinising proposals for data utilisation and approving output; and 7) gain external verification of compliance with Information Governance.The SAIL databank has been established and it operates on a DB2 platform (Data Warehouse Edition on AIX) running on an IBM 'P' series Supercomputer: Blue-C. The findings of an independent internal audit were favourable and concluded that the systems in place provide adequate assurance of compliance with Information Governance. This expanding databank already holds over 500 million anonymised and encrypted individual-level records from a range of sources relevant to health and well-being. This includes national datasets covering the whole of Wales (approximately 3 million population) and local provider-level datasets, with further growth in progress. The utility of the databank is demonstrated by increasing engagement in high quality research studies.Through the pragmatic approach that has been adopted, we have been able to address the key challenges in establishing a national databank of anonymised person-based records, so that the data are available for research and evaluation whilst meeting the requirements of Information Governance.Vast amounts of personal data are collected routinely by health and social care systems in order to support clinical management and patient care. The secondary use of this data has enormous potential in health-related research, quality im
The SAIL databank: linking multiple health and social care datasets
Ronan A Lyons, Kerina H Jones, Gareth John, Caroline J Brooks, Jean-Philippe Verplancke, David V Ford, Ginevra Brown, Ken Leake
BMC Medical Informatics and Decision Making , 2009, DOI: 10.1186/1472-6947-9-3
Abstract: Having established the infrastructure of the databank, the aim of this work was to develop and implement an accurate matching process to enable the assignment of a unique Anonymous Linking Field (ALF) to person-based records to make the databank ready for record-linkage research studies. An SQL-based matching algorithm (MACRAL, Matching Algorithm for Consistent Results in Anonymised Linkage) was developed for this purpose. Firstly the suitability of using a valid NHS number as the basis of a unique identifier was assessed using MACRAL. Secondly, MACRAL was applied in turn to match primary care, secondary care and social services datasets to the NHS Administrative Register (NHSAR), to assess the efficacy of this process, and the optimum matching technique.The validation of using the NHS number yielded specificity values > 99.8% and sensitivity values > 94.6% using probabilistic record linkage (PRL) at the 50% threshold, and error rates were < 0.2%. A range of techniques for matching datasets to the NHSAR were applied and the optimum technique resulted in sensitivity values of: 99.9% for a GP dataset from primary care, 99.3% for a PEDW dataset from secondary care and 95.2% for the PARIS database from social care.With the infrastructure that has been put in place, the reliable matching process that has been developed enables an ALF to be consistently allocated to records in the databank. The SAIL databank represents a research-ready platform for record-linkage studies.Recent years have seen a huge growth in the development of electronic systems to capture individual records in the course of health and social care service delivery [1]. These routinely-collected data have enormous potential in health-related research, quality improvement, service planning and enhanced clinical decision-making [2], and such information could revolutionise health research if longitudinal individual health records can be developed from existing systems or through new developments [3].The He
Protocol for a population-based Ankylosing Spondylitis (PAS) cohort in Wales
Mark D Atkinson, Sinead Brophy, Stefan Siebert, Mike B Gravenor, Ceri Phillips, David V Ford, Kerina H Jones, Ronan A Lyons
BMC Musculoskeletal Disorders , 2010, DOI: 10.1186/1471-2474-11-197
Abstract: This data model will include and link (1) secondary care clinician datasets (i.e. electronic patient notes from the rheumatologist) (2) patient completed questionnaires (giving information on disease activity, medication, function, quality of life, work limitations and health service utilisation) and (3) a broad range of routinely collected data (including; GP records, in-patient hospital admission data, emergency department data, laboratory/pathology data and social services databases). The protocol involves the use of a unique and powerful data linkage system which allows datasets to be interlinked and to complement each other.This cohort can integrate patient supplied, primary and secondary care data into a unified data model. This can be used to study a range of issues such as; the true economic costs to the health care system and the patient, factors associated with the development of severe disease, long term adverse events of new and existing medication and to understand the disease history of this condition. It will benefit patients, clinicians and health care managers. This study forms a pilot project for the use of routine data/patient data linked cohorts for other chronic conditions.Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis affecting between 1 in 400 and 1 in 270 people [1,2]. AS is characterised by inflammation of the spine, resulting in progressive and irreversible fusion of the spine. Peripheral joints, particularly the hips [3] can also be involved, often requiring hip replacement surgery. In a significant number of patients, AS is also associated with inflammation of other organs such as the heart [4,5], eyes [6], bowel [7] and skin [8]. In common with most chronic inflammatory conditions, AS is heterogeneous, having a variable course and unpredictable episodes of exacerbation [9].AS typically strikes people in their late teens or early adult life and runs for the remainder of the life-course. It therefore has a significant impa
HIV Diversity and Classification, Role in Transmission  [PDF]
Duri Kerina, Stray-Pedersen Babill, F. Muller
Advances in Infectious Diseases (AID) , 2013, DOI: 10.4236/aid.2013.32022

The hallmark of HIV-1 is its extensive genetic diversity that emanates mainly from high mutations. Phylogenetically, HIV can be classified into geographically confined groups, types, subtypes and circulating recombinant forms (CRFs) that are however subject to change over time. HIV genetic diversity may partially explain the observed heterogeneity in HIV prevalence and has also been reported to impact on viral transmissibility and differential rates of disease progression. The aim of this review is to present a simple overview of the principles and concepts of HIV diversity and classification. Tracking the presence of new HIV strains is not only important for surveillance purposes but is also critical in facilitating personalized targeted therapy as well as forming the basis for development of the much anticipated effective vaccines against this scourge.

Pushing, Pulling, Twisting, Stretching: the Power of Light under the Microscope
Philip H. Jones
Opticon1826 , 2009, DOI: 10.5334/opt.070907
Abstract: Of the many uses we have for light such as illumination or digital communication, perhaps the most surprising is physical manipulation of matter. Holding and moving objects without touching them may seem like the stuff of science fiction, but a profound understanding of the interaction between light and matter can make this a reality, at least on the microscopic scale. Since its invention, the technique of ‘optical trapping’ has evolved into a tool with applications beyond the narrow scope of physics, and in particular, has enabled remarkable discoveries in biology and medicine.
A new species of land planarian (Platyhelminthes: Tricladida: Terricola:Rhynchodemidae) from South Africa, with a list of African terrestrial planarian species
H.D. Jones
African Zoology , 2011,
Abstract: Othelosoma joburgi is described from Roodepoort, Gauteng province, South Africa. Preserved worms are up to 16mmlong and 3mmwide, cylindrical, plump, and ‘sick green’ in colour with no obvious stripes or markings. There is a dorsal anterior retractor muscle which causes the head to be strongly retracted, and strong parenchymal longitudinal musculature. The penis has a distinct conical papilla. There is a large copulatory bursa with both a ductus vaginalis opening directly to the exterior and a Beauchamp’s canal connecting to the common ovovitelline duct. A list of all African land planarian species with brief descriptions and ocations is included in the hope of encouraging further records
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