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Search Results: 1 - 10 of 629 matches for " Katie Wojnoonski "
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Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment
Rima Kaddurah-Daouk, Rebecca A. Baillie, Hongjie Zhu, Zhao-Bang Zeng, Michelle M. Wiest, Uyen Thao Nguyen, Katie Wojnoonski, Steven M. Watkins, Miles Trupp, Ronald M. Krauss
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0025482
Abstract: Although statins are widely prescribed medications, there remains considerable variability in therapeutic response. Genetics can explain only part of this variability. Metabolomics is a global biochemical approach that provides powerful tools for mapping pathways implicated in disease and in response to treatment. Metabolomics captures net interactions between genome, microbiome and the environment. In this study, we used a targeted GC-MS metabolomics platform to measure a panel of metabolites within cholesterol synthesis, dietary sterol absorption, and bile acid formation to determine metabolite signatures that may predict variation in statin LDL-C lowering efficacy. Measurements were performed in two subsets of the total study population in the Cholesterol and Pharmacogenetics (CAP) study: Full Range of Response (FR), and Good and Poor Responders (GPR) were 100 individuals randomly selected from across the entire range of LDL-C responses in CAP. GPR were 48 individuals, 24 each from the top and bottom 10% of the LDL-C response distribution matched for body mass index, race, and gender. We identified three secondary, bacterial-derived bile acids that contribute to predicting the magnitude of statin-induced LDL-C lowering in good responders. Bile acids and statins share transporters in the liver and intestine; we observed that increased plasma concentration of simvastatin positively correlates with higher levels of several secondary bile acids. Genetic analysis of these subjects identified associations between levels of seven bile acids and a single nucleotide polymorphism (SNP), rs4149056, in the gene encoding the organic anion transporter SLCO1B1. These findings, along with recently published results that the gut microbiome plays an important role in cardiovascular disease, indicate that interactions between genome, gut microbiome and environmental influences should be considered in the study and management of cardiovascular disease. Metabolic profiles could provide valuable information about treatment outcomes and could contribute to a more personalized approach to therapy.
Quantifying the Carbon Footprint of Lean Waste  [PDF]
Kristen D. Balinski, Katie Grantham
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.51013

The objective of this paper is to provide a method of quantifying lean wastes in terms of carbon dioxide emissions by using value stream mapping. Lean manufacturing, based on waste identification and reduction, is a growing trend in industry and a proven method of lowering costs. The environmental impact of these wastes can be quantified in a new way by treating green waste as an outcome of lean wastes. Growing environmental concerns are prompting federal government regulation of greenhouse gas or carbon dioxide emissions, as introduced in the American Clean Energy and Security Act of 2009. This bill would have a significant economic impact on manufacturing businesses. And while many carbon footprint calculators are available for citizens to quantify their own emissions, there are currently none available for manufacturing companies to use in order to accurately quantify their carbon dioxide emissions to meet impending governmental regulations.

Adverse Influence of Radio Frequency Background on Trembling Aspen Seedlings: Preliminary Observations
Katie Haggerty
International Journal of Forestry Research , 2010, DOI: 10.1155/2010/836278
Abstract: Numerous incidents of aspen decline have been recorded in North America over the past half century, and incidents of very rapid mortality of aspen clones have been observed in Colorado since 2004. The radio frequency (RF) environment of the earth has undergone major changes in the past two centuries due to the development and use of electricity in power and communications applications, and the anthropogenic RF background continues to increase in intensity and complexity. This study suggests that the RF background may have strong adverse effects on growth rate and fall anthocyanin production in aspen, and may be an underlying factor in aspen decline. 1. Introduction Incidents of aspen decline in North America have been observed since the mid-20th Century [1–3]. Stands at the limits of aspen’s lower elevation range, on sites with poor drainage, with limited water [4] or nutrient supply [5], are more susceptible to decline. Stand age and clonal differences are also factors in susceptibility to decline [6]. Factors initiating decline include: defoliation by insects, damage caused by wildlife, severe drought, and extreme weather incidents [7]. Damage caused by these factors can diminish the vigor of affected clones and make them vulnerable to opportunistic fungal pathogens and insects [8]. The concept of forest decline has been used to describe the interaction of these various factors; however, the underlying causes of aspen decline are not well understood [9]. Since 2004, incidents of very rapid aspen clone mortality have been seen in Colorado [10]. Because the electromagnetic (EM) environment of the earth has changed radically in the past two centuries, this study investigates the possibility that anthropogenic changes in this environment, particularly in the radio frequency (RF) spectrum, are adversely affecting growth and health of aspen populations, making them vulnerable to decline. Electromagnetic energy from the sun is essential for life on earth. Plants rely on inputs of EM energy for photosynthesis and for regulation of periodic functions (flowering, shoot and root growth, respiration, and dormancy). A plant’s response to EM energy is dependant on frequency, timing, and intensity of the signal. The source of the EM input, however, makes no difference. Timing of plant processes is an important mechanism for plant protection and efficient functioning in changing day/night and seasonal environmental conditions [11]. Although photosynthesis requires fairly strong energy input in the blue and red visual frequencies (full sun/shade) [12], photoperiodic
The four principles: Can they be measured and do they predict ethical decision making?
Katie Page
BMC Medical Ethics , 2012, DOI: 10.1186/1472-6939-13-10
Abstract: The Analytic Hierarchy Process was used as a tool for the measurement of the principles. Four scenarios, which involved conflicts between the medical ethical principles, were presented to participants who then made judgments about the ethicality of the action in the scenario, and their intentions to act in the same manner if they were in the situation.Individual preferences for these medical ethical principles can be measured using the Analytic Hierarchy Process. This technique provides a useful tool in which to highlight individual medical ethical values. On average, individuals have a significant preference for non-maleficence over the other principles, however, and perhaps counter-intuitively, this preference does not seem to relate to applied ethical judgements in specific ethical dilemmas.People state they value these medical ethical principles but they do not actually seem to use them directly in the decision making process. The reasons for this are explained through the lack of a behavioural model to account for the relevant situational factors not captured by the principles. The limitations of the principles in predicting ethical decision making are discussed.
Mehr als Kodieren? Evaluation Computerunterstützter qualitativer Datenanalyse-Software (CAQDAS) für die Diskursanalyse von Nachrichtentexten More Than Just Coding? Evaluating CAQDAS in a Discourse Analysis of News Texts Algo más que simplemente codificar? Evaluando CAQDAS en un análisis del discurso de textos de noticias
Katie MacMillan
Forum : Qualitative Social Research , 2005,
Abstract: Computerunterstützte qualitative Datenanalyse-Software (CAQDAS) wird h ufig als Werkzeug für qualitative Forschung generell beschrieben, wobei "qualitative Forschung" meist als homogene Kategorie behandelt wird. Nur wenige Studien haben sich mit der Tauglichkeit von CAQDAS für spezifische Methoden besch ftigt, und ein noch kleinerer Teil mit der Nutzung von CAQDAS im Feld der Diskursanalyse (DA). In der Regel wird in solchen Studien kurz angemerkt, dass aus CAQDAS technische Begrenzungen für die Diskursanalyse erwachsen, eine hierüber hinausgehende Besch ftigung fehlt jedoch meist. In dem vorliegenden Beitrag soll untersucht werden, ob das geringe Interesse an CAQDAS auf Seiten der Diskursanalytiker(innen) bzw. umgekehrt an Diskursanalyse auf Seiten der CAQDAS-Nutzer(innen) praktische Gründe hat bzw. aus der Unsicherheit über Analyseverfahren (wie DA) erw chst, oder ob es sich um eine methodologische Inkompatibilit t handelt. Um diese Frage zu beantworten, wird zum einen die vorliegende Literatur zu CAQDAS und Diskursanalyse gesichtet, zum anderen wird CAQDAS auch einer praktischen Prüfung unterzogen, indem entlang der eigenen Erfahrungen als Diskursanalytiker(innen) einige der bekanntesten Software-Tools an einer Medienanalyse von Nachrichtentexten geprobt werden. URN: urn:nbn:de:0114-fqs0503257 Computer assisted qualitative data ana-lysis software (CAQDAS) is frequently described as a tool that can be used for "qualitative research" in general, with qualitative analysis treated as a "catch-all" homogeneous category. Few studies have detailed its use within specific methods, and even fewer have appraised its value for discourse analysis (DA). While some briefly comment that CAQDAS has technical limitations for discourse analysis, in general, the topic as a whole is given scant attention. Our aim is to investigate whether this limited interest in CAQDAS as a qualitative tool amongst discourse analysts, and in DA as a research method amongst CAQDAS users, is prac-tically based; due to an uncertainty about research methods, including DA; or because of method-ol-ogical incompatibilities. In order to address these questions, this study is based not only on a review of the literature on CAQDAS and on DA, but also on our own experience as discourse analysts put-ting some of the main CAQDAS to the test in a media analysis of news texts. URN: urn:nbn:de:0114-fqs0503257 El análisis cualitativo de datos asistido por computadora (CAQDAS) se describe frecuentemente como una herramienta que puede usarse en general para la "investigación cualitativa", con el análisis
Helpful tools for criminal prosecution in domestic violence cases: Some ideas from the United States of America
Zoglin Katie
Temida , 2003, DOI: 10.2298/tem0302067z
Abstract: In this paper author presents three instruments that have been proven helpful in domestic violence prosecutions in the United States, particularly in California: (1) laws, (2) inter-agency protocols, and (3) victim support services. Prosecutors have found that certain laws have been helpful in domestic violence prosecutions. These include restraining orders, criminal penalties for violations of restraining orders, and evidence code provisions permitting certain kinds of testimony. Second, many jurisdictions in California have drafted inter-agency protocols. The purpose of these protocols is to help law enforcement, health care workers, and social workers in gathering evidence relating to domestic violence cases. Finally, most victims are not familiar with the criminal justice system many are nervous about going to court for domestic violence cases, for a variety of reasons. As a result, many jurisdictions have established victim support services.
An (Other) Scribbler: Grace Aguilar's Anglicized Jewish Woman
Katie Klein
E-Sharp , 2005,
Abstract: “The Fugitive; A True Tale”, the subject of this paper, offers a glimpse of Grace Aguilar’s early-modern period of writing, in which she uses the history of the Spanish Inquisition and Marranos to consider the role of women in the Jewish home and the Jew in Christian England. Grace Aguilar (1816-1847) is best known as a poet, historical romance writer, domestic novelist, Jewish emancipator, religious reformer, educator, social historian, theologian, and liturgist. Jews and Christians, men and women, and religious traditionalists and reformers, read her throughout the nineteenth century in England, America, and Europe. Within her writing, she was various and although she is one of the most visible spokespersons for Jewish emancipation, her presence in the Victorian literary marketplace reveals that she does not merely seek Jewish civil rights; she uses her faith and femininity to empower women’s domesticity. This essay focuses on the place of the Victorian Jewess in society as both a woman and a Jew. Aguilar uses this story as a case study on the figure of the Anglicized Jew and the soon to be Anglicized Jewess. She attempts to diminish the difference between Judaism and Christianity by creating human characters who highlight a similarly of spirit shared between the two religions. She also explores the Anglicization of the Jew by writing a heroine evocative of traditional domestic ideals surrounding images and expectations of womanhood. By engaging in the Anglo-Victorian literary marketplace, Aguilar writes a story of the ideal domestic woman regardless of religion.
It’s an Empirical Question: On Cognition and Ego
Katie Heikkinen
Integral Review , 2009,
Tam Lin Transformed
Katie Paddie
Skepsi , 2012,
Abstract: N/A
Mourning with Antigone: Civil War and Public Mourning in Patricia Ariza’s Antígona
Katie Billotte
Skepsi , 2010,
Abstract: Antigone is the oldest (if not the favourite) heroine of political rabble rousing. Part of the enduring legacy of the Antigone has been its ability to be reshaped and re-imagined in a variety of contexts. Patricia Ariza’s Antígona (2006) follows in this tradition and invites anew many of the central questions of the myth. While Antigone has traditionally been understood to be primarily concerned with the relationship between the state and the individual, the article proposes that there are other more important ‘political’ questions at play. Among these are the connection between mourning and the justification of violence. The article examines, first, the issues of public mourning and violence as they are present both in Sophocles’ Antigone and in Ariza’s Antígona and, secondly, the connection between violence and mourning and the unique role which they both occupy at the threshold between the public and the private. It suggests that human identity is dependent upon community consensus and that this consensus determines both whether an individual can be mourned and whether an individual can be the target of violence. The article’s ultimate goal is to demonstrate the connection between mourning and violence as outward manifestations of the worth bestowed by the community on an individual.
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