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Search Results: 1 - 10 of 1044 matches for " Katharina Gallois "
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Gêneses wai?pi, entre diversos e diferentes
Gallois, Dominique Tilkin;
Revista de Antropologia , 2007, DOI: 10.1590/S0034-77012007000100002
Abstract: based on the revision of material registered with the waj?pi of amapá in different situations of interlocution, this article seeks to comprehend the construction of differences based on the native models concerning humanity. the indigenous reflections and their use of social distance markers are treated as "ethno gênesis", in the plural. in these cases, such processes are not limited to the construction of identities in the colonial encounter, but are dynamically transformed in the contexts of social networks.
Using the intervention mapping protocol to develop a community-based intervention for the prevention of childhood obesity in a multi-centre European project: the IDEFICS intervention
Vera Verbestel, Stefaan De Henauw, Lea Maes, Leen Haerens, Staffan M?rild, Gabriele Eiben, Lauren Lissner, Luis A Moreno, Natalia Frauca, Gianvincenzo Barba, éva Kovács, Kenn Konstabel, Michael Tornaritis, Katharina Gallois, Holger Hassel, Ilse De Bourdeaudhuij
International Journal of Behavioral Nutrition and Physical Activity , 2011, DOI: 10.1186/1479-5868-8-82
Abstract: The intervention mapping protocol (IMP) was used to develop the community-based intervention for the prevention of childhood obesity in 3 to 10 years old children. It is a theory- and evidence-based tool for the structured planning and development of health promotion programs that requires the completion of six different steps. These steps were elaborated by two coordinating centers and discussed with the other participating centers until agreement was reached. Focus group research was performed in all participating centers to provide an informed basis for intervention development.The application of the IMP resulted in an overall intervention framework with ten intervention modules targeting environmental and personal factors through the family, the school and the community. The summary results of the focus group research were used to inform the development of the overall intervention. The cultural adaptation of the overall intervention was realised by using country specific focus group results. The need for cultural adaptation was considered during the entire process to improve program adoption and implementation. A plan was developed to evaluate program effectiveness and quality of implementation.The IDEFICS project developed a community-based intervention for the prevention of childhood obesity by using to the intervention mapping heuristic. The IDEFICS intervention consists of a general and standardized intervention framework that allows for cultural adaptation to make the intervention feasible and to enhance deliverability in all participating countries. The present manuscript demonstrates that the development of an intervention is a long process that needs to be done systematically. Time, human resources and finances need to be planned beforehand to make interventions evidence-based and culturally relevant.The prevalence of overweight and obesity in Europe has increased during the past decades [1,2] and is considered a significant public health problem [2]. Th
Opinion Leaders and Lead Users in Marketing and Management Accounting and Impact on Small Business Performance  [PDF]
Katharina Simbeck
Social Networking (SN) , 2013, DOI: 10.4236/sn.2013.21002
Abstract: This paper empirically investigates into the business performance benefit that lead users or opinion leaders among small business owners draw from their higher involvement in management accounting or marketing topics. This work also contributes to a better identification of network members’ roles solely through their ties between each other. Indeed, lead users and opinion leaders can be differentiated by a higher degree centrality in comparison to their peers. However, being an opinion leader or a lead user does not yield a measurable business benefit to the small businesses studied in this sample.
Kinetic and binding equilibrium studies of dihydroflavonol 4-reductase from Vitis vinifera and its unusually strong substrate inhibition  [PDF]
Nadia Trabelsi, Béatrice Langlois d'Estaintot, Gilles Sigaud, Bernard Gallois, Jean Chaudière
Journal of Biophysical Chemistry (JBPC) , 2011, DOI: 10.4236/jbpc.2011.23038
Abstract: Dihydroflavonol 4-reductase (DFR), a member of the short-chain dehydrogenase family, catalyzes the last common step in the biosynthesis of flavan-3-ols and condensed tannins. Initial rates of DFR were measured by monitoring the 340-nm absorbance decrease resulting from the joint consumption of dihydroquercetin (DHQ) and NADPH, as a function of pH, temperature and ionic strength. At pH 6.5 and 30o C, substrate inhibition was observed above 30 µM DHQ. At lower/non-inhibitory DHQ concentrations, NADP+ behaves as a competitive inhibitor with respect to NADPH and as a mixed inhibitor with respect to DHQ, which supports a sequential ordered mechanism, with NADPH binding first and NADP+ released last. Binding-equilib-rium data obtained by means of the chromatographic method of Hummel and Dreyer at pH 7.5 and by isothermal calorimetric titration at pH 6.5 led to the conclusion that ligands of the apoenzyme included NADPH, NADP+ and DHQ. The mechanism which best accounts for substrate inhibition at pH 6.5 in the absence of product involves the formation of a binary non-productive E.DHQ complex. Thus, a productive ternary complex cannot be formed when DHQ binds first. This mechanism of inhibition may prevent the accumulation of unstable leucoanthocyanidins within cells.
Alcaftadine, a new antihistamine with combined antagonist activity at histamine H1, H2, and H4 receptors
Gallois-Bernos AC, Thurmond RL
Journal of Receptor, Ligand and Channel Research , 2012, DOI: http://dx.doi.org/10.2147/JRLCR.S39369
Abstract: lcaftadine, a new antihistamine with combined antagonist activity at histamine H1, H2, and H4 receptors Original Research (944) Total Article Views Authors: Gallois-Bernos AC, Thurmond RL Published Date December 2012 Volume 2012:5 Pages 9 - 20 DOI: http://dx.doi.org/10.2147/JRLCR.S39369 Received: 19 October 2012 Accepted: 18 November 2012 Published: 20 December 2012 Annabelle C Gallois-Bernos,1 Robin L Thurmond2 1Johnson & Johnson Vision Care Inc, Jacksonville, FL, 2Janssen Research and Development, San Diego, CA, USA Abstract: Current therapy for ocular allergy includes H1 antihistamines, mast cell stabilizers, dual action antihistamines (H1 antihistamines + mast cell stabilizers), and steroids. In this report, we describe the in vivo and in vitro characterization of alcaftadine, a recently approved antihistamine that exhibits a distinct set of therapeutic properties. When tested in a guinea pig model of conjunctivitis, alcaftadine prevented immediate allergic responses with an efficacy comparable with that of ketotifen, and was also able to attenuate delayed eosinophil influx with a potency similar to that of dexamethasone. Given recent reports suggesting a possible role for histamine H2 or H4 receptors in the etiology of ocular allergy, we examined the binding properties of alcaftadine at all histamine receptor types. Alcaftadine is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. It also shows an higher affinity for the H2 receptor than ketotifen. Alcaftadine exhibited modest binding affinity for the H4 receptor (pKi = 5.8) with no affinity for the H3 receptor. The affinity for the H4 is higher than the value for ketotifen (pKi < 5). Using a cellular assay of H4 receptor activity, alcaftadine was shown to act as a functional antagonist of H4 receptor signaling. Overall, the studies suggest that alcaftadine is a histamine receptor antagonist with a broad spectrum of antihistamine activity and a unique combination of therapeutic effects. As such, it represents a new therapeutic option for the treatment of allergic conditions.
Alcaftadine, a new antihistamine with combined antagonist activity at histamine H1, H2, and H4 receptors
Gallois-Bernos AC,Thurmond RL
Journal of Receptor, Ligand and Channel Research , 2012,
Abstract: Annabelle C Gallois-Bernos,1 Robin L Thurmond21Johnson & Johnson Vision Care Inc, Jacksonville, FL, 2Janssen Research and Development, San Diego, CA, USAAbstract: Current therapy for ocular allergy includes H1 antihistamines, mast cell stabilizers, dual action antihistamines (H1 antihistamines + mast cell stabilizers), and steroids. In this report, we describe the in vivo and in vitro characterization of alcaftadine, a recently approved antihistamine that exhibits a distinct set of therapeutic properties. When tested in a guinea pig model of conjunctivitis, alcaftadine prevented immediate allergic responses with an efficacy comparable with that of ketotifen, and was also able to attenuate delayed eosinophil influx with a potency similar to that of dexamethasone. Given recent reports suggesting a possible role for histamine H2 or H4 receptors in the etiology of ocular allergy, we examined the binding properties of alcaftadine at all histamine receptor types. Alcaftadine is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. It also shows an higher affinity for the H2 receptor than ketotifen. Alcaftadine exhibited modest binding affinity for the H4 receptor (pKi = 5.8) with no affinity for the H3 receptor. The affinity for the H4 is higher than the value for ketotifen (pKi < 5). Using a cellular assay of H4 receptor activity, alcaftadine was shown to act as a functional antagonist of H4 receptor signaling. Overall, the studies suggest that alcaftadine is a histamine receptor antagonist with a broad spectrum of antihistamine activity and a unique combination of therapeutic effects. As such, it represents a new therapeutic option for the treatment of allergic conditions.Keywords: ocular, allergic conjunctivitis, antihistamine, ketotifen, pheniramine
Intense Long-Lived Fluorescence of 1,6-Diphenyl-1,3,5-Hexatriene: Emission from the S1-State Competes with Formation of O2 Contact Charge Transfer Complex  [PDF]
Katharina Hunger, Karl Kleinermanns
Open Journal of Physical Chemistry (OJPC) , 2013, DOI: 10.4236/ojpc.2013.31008
Abstract:

The fluorescence kinetics of 1,6-diphenyl-1,3,5-hexatriene (DPH) dissolved in cyclohexane was investigated as a function of temperature, concentration and 355 nm excitation pulse energy. At concentrations above 2.5 μM and excitation energies above 1 mJ a long-lived, very intense emission, which appears within less than 5 ns and lasts up to 70 ns, is observed. During the first 50 ns the decay does not follow an exponential but rather a linear behaviour. In oxygen saturated solutions the long-lived emission is suppressed and solely short-lived fluorescence with τ < 5 ns can be detected. A kinetic simulation was performed, based on a model whereupon the long-lived emission originates from the S1-state and competes with the formation of DPH-O2 contact charge-transfer complexes and intersystem crossing which both quench the fluorescence. Our investigations show that even the small amount of oxygen dissolved in nitrogen saturated solutions has a distinct influence on the fluorescence kinetics of DPH.

Visualising Conversation Structure across Time: Insights into Effective Doctor-Patient Consultations
Daniel Angus, Bernadette Watson, Andrew Smith, Cindy Gallois, Janet Wiles
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038014
Abstract: Effective communication between healthcare professionals and patients is critical to patients’ health outcomes. The doctor/patient dialogue has been extensively researched from different perspectives, with findings emphasising a range of behaviours that lead to effective communication. Much research involves self-reports, however, so that behavioural engagement cannot be disentangled from patients’ ratings of effectiveness. In this study we used a highly efficient and time economic automated computer visualisation measurement technique called Discursis to analyse conversational behaviour in consultations. Discursis automatically builds an internal language model from a transcript, mines the transcript for its conceptual content, and generates an interactive visual account of the discourse. The resultant visual account of the whole consultation can be analysed for patterns of engagement between interactants. The findings from this study show that Discursis is effective at highlighting a range of consultation techniques, including communication accommodation, engagement and repetition.
Caspase-like activities and UV-induced programmed cell death in Arabidopsis
Rotari V,Gordon A,He R,Gallois Patrick
BMC Plant Biology , 2005, DOI: 10.1186/1471-2229-5-s1-s18
Abstract:
Proteins with RNA Chaperone Activity: A World of Diverse Proteins with a Common Task—Impediment of RNA Misfolding
Katharina Semrad
Biochemistry Research International , 2011, DOI: 10.1155/2011/532908
Abstract: Proteins with RNA chaperone activity are ubiquitous proteins that play important roles in cellular mechanisms. They prevent RNA from misfolding by loosening misfolded structures without ATP consumption. RNA chaperone activity is studied in vitro and in vivo using oligonucleotide- or ribozyme-based assays. Due to their functional as well as structural diversity, a common chaperoning mechanism or universal motif has not yet been identified. A growing database of proteins with RNA chaperone activity has been established based on evaluation of chaperone activity via the described assays. Although the exact mechanism is not yet understood, it is more and more believed that disordered regions within proteins play an important role. This possible mechanism and which proteins were found to possess RNA chaperone activity are discussed here.
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