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Search Results: 1 - 10 of 1369 matches for " Kate Dinneen "
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Prognostic Significance of Deregulated Dicer Expression in Breast Cancer
Emer Caffrey, Helen Ingoldsby, Deirdre Wall, Mark Webber, Kate Dinneen, Laura S. Murillo, Celine Inderhaug, John Newell, Sanjeev Gupta, Grace Callagy
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083724
Abstract: Background Dicer, an RNase III-type endonuclease, is the key enzyme involved in RNA interference and microRNA pathways. Aberrant expression of Dicer is reported in several human cancers. Our aim was to assess the prognostic role of Dicer in breast cancer. Methods The entire series comprised 666 invasive breast cancers (IBCs), 480 DCIS cases (397 associated with IBC and 83 pure DCIS) and 305 lymph node metastases. Cytoplasmic Dicer expression by immunohistochemistry was scored as negative (no staining) and positive (weak, moderate or strong staining). Results Dicer staining was assessable in 446 IBC, 128 DCIS and 101 lymph node metastases. Expression of Dicer was observed in 33% (145/446) of IBCs, 34% (44/128) of DCIS and 57% (58/101) of lymph node metastases. Dicer expression was increased in nodal metastases compared to primary tumours (p<0.001); and was associated with ER negativity (p<0.001), HER2 positivity (p<0.001), high Ki67 labeling index (p<0.001) and expression of basal-like biomarkers (p = 0.002). Dicer positivity was more frequent in the HER2 overexpressing (p<0.001) and basal-like (p = 0.002) subtypes compared to luminal A subtype. Dicer expression was associated with reduced overall survival (OS) on univariate analysis (p = 0.058) and remained an independent predictor of OS on multivariate analysis (HR 2.84, 95% CI 1.43–5.62, p = 0.003), with nodal status (HR 2.61, 95% CI 1.18–5.80, p = 0.018) and PR (HR 0.28, 95% CI 0.13–0.59, p = 0.001). Further, moderate or strong expression of Dicer was associated with improved disease-free survival in the HER2-overexpressing subtype compared to negative or weak expression (p = 0.038). Conclusion Deregulated Dicer expression is associated with aggressive tumour characteristics and is an independent prognostic factor for OS. Our findings suggest that Dicer is an important prognostic marker in breast cancer and that its prognostic role may be subtype specific.
The complexity of broadcasting in bounded-degree networks
Michael J. Dinneen
Mathematics , 1994,
Abstract: Broadcasting concerns the dissemination of a message originating at one node of a network to all other nodes. This task is accomplished by placing a series of calls over the communication lines of the network between neighboring nodes, where each call requires a unit of time and a call can involve only two nodes. We show that for bounded-degree networks determining the minimum broadcast time from an originating node remains NP-complete.
VLSI layouts and DNA physical mappings
Michael J. Dinneen
Mathematics , 1995,
Abstract: We show that an important problem ($k$-ICG) in computational biology is equivalent to a colored version of a well-known graph layout problem ($k$-CVS).
Bringing Back the Body into Positive Psychology: The Theory of Corporeal Posttraumatic Growth in Breast Cancer Survivorship  [PDF]
Kate Hefferon
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.312A183
Abstract:

Objective: Posttraumatic growth (PTG) is the phenomenon of surpassing levels of functioning than which existed before a traumatic event occurred. The objective of this study was to assess how the body may have had an influence on the facilitation, and as an outcome, of PTG. Methods: 83 female breast cancer survivors, 5 years post cancer diagnosis, were interviewed on their long-term experience of physical activity engagement. Inductive thematic analysis was used in order to ascertain whether or not there were any serendipitous expressions of posttraumatic growth. Results: 24% (n = 20) of the study mentioned experiencing some form of PTG, including both generic and corporeal specific domains. Of those that reported PTG, 70% were from the original physical activity intervention group indicating potential links between activity participation during cancer treatment and long term PTG. Discussion: The results support the theoretical viewpoint that recovery from physical illness may have a unique PTG journey in comparison to more cognitive/external sources of trauma. Conclusions: This is the first study to qualitatively collect longitudinal data from a large and unique sample on the experience of PTG following breast cancer survivorship. Furthermore, the author has coined this new addition of a more embodied experience of PTG, the theory of ‘Corporeal Posttraumatic Growth’ and presents suggestions for future research.

New results for the degree/diameter problem
Michael J. Dinneen,Paul R. Hafner
Mathematics , 1995,
Abstract: The results of computer searches for large graphs with given (small) degree and diameter are presented. The new graphs are Cayley graphs of semidirect products of cyclic groups and related groups. One fundamental use of our ``dense graphs'' is in the design of efficient communication network topologies.
Suprafibrillar structures of collagen, evidence for local organization and auxetic behaviour in architectures  [PDF]
Kate Patten, Tim Wess
Journal of Biophysical Chemistry (JBPC) , 2013, DOI: 10.4236/jbpc.2013.43014
Abstract: The suprafibrillar organisation of collagen rich tissues is the keystone to the diversity of resultant structures made from relatively similar materials. The local organisation between fibrils may be essential to suprafibril structures that are critical to functionality such as transparency in cornea, where specific lateral relationships between fibrils dictate optical properties. Here we show that corneal X-ray diffraction combined with mechanical strains to disrupt a specific suprafibrillar relationship between fibrils evidence and a coherent staggered axial relationship between collagen fibrils. The data also shows evidence for auxetic behavior of the collagen fibrils and reveals a 120 nm diffraction feature previously unreported in collagen tissues. The results show that suprafibrillar organisation can be an essential component in tissue architecture that has hitherto been ignored, but now must be considered in mechanical and structural models.
The Impact of Statin Intolerance in Lipid Clinic Patients  [PDF]
Kate Williams, Vinita Mishra
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.65040
Abstract:
Context: Cardiovascular disease is a very common and serious problem in the western world. Statin drug therapy is used in primary, secondary prevention and familial hypercholesterolemia. However, these are frequently associated with adverse effects, causing poor adherence and thus putting patients at risk for future cardiovascular events. Aim: The objective of this study was to review the statin intolerance in lipid patients and to assess the impact of alternative lipid lowering therapy on lipid parameters and cardiovascular outcome in statin intolerant patients. Methodology: 50 patients attending the out-patient lipid clinic of our hospital with statin intolerance were identified. Clinical data on the study patients were gathered retrospectively relating to statin intolerance and the clinical effectiveness of alternative lipid lowering therapy on lipid parameters and cardiovascular outcome. Results: Rosuvastatin was the most intolerable whereas pravastatin or fluvastatin was the most tolerable statin in our study patients. Myalgia was the commonly reported adverse effect of statin. The low dose statin monotherapy or combination of low dose statin and ezetemibe was the most tolerable alternative lipid lowering therapy in statin intolerant patients. After an average period of 10 months of initiation of alternative lipid lowering therapy; combination of low dose statin plus ezetimibe showed the largest reduction in serum total cholesterol and low-density lipoprotein (LDL) cholesterol levels. Conclusions: Pravastatin should be preferred in statin intolerant patients. A combination of low dose statin plus ezetimibe appeared to be the most tolerable and clinically effective therapy in statin intolerant patients.
The Psychosocial Impact and Value of Participating in a Storytelling Intervention for Patients Diagnosed with Cancer: An Integrative Review  [PDF]
Andrew Soundy, Kate Reid
Open Journal of Therapy and Rehabilitation (OJTR) , 2019, DOI: 10.4236/ojtr.2019.72004
Abstract: Background: Interventions have recently been developed to test the therapeutic value of storytelling for people with cancer. This evidence includes different designs, as a result an integrative review is needed that can determine the impact and value of storytelling interventions for people with cancer. Aims: To undertake an integrative review of evidence identifying the impact and outcomes from storytelling interventions for people with cancer. Methods: An integrative review of group based storytelling interventions using a qualitative led-synthesis. Results: Eleven studies were identified with a total of 493 (49 female, 16 male, 428 not disclosed) people included. Two major themes were identified: 1) content of interaction and
Edge- and Node-Disjoint Paths in P Systems
Michael J. Dinneen,Yun-Bum Kim,Radu Nicolescu
Electronic Proceedings in Theoretical Computer Science , 2010, DOI: 10.4204/eptcs.40.9
Abstract: In this paper, we continue our development of algorithms used for topological network discovery. We present native P system versions of two fundamental problems in graph theory: finding the maximum number of edge- and node-disjoint paths between a source node and target node. We start from the standard depth-first-search maximum flow algorithms, but our approach is totally distributed, when initially no structural information is available and each P system cell has to even learn its immediate neighbors. For the node-disjoint version, our P system rules are designed to enforce node weight capacities (of one), in addition to edge capacities (of one), which are not readily available in the standard network flow algorithms.
New Solutions to the Firing Squad Synchronization Problems for Neural and Hyperdag P Systems
Michael J. Dinneen,Yun-Bum Kim,Radu Nicolescu
Electronic Proceedings in Theoretical Computer Science , 2009, DOI: 10.4204/eptcs.11.7
Abstract: We propose two uniform solutions to an open question: the Firing Squad Synchronization Problem (FSSP), for hyperdag and symmetric neural P systems, with anonymous cells. Our solutions take e_c+5 and 6e_c+7 steps, respectively, where e_c is the eccentricity of the commander cell of the dag or digraph underlying these P systems. The first and fast solution is based on a novel proposal, which dynamically extends P systems with mobile channels. The second solution is substantially longer, but is solely based on classical rules and static channels. In contrast to the previous solutions, which work for tree-based P systems, our solutions synchronize to any subset of the underlying digraph; and do not require membrane polarizations or conditional rules, but require states, as typically used in hyperdag and neural P systems.
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