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Search Results: 1 - 10 of 152376 matches for " Katherine H Hull "
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The Experience of Male Rape in Non-Institutionalised Settings
H Gertie Pretorius, Richard M Hull
Indo-Pacific Journal of Phenomenology , 2005,
Abstract: The aim of this article is to describe the phenomenon of male rape from the victims’ perspectives. The methodology employed relied on transcendental phenomenology in order to create the rich descriptions of the lived experiences of three male survivors of rape. From the descriptions elicited from the formulation of an open-ended question, it was discovered that the phenomenon of male rape has a dominant structure that is related to the destruction and reconstruction of the masculine self. The research also revealed several textural themes that include the characteristics of the assault, treatment and support that victims receive, the effects of the assault on the self, disclosure, the learning and life changes brought about by the assault, the victims’ feelings towards their assailants and the effect of the assault on the victims’ relationships. This study hopes to facilitate further descriptive research on the phenomenon of male rape in order that greater knowledge be gleaned and applied regarding its prevention and healing processes. Indo-Pacific Journal of Phenomenology, Volume 5, Edition 2 December 2005
Environmental design—An expanding role in hearing rehabilitation for older adults
Raymond H. Hull, PhD, FASHA, FAAA
Journal of Rehabilitation Research and Development , 2011,
Abstract: The role of the audiologist in aural rehabilitation services on behalf of older adults with hearing impairment is expanding, just as our knowledge of hearing in aging likewise expands.
The 1.3 mm Full-Stokes Polarization System at CARMA
Charles L. H. Hull,Richard L. Plambeck
Physics , 2015,
Abstract: The CARMA 1.3 mm polarization system consists of dual-polarization receivers that are sensitive to right- (R) and left-circular (L) polarization, and a spectral-line correlator that measures all four cross polarizations (RR, LL, LR, RL) on each of the 105 baselines connecting the 15 telescopes. Each receiver comprises a single feed horn, a waveguide circular polarizer, an orthomode transducer (OMT), two heterodyne mixers, and two low-noise amplifiers (LNAs), all mounted in a cryogenically cooled dewar. Here we review the basics of polarization observations, describe the construction and performance of key receiver components (circular polarizer, OMT, and mixers -- but not the correlator), and discuss in detail the calibration of the system, particularly the calibration of the R-L phase offsets and the polarization leakage corrections. The absolute accuracy of polarization position angle measurements was checked by mapping the radial polarization pattern across the disk of Mars. Transferring the Mars calibration to the well known polarization calibrator 3C286, we find a polarization position angle of $\chi = 39.2 \pm 1^{\circ}$ for 3C286 at 225 GHz, consistent with other observations at millimeter wavelengths. Finally, we consider what limitations in accuracy are expected due to the signal-to-noise ratio, dynamic range, and primary beam polarization.
Misalignment of Magnetic Fields and Outflows in Protostellar Cores
Charles L. H. Hull,Richard L. Plambeck,Alberto D. Bolatto,Geoffrey C. Bower,John M. Carpenter,Richard M. Crutcher,Jason D. Fiege,Erica Franzmann,Nicholas S. Hakobian,Carl Heiles,Martin Houde,A. Meredith Hughes,Katherine Jameson,Woojin Kwon,James W. Lamb,Leslie W. Looney,Brenda C. Matthews,Lee Mundy,Thushara Pillai,Marc W. Pound,Ian W. Stephens,John J. Tobin,John E. Vaillancourt,N. H. Volgenau,Melvyn C. H. Wright
Physics , 2012, DOI: 10.1088/0004-637X/768/2/159
Abstract: We present results of 1.3 mm dust polarization observations toward 16 nearby, low-mass protostars, mapped with ~2.5" resolution at CARMA. The results show that magnetic fields in protostellar cores on scales of ~1000 AU are not tightly aligned with outflows from the protostars. Rather, the data are consistent with scenarios where outflows and magnetic fields are preferentially misaligned (perpendicular), or where they are randomly aligned. If one assumes that outflows emerge along the rotation axes of circumstellar disks, and that the outflows have not disrupted the fields in the surrounding material, then our results imply that the disks are not aligned with the fields in the cores from which they formed.
The genome of Rhizobium leguminosarum has recognizable core and accessory components
J Peter W Young, Lisa C Crossman, Andrew WB Johnston, Nicholas R Thomson, Zara F Ghazoui, Katherine H Hull, Margaret Wexler, Andrew RJ Curson, Jonathan D Todd, Philip S Poole, Tim H Mauchline, Alison K East, Michael A Quail, Carol Churcher, Claire Arrowsmith, Inna Cherevach, Tracey Chillingworth, Kay Clarke, Ann Cronin, Paul Davis, Audrey Fraser, Zahra Hance, Heidi Hauser, Kay Jagels, Sharon Moule, Karen Mungall, Halina Norbertczak, Ester Rabbinowitsch, Mandy Sanders, Mark Simmonds, Sally Whitehead, Julian Parkhill
Genome Biology , 2006, DOI: 10.1186/gb-2006-7-4-r34
Abstract: The 7.75 Mb genome comprises a circular chromosome and six circular plasmids, with 61% G+C overall. All three rRNA operons and 52 tRNA genes are on the chromosome; essential protein-encoding genes are largely chromosomal, but most functional classes occur on plasmids as well. Of the 7,263 protein-encoding genes, 2,056 had orthologs in each of three related genomes (Agrobacterium tumefaciens, Sinorhizobium meliloti, and Mesorhizobium loti), and these genes were over-represented in the chromosome and had above average G+C. Most supported the rRNA-based phylogeny, confirming A. tumefaciens to be the closest among these relatives, but 347 genes were incompatible with this phylogeny; these were scattered throughout the genome but were over-represented on the plasmids. An unexpectedly large number of genes were shared by all three rhizobia but were missing from A. tumefaciens.Overall, the genome can be considered to have two main components: a 'core', which is higher in G+C, is mostly chromosomal, is shared with related organisms, and has a consistent phylogeny; and an 'accessory' component, which is sporadic in distribution, lower in G+C, and located on the plasmids and chromosomal islands. The accessory genome has a different nucleotide composition from the core despite a long history of coexistence.The symbiosis between legumes and N2-fixing bacteria (rhizobia) is of huge agronomic benefit, allowing many crops to be grown without N fertilizer. It is a sophisticated example of coupled development between bacteria and higher plants, culminating in the organogenesis of root nodules [1]. There have been many genetic analyses of rhizobia, notably of Sinorhizobium meliloti (the symbiont of alfalfa), Bradyrhizobium japonicum (soybean), and Rhizobium leguminosarum, which has biovars that nodulate peas and broad beans (biovar viciae), clovers (biovar trifolii), or kidney beans (biovar phaseoli).The Rhizobiales, an α-proteobacterial order that also includes mammalian pathogens B
Approach to the diagnosis and management of suspected exercise-induced bronchoconstriction by primary care physicians
James H Hull, Peter J Hull, Jonathan P Parsons, John W Dickinson, Les Ansley
BMC Pulmonary Medicine , 2009, DOI: 10.1186/1471-2466-9-29
Abstract: An electronic survey was distributed to a random selection of family practitioners in England. The survey was designed to assess the frequency with which family practitioners encounter adults with exercise-related respiratory symptoms and how they would approach diagnostic work-up and management. The survey also evaluated awareness of and access to diagnostic tests in this setting and general knowledge of prescribing asthma treatments to competitive athletes.257 family practitioners completed the online survey. One-third of respondents indicated they encountered individuals with this problem at a frequency of more than one case per month. Over two-thirds of family practitioners chose investigation as an initial management strategy, while one-quarter would initiate treatment based on clinical information alone. PEFR pre- and post-exercise was the most commonly selected test for investigation (44%), followed by resting spirometry pre- and post-bronchodilator (35%). Short-acting β2-agonists were the most frequently selected choice of treatment indicated by respondents (90%).Family practitioners encounter individuals with exercise-related respiratory symptoms commonly and although objective testing is often employed in diagnostic work-up, the tests most frequently utilised are not the most accurate for diagnosis of EIB. This diagnostic approach may be dictated by the reported lack of access to more precise testing methods, or may reflect a lack of dissemination or awareness of current evidence. Overall the findings have implications both for the management and hence welfare of athletes presenting with this problem to family practitioners and also for the competitive athletes requiring therapeutic use exemption.Exercise-induced bronchoconstriction (EIB) is highly prevalent in athletes at all levels of competition and its diagnosis and treatment is important to ensure their well-being [1,2]. Accurate diagnosis is essential to avoid misclassification and inappropriate trea
Ixabepilone as Monotherapy or in Combination with Capecitabine for the Treatment of Advanced Breast Cancer
Katherine H. Rak Tkaczuk
Breast Cancer: Basic and Clinical Research , 2012, DOI: 10.4137/BCBCR.S5331
Abstract: Breast Cancer is the most prevalent cancer in the world with 4.4 million survivors up to 5 years following the diagnosis.1 In the US alone approximately forty thousand women die annually of metastatic breast cancer (MBC). Despite many effective systemic treatment options approximately 50% of women with MBC succumb to the disease within 24 months of the diagnosis.2 Ixabepilone is a novel, first in class member of the epothilone class of antineoplastic agents. Ixabepilone is indicated as monotherapy for the treatment of metastatic or locally advanced breast cancer in patients whose tumors are resistant or refractory to anthracyclines, taxanes, and Capecitabine. Ixabepilone is also indicated in combination with Capecitabine for the treatment of patients with metastatic or locally advanced breast cancer resistant to treatment with an anthracycline and a taxane, or whose cancer is taxane resistant and for whom further anthracycline therapy is contraindicated. Ixabepilone was extensively studied as a single agent in patients with MBC and was found to be effective and well tolerated with a predictable and manageable safety profile. Not surprisingly prior exposure to anthracyclines and taxanes affects significantly the potential for response to therapy with single agent Ixabepilone in metastatic setting. MBC patients with taxane resistant MBC have objective response rate (RR) of 12%, patients with prior low exposure to taxanes and/or resistance RR = 22%, Ixabepilone treatment after adjuvant anthracycline therapy exposure renders RR = 42% and in Taxane na ve patients RR = 57%. In two large phase III studies of Ixabepilone + Capecitabine versus Capecitabine alone, progression free survival (PFS) and overall response rates (RR) were higher in the combination treatment arms, but no survival advantage was seen overall. Treatment with Ixabepilone + Capecitabine in a phase II study resulted in an overall response rate (ORR) of 23% in ER/PR/HER2 negative, triple-negative breast cancer patients (TNBC) while ORR of 31% was seen in a preplanned pooled analysis of TNBC in the phase III trials of Ixabepilone + Capecitabine. Significantly prolonged median PFS was seen for TNBC treated with the combination of Ixabepilone + Capecitabine compared to Capecitabine alone 4.2 vs. 1.7 months respectively. Ixabepilone as single agent appears to show excellent antitumor activity in patients with TNBC MBC. Addition of Ixabepilone to Capecitabine results in approximately doubling in median PFS for TNBC versus Capecitabine alone. Single agent Ixabepilone is generally well tolerated, and its toxicity profile does not overlap with that of Capecitabine and therefore depending on prior exposure to chemotherapy both single agent Ixabepilone or in combination with Capecitabine can be used safely and effectively for treatment of advanced breast cancer.
Science Signaling, Perspective – Cancer: Wnt/β-Catenin and MAPK Signaling: Allies and Enemies in Different Battlefields, April 2012 [Science Signaling, Ausblick – Krebs: Wnt/β-Catenin- und MAPK-Signaltransduktion: Verbündete und Feinde in unterschiedlichen Kampfzonen, April 2012]
Forsythe, Katherine H.
GMS Medizin-Bibliothek-Information , 2012, DOI: 10.3205/mbi000250
Abstract: [english] Research published in represents major advances in cell signaling in many disciplines, including the rapidly expanding areas of signaling networks, systems biology, synthetic biology, computation and modeling of regulatory pathways, and drug discovery. The published research content offers discoveries that substantially refine current understanding of important signaling processes, provide new concepts, and are likely to find application in multiple biological systems. Two papers this year in describe previously unknown links between two signaling pathways that are associated with cancer – melanoma and colon cancer. The Perspective, and MAPK Signaling: Allies and Enemies in Different Battlefields,” describes how both studies have implications for the development of combination therapies for skin and colon cancer . [german] Die in ver ffentlichten Forschungsarbeiten stellen die wichtigsten Fortschritte zur Zellsignaltransduktion in vielen Fachbereichen dar und umfassen die schnell wachsenden Gebiete der Signaltransduktionsnetzwerke, der Systembiologie, der synthetischen Biologie, der Berechnung und Modelldarstellung regulatorischer Pfade sowie der Pharmaforschung. Die ver ffentlichten Forschungsergebnisse bieten Entdeckungen, die das derzeitige Wissen zu wichtigen Signaltransduktionsprozessen betr chtlich vertiefen, neue Konzepte anbieten und wahrscheinlich Anwendung in mehreren biologischen Systemen finden werden. Zwei Arbeiten, die dieses Jahr in erschienen sind, beschreiben zuvor noch nicht bekannte Zusammenh nge zwischen zwei Signaltransduktionswegen, die mit Krebs (Melanom und Darmkrebs) assoziiert sind. Der Ausblick Wnt/β-Catenin- und MAPK-Signaltransduktion: Verbündete und Feinde in unterschiedlichen Kampfzonen“ beschreibt, wie beide Studien Auswirkungen auf die Entwicklung von Kombinationstherapien gegen Haut- und Darmkrebs haben .
Ixabepilone as Monotherapy or in Combination with Capecitabine for the Treatment of Advanced Breast Cancer
Katherine H. Rak Tkaczuk
Breast Cancer: Basic and Clinical Research , 2011,
Abstract:
Immigrant Entrepreneurs: The Face of the New Nashville  [PDF]
Galen Spencer Hull
iBusiness (IB) , 2010, DOI: 10.4236/ib.2010.21001
Abstract: This paper examines the remarkable growth of the foreign-born population in Middle Tennessee over the past couple of decades and the significant role that immigrant entrepreneurs are playing in the economic development of the region. The largest segment of the foreign-born is Hispanic, with Mexico accounting for the greatest percentage, and sizeable numbers of Kurds, Somalis, Sudanese, and Laotians. The Chinese and Indian communities are prominent in business. At the same time, the issue of illegal immigration is working its way to the top of the legislative agenda in the U.S. Congress, making it all the more important for us to document this phenomenon. Middle Tennessee, comprising the greater Nashville metropolitan area, is now home to thousands of new residents from around the world, earning it the sobriquet as one of the nation’s New Ellis Islands. Since the 1970s research has confirmed the important contribution that the small business sector is making to the U.S. economy, accounting for a large portion of job creation and innovation. Richard Herman and Robert Smith, in their recent book entitled Immigrant, Inc., make the case that immigrant entrepreneurs are driving the new American economy and will save the American worker. The paper draws upon research conducted by faculty and graduate students in the College of Business at Tennessee State University during 2008-2009. With funding from the Tennessee Board of Regents, a College of Business team conducted a series of focus groups, face to face interviews, and an extensive questionnaire in the fall of 2008 and spring of 2009. On three occasions the TSU team hosted public forums in which the results of the survey were shared with those participating in it as well as public officials responsible for economic and community development. Team members relied upon the intermediary services of immigrant chambers of commerce and other community organizations with ties to foreign-born business owners. In the course of the survey the Metro Nashville government conducted a referendum on a proposal to require an English Only amendment on public documents. The Mayor’s Office and Nashville Chamber of Commerce lobbied against the amendment, which was roundly defeated. But it was a coalition of immigrant groups that rallied against the amendment, bringing them together in a common cause that made the difference. There is reason to believe that a New Nashville is taking form and finding its voice.
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