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Search Results: 1 - 10 of 402309 matches for " Kathleen M Potempa "
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A vision and compass for healthcare leadership: Lessons from the migrant nurse resolution for recurrent nursing shortages
Deleise S Wilson, Richard W Redman, Kathleen M Potempa
Journal of Healthcare Leadership , 2010, DOI: http://dx.doi.org/10.2147/JHL.S12062
Abstract: vision and compass for healthcare leadership: Lessons from the migrant nurse resolution for recurrent nursing shortages Review (4819) Total Article Views Authors: Deleise S Wilson, Richard W Redman, Kathleen M Potempa Published Date August 2010 Volume 2010:2 Pages 91 - 96 DOI: http://dx.doi.org/10.2147/JHL.S12062 Deleise S Wilson, Richard W Redman, Kathleen M Potempa School of Nursing, University of Michigan, Ann Arbor, MI, USA Abstract: The ways migrant health care workers have been used internationally over the past decades demonstrates, in part, the global factors and effects of institutional leadership decisions. This example is especially illustrative in nursing given decades of the recruitment and exportation of nurses. The lessons for leadership in nursing may inform leaders in other health professions.
Building the Clinical Bridge to Support Nursing Effectiveness Science
Kathleen Potempa,John Daly,Marita G. Titler
Nursing Research and Practice , 2012, DOI: 10.1155/2012/194147
Abstract:
Building the Clinical Bridge to Support Nursing Effectiveness Science
Kathleen Potempa,John Daly,Marita G. Titler
Nursing Research and Practice , 2012, DOI: 10.1155/2012/194147
Abstract:
Building the Clinical Bridge to Advance Education, Research, and Practice Excellence
Marilyn Svejda,Janet Goldberg,Maureen Belden,Kathleen Potempa,Margaret Calarco
Nursing Research and Practice , 2012, DOI: 10.1155/2012/826061
Abstract: The University of Michigan School of Nursing and the Health System partnered to develop an undergraduate clinical education model as part of a larger project to advance clinical education, practice, and scholarship with education serving as the clinical bridge that anchors all three areas. The clinical model includes clusters of clinical units as the clinical home for four years of a student's education, clinical instruction through team mentorship, clinical immersion, special skills preparation, and student portfolio. The model was examined during a one-year pilot with junior students. Stakeholders were largely positive. Findings showed that Clinical Faculty engaged in more role modeling of teaching strategies as Mentors assumed more direct teaching used more clinical reasoning strategies. Students reported increased confidence and competence in clinical care by being integrated into the team and the Mentor's assignment. Two new full time faculty roles in the Health System support education, practice, and research. 1. Introduction Over the past several years, schools of nursing have been called upon to restructure education programs to better prepare graduates for increasingly complex and rapidly changing health care environments [1–3]. According to Benner and associates [2], nursing education programs must be redesigned to prepare nurses for new responsibilities and challenges in these health care environments. To accomplish this, the practice-education gap must be addressed by major shifts in both curricula and teaching methods [2]. The call to revise nursing education programs is paralleled by similar calls from other organizations including the Robert Wood Johnson Foundation (RWJF) [4] and the Institute of Medicine (IOM) [5]. The Institute of Medicine’s 2001 report, Crossing the Quality Chasm: A New Health System for the 21st Century, recommended that leaders in health professions should develop strategies for “restructuring clinical education to be consistent with the principles of the 21st-century health system throughout the continuum of undergraduate, graduate, and continuing education for medical, nursing, and other professional training programs” (Recommendation 12, p. 208). The recent consensus report of the RWJF in collaboration with the IOM, “Initiative on the Future of Nursing: Leading Change, Advancing Health” [6], emphasizes that nurses should achieve higher levels of education and training through an improved education system that promotes seamless academic progression. Recently, partnerships between schools of nursing and service
A Concept Analysis of Mentoring in Nursing Leadership  [PDF]
Alexis Kathleen Hodgson, Judith M. Scanlan
Open Journal of Nursing (OJN) , 2013, DOI: 10.4236/ojn.2013.35052
Abstract:

Attention in the literature has been given to the critical state of nursing leadership development. There is a need to identify effective ways to sustain and develop nursing leaders. Mentoring has been identified as an invaluable tool to attract and retain new nurse leaders. Examining the concept of mentoring in nursing leadership provides a greater understanding of its importance in today’s healthcare system. The concept of mentoring will be analyzed using the framework developed by Walker and Avant. A literature review was conducted to examine the current usage of the concept of mentoring. Consistent with Walker and Avant’s framework, defining attributes, antecedents, and consequences of mentoring have been identified. Further illustration of this concept is provided by describing model, borderline, related, and contrary cases. Demonstrating the occurrence of the concept of mentoring, Empirical referents will also be explored.

Compilation and Analysis of Atherosclerosis Gene Expression Data  [PDF]
Michelle L. Booze, Kathleen M. Eyster
Advances in Biological Chemistry (ABC) , 2015, DOI: 10.4236/abc.2015.52011
Abstract: The objective of this project was to search for consensus in differential gene expression data and in regulation of differentially expressed genes among DNA microarray studies of atherosclerotic vessels and plaque. Seventeen DNA microarray studies of atherosclerosis were analyzed. Only 19 genes were found to be differentially expressed in 3 or more of the studies. The nineteen genes belong to classic gene ontologies known to be involved in atherosclerosis: immunity and defense, metabolism, proteases, receptors, and signal transduction. Four bioinformatics programs (TRED, rVISTA, JASPAR, and Ariadne Pathways) were used to further analyze the promoter regions and common upstream regulators of the 19 genes. Twelve of the genes shared nine common upstream regulators, many of them known to affect atherosclerosis, and one possible new pathway was identified that may be involved in this disease.
Interpain A, a Cysteine Proteinase from Prevotella intermedia, Inhibits Complement by Degrading Complement Factor C3
Michal Potempa,Jan Potempa,Tomasz Kantyka,Ky-Anh Nguyen,Katarzyna Wawrzonek,Surya P. Manandhar,Katarzyna Popadiak,Kristian Riesbeck,Sigrun Eick,Anna M. Blom
PLOS Pathogens , 2009, DOI: 10.1371/journal.ppat.1000316
Abstract: Periodontitis is an inflammatory disease of the supporting structures of the teeth caused by, among other pathogens, Prevotella intermedia. Many strains of P. intermedia are resistant to killing by the human complement system, which is present at up to 70% of serum concentration in gingival crevicular fluid. Incubation of human serum with recombinant cysteine protease of P. intermedia (interpain A) resulted in a drastic decrease in bactericidal activity of the serum. Furthermore, a clinical strain 59 expressing interpain A was more serum-resistant than another clinical strain 57, which did not express interpain A, as determined by Western blotting. Moreover, in the presence of the cysteine protease inhibitor E64, the killing of strain 59 by human serum was enhanced. Importantly, we found that the majority of P. intermedia strains isolated from chronic and aggressive periodontitis carry and express the interpain A gene. The protective effect of interpain A against serum bactericidal activity was found to be attributable to its ability to inhibit all three complement pathways through the efficient degradation of the α-chain of C3—the major complement factor common to all three pathways. P. intermedia has been known to co-aggregate with P. gingivalis, which produce gingipains to efficiently degrade complement factors. Here, interpain A was found to have a synergistic effect with gingipains on complement degradation. In addition, interpain A was able to activate the C1 complex in serum, causing deposition of C1q on inert and bacterial surfaces, which may be important at initial stages of infection when local inflammatory reaction may be beneficial for a pathogen. Taken together, the newly characterized interpain A proteinase appears to be an important virulence factor of P. intermedia.
Getting by with a Little Help from My Friends: Mental Rotation Ability after Tacit Peer Encouragement  [PDF]
Sheila Brownlow, Amanda J. Janas, Kathleen A. Blake, Kathleen T. Rebadow, Lindsay M. Mello
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.24057
Abstract: We examined how Mental Rotation (MR) ability was improved by presenting information that the task was one that could be accomplished. This information purportedly came from either peers or the experimenter. Men and women students completed 10 MR items from the Purdue Visualization of Rotations Test (Bodner & Guay, 1997) and provided self-reports about their confidence in their abilities to perform rotations, background skills and experiences, and effort with the task. The peer-presentation technique improved performance on MR, as both men and women who read that other students had previously managed the tasks performed better than those who merely heard about the tasks, leaving an implied difficulty unaddressed or “in the air.” When self-reported confidence in MR ability was held constant there were no gender differences in MR performance. The results suggest that appropriate peer models may improve performance on cognitive tasks, perhaps by increasing confidence in ability.
Xenobiotic Exposure and Autoimmune Hepatitis
Kathleen M. Gilbert
Hepatitis Research and Treatment , 2010, DOI: 10.1155/2010/248157
Abstract: Although genetics contributes to the development of autoimmune diseases, it is clear that “environmental” factors are also required. These factors are thought to encompass exposure to certain drugs and environmental pollutants. This paper examines the mechanisms that normally maintain immune unresponsiveness in the liver and discusses how exposure to certain xenobiotics such as trichloroethylene may disrupt those mechanisms and promote autoimmune hepatitis. 1. Immunological Characteristics of Autoimmune Hepatitis Autoimmune hepatitis (AIH) is a disease characterized by progressive liver inflammation of unknown etiology that may advance to fibrosis. The inflammation encompasses both cell-mediated cytotoxicity by infiltrating lymphocytes and the production of autoantibodies. Although not restricted to AIH, many patients with AIH make autoantibodies specific for asialoglycoprotein receptor (ASGPR) [1] and alcohol dehydrogenase (ADH) [2]. Type 1 AIH is characterized by circulating antinuclear antibodies (ANA) and smooth-muscle antibodies (SMA) [3]. Some individuals may have antineutrophil cytoplasmic autoantibodies (ANCA), antibodies to soluble liver antigens or liver pancreas (anti-SLA/LP). Type 2 AIH is associated with antibodies against liver-kidney microsome 1 (LKM-1) and/or antibodies against liver cytosol 1 antigen (LC1) [4]. LKM-1 autoantibodies react with linear epitopes within cytochrome P450 2D6 (CYP2D6), a phase-I drug- and toxicant-metabolizing enzyme in the liver, and perhaps major antigen target of type 2 AIH. Diagnosis of AIH usually involves more than the measurement of autoantibodies since patients may express them intermittently or produce antibodies that are not part of the standard repertoire. As described in Table 1 a definitive diagnosis of AIH is multifactorial. One classic indicator of AIH is liver pathology associated with lymphocyte infiltration of portal region. The liver infiltrate includes macrophages, antibody-secreting plasma cells, and T lymphocytes of both CD4+ and CD8+ subsets. Several investigators have reported a predominance of CD4+ T cells in the liver infiltrate, while others have reported a predominance of CD8+ T cells [5–7]. Regardless of the exact cell makeup the periportal lymphocyte infiltration characteristic of AIH differs from other autoimmune liver diseases such as primary biliary cirrhosis and autoimmune cholangitis in which lymphocytes instead target the bile ducts. Table 1: Revised scoring system of the international autoimmune hepatitis group. The specificity of the T cells that infiltrate the liver in AIH
Schools of Excellence AND Equity? Using Equity Audits as a Tool to Expose a Flawed System of Recognition
Kathleen M Brown
International Journal of Education Policy and Leadership , 2010,
Abstract: The purpose of this article is to demonstrate how equity audits can be used as a tool to expose disparate achievement in schools that, on the surface and to the public, appear quite similar. To that end, the researcher probed beyond surface-level performance composite scores into deeper, more hidden data associated with state-recognized "Honor Schools of Excellence." How is "excellence" defined and operationalized in these schools? Are these schools "excellent" for all students? Can a school really be classified by the state as "excellent" and yet still have significant "gaps" and disparities? If so, is the state's formula used to identify exemplary schools too simple, dogmatic, and institutionally flawed? Through the use of equity audits, quantitative data was collected to scan for systemic patterns of equity and inequity across multiple domains of student learning and activities within 24 elementary schools. The intent was to document and distinguish between schools that are promoting and supporting both academic excellence (small gap schools; SGS) and systemic equity and schools that are not (large gap schools; LGS). Results reveal that although demographic, teacher quality, and programmatic audits all indicated a fair amount of equity between SGS and LGS, the achievement audit between both types of schools indicated great disparities. By controlling for or eliminating some of the external variables and internal factors often cited for the achievement gaps between white middle-class children and children of color or children from low-income families, the findings from this study raise more questions than answers. Results do indicate that equity audits are a practical, easy-to-apply tool that educators can use to identify inequalities objectively.
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