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Search Results: 1 - 10 of 1814 matches for " Keisuke Takeuchi "
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The Impact of Travel Time on Geographic Distribution of Dialysis Patients
Saori Kashima, Masatoshi Matsumoto, Takahiko Ogawa, Akira Eboshida, Keisuke Takeuchi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047753
Abstract: Backgrounds The geographic disparity of prevalence rates among dialysis patients is unclear. We evaluate the association between travel time to dialysis facilities and prevalence rates of dialysis patients living in 1,867 census areas of Hiroshima, Japan. Furthermore, we study the effects of geographic features (mainland or island) on the prevalence rates and assess if these effects modify the association between travel time and prevalence. Methods The study subjects were all 7,374 people that were certified as the “renal disabled” by local governments in 2011. The travel time from each patient to the nearest available dialysis facility was calculated by incorporating both travel time and the capacity of all 98 facilities. The effect of travel time on the age- and sex-adjusted standard prevalence rate (SPR) and 95% confidence intervals (CIs) at each census area was evaluated in two-level Poisson regression models with 1,867 census areas (level 1) nested within 35 towns or cities (level 2). The results were adjusted for area-based parameters of socioeconomic status, urbanity, and land type. Furthermore, the SPR of dialysis patients was calculated in each specific subgroup of population for travel time, land type, and combination of land type and travel time. Results In the regression analysis, SPR decreased by 5.2% (95% CI: ?7.9–?2.3) per 10-min increase in travel time even after adjusting for potential confounders. The effect of travel time on prevalence was different in the mainland and island groups. There was no travel time-dependent SPR disparity on the islands. The SPR among remote residents (>30 min from facilities) in the mainland was lower (0.77, 95% CI: 0.71–0.85) than that of closer residents (≤30 min; 0.95, 95% CI: 0.92–0.97). Conclusions The prevalence of dialysis patients was lower among remote residents. Geographic difficulties for commuting seem to decrease the prevalence rate.
The impact of rural hospital closures on equity of commuting time for haemodialysis patients: simulation analysis using the capacity-distance model
Matsumoto Masatoshi,Ogawa Takahiko,Kashima Saori,Takeuchi Keisuke
International Journal of Health Geographics , 2012, DOI: 10.1186/1476-072x-11-28
Abstract: Background Frequent and long-term commuting is a requirement for dialysis patients. Accessibility thus affects their quality of lives. In this paper, a new model for accessibility measurement is proposed in which both geographic distance and facility capacity are taken into account. Simulation of closure of rural facilities and that of capacity transfer between urban and rural facilities are conducted to evaluate the impacts of these phenomena on equity of accessibility among dialysis patients. Methods Post code information as of August 2011 of all the 7,374 patients certified by municipalities of Hiroshima prefecture as having first or third grade renal disability were collected. Information on post code and the maximum number of outpatients (capacity) of all the 98 dialysis facilities were also collected. Using geographic information systems, patient commuting times were calculated in two models: one that takes into account road distance (distance model), and the other that takes into account both the road distance and facility capacity (capacity-distance model). Simulations of closures of rural and urban facilities were then conducted. Results The median commuting time among rural patients was more than twice as long as that among urban patients (15 versus 7 minutes, p < 0.001). In the capacity-distance model 36.1% of patients commuted to the facilities which were different from the facilities in the distance model, creating a substantial gap of commuting time between the two models. In the simulation, when five rural public facilitiess were closed, Gini coefficient of commuting times among the patients increased by 16%, indicating a substantial worsening of equity, and the number of patients with commuting times longer than 90 minutes increased by 72 times. In contrast, closure of four urban public facilities with similar capacities did not affect these values. Conclusions Closures of dialysis facilities in rural areas have a substantially larger impact on equity of commuting times among dialysis patients than closures of urban facilities. The accessibility simulations using thecapacity-distance model will provide an analytic framework upon which rational resource distribution policies might be planned.
Expression of SPIG1 Reveals Development of a Retinal Ganglion Cell Subtype Projecting to the Medial Terminal Nucleus in the Mouse
Keisuke Yonehara, Takafumi Shintani, Ryoko Suzuki, Hiraki Sakuta, Yasushi Takeuchi, Kayo Nakamura-Yonehara, Masaharu Noda
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0001533
Abstract: Visual information is transmitted to the brain by roughly a dozen distinct types of retinal ganglion cells (RGCs) defined by a characteristic morphology, physiology, and central projections. However, our understanding about how these parallel pathways develop is still in its infancy, because few molecular markers corresponding to individual RGC types are available. Previously, we reported a secretory protein, SPIG1 (clone name; D/Bsp120I #1), preferentially expressed in the dorsal region in the developing chick retina. Here, we generated knock-in mice to visualize SPIG1-expressing cells with green fluorescent protein. We found that the mouse retina is subdivided into two distinct domains for SPIG1 expression and SPIG1 effectively marks a unique subtype of the retinal ganglion cells during the neonatal period. SPIG1-positive RGCs in the dorsotemporal domain project to the dorsal lateral geniculate nucleus (dLGN), superior colliculus, and accessory optic system (AOS). In contrast, in the remaining region, here named the pan-ventronasal domain, SPIG1-positive cells form a regular mosaic and project exclusively to the medial terminal nucleus (MTN) of the AOS that mediates the optokinetic nystagmus as early as P1. Their dendrites costratify with ON cholinergic amacrine strata in the inner plexiform layer as early as P3. These findings suggest that these SPIG1-positive cells are the ON direction selective ganglion cells (DSGCs). Moreover, the MTN-projecting cells in the pan-ventronasal domain are apparently composed of two distinct but interdependent regular mosaics depending on the presence or absence of SPIG1, indicating that they comprise two functionally distinct subtypes of the ON DSGCs. The formation of the regular mosaic appears to be commenced at the end of the prenatal stage and completed through the peak period of the cell death at P6. SPIG1 will thus serve as a useful molecular marker for future studies on the development and function of ON DSGCs.
Muon g-2 and LHC phenomenology in the $L_μ-L_τ$ gauge symmetric model
Keisuke Harigaya,Takafumi Igari,Mihoko M. Nojiri,Michihisa Takeuchi,Kazuhiro Tobe
Physics , 2013, DOI: 10.1007/JHEP03(2014)105
Abstract: In this paper, we consider phenomenology of a model with an $L_\mu-L_\tau$ gauge symmetry. Since the muon couples to the $L_\mu-L_\tau$ gauge boson (called $Z''$ boson), its contribution to the muon anomalous magnetic moment (muon g-2) can account for the discrepancy between the standard model prediction and the experimental measurements. On the other hand, the $Z''$ boson does not interact with the electron and quarks, and hence there are no strong constraints from collider experiments even if the $Z''$ boson mass is of the order of the electroweak scale. We show an allowed region of a parameter space in the $L_\mu-L_\tau$ symmetric model, taking into account consistency with the electroweak precision measurements as well as the muon g-2. We study the Large Hadron Collider (LHC) phenomenology, and show that the current and future data would probe the interesting parameter space for this model.
Infrared 3-4 Micron Spectroscopy of Nearby PG QSOs and AGN-Nuclear Starburst Connections in High-luminosity AGN Populations
Masatoshi Imanishi,Kohei Ichikawa,Tomoe Takeuchi,Nozomu Kawakatu,Nagisa Oi,Keisuke Imase
Physics , 2011, DOI: 10.1093/pasj/63.sp2.S447
Abstract: We present the results of infrared L-band (3-4 micron) slit spectroscopy of 30 PG QSOs at z < 0.17, the representative sample of local high-luminosity, optically selected AGNs. The 3.3 micron polycyclic aromatic hydrocarbon (PAH) emission feature is used to probe nuclear (< a few kpc) starburst activity and to investigate the connections between AGNs and nuclear starbursts in PG QSOs. The 3.3 micron PAH emission is detected in the individual spectra of 5/30 of the observed PG QSOs. We construct a composite spectrum of PAH-undetected PG QSOs and discern the presence of the 3.3 micron PAH emission therein. We estimate the nuclear-starburst and AGN luminosities from the observed 3.3 micron PAH emission and 3.35 micron continuum luminosities, respectively, and find that the nuclear-starburst-to-AGN luminosity ratios in PG QSOs are similar to those of previously studied AGN populations with lower luminosities, suggesting that AGN-nuclear starburst connections are valid over the wide luminosity range of AGNs in the local universe. The observed nuclear-starburst-to-AGN luminosity ratios in PG QSOs with available supermassive black hole masses are comparable to a theoretical prediction based on the assumption that the growth of a supermassive black hole is controlled by starburst-induced turbulence.
Analysis of Dose Calculation Accuracy in Cone Beam Computed Tomography with Various Amount of Scattered Photon Contamination  [PDF]
Keisuke Usui, Koichi Ogawa, Keisuke Sasai
International Journal of Medical Physics,Clinical Engineering and Radiation Oncology (IJMPCERO) , 2017, DOI: 10.4236/ijmpcero.2017.63022
Abstract: Cone-beam computed tomography (CBCT) images have inaccurate CT numbers because of scattered photons. Thus, quantitative analysis of scattered photons that affect an electron density (ED) curve and calculated doses may be effective information to achieve CBCT-based radiation treatment planning. We quantitatively evaluated the effect of scattered photons on the accuracy of dose calculations from a lung image. The Monte Carlo method was used to calculate CBCT projection data, and we made two calibration curves for conditions with or without scattered photons. Moreover, we applied cupping artifact correction and evaluated the effects on image uniformity and dose calculation accuracy. Dose deviations were compared with those of conventional CT in conventional and volumetric intensity modulated arc therapy (VMAT) planning by using γ analysis and dose volume histogram (DVH) analysis. We found that cupping artifacts contaminated the scattered photons, and the γ analysis showed that the dose distribution was most decreased for a scattered photon ratio of 40%. Cupping artifact correction significantly improved image uniformity; therefore, ED curves were near ideal, and the pass rate results were significantly higher than those associated with the scattered photon effect in 65.1% and 78.4% without correction, 99.5% and 97.7% with correction, in conventional and VMAT planning, respectively. In the DVH analysis, all organ dose indexes were reduced in the scattered photon images, but dose index error rates with cupping artifact correction were improved within approximately 10%. CBCT image quality was strongly affected by scattered photons, and the dose calculation accuracy based on the CBCT image was improved by removing cupping artifacts caused by the scattered photons.
Implementation and Evaluation of Transport Layer Protocol Executing Error Correction (ECP)  [PDF]
Tomofumi Matsuzawa, Keisuke Shimazu
Communications and Network (CN) , 2014, DOI: 10.4236/cn.2014.63019

Technologies for retransmission control and error correction are available for communications over the Internet to improve reliability of data. For communications that require the data reliability be ensured, TCP, which performs retransmission control, is often employed. However, for environments and services where response confirmation and retransmission are difficult, error correction technologies are employed. Error correction is generally implemented on UDP, but the existing framework implemented on UDP frequently does not consider the maximum frame size of the data link layer and relegates data division to the IP module. The IP module divides data according to the maximum size for the data link, and the receiving IP module reconstructs the divided data. For a data link layer typified by the current Ethernet with an error detection function, the frame is often destroyed upon error detection. At the IP module, the specification allows destruction of the entire dataset whenever divided data necessary for reconstruction is incomplete. Consequently, an error in a single bit results in a total loss of data handed to the IP module, and thus error correction performance declines with the increase in data size handed to the IP module. The present study considers the MTU of the data link layer and proposes error correction protocol (ECP) over IP, which decreases the transfer data volume flowing to the data link layer by dividing data into blocks of appropriate size based on designated error correction code and its parameters (thus improving error correction performance) and assesses the performance of ECP. Experimental results demonstrate that performance is comparable or better than existing error correction frameworks. Results also show that when a specification not ensuring the reliability of the data link layer was employed, error correction was superior to existing frameworks on UDP.

Prevalence and Characteristics of Treatment-Resistant Hypertension among Hypertensive Japanese Outpatients  [PDF]
Keisuke Okamura, Hidenori Urata
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.69083
Abstract: Aims: To retrospectively investigate the prevalence and characteristics of treatment-resistant hypertension (R-HT) among consecutive hypertensive outpatients, since patients with R-HT are candidates for catheter-based renal sympathetic denervation (RD). Methods: Consecutive hypertensive outpatients (n = 999) were recruited in our hospital. R-HT patients who were candidates for RD had clinic systolic blood pressure > 160 mmHg despite taking three or more antihypertensive drugs including at least one diuretics at higher than standard doses. Results: Our survey indicated that only 26 patients (2.6%) were potential candidates for renal denervation. Candidates for RD showed a significantly higher age (P < 0.005), brain natriuretic peptide level (P = 0.0001), urinary albumin/creatinine excretion ratio in spot urine (P < 0.005), pulse wave velocity (P < 0.01), left ventricular end-diastolic diameter (P < 0.005), and interventricular septal thickness (P < 0.005) than the other 973 patients. Candidates for denervation had a significantly lower hemoglobin (P = 0.0001), serum albumin (P < 0.001), eGFR (P < 0.0005), plasma renin activity (P = 0.0001), and plasma aldosterone level (P < 0.005) than other patients, while their urinary sodium/creatinine ratio was higher, indicating that patients with R-HT appeared to have a high salt intake. Conclusion: Our retrospective clinical survey indicated that only 0.5% of Japanese hypertensive outpatients (5/999 patients) were candidates for RD. Therefore, establishment of hypertension cohort network will be essential to recruit R-HT patients for RD.
Production of CH4 in a Low-Pressure CO2/H2 Discharge with Magnetic Field  [PDF]
Keisuke Arita, Satoru Iizuka
Journal of Materials Science and Chemical Engineering (MSCE) , 2015, DOI: 10.4236/msce.2015.312011
Abstract: Production of CH4 has been established using a low-pressure square-pulse cross-field CO2/H2 discharge with magnetic field. The conversion rate from CO2 to CH4 was investigated by changing the discharge parameters such as applied power and discharge distance, together with magnetic field strength. Carbon dioxide was reduced by hydrogen. The discharge took place across the magnetic field inside a glass tube. Decomposition of CO2 and CH4 selectivity are found to be dependent on power density. Energy efficiency for methane production is increased in a narrow discharge. Preferable improvements of CO2 decomposition, CH4 selectivity, and energy efficiency were established.
Analysis of Rooftop Rainwater Harvesting in Kabul New City: A Case Study for Family Houses and Educational Facilities  [PDF]
Obaidullah Rahimi, Keisuke Murakami
Open Journal of Civil Engineering (OJCE) , 2018, DOI: 10.4236/ojce.2018.82013
Abstract: The Afghan government has planned the project of Kabul New City (KNC) to cope with the rapid growth of Kabul, an existing capital city. Due to climatic and topographical reasons, it is supposed that KNC suffers from a water scarcity problem. This study investigates the feasibility of a rooftop rainwater harvesting system in KNC to relieve the water scarcity problem. An applicability of the rooftop rainwater harvesting system was discussed for several types of residential houses and schools, using 11 years rainfall data. This study also examined the cost-effectiveness of the system by considering the service life of the system. Furthermore, an optimal size of the rainwater storage tank was discussed based on the balance among harvested rainwater volume, non-potable water demand, and cost-effectiveness.
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